SIMILAR PATTERNS OF AMINO ACIDS FOR 6BAA_G_GBMG2001_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d8c | MALATE SYNTHASE G (Escherichiacoli) |
PF01274(Malate_synthase) | 3 | LEU A 494THR A 451ASN A 450 | None | 0.71A | 6baaG-1d8cA:0.4 | 6baaG-1d8cA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evj | GLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 264THR A 371ASN A 370 | None | 0.66A | 6baaG-1evjA:0.0 | 6baaG-1evjA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1exf | EXFOLIATVE TOXIN A (Staphylococcusaureus) |
PF13365(Trypsin_2) | 3 | LEU A 181THR A 190ASN A 194 | None | 0.73A | 6baaG-1exfA:undetectable | 6baaG-1exfA:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxz | GLYCININ G1 (Glycine max) |
PF00190(Cupin_1) | 3 | LEU A 338THR A 66ASN A 67 | None | 0.73A | 6baaG-1fxzA:0.0 | 6baaG-1fxzA:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gll | GLYCEROL KINASE (Escherichiacoli) |
no annotation | 3 | LEU Y 272THR Y 80ASN Y 81 | None | 0.68A | 6baaG-1gllY:undetectable | 6baaG-1gllY:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzv | GLUCOSE-6-PHOSPHATEISOMERASE (Sus scrofa) |
PF00342(PGI) | 3 | LEU A 161THR A 217ASN A 220 | NonePA5 A 600 ( 4.3A)None | 0.67A | 6baaG-1gzvA:0.0 | 6baaG-1gzvA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h67 | CALPONIN ALPHA (Gallus gallus) |
PF00307(CH) | 3 | LEU A 92THR A 115ASN A 114 | None | 0.64A | 6baaG-1h67A:undetectable | 6baaG-1h67A:4.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 316THR A 423ASN A 422 | None | 0.59A | 6baaG-1h6dA:0.0 | 6baaG-1h6dA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jiu | DNABETA-GLUCOSYLTRANSFERASE (Escherichiavirus T4) |
PF09198(T4-Gluco-transf) | 3 | LEU A 306THR A 273ASN A 247 | None | 0.70A | 6baaG-1jiuA:0.0 | 6baaG-1jiuA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k6m | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BIPHOSPHATASE2-PHOSPHATASE (Homo sapiens) |
PF00300(His_Phos_1)PF01591(6PF2K) | 3 | LEU A 422THR A 445ASN A 444 | None | 0.67A | 6baaG-1k6mA:undetectable | 6baaG-1k6mA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvt | SHIKIMATE5'-DEHYDROGENASE (Methanocaldococcusjannaschii) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 3 | LEU A 16THR A 110ASN A 109 | None | 0.50A | 6baaG-1nvtA:undetectable | 6baaG-1nvtA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7x | CITRATE SYNTHASE (Sulfolobussolfataricus) |
PF00285(Citrate_synt) | 3 | LEU A 340THR A 16ASN A 17 | None | 0.69A | 6baaG-1o7xA:undetectable | 6baaG-1o7xA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9b | HYPOTHETICALSHIKIMATE5-DEHYDROGENASE-LIKEPROTEIN YDIB (Escherichiacoli) |
PF08501(Shikimate_dh_N) | 3 | LEU A 12THR A 106ASN A 105 | None | 0.58A | 6baaG-1o9bA:undetectable | 6baaG-1o9bA:10.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 3 | LEU A 620THR A 692ASN A 695 | None | 0.71A | 6baaG-1qu2A:undetectable | 6baaG-1qu2A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rz2 | CONSERVEDHYPOTHETICAL PROTEINBA4783 (Bacillusanthracis) |
PF04203(Sortase) | 3 | LEU A 166THR A 135ASN A 134 | None | 0.73A | 6baaG-1rz2A:undetectable | 6baaG-1rz2A:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1si8 | CATALASE (Enterococcusfaecalis) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | LEU A 244THR A 217ASN A 218 | None | 0.65A | 6baaG-1si8A:undetectable | 6baaG-1si8A:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8x | MALTOSE-6'-PHOSPHATEGLUCOSIDASE (Bacillussubtilis) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | LEU X 145THR X 335ASN X 334 | None | 0.71A | 6baaG-1u8xX:undetectable | 6baaG-1u8xX:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8x | MALTOSE-6'-PHOSPHATEGLUCOSIDASE (Bacillussubtilis) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | LEU X 168THR X 335ASN X 334 | None | 0.67A | 6baaG-1u8xX:undetectable | 6baaG-1u8xX:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua4 | ADP-DEPENDENTGLUCOKINASE (Pyrococcusfuriosus) |
PF04587(ADP_PFK_GK) | 3 | LEU A 145THR A 31ASN A 32 | NoneNoneGLC A1457 ( 3.5A) | 0.72A | 6baaG-1ua4A:2.0 | 6baaG-1ua4A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl4 | PMBA-RELATED PROTEIN (Thermotogamaritima) |
PF01523(PmbA_TldD) | 3 | LEU A 83THR A 156ASN A 155 | None | 0.75A | 6baaG-1vl4A:undetectable | 6baaG-1vl4A:14.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1we5 | PUTATIVE FAMILY 31GLUCOSIDASE YICI (Escherichiacoli) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | LEU A 123THR A 97ASN A 96 | None | 0.70A | 6baaG-1we5A:undetectable | 6baaG-1we5A:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wv2 | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Pseudomonasaeruginosa) |
PF05690(ThiG) | 3 | LEU A1152THR A1080ASN A1079 | None | 0.71A | 6baaG-1wv2A:undetectable | 6baaG-1wv2A:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr5 | GENOME POLYPROTEIN (Rhinovirus B) |
PF00680(RdRP_1) | 3 | LEU A 351THR A 68ASN A 67 | None | 0.71A | 6baaG-1xr5A:undetectable | 6baaG-1xr5A:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvu | TOPOISOMERASE IVSUBUNIT A (Escherichiacoli) |
PF00521(DNA_topoisoIV)PF03989(DNA_gyraseA_C) | 3 | LEU A 165THR A 178ASN A 328 | None | 0.66A | 6baaG-1zvuA:undetectable | 6baaG-1zvuA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0u | INITIATION FACTOR 2B (Leishmaniamajor) |
PF01008(IF-2B) | 3 | LEU A 282THR A 187ASN A 186 | None | 0.71A | 6baaG-2a0uA:0.7 | 6baaG-2a0uA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaf | ARGININE DEIMINASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 3 | LEU A 41THR A 167ASN A 178 | CYR A 406 ( 4.5A)NoneNone | 0.73A | 6baaG-2aafA:undetectable | 6baaG-2aafA:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ag8 | PYRROLINE-5-CARBOXYLATE REDUCTASE (Neisseriameningitidis) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 3 | LEU A 175THR A 113ASN A 112 | NoneNAP A 311 ( 4.7A)None | 0.72A | 6baaG-2ag8A:undetectable | 6baaG-2ag8A:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cgj | L-RHAMNULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | LEU A 196THR A 282ASN A 283 | None | 0.70A | 6baaG-2cgjA:undetectable | 6baaG-2cgjA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxn | GLUCOSE-6-PHOSPHATEISOMERASE (Mus musculus) |
PF00342(PGI) | 3 | LEU A 162THR A 218ASN A 221 | NonePO4 A1601 ( 4.7A)None | 0.72A | 6baaG-2cxnA:undetectable | 6baaG-2cxnA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpn | GLYCEROL KINASE (Thermusthermophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | LEU A 269THR A 78ASN A 79 | None | 0.73A | 6baaG-2dpnA:0.0 | 6baaG-2dpnA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dzn | 26S PROTEASEREGULATORY SUBUNIT6B HOMOLOGPROBABLE 26SPROTEASOMEREGULATORY SUBUNITP28 (Saccharomycescerevisiae) |
PF12796(Ank_2)no annotation | 3 | LEU B 371THR A 104ASN A 105 | None | 0.66A | 6baaG-2dznB:undetectable | 6baaG-2dznB:4.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 3 | LEU A 658THR A 576ASN A 575 | None | 0.61A | 6baaG-2eaeA:2.4 | 6baaG-2eaeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2egg | SHIKIMATE5-DEHYDROGENASE (Geobacilluskaustophilus) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 3 | LEU A 28THR A 122ASN A 121 | None | 0.62A | 6baaG-2eggA:undetectable | 6baaG-2eggA:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2enq | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT ALPHAISOFORM (Homo sapiens) |
PF00792(PI3K_C2) | 3 | LEU A 99THR A 50ASN A 49 | None | 0.68A | 6baaG-2enqA:undetectable | 6baaG-2enqA:7.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fck | RIBOSOMAL-PROTEIN-SERINEACETYLTRANSFERASE,PUTATIVE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 3 | LEU A 119THR A 58ASN A 61 | None | 0.70A | 6baaG-2fckA:undetectable | 6baaG-2fckA:8.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmy | CARBON MONOXIDEOXIDATION SYSTEMTRANSCRIPTIONREGULATOR COOA-1 (Carboxydothermushydrogenoformans) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 3 | LEU A 198THR A 130ASN A 133 | None | 0.51A | 6baaG-2fmyA:undetectable | 6baaG-2fmyA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmy | CARBON MONOXIDEOXIDATION SYSTEMTRANSCRIPTIONREGULATOR COOA-1 (Carboxydothermushydrogenoformans) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 3 | LEU A 214THR A 130ASN A 133 | None | 0.73A | 6baaG-2fmyA:undetectable | 6baaG-2fmyA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 3 | LEU A 550THR A 607ASN A 606 | None | 0.72A | 6baaG-2fuqA:0.5 | 6baaG-2fuqA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ger | PYRROLINE-5-CARBOXYLATE REDUCTASE 1 (Homo sapiens) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 3 | LEU A 185THR A 124ASN A 123 | None | 0.73A | 6baaG-2gerA:undetectable | 6baaG-2gerA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 3 | LEU A 245THR A 107ASN A 106 | None | 0.73A | 6baaG-2gmhA:undetectable | 6baaG-2gmhA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gq3 | MALATE SYNTHASE G (Mycobacteriumtuberculosis) |
PF01274(Malate_synthase) | 3 | LEU A 501THR A 458ASN A 457 | None | 0.69A | 6baaG-2gq3A:undetectable | 6baaG-2gq3A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gr9 | PYRROLINE-5-CARBOXYLATE REDUCTASE 1 (Homo sapiens) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 3 | LEU A 185THR A 124ASN A 123 | None | 0.63A | 6baaG-2gr9A:undetectable | 6baaG-2gr9A:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h5g | DELTA1-PYRROLINE-5-CARBOXYLATE SYNTHETASE (Homo sapiens) |
PF00171(Aldedh) | 3 | LEU A 487THR A 538ASN A 537 | None | 0.67A | 6baaG-2h5gA:2.0 | 6baaG-2h5gA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hna | PROTEIN MIOC (Escherichiacoli) |
PF00258(Flavodoxin_1) | 3 | LEU A 109THR A 56ASN A 65 | None | 0.62A | 6baaG-2hnaA:undetectable | 6baaG-2hnaA:6.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5c | 1,8-CINEOLE SYNTHASE (Salviafruticosa) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | LEU A 585THR A 335ASN A 338 | None | 0.73A | 6baaG-2j5cA:0.6 | 6baaG-2j5cA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6i | FORMATEDEHYDROGENASE ([Candida]boidinii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | LEU A 180THR A 256ASN A 255 | None | 0.65A | 6baaG-2j6iA:undetectable | 6baaG-2j6iA:12.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 3 | LEU A 206THR A 191ASN A 190 | None | 0.75A | 6baaG-2jg5A:undetectable | 6baaG-2jg5A:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jov | HYPOTHETICAL PROTEINCPE0013 (Clostridiumperfringens) |
PF07892(DUF1667) | 3 | LEU A 41THR A 63ASN A 59 | None | 0.65A | 6baaG-2jovA:undetectable | 6baaG-2jovA:4.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2moq | IRON-REGULATEDSURFACE DETERMINANTPROTEIN B (Staphylococcusaureus) |
PF05031(NEAT) | 3 | LEU A 207THR A 179ASN A 262 | None | 0.71A | 6baaG-2moqA:undetectable | 6baaG-2moqA:7.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1s | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF02779(Transket_pyr)PF02780(Transketolase_C)PF13292(DXP_synthase_N) | 3 | LEU A 28THR A 69ASN A 68 | None | 0.71A | 6baaG-2o1sA:undetectable | 6baaG-2o1sA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2c | GLUCOSE-6-PHOSPHATEISOMERASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00342(PGI) | 3 | LEU A 210THR A 266ASN A 269 | NoneG6Q A5001 ( 4.7A)None | 0.71A | 6baaG-2o2cA:undetectable | 6baaG-2o2cA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 3 | LEU A 221THR A 257ASN A 260 | None | 0.65A | 6baaG-2og2A:2.6 | 6baaG-2og2A:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pli | UNCHARACTERIZEDPROTEIN (Neisseriameningitidis) |
PF03471(CorC_HlyC) | 3 | LEU A 82THR A 34ASN A 29 | None | 0.67A | 6baaG-2pliA:undetectable | 6baaG-2pliA:4.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qed | HYDROXYACYLGLUTATHIONE HYDROLASE (Salmonellaenterica) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 3 | LEU A 207THR A 168ASN A 171 | None | 0.68A | 6baaG-2qedA:undetectable | 6baaG-2qedA:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgy | ENOLASE FROM THEENVIRONMENTAL GENOMESHOTGUN SEQUENCINGOF THE SARGASSO SEA (-) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 367THR A 31ASN A 21 | None | 0.73A | 6baaG-2qgyA:0.0 | 6baaG-2qgyA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uz0 | TRIBUTYRIN ESTERASE (Streptococcuspneumoniae) |
PF00756(Esterase) | 3 | LEU A 119THR A 74ASN A 73 | NoneNoneEDO A1261 (-3.5A) | 0.68A | 6baaG-2uz0A:undetectable | 6baaG-2uz0A:10.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w40 | GLYCEROL KINASE,PUTATIVE (Plasmodiumfalciparum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | LEU A 273THR A 80ASN A 81 | None | 0.69A | 6baaG-2w40A:undetectable | 6baaG-2w40A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6r | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISF (Thermotogamaritima) |
PF00977(His_biosynth) | 3 | LEU A 49THR A 28ASN A 27 | None | 0.70A | 6baaG-2w6rA:undetectable | 6baaG-2w6rA:9.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6r | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISF (Thermotogamaritima) |
PF00977(His_biosynth) | 3 | LEU A 175THR A 154ASN A 153 | None | 0.62A | 6baaG-2w6rA:undetectable | 6baaG-2w6rA:9.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu8 | GLUCOSE-6-PHOSPHATEISOMERASE (Mycobacteriumtuberculosis) |
PF00342(PGI) | 3 | LEU A 162THR A 218ASN A 221 | None | 0.73A | 6baaG-2wu8A:undetectable | 6baaG-2wu8A:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdr | BETAINE ALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 3 | LEU A 328THR A 323ASN A 324 | None | 0.53A | 6baaG-2xdrA:2.3 | 6baaG-2xdrA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfb | E2 ENVELOPEGLYCOPROTEIN (Chikungunyavirus) |
PF00943(Alpha_E2_glycop) | 3 | LEU B 312THR B 294ASN B 295 | None | 0.60A | 6baaG-2xfbB:undetectable | 6baaG-2xfbB:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y27 | PHENYLACETATE-COENZYME A LIGASE (Burkholderiacenocepacia) |
PF00501(AMP-binding)PF14535(AMP-binding_C_2) | 3 | LEU A 21THR A 112ASN A 115 | None | 0.51A | 6baaG-2y27A:undetectable | 6baaG-2y27A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbv | UNCHARACTERIZEDCONSERVED PROTEIN (Thermotogamaritima) |
PF01887(SAM_adeno_trans) | 3 | LEU A 195THR A 185ASN A 186 | None | 0.56A | 6baaG-2zbvA:undetectable | 6baaG-2zbvA:10.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a76 | GAMMA-HEXACHLOROCYCLOHEXANEDEHYDROCHLORINASE (Sphingomonaspaucimobilis) |
PF13577(SnoaL_4) | 3 | LEU A 21THR A 133ASN A 134 | NoneSPD A 300 (-4.0A)None | 0.74A | 6baaG-3a76A:undetectable | 6baaG-3a76A:7.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aj6 | MAIN HEMAGGLUTININCOMPONENT (Clostridiumbotulinum) |
no annotation | 3 | LEU A 147THR A 4ASN A 5 | None | 0.72A | 6baaG-3aj6A:undetectable | 6baaG-3aj6A:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ba3 | PYRIDOXAMINE5'-PHOSPHATEOXIDASE-LIKE PROTEIN (Lactobacillusplantarum) |
no annotation | 3 | LEU A 123THR A 13ASN A 14 | NoneNoneSO4 A 146 (-2.9A) | 0.58A | 6baaG-3ba3A:undetectable | 6baaG-3ba3A:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3baz | HYDROXYPHENYLPYRUVATE REDUCTASE (Plectranthusscutellarioides) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | LEU A 192THR A 181ASN A 182 | None | 0.65A | 6baaG-3bazA:undetectable | 6baaG-3bazA:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bif | PROTEIN(6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE) (Rattusnorvegicus) |
PF00300(His_Phos_1)PF01591(6PF2K) | 3 | LEU A 420THR A 443ASN A 442 | None | 0.59A | 6baaG-3bifA:2.6 | 6baaG-3bifA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2g | SYS-1 PROTEIN (Caenorhabditiselegans) |
no annotation | 3 | LEU A 501THR A 583ASN A 586 | None | 0.54A | 6baaG-3c2gA:2.4 | 6baaG-3c2gA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cue | TRANSPORT PROTEINPARTICLE 22 KDASUBUNIT (Saccharomycescerevisiae) |
PF04051(TRAPP) | 3 | LEU D 67THR D 22ASN D 20 | None | 0.74A | 6baaG-3cueD:undetectable | 6baaG-3cueD:9.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d31 | SULFATE/MOLYBDATEABC TRANSPORTER,ATP-BINDING PROTEIN (Methanosarcinaacetivorans) |
PF00005(ABC_tran)PF03459(TOBE) | 3 | LEU A 120THR A 162ASN A 165 | None | 0.71A | 6baaG-3d31A:6.4 | 6baaG-3d31A:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d9i | RNA-BINDING PROTEIN16 (Homo sapiens) |
PF04818(CTD_bind) | 3 | LEU A 11THR A 95ASN A 98 | None | 0.73A | 6baaG-3d9iA:undetectable | 6baaG-3d9iA:6.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpr | PROTEIN VP2PROTEIN VP3 (Rhinovirus A) |
PF00073(Rhv) | 3 | LEU B 180THR C 226ASN C 227 | None | 0.71A | 6baaG-3dprB:undetectable | 6baaG-3dprB:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwo | PROBABLE OUTERMEMBRANE PROTEIN (Pseudomonasaeruginosa) |
PF03349(Toluene_X) | 3 | LEU X 424THR X 85ASN X 86 | None | 0.71A | 6baaG-3dwoX:undetectable | 6baaG-3dwoX:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebb | PHOSPHOLIPASEA2-ACTIVATINGPROTEIN (Homo sapiens) |
PF08324(PUL) | 3 | LEU A 596THR A 662ASN A 665 | None | 0.65A | 6baaG-3ebbA:undetectable | 6baaG-3ebbA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g25 | GLYCEROL KINASE (Staphylococcusaureus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | LEU A 271THR A 79ASN A 80 | None | 0.74A | 6baaG-3g25A:undetectable | 6baaG-3g25A:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6l | CHITINASE (Clonostachysrosea) |
PF00704(Glyco_hydro_18) | 3 | LEU A 375THR A 256ASN A 257 | None | 0.62A | 6baaG-3g6lA:undetectable | 6baaG-3g6lA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gh8 | IODOTYROSINEDEHALOGENASE 1 (Mus musculus) |
PF00881(Nitroreductase) | 3 | LEU A 258THR A 174ASN A 175 | NoneTYI A 302 ( 3.7A)None | 0.66A | 6baaG-3gh8A:undetectable | 6baaG-3gh8A:10.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwe | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE III (Burkholderiapseudomallei) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | LEU A 155THR A 45ASN A 274 | None | 0.73A | 6baaG-3gweA:undetectable | 6baaG-3gweA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyb | TRANSCRIPTIONALREGULATORS(LACI-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN) (Corynebacteriumglutamicum) |
PF13377(Peripla_BP_3) | 3 | LEU A 250THR A 272ASN A 271 | None | 0.67A | 6baaG-3gybA:undetectable | 6baaG-3gybA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5o | TRANSCRIPTIONALREGULATOR GNTR (Chromobacteriumviolaceum) |
PF13377(Peripla_BP_3) | 3 | LEU A 295THR A 83ASN A 82 | None | 0.64A | 6baaG-3h5oA:undetectable | 6baaG-3h5oA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 3 | LEU A 161THR A 216ASN A 219 | None | 0.71A | 6baaG-3hjbA:undetectable | 6baaG-3hjbA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 3 | LEU A 402THR A 431ASN A 434 | None | 0.54A | 6baaG-3hoaA:2.0 | 6baaG-3hoaA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvm | AGMATINE DEIMINASE (Helicobacterpylori) |
PF04371(PAD_porph) | 3 | LEU A 181THR A 203ASN A 155 | None | 0.74A | 6baaG-3hvmA:undetectable | 6baaG-3hvmA:11.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilw | DNA GYRASE SUBUNIT A (Mycobacteriumtuberculosis) |
PF00521(DNA_topoisoIV) | 3 | LEU A 174THR A 187ASN A 344 | None | 0.61A | 6baaG-3ilwA:undetectable | 6baaG-3ilwA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3im0 | VAL-1 (ParameciumbursariaChlorella virusCVK2) |
no annotation | 3 | LEU A 7THR A 219ASN A 218 | None | 0.74A | 6baaG-3im0A:undetectable | 6baaG-3im0A:9.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv0 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | LEU A 195THR A 171ASN A 125 | CSO A 191 ( 3.5A)NoneNone | 0.73A | 6baaG-3iv0A:0.6 | 6baaG-3iv0A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyo | QUINATE/SHIKIMATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF08501(Shikimate_dh_N) | 3 | LEU A 9THR A 109ASN A 108 | None | 0.74A | 6baaG-3jyoA:undetectable | 6baaG-3jyoA:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9h | PF-32 PROTEIN (Borreliellaburgdorferi) |
PF13614(AAA_31) | 3 | LEU A 173THR A 131ASN A 132 | None | 0.46A | 6baaG-3k9hA:undetectable | 6baaG-3k9hA:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2p | DNA LIGASE 3 (Homo sapiens) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 3 | LEU A 744THR A 733ASN A 734 | None | 0.62A | 6baaG-3l2pA:undetectable | 6baaG-3l2pA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | HYDROGENASE (NIFE)SMALL SUBUNIT HYDANICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 3 | LEU B1352THR A 89ASN A 95 | None | 0.63A | 6baaG-3myrB:undetectable | 6baaG-3myrB:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzb | NICKEL-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF00496(SBP_bac_5) | 3 | LEU A 293THR A 255ASN A 254 | NoneGOL A 516 (-4.3A)None | 0.72A | 6baaG-3mzbA:undetectable | 6baaG-3mzbA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 3 | LEU A 160THR A 215ASN A 218 | None | 0.72A | 6baaG-3nbuA:undetectable | 6baaG-3nbuA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nda | SERPIN-2 (Ixodes ricinus) |
PF00079(Serpin) | 3 | LEU A 92THR A 8ASN A 11 | None | 0.74A | 6baaG-3ndaA:undetectable | 6baaG-3ndaA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o9p | PERIPLASMIC MUREINPEPTIDE-BINDINGPROTEIN (Escherichiacoli) |
PF00496(SBP_bac_5) | 3 | LEU A 427THR A 277ASN A 276 | None | 0.70A | 6baaG-3o9pA:undetectable | 6baaG-3o9pA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otn | SUSD SUPERFAMILYPROTEIN (Parabacteroidesdistasonis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | LEU A 200THR A 206ASN A 269 | None | 0.55A | 6baaG-3otnA:undetectable | 6baaG-3otnA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q88 | GLUCOSE-6-PHOSPHATEISOMERASE (Francisellatularensis) |
PF00342(PGI) | 3 | LEU A 150THR A 206ASN A 209 | NoneRI2 A 601 ( 4.6A)None | 0.72A | 6baaG-3q88A:undetectable | 6baaG-3q88A:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qki | GLUCOSE-6-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00342(PGI) | 3 | LEU A 161THR A 239ASN A 242 | None | 0.66A | 6baaG-3qkiA:undetectable | 6baaG-3qkiA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qml | NUCLEOTIDE EXCHANGEFACTOR SIL1 (Saccharomycescerevisiae) |
PF16782(SIL1) | 3 | LEU C 261THR C 347ASN C 350 | None | 0.73A | 6baaG-3qmlC:undetectable | 6baaG-3qmlC:11.22 |