SIMILAR PATTERNS OF AMINO ACIDS FOR 6B89_B_NOVB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 PHE A 106
ARG A 101
LEU A 103
ALA A 119
 None
 1.29A 6b89A-1avbA:
0.0		 6b89A-1avbA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  45
ARG A  81
GLN A  95
GLN A  48
 None
None
SO4  A2001 (-3.8A)
None
 1.28A 6b89A-1ef1A:
undetectable		 6b89A-1ef1A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 387
ARG B 388
LEU B 352
ALA B 486
 None
 0.90A 6b89A-1ffvB:
0.0		 6b89A-1ffvB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 PHE A 446
ALA A 480
GLN A 483
GLN A 452
 None
 1.13A 6b89A-1hn0A:
0.0		 6b89A-1hn0A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		4 PHE A 248
ARG A 247
LEU A 249
ALA A 224
 None
None
EDO  A 503 (-4.7A)
None
 1.12A 6b89A-1n0wA:
8.9		 6b89A-1n0wA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 4 PHE A 230
ARG A 194
LEU A 234
ALA A 207
 None
 1.04A 6b89A-1onsA:
0.0		 6b89A-1onsA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		4 PHE A 172
LEU A 175
ALA A 193
GLN A 196
 None
 1.07A 6b89A-1u6zA:
0.5		 6b89A-1u6zA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		4 PHE A 258
ALA A 197
GLN A 196
GLN A 326
 None
 1.11A 6b89A-1uwvA:
1.1		 6b89A-1uwvA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		4 PHE A   6
ARG A 295
LEU A 299
ALA A 303
 None
 1.28A 6b89A-1vkyA:
0.0		 6b89A-1vkyA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 PHE A 266
ARG A  19
LEU A  18
ALA A  37
 None
 0.97A 6b89A-1y3tA:
undetectable		 6b89A-1y3tA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 PHE A  88
LEU A  71
ALA A  18
GLN A  68
 None
 1.16A 6b89A-2a1rA:
undetectable		 6b89A-2a1rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3s MYOCYTE NUCLEAR
FACTOR

(Mus musculus) 		PF00250
(Forkhead) 		4 ARG A  95
LEU A  11
GLN A  48
GLN A  90
 None
 1.26A 6b89A-2a3sA:
undetectable		 6b89A-2a3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		4 ARG A 193
ARG A 139
LEU A 135
ALA A 130
 None
 1.20A 6b89A-2bb3A:
undetectable		 6b89A-2bb3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		4 PHE A 258
ARG A 257
LEU A 296
ALA A 300
 None
ACT  A1500 ( 4.2A)
None
None
 1.29A 6b89A-2bfwA:
undetectable		 6b89A-2bfwA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 ARG A  19
LEU A  22
ALA A  27
GLN A 226
 None
 1.10A 6b89A-2d4eA:
0.6		 6b89A-2d4eA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ARG A 136
LEU A 133
ALA A 147
GLN A 137
 None
 1.30A 6b89A-2dg7A:
undetectable		 6b89A-2dg7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 165
ARG A 166
LEU A 163
GLN A 261
 None
 1.31A 6b89A-2f3oA:
1.5		 6b89A-2f3oA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		4 ARG A  15
LEU A  12
GLN A 109
GLN A   6
 None
 1.17A 6b89A-2fckA:
undetectable		 6b89A-2fckA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ARG A 942
ARG A 938
ALA A 831
GLN A 939
 None
 1.09A 6b89A-2fgeA:
undetectable		 6b89A-2fgeA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 ARG A 414
LEU A 178
ALA A 198
GLN A 378
 None
 1.25A 6b89A-2fgyA:
undetectable		 6b89A-2fgyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 PHE A1856
ARG A1857
ARG A1858
ALA A1807
 None
 1.24A 6b89A-2fr1A:
2.0		 6b89A-2fr1A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrs RNA-BINDING PROTEIN
39

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A  75
ARG A  28
ALA A  84
GLN A  57
 PHE  A  75 ( 1.3A)
ARG  A  28 ( 0.6A)
ALA  A  84 ( 0.0A)
GLN  A  57 ( 0.6A)
 1.31A 6b89A-2jrsA:
undetectable		 6b89A-2jrsA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpo ROSSMANN 2X2 FOLD
PROTEIN

(synthetic
construct) 		no annotation 4 ARG A  79
ARG A  81
LEU A  57
ALA A  18
 None
 1.06A 6b89A-2kpoA:
undetectable		 6b89A-2kpoA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obk SELT/SELW/SELH
SELENOPROTEIN DOMAIN

(Pseudomonas
protegens) 		PF10262
(Rdx) 		4 LEU A  19
ALA A  23
GLN A  27
GLN A  15
 None
 1.31A 6b89A-2obkA:
undetectable		 6b89A-2obkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		4 PHE A 114
ARG A 162
LEU A 161
ALA A 208
 NAD  A 401 (-4.9A)
None
None
None
 1.30A 6b89A-2pzkA:
undetectable		 6b89A-2pzkA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8q IRON-REGULATED
SURFACE DETERMINANT
E

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		4 PHE A 136
ARG A 138
LEU A 132
GLN A 141
 None
 1.17A 6b89A-2q8qA:
undetectable		 6b89A-2q8qA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A1216
ALA A1186
GLN A1189
GLN A1253
 None
 1.18A 6b89A-2vz9A:
undetectable		 6b89A-2vz9A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 PHE C 182
ARG C 184
LEU C 185
ALA C 250
 None
 0.76A 6b89A-2ynmC:
undetectable		 6b89A-2ynmC:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 PHE A 359
ARG A 368
LEU A 367
GLN A 372
 None
 1.26A 6b89A-3a6pA:
undetectable		 6b89A-3a6pA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 PHE A 710
ARG A 766
LEU A 713
ALA A 723
 None
 1.24A 6b89A-3apoA:
undetectable		 6b89A-3apoA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdl TRANSCRIPTIONAL
REGULATOR AEFR

(Pseudomonas
syringae group
genomosp. 3) 		PF00440
(TetR_N)
PF14246
(TetR_C_7) 		4 ARG A 143
LEU A 144
ALA A 152
GLN A 155
 None
 1.08A 6b89A-3cdlA:
undetectable		 6b89A-3cdlA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 PHE A 231
ARG A 229
LEU A 228
ALA A 184
 None
 1.29A 6b89A-3d19A:
undetectable		 6b89A-3d19A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		4 PHE I 226
ALA I 171
GLN I 170
GLN I 217
 None
 1.25A 6b89A-3d1nI:
undetectable		 6b89A-3d1nI:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 PHE A  88
LEU A  71
ALA A  18
GLN A  68
 None
 1.21A 6b89A-3d45A:
undetectable		 6b89A-3d45A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		4 PHE A  50
LEU A 104
ALA A   4
GLN A 111
 None
 1.29A 6b89A-3dn7A:
undetectable		 6b89A-3dn7A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		4 ARG A 103
LEU A 104
ALA A  82
GLN A 254
 None
 1.06A 6b89A-3fbsA:
undetectable		 6b89A-3fbsA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A1214
ARG A1175
LEU A1202
ALA A1204
 None
 1.09A 6b89A-3greA:
undetectable		 6b89A-3greA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		4 ARG A1238
LEU A1236
ALA A1269
GLN A1272
 None
 1.10A 6b89A-3i5pA:
undetectable		 6b89A-3i5pA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A  36
ALA A  71
GLN A  72
GLN A  32
 None
 1.30A 6b89A-3kyoA:
undetectable		 6b89A-3kyoA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzz SNAP-TAG

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 LEU A 117
ALA A 121
GLN A  97
GLN A 150
 None
 1.01A 6b89A-3kzzA:
undetectable		 6b89A-3kzzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		4 PHE A 175
ARG A 237
ALA A 184
GLN A 187
 None
 0.98A 6b89A-3lhoA:
undetectable		 6b89A-3lhoA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 PHE A 108
ARG A 115
LEU A 132
ALA A 136
 None
 1.01A 6b89A-3m1uA:
undetectable		 6b89A-3m1uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1044
ARG A1042
LEU A1043
ALA A1081
 None
 1.29A 6b89A-3mpxA:
undetectable		 6b89A-3mpxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw6 UNCHARACTERIZED
PROTEIN NMB1681

(Neisseria
meningitidis) 		PF04352
(ProQ) 		4 LEU A 116
ALA A  82
GLN A 103
GLN A 122
 None
 1.28A 6b89A-3mw6A:
undetectable		 6b89A-3mw6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 PHE A  89
ARG A  88
ARG A  75
ALA A 133
 None
 1.28A 6b89A-3p94A:
undetectable		 6b89A-3p94A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 PHE A 255
LEU A 346
ALA A 350
GLN A 340
 None
 1.06A 6b89A-3pdxA:
undetectable		 6b89A-3pdxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 PHE A1149
ARG A1086
LEU A1085
ALA A1032
 None
 1.29A 6b89A-3s5kA:
undetectable		 6b89A-3s5kA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shp PUTATIVE
ACETYLTRANSFERASE
STHE_0691

(Sphaerobacter
thermophilus) 		no annotation 4 PHE A  86
ARG A  85
ARG A  74
ALA A 102
 None
 1.31A 6b89A-3shpA:
undetectable		 6b89A-3shpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR

(Streptococcus
pneumoniae) 		PF01047
(MarR) 		4 ARG A  59
ARG A  60
LEU A  61
ALA A  67
 None
 1.06A 6b89A-3tgnA:
undetectable		 6b89A-3tgnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		4 PHE A 247
ARG A 266
ALA A 225
GLN A 263
 None
 1.27A 6b89A-3ujhA:
undetectable		 6b89A-3ujhA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A 117
ARG A 118
ALA A  44
GLN A  47
 None
 1.27A 6b89A-3ut3A:
undetectable		 6b89A-3ut3A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 ARG A 264
LEU A  34
ALA A  38
GLN A 349
 None
 1.31A 6b89A-3vr1A:
undetectable		 6b89A-3vr1A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		4 ARG A 209
LEU A 212
ALA A 156
GLN A 181
 None
None
MES  A1296 (-3.1A)
None
 1.12A 6b89A-4asyA:
undetectable		 6b89A-4asyA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Mus musculus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		4 PHE A  78
LEU A  79
ALA A   6
GLN A 132
 None
 1.18A 6b89A-4b93A:
undetectable		 6b89A-4b93A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csb VIRULENCE ASSOCIATED
PROTEIN VAPD

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 PHE A  91
ARG A 111
ALA A  61
GLN A  40
 None
 1.31A 6b89A-4csbA:
undetectable		 6b89A-4csbA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dci UNCHARACTERIZED
PROTEIN

(Synechococcus
sp. WH 8102) 		PF11068
(YlqD) 		4 LEU A  93
ALA A  38
GLN A  41
GLN A  99
 None
 1.26A 6b89A-4dciA:
2.2		 6b89A-4dciA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		4 PHE A 181
ARG A  36
LEU A  37
GLN B 101
 None
 1.26A 6b89A-4f6tA:
undetectable		 6b89A-4f6tA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		4 PHE D 160
ARG D 171
ALA D 155
GLN D 156
 None
 1.27A 6b89A-4gomD:
2.9		 6b89A-4gomD:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 444
LEU A 447
ALA A 218
GLN A 219
 None
 1.31A 6b89A-4grhA:
undetectable		 6b89A-4grhA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 448
ARG A 444
ALA A 218
GLN A 219
 None
 1.13A 6b89A-4grhA:
undetectable		 6b89A-4grhA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf7 PUTATIVE
ACYLHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		4 PHE A  97
ARG A  96
ARG A  83
ALA A 141
 None
 1.31A 6b89A-4hf7A:
undetectable		 6b89A-4hf7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)

(Treponema
pallidum) 		PF02608
(Bmp) 		4 ARG A 100
LEU A 102
ALA A 259
GLN A  99
 None
 1.10A 6b89A-4iilA:
undetectable		 6b89A-4iilA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A  36
ARG A  35
ALA A  71
GLN A  72
 None
 1.08A 6b89A-4lcyA:
undetectable		 6b89A-4lcyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 PHE A 248
LEU A 239
ALA A 336
GLN A 278
 None
 1.24A 6b89A-4ls9A:
undetectable		 6b89A-4ls9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 PHE A 162
ARG A  78
LEU A  79
ALA A 336
 None
 1.29A 6b89A-4m8jA:
undetectable		 6b89A-4m8jA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4moz FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Slackia
heliotrinireducens) 		PF01791
(DeoC) 		4 PHE A  69
LEU A  68
GLN A  83
GLN A  74
 None
 1.28A 6b89A-4mozA:
1.3		 6b89A-4mozA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
cenocepacia) 		PF00464
(SHMT) 		4 PHE A 184
ARG A 186
LEU A 187
ALA A 173
 None
 1.24A 6b89A-4msoA:
undetectable		 6b89A-4msoA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		4 PHE A  15
ARG A  17
ALA A  67
GLN A  65
 None
 1.16A 6b89A-4n18A:
undetectable		 6b89A-4n18A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		4 PHE A 350
ARG A 351
LEU A 347
ALA A 379
 None
 1.20A 6b89A-4opuA:
1.0		 6b89A-4opuA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A 317
ARG A 320
ALA A 138
GLN A 123
 None
 1.25A 6b89A-4p08A:
undetectable		 6b89A-4p08A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		4 LEU A 279
ALA A 125
GLN A 126
GLN A 345
 None
 1.28A 6b89A-4pdyA:
undetectable		 6b89A-4pdyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A3527
ARG A3529
ALA A3499
GLN A3532
 None
 1.29A 6b89A-4rh7A:
undetectable		 6b89A-4rh7A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 ARG A  83
LEU A  82
ALA A  38
GLN A  27
 None
 1.06A 6b89A-4rniA:
1.5		 6b89A-4rniA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 PHE A 113
ARG A 115
ALA A 171
GLN A 174
 None
 1.17A 6b89A-4wnzA:
undetectable		 6b89A-4wnzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 PHE A 265
ARG A 244
LEU A 193
ALA A 191
 None
2HP  A 404 (-2.9A)
None
None
 0.95A 6b89A-4xixA:
undetectable		 6b89A-4xixA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 PHE B  37
ARG B 168
LEU B 167
ALA B 121
 None
 1.07A 6b89A-4xl1B:
undetectable		 6b89A-4xl1B:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 PHE B  37
ARG B 168
LEU B 167
ALA B 121
 None
 1.10A 6b89A-4xlwB:
undetectable		 6b89A-4xlwB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I

(Pyrococcus
horikoshii) 		PF13680
(DUF4152) 		4 PHE A 123
ARG A  89
ALA A  69
GLN A 117
 None
 1.11A 6b89A-4yotA:
undetectable		 6b89A-4yotA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 171
ALA A 179
GLN A 182
GLN A 199
 None
 0.88A 6b89A-5c2cA:
undetectable		 6b89A-5c2cA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		4 PHE A 103
ARG A 107
LEU A 125
ALA A 156
 None
 1.15A 6b89A-5gl6A:
2.2		 6b89A-5gl6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 4 ARG B1084
LEU B1082
ALA B1115
GLN B1118
 None
 0.95A 6b89A-5hb0B:
undetectable		 6b89A-5hb0B:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF03177
(Nucleoporin_C) 		4 ARG A1084
LEU A1082
ALA A1115
GLN A1118
 None
 1.00A 6b89A-5hb1A:
undetectable		 6b89A-5hb1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 PHE B 646
ARG B 539
LEU B 651
GLN B  42
 None
 1.30A 6b89A-5hccB:
undetectable		 6b89A-5hccB:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A  99
ARG A 101
ARG A  97
LEU A  98
 None
 1.30A 6b89A-5macA:
undetectable		 6b89A-5macA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvx DELTA-LIKE PROTEIN 4

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		4 PHE A  37
ARG A 166
ARG A 168
ALA A 121
 None
 1.31A 6b89A-5mvxA:
undetectable		 6b89A-5mvxA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvx DELTA-LIKE PROTEIN 4

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		4 PHE A  37
ARG A 168
LEU A 167
ALA A 121
 None
 1.11A 6b89A-5mvxA:
undetectable		 6b89A-5mvxA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 PHE A 277
LEU A 306
ALA A 353
GLN A 303
 None
 1.17A 6b89A-5nlmA:
undetectable		 6b89A-5nlmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 PHE A 326
ARG A 328
ALA A 132
GLN A 344
 None
 1.02A 6b89A-5o1mA:
undetectable		 6b89A-5o1mA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 ARG B  99
ARG B  98
LEU B  97
ALA B 152
 None
 1.19A 6b89A-5sy5B:
undetectable		 6b89A-5sy5B:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 ARG A  94
LEU A  93
ALA A  84
GLN A  96
 None
 1.26A 6b89A-5tf2A:
undetectable		 6b89A-5tf2A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE

(uncultured
bacterium) 		PF13561
(adh_short_C2) 		4 ARG A 113
ARG A  41
LEU A  68
ALA A 122
 None
 0.91A 6b89A-5tiiA:
undetectable		 6b89A-5tiiA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 PHE A  70
LEU A 120
ALA A 122
GLN A  75
 None
 1.27A 6b89A-5tu4A:
undetectable		 6b89A-5tu4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		4 ARG A 247
LEU A 177
ALA A 237
GLN A 250
 None
 1.25A 6b89A-5uqjA:
undetectable		 6b89A-5uqjA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 PHE A 415
ARG A 416
LEU A 396
ALA A 376
 None
 1.31A 6b89A-5v1wA:
undetectable		 6b89A-5v1wA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 ARG A 325
ARG A 254
ALA A 539
GLN A 538
 None
 0.98A 6b89A-5w7dA:
undetectable		 6b89A-5w7dA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 PHE A 218
ARG A 247
ALA A 185
GLN A 246
 None
 1.10A 6b89A-5xapA:
undetectable		 6b89A-5xapA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 4 PHE A  37
ARG A  36
ALA A  72
GLN A  73
 None
 1.22A 6b89A-5xmmA:
undetectable		 6b89A-5xmmA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 PHE B 441
ARG B 443
LEU B 444
ALA B 410
 None
 0.88A 6b89A-6bcqB:
1.7		 6b89A-6bcqB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A  35
ALA A  11
GLN A  14
GLN A 282
 None
 1.27A 6b89A-6conA:
undetectable		 6b89A-6conA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A

(Danio rerio) 		no annotation 4 ARG A 296
ALA A 302
GLN A 307
GLN A 228
 None
 0.83A 6b89A-6g1kA:
undetectable		 6b89A-6g1kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 ALA A 533
PRO A 463
GLU A 460
VAL A 526
ARG A 253
 None
 1.35A 6b89B-1vrqA:
0.0		 6b89B-1vrqA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  99
ALA A 102
TYR A 153
GLU A 324
VAL A  85
 None
 1.31A 6b89B-1xkwA:
undetectable		 6b89B-1xkwA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ALA A 534
PRO A 464
GLU A 461
VAL A 527
ARG A 254
 None
 1.37A 6b89B-2gahA:
0.0		 6b89B-2gahA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 LEU A 303
ALA A 307
TYR A 290
GLU A 253
SER A 217
 None
 0.92A 6b89B-2iv0A:
0.8		 6b89B-2iv0A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 714
ALA A 672
GLU A 616
SER A 618
VAL A 611
 None
 1.46A 6b89B-2jgdA:
2.4		 6b89B-2jgdA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		5 LEU A  82
ALA A 375
PRO A  85
SER A  67
PHE A 297
 None
 1.29A 6b89B-2pefA:
undetectable		 6b89B-2pefA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 202
ALA A 250
TYR A 265
PRO A 267
VAL A 327
 None
 1.00A 6b89B-2vcaA:
0.5		 6b89B-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X 305
ALA X 319
GLU X 283
SER X 295
ARG X 135
 None
 1.48A 6b89B-3e3bX:
0.4		 6b89B-3e3bX:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 661
ALA A 633
PRO A 458
PHE A 695
VAL A 626
 None
 1.35A 6b89B-3fedA:
0.2		 6b89B-3fedA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 LEU A  96
ALA A 434
PRO A 362
SER A 298
PHE A 280
 QRP  A 502 (-4.3A)
None
None
None
QRP  A 502 (-4.3A)
 1.43A 6b89B-3o2kA:
undetectable		 6b89B-3o2kA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 HIS A 109
ALA A 112
SER A 148
VAL A 453
ARG A 455
 None
 0.99A 6b89B-3sfwA:
0.7		 6b89B-3sfwA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 143
ALA A 139
SER A 225
VAL A  95
ARG A  44
 None
 1.44A 6b89B-3vlaA:
undetectable		 6b89B-3vlaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		5 ALA T 137
PRO T 169
SER A 139
PHE A  94
ARG T 166
 None
 1.34A 6b89B-4hzuT:
undetectable		 6b89B-4hzuT:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 LEU A 237
ALA A  98
PRO A  78
SER A 193
VAL A  82
 None
 1.46A 6b89B-4l69A:
undetectable		 6b89B-4l69A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		5 ALA A  44
TYR A  31
GLU A  88
VAL A  36
ARG A  37
 None
 1.43A 6b89B-4mynA:
undetectable		 6b89B-4mynA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		5 HIS A 123
ALA A 109
PRO A  32
PHE A  38
VAL A 269
 None
None
None
INS  A 401 (-4.5A)
None
 0.99A 6b89B-4rxmA:
2.5		 6b89B-4rxmA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 662
ALA A 632
PRO A 460
PHE A 693
VAL A 625
 None
 1.47A 6b89B-4tweA:
undetectable		 6b89B-4tweA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		5 LEU B 655
ALA B 562
PRO B 674
SER B 539
VAL B 532
 None
 1.42A 6b89B-4wwxB:
2.7		 6b89B-4wwxB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 295
ALA A 302
GLU A 107
SER A 397
PHE A 394
 None
 1.26A 6b89B-4zi6A:
undetectable		 6b89B-4zi6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 LEU A1208
HIS A1195
PRO A1311
SER A1331
VAL A1201
 None
 1.44A 6b89B-5dotA:
undetectable		 6b89B-5dotA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 LEU A 150
ALA A  37
GLU A  69
SER A  98
VAL A  40
 None
 1.42A 6b89B-5h5jA:
undetectable		 6b89B-5h5jA:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		8 LEU A  72
ALA A  76
TYR A  82
PRO A  84
SER A  88
PHE A  90
VAL A 102
ARG A 150
 None
 1.05A 6b89B-5l75A:
31.0		 6b89B-5l75A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		5 LEU A 167
PRO A 259
GLU A 256
PHE A 111
VAL A  90
 None
 0.97A 6b89B-5o9eA:
undetectable		 6b89B-5o9eA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A 586
HIS A 100
TYR A 590
SER A 635
VAL A 540
 None
 1.32A 6b89B-5u1sA:
0.3		 6b89B-5u1sA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR

(Bacillus
subtilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 265
PRO A 246
SER A 247
VAL A 168
ARG A 166
 None
 1.29A 6b89B-5x03A:
undetectable		 6b89B-5x03A:
12.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 ALA B  76
TYR B  82
PRO B  84
PHE B  90
ARG B 150
 None
 0.77A 6b89B-5x5yB:
30.7		 6b89B-5x5yB:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 ALA B  76
TYR B  82
PRO B  84
SER B  88
PHE B  90
 None
 0.82A 6b89B-5x5yB:
30.7		 6b89B-5x5yB:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 TYR B  82
PRO B  84
GLU B  86
PHE B  90
ARG B 150
 None
 1.03A 6b89B-5x5yB:
30.7		 6b89B-5x5yB:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 655
ALA A 562
PRO A 674
SER A 539
VAL A 532
 None
 1.21A 6b89B-6cg0A:
1.6		 6b89B-6cg0A:
13.10