SIMILAR PATTERNS OF AMINO ACIDS FOR 6BAA_H_GBMH2001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli)
PF01274
(Malate_synthase)
3 LEU A 494
THR A 451
ASN A 450
None
0.72A 6baaH-1d8cA:
0.3
6baaH-1d8cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A 264
THR A 371
ASN A 370
None
0.66A 6baaH-1evjA:
0.0
6baaH-1evjA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
3 LEU A 181
THR A 190
ASN A 194
None
0.73A 6baaH-1exfA:
0.0
6baaH-1exfA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max)
PF00190
(Cupin_1)
3 LEU A 338
THR A  66
ASN A  67
None
0.73A 6baaH-1fxzA:
0.0
6baaH-1fxzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli)
no annotation 3 LEU Y 272
THR Y  80
ASN Y  81
None
0.68A 6baaH-1gllY:
undetectable
6baaH-1gllY:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE


(Sus scrofa)
PF00342
(PGI)
3 LEU A 161
THR A 217
ASN A 220
None
PA5  A 600 ( 4.3A)
None
0.68A 6baaH-1gzvA:
0.0
6baaH-1gzvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h67 CALPONIN ALPHA

(Gallus gallus)
PF00307
(CH)
3 LEU A  92
THR A 115
ASN A 114
None
0.64A 6baaH-1h67A:
undetectable
6baaH-1h67A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 LEU A 316
THR A 423
ASN A 422
None
0.59A 6baaH-1h6dA:
0.0
6baaH-1h6dA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE


(Escherichia
virus T4)
PF09198
(T4-Gluco-transf)
3 LEU A 306
THR A 273
ASN A 247
None
0.70A 6baaH-1jiuA:
0.0
6baaH-1jiuA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE


(Homo sapiens)
PF00300
(His_Phos_1)
PF01591
(6PF2K)
3 LEU A 422
THR A 445
ASN A 444
None
0.67A 6baaH-1k6mA:
2.9
6baaH-1k6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
3 LEU A  16
THR A 110
ASN A 109
None
0.50A 6baaH-1nvtA:
undetectable
6baaH-1nvtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus)
PF00285
(Citrate_synt)
3 LEU A 340
THR A  16
ASN A  17
None
0.69A 6baaH-1o7xA:
undetectable
6baaH-1o7xA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB


(Escherichia
coli)
PF08501
(Shikimate_dh_N)
3 LEU A  12
THR A 106
ASN A 105
None
0.58A 6baaH-1o9bA:
undetectable
6baaH-1o9bA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE


(Staphylococcus
aureus)
PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1)
3 LEU A 620
THR A 692
ASN A 695
None
0.71A 6baaH-1qu2A:
0.2
6baaH-1qu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz2 CONSERVED
HYPOTHETICAL PROTEIN
BA4783


(Bacillus
anthracis)
PF04203
(Sortase)
3 LEU A 166
THR A 135
ASN A 134
None
0.73A 6baaH-1rz2A:
undetectable
6baaH-1rz2A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 LEU A 244
THR A 217
ASN A 218
None
0.65A 6baaH-1si8A:
undetectable
6baaH-1si8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE


(Bacillus
subtilis)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 LEU X 145
THR X 335
ASN X 334
None
0.71A 6baaH-1u8xX:
undetectable
6baaH-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE


(Bacillus
subtilis)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 LEU X 168
THR X 335
ASN X 334
None
0.67A 6baaH-1u8xX:
undetectable
6baaH-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE


(Pyrococcus
furiosus)
PF04587
(ADP_PFK_GK)
3 LEU A 145
THR A  31
ASN A  32
None
None
GLC  A1457 ( 3.5A)
0.72A 6baaH-1ua4A:
undetectable
6baaH-1ua4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima)
PF01523
(PmbA_TldD)
3 LEU A  83
THR A 156
ASN A 155
None
0.74A 6baaH-1vl4A:
undetectable
6baaH-1vl4A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
3 LEU A 123
THR A  97
ASN A  96
None
0.69A 6baaH-1we5A:
undetectable
6baaH-1we5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Pseudomonas
aeruginosa)
PF05690
(ThiG)
3 LEU A1152
THR A1080
ASN A1079
None
0.71A 6baaH-1wv2A:
undetectable
6baaH-1wv2A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B)
PF00680
(RdRP_1)
3 LEU A 351
THR A  68
ASN A  67
None
0.71A 6baaH-1xr5A:
undetectable
6baaH-1xr5A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A


(Escherichia
coli)
PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C)
3 LEU A 165
THR A 178
ASN A 328
None
0.66A 6baaH-1zvuA:
2.3
6baaH-1zvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major)
PF01008
(IF-2B)
3 LEU A 282
THR A 187
ASN A 186
None
0.71A 6baaH-2a0uA:
0.6
6baaH-2a0uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa)
PF02274
(Amidinotransf)
3 LEU A  41
THR A 167
ASN A 178
CYR  A 406 ( 4.5A)
None
None
0.72A 6baaH-2aafA:
undetectable
6baaH-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE


(Neisseria
meningitidis)
PF03807
(F420_oxidored)
PF14748
(P5CR_dimer)
3 LEU A 175
THR A 113
ASN A 112
None
NAP  A 311 ( 4.7A)
None
0.72A 6baaH-2ag8A:
undetectable
6baaH-2ag8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 LEU A 196
THR A 282
ASN A 283
None
0.70A 6baaH-2cgjA:
undetectable
6baaH-2cgjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mus musculus)
PF00342
(PGI)
3 LEU A 162
THR A 218
ASN A 221
None
PO4  A1601 ( 4.7A)
None
0.72A 6baaH-2cxnA:
undetectable
6baaH-2cxnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 LEU A 269
THR A  78
ASN A  79
None
0.73A 6baaH-2dpnA:
undetectable
6baaH-2dpnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28


(Saccharomyces
cerevisiae)
PF12796
(Ank_2)
no annotation
3 LEU B 371
THR A 104
ASN A 105
None
0.66A 6baaH-2dznB:
undetectable
6baaH-2dznB:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
3 LEU A 658
THR A 576
ASN A 575
None
0.61A 6baaH-2eaeA:
2.5
6baaH-2eaeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE


(Geobacillus
kaustophilus)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
3 LEU A  28
THR A 122
ASN A 121
None
0.62A 6baaH-2eggA:
undetectable
6baaH-2eggA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enq PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM


(Homo sapiens)
PF00792
(PI3K_C2)
3 LEU A  99
THR A  50
ASN A  49
None
0.67A 6baaH-2enqA:
undetectable
6baaH-2enqA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
3 LEU A 119
THR A  58
ASN A  61
None
0.70A 6baaH-2fckA:
undetectable
6baaH-2fckA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmy CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1


(Carboxydothermus
hydrogenoformans)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
3 LEU A 198
THR A 130
ASN A 133
None
0.51A 6baaH-2fmyA:
undetectable
6baaH-2fmyA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmy CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1


(Carboxydothermus
hydrogenoformans)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
3 LEU A 214
THR A 130
ASN A 133
None
0.73A 6baaH-2fmyA:
undetectable
6baaH-2fmyA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN


(Pedobacter
heparinus)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
3 LEU A 550
THR A 607
ASN A 606
None
0.72A 6baaH-2fuqA:
0.5
6baaH-2fuqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1


(Homo sapiens)
PF03807
(F420_oxidored)
PF14748
(P5CR_dimer)
3 LEU A 185
THR A 124
ASN A 123
None
0.73A 6baaH-2gerA:
undetectable
6baaH-2gerA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
3 LEU A 245
THR A 107
ASN A 106
None
0.73A 6baaH-2gmhA:
undetectable
6baaH-2gmhA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis)
PF01274
(Malate_synthase)
3 LEU A 501
THR A 458
ASN A 457
None
0.69A 6baaH-2gq3A:
undetectable
6baaH-2gq3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1


(Homo sapiens)
PF03807
(F420_oxidored)
PF14748
(P5CR_dimer)
3 LEU A 185
THR A 124
ASN A 123
None
0.63A 6baaH-2gr9A:
undetectable
6baaH-2gr9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE


(Homo sapiens)
PF00171
(Aldedh)
3 LEU A 487
THR A 538
ASN A 537
None
0.67A 6baaH-2h5gA:
2.0
6baaH-2h5gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hna PROTEIN MIOC

(Escherichia
coli)
PF00258
(Flavodoxin_1)
3 LEU A 109
THR A  56
ASN A  65
None
0.62A 6baaH-2hnaA:
undetectable
6baaH-2hnaA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 LEU A 585
THR A 335
ASN A 338
None
0.73A 6baaH-2j5cA:
undetectable
6baaH-2j5cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE


([Candida]
boidinii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 LEU A 180
THR A 256
ASN A 255
None
0.65A 6baaH-2j6iA:
undetectable
6baaH-2j6iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
3 LEU A 206
THR A 191
ASN A 190
None
0.74A 6baaH-2jg5A:
undetectable
6baaH-2jg5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jov HYPOTHETICAL PROTEIN
CPE0013


(Clostridium
perfringens)
PF07892
(DUF1667)
3 LEU A  41
THR A  63
ASN A  59
None
0.65A 6baaH-2jovA:
undetectable
6baaH-2jovA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B


(Staphylococcus
aureus)
PF05031
(NEAT)
3 LEU A 207
THR A 179
ASN A 262
None
0.71A 6baaH-2moqA:
undetectable
6baaH-2moqA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N)
3 LEU A  28
THR A  69
ASN A  68
None
0.70A 6baaH-2o1sA:
undetectable
6baaH-2o1sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00342
(PGI)
3 LEU A 210
THR A 266
ASN A 269
None
G6Q  A5001 ( 4.7A)
None
0.72A 6baaH-2o2cA:
undetectable
6baaH-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
3 LEU A 221
THR A 257
ASN A 260
None
0.65A 6baaH-2og2A:
3.3
6baaH-2og2A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pli UNCHARACTERIZED
PROTEIN


(Neisseria
meningitidis)
PF03471
(CorC_HlyC)
3 LEU A  82
THR A  34
ASN A  29
None
0.68A 6baaH-2pliA:
undetectable
6baaH-2pliA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE


(Salmonella
enterica)
PF00753
(Lactamase_B)
PF16123
(HAGH_C)
3 LEU A 207
THR A 168
ASN A 171
None
0.68A 6baaH-2qedA:
undetectable
6baaH-2qedA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA


(-)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 LEU A 367
THR A  31
ASN A  21
None
0.73A 6baaH-2qgyA:
0.5
6baaH-2qgyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae)
PF00756
(Esterase)
3 LEU A 119
THR A  74
ASN A  73
None
None
EDO  A1261 (-3.5A)
0.68A 6baaH-2uz0A:
undetectable
6baaH-2uz0A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE


(Plasmodium
falciparum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 LEU A 273
THR A  80
ASN A  81
None
0.69A 6baaH-2w40A:
undetectable
6baaH-2w40A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF


(Thermotoga
maritima)
PF00977
(His_biosynth)
3 LEU A  49
THR A  28
ASN A  27
None
0.71A 6baaH-2w6rA:
undetectable
6baaH-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF


(Thermotoga
maritima)
PF00977
(His_biosynth)
3 LEU A 175
THR A 154
ASN A 153
None
0.62A 6baaH-2w6rA:
undetectable
6baaH-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00342
(PGI)
3 LEU A 162
THR A 218
ASN A 221
None
0.73A 6baaH-2wu8A:
0.6
6baaH-2wu8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
3 LEU A 328
THR A 323
ASN A 324
None
0.53A 6baaH-2xdrA:
undetectable
6baaH-2xdrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E2 ENVELOPE
GLYCOPROTEIN


(Chikungunya
virus)
PF00943
(Alpha_E2_glycop)
3 LEU B 312
THR B 294
ASN B 295
None
0.60A 6baaH-2xfbB:
undetectable
6baaH-2xfbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE


(Burkholderia
cenocepacia)
PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2)
3 LEU A  21
THR A 112
ASN A 115
None
0.51A 6baaH-2y27A:
undetectable
6baaH-2y27A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN


(Thermotoga
maritima)
PF01887
(SAM_adeno_trans)
3 LEU A 195
THR A 185
ASN A 186
None
0.56A 6baaH-2zbvA:
undetectable
6baaH-2zbvA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE


(Sphingomonas
paucimobilis)
PF13577
(SnoaL_4)
3 LEU A  21
THR A 133
ASN A 134
None
SPD  A 300 (-4.0A)
None
0.74A 6baaH-3a76A:
undetectable
6baaH-3a76A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj6 MAIN HEMAGGLUTININ
COMPONENT


(Clostridium
botulinum)
no annotation 3 LEU A 147
THR A   4
ASN A   5
None
0.72A 6baaH-3aj6A:
undetectable
6baaH-3aj6A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN


(Lactobacillus
plantarum)
no annotation 3 LEU A 123
THR A  13
ASN A  14
None
None
SO4  A 146 (-2.9A)
0.59A 6baaH-3ba3A:
undetectable
6baaH-3ba3A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE


(Plectranthus
scutellarioides)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 LEU A 192
THR A 181
ASN A 182
None
0.65A 6baaH-3bazA:
undetectable
6baaH-3bazA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)


(Rattus
norvegicus)
PF00300
(His_Phos_1)
PF01591
(6PF2K)
3 LEU A 420
THR A 443
ASN A 442
None
0.59A 6baaH-3bifA:
undetectable
6baaH-3bifA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans)
no annotation 3 LEU A 501
THR A 583
ASN A 586
None
0.55A 6baaH-3c2gA:
2.4
6baaH-3c2gA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF04051
(TRAPP)
3 LEU D  67
THR D  22
ASN D  20
None
0.74A 6baaH-3cueD:
undetectable
6baaH-3cueD:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
acetivorans)
PF00005
(ABC_tran)
PF03459
(TOBE)
3 LEU A 120
THR A 162
ASN A 165
None
0.71A 6baaH-3d31A:
6.0
6baaH-3d31A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9i RNA-BINDING PROTEIN
16


(Homo sapiens)
PF04818
(CTD_bind)
3 LEU A  11
THR A  95
ASN A  98
None
0.73A 6baaH-3d9iA:
undetectable
6baaH-3d9iA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2
PROTEIN VP3


(Rhinovirus A)
PF00073
(Rhv)
3 LEU B 180
THR C 226
ASN C 227
None
0.71A 6baaH-3dprB:
undetectable
6baaH-3dprB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN


(Pseudomonas
aeruginosa)
PF03349
(Toluene_X)
3 LEU X 424
THR X  85
ASN X  86
None
0.71A 6baaH-3dwoX:
undetectable
6baaH-3dwoX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN


(Homo sapiens)
PF08324
(PUL)
3 LEU A 596
THR A 662
ASN A 665
None
0.64A 6baaH-3ebbA:
undetectable
6baaH-3ebbA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 LEU A 271
THR A  79
ASN A  80
None
0.74A 6baaH-3g25A:
undetectable
6baaH-3g25A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea)
PF00704
(Glyco_hydro_18)
3 LEU A 375
THR A 256
ASN A 257
None
0.62A 6baaH-3g6lA:
undetectable
6baaH-3g6lA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gh8 IODOTYROSINE
DEHALOGENASE 1


(Mus musculus)
PF00881
(Nitroreductase)
3 LEU A 258
THR A 174
ASN A 175
None
TYI  A 302 ( 3.7A)
None
0.67A 6baaH-3gh8A:
undetectable
6baaH-3gh8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III


(Burkholderia
pseudomallei)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
3 LEU A 155
THR A  45
ASN A 274
None
0.73A 6baaH-3gweA:
undetectable
6baaH-3gweA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)


(Corynebacterium
glutamicum)
PF13377
(Peripla_BP_3)
3 LEU A 250
THR A 272
ASN A 271
None
0.66A 6baaH-3gybA:
undetectable
6baaH-3gybA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
3 LEU A 295
THR A  83
ASN A  82
None
0.64A 6baaH-3h5oA:
undetectable
6baaH-3h5oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
3 LEU A 161
THR A 216
ASN A 219
None
0.72A 6baaH-3hjbA:
undetectable
6baaH-3hjbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1


(Thermus
thermophilus)
PF02074
(Peptidase_M32)
3 LEU A 402
THR A 431
ASN A 434
None
0.54A 6baaH-3hoaA:
2.0
6baaH-3hoaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori)
PF04371
(PAD_porph)
3 LEU A 181
THR A 203
ASN A 155
None
0.74A 6baaH-3hvmA:
undetectable
6baaH-3hvmA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis)
PF00521
(DNA_topoisoIV)
3 LEU A 174
THR A 187
ASN A 344
None
0.61A 6baaH-3ilwA:
undetectable
6baaH-3ilwA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2)
no annotation 3 LEU A   7
THR A 219
ASN A 218
None
0.73A 6baaH-3im0A:
undetectable
6baaH-3im0A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 LEU A 195
THR A 171
ASN A 125
CSO  A 191 ( 3.5A)
None
None
0.73A 6baaH-3iv0A:
0.0
6baaH-3iv0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF08501
(Shikimate_dh_N)
3 LEU A   9
THR A 109
ASN A 108
None
0.74A 6baaH-3jyoA:
undetectable
6baaH-3jyoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi)
PF13614
(AAA_31)
3 LEU A 173
THR A 131
ASN A 132
None
0.46A 6baaH-3k9hA:
2.5
6baaH-3k9hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
3 LEU A 744
THR A 733
ASN A 734
None
0.62A 6baaH-3l2pA:
undetectable
6baaH-3l2pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Allochromatium
vinosum)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
3 LEU B1352
THR A  89
ASN A  95
None
0.64A 6baaH-3myrB:
undetectable
6baaH-3myrB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
3 LEU A 293
THR A 255
ASN A 254
None
GOL  A 516 (-4.3A)
None
0.73A 6baaH-3mzbA:
undetectable
6baaH-3mzbA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
3 LEU A 160
THR A 215
ASN A 218
None
0.72A 6baaH-3nbuA:
undetectable
6baaH-3nbuA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus)
PF00079
(Serpin)
3 LEU A  92
THR A   8
ASN A  11
None
0.74A 6baaH-3ndaA:
undetectable
6baaH-3ndaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
3 LEU A 427
THR A 277
ASN A 276
None
0.71A 6baaH-3o9pA:
undetectable
6baaH-3o9pA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN


(Parabacteroides
distasonis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 LEU A 200
THR A 206
ASN A 269
None
0.55A 6baaH-3otnA:
undetectable
6baaH-3otnA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Francisella
tularensis)
PF00342
(PGI)
3 LEU A 150
THR A 206
ASN A 209
None
RI2  A 601 ( 4.6A)
None
0.72A 6baaH-3q88A:
undetectable
6baaH-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00342
(PGI)
3 LEU A 161
THR A 239
ASN A 242
None
0.66A 6baaH-3qkiA:
undetectable
6baaH-3qkiA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1


(Saccharomyces
cerevisiae)
PF16782
(SIL1)
3 LEU C 261
THR C 347
ASN C 350
None
0.73A 6baaH-3qmlC:
0.5
6baaH-3qmlC:
11.22