SIMILAR PATTERNS OF AMINO ACIDS FOR 6B89_A_NOVA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjj LAP2

(Homo sapiens) 		PF03020
(LEM)
PF08198
(Thymopoietin) 		5 LEU A  20
TYR A  41
PRO A   8
GLU A 114
SER A   9
 None
 1.43A 6b89A-1gjjA:
undetectable		 6b89A-1gjjA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 257
HIS A 244
ALA A 247
PRO A 217
SER A 220
 FAD  A 800 (-4.3A)
CL  A 541 (-4.8A)
None
None
None
 1.50A 6b89A-1knrA:
undetectable		 6b89A-1knrA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 414
ALA A 381
TYR A 373
PRO A 118
GLU A 122
 None
 1.04A 6b89A-1up4A:
0.0		 6b89A-1up4A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		5 LEU A  48
ALA A 159
GLU A  96
VAL A 147
ARG A 130
 None
None
None
None
ACT  A1200 (-3.1A)
 1.33A 6b89A-1y25A:
0.0		 6b89A-1y25A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		5 LEU A  40
HIS A  38
TYR A 378
PHE A 253
VAL A 283
 None
 1.34A 6b89A-2gduA:
1.0		 6b89A-2gduA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		5 LEU A  67
ALA A  73
PRO A 211
GLU A 143
VAL A  58
 None
 1.47A 6b89A-2p0lA:
0.0		 6b89A-2p0lA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		5 LEU A  67
ALA A  73
PRO A 211
GLU A 145
VAL A  58
 None
 1.16A 6b89A-2p0lA:
0.0		 6b89A-2p0lA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		5 LEU A  82
ALA A 375
PRO A  85
SER A  67
PHE A 297
 None
 1.21A 6b89A-2pefA:
undetectable		 6b89A-2pefA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 202
ALA A 250
TYR A 265
PRO A 267
VAL A 327
 None
 1.13A 6b89A-2vcaA:
0.6		 6b89A-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF02661
(Fic) 		5 HIS A 185
ALA A 182
TYR A 260
GLU A 223
PHE A  35
 None
 1.48A 6b89A-3cucA:
0.0		 6b89A-3cucA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 LEU A  96
ALA A 434
PRO A 362
SER A 298
PHE A 280
 QRP  A 502 (-4.3A)
None
None
None
QRP  A 502 (-4.3A)
 1.48A 6b89A-3o2kA:
0.0		 6b89A-3o2kA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		5 LEU A 308
ALA A 449
GLU A 374
SER A 329
VAL A 428
 None
 1.27A 6b89A-3o6pA:
undetectable		 6b89A-3o6pA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 143
ALA A 139
SER A 225
VAL A  95
ARG A  44
 None
 1.39A 6b89A-3vlaA:
undetectable		 6b89A-3vlaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		5 ALA A  77
TYR A  47
GLU A 247
SER A 242
VAL A 163
 None
None
None
EDO  A 306 ( 2.4A)
None
 1.45A 6b89A-4ev1A:
undetectable		 6b89A-4ev1A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt GLOBIN-2 A CHAIN

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		5 LEU A  18
ALA A 137
GLU A  95
PHE A 111
VAL A 115
 None
None
None
HEM  A 201 (-3.8A)
None
 1.31A 6b89A-4hrtA:
undetectable		 6b89A-4hrtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 303
ALA A 307
TYR A 271
PRO A 279
GLU A 281
 None
 1.49A 6b89A-4i6fA:
undetectable		 6b89A-4i6fA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqr HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF14717
(DUF4465) 		5 ALA A 185
PRO A 221
SER A 117
PHE A  85
VAL A 217
 None
 1.40A 6b89A-4jqrA:
undetectable		 6b89A-4jqrA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 226
ALA A 244
PRO A 213
GLU A 187
SER A 190
 None
 1.50A 6b89A-4lxrA:
undetectable		 6b89A-4lxrA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdi CHLAMYDOMONAS
REINHARDTII THB1

(Chlamydomonas
reinhardtii) 		PF01152
(Bac_globin) 		5 LEU A  73
ALA A 122
GLU A  83
PHE A  42
VAL A  94
 HEM  A 201 (-4.6A)
HEM  A 201 (-3.3A)
None
HEM  A 201 (-3.8A)
HEM  A 201 (-4.2A)
 1.12A 6b89A-4xdiA:
0.9		 6b89A-4xdiA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 LEU A 352
ALA A 440
GLU A 365
SER A 363
VAL A 376
 None
 1.46A 6b89A-5b5rA:
undetectable		 6b89A-5b5rA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 ALA D 529
TYR D 509
PRO D 514
GLU D 516
VAL D 219
 None
 1.29A 6b89A-5exrD:
undetectable		 6b89A-5exrD:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 ALA A  88
TYR A 125
GLU A 114
PHE A 333
VAL A  71
 None
 1.39A 6b89A-5h71A:
undetectable		 6b89A-5h71A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		5 LEU A 290
ALA A 293
GLU A  58
VAL A 166
ARG A 165
 None
 1.03A 6b89A-5igpA:
undetectable		 6b89A-5igpA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 PRO A 477
SER A 427
PHE A 429
VAL A 408
ARG A 413
 None
 1.50A 6b89A-5j7xA:
undetectable		 6b89A-5j7xA:
9.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		8 LEU A  72
ALA A  76
TYR A  82
PRO A  84
SER A  88
PHE A  90
VAL A 102
ARG A 150
 None
 1.09A 6b89A-5l75A:
32.2		 6b89A-5l75A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR

(Bacillus
subtilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 265
PRO A 246
SER A 247
VAL A 168
ARG A 166
 None
 1.19A 6b89A-5x03A:
0.0		 6b89A-5x03A:
12.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 ALA B  76
TYR B  82
PRO B  84
PHE B  90
ARG B 150
 None
 0.86A 6b89A-5x5yB:
31.7		 6b89A-5x5yB:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 ALA B  76
TYR B  82
PRO B  84
SER B  88
PHE B  90
 None
 0.91A 6b89A-5x5yB:
31.7		 6b89A-5x5yB:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 655
ALA A 562
PRO A 674
SER A 539
VAL A 532
 None
 1.32A 6b89A-6cg0A:
undetectable		 6b89A-6cg0A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 PHE A 282
ARG A 283
LEU A 215
ALA A 268
 None
 1.06A 6b89B-1c4kA:
undetectable		 6b89B-1c4kA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 ARG A 188
ARG A 197
ALA A 120
GLN A 194
 None
 0.96A 6b89B-1dqzA:
undetectable		 6b89B-1dqzA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 387
ARG B 388
LEU B 352
ALA B 486
 None
 0.81A 6b89B-1ffvB:
undetectable		 6b89B-1ffvB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 PHE A 414
LEU A 411
ALA A 452
GLN A 409
 None
 0.92A 6b89B-1fohA:
undetectable		 6b89B-1fohA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		4 PHE A 128
ARG A 130
ALA A  81
GLN A 133
 None
 0.86A 6b89B-1igwA:
0.6		 6b89B-1igwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 PHE A 524
ARG A 522
ALA A 557
GLN A 527
 None
 1.01A 6b89B-1kehA:
undetectable		 6b89B-1kehA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 PHE A  25
ARG A  30
LEU A  28
ALA A  59
 None
 1.02A 6b89B-1lfpA:
undetectable		 6b89B-1lfpA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE

(Clarkia breweri) 		PF03492
(Methyltransf_7) 		4 PHE X 135
ARG X 137
ALA X  56
GLN X 197
 None
 1.09A 6b89B-1m6eX:
undetectable		 6b89B-1m6eX:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 PHE A 231
ARG A 242
ALA A 198
GLN A 294
 None
 1.08A 6b89B-1m9qA:
undetectable		 6b89B-1m9qA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 PHE A  85
ARG A  87
LEU A  88
ALA A 139
 None
 1.09A 6b89B-1mo2A:
undetectable		 6b89B-1mo2A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		4 PHE A 248
ARG A 247
LEU A 249
ALA A 224
 None
None
EDO  A 503 (-4.7A)
None
 1.05A 6b89B-1n0wA:
8.8		 6b89B-1n0wA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 PHE A  90
ARG A  91
LEU A  31
ALA A  53
 None
 0.98A 6b89B-1nneA:
9.7		 6b89B-1nneA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A  11
ARG A  13
LEU A  14
GLN A  16
 None
 0.77A 6b89B-1pvdA:
undetectable		 6b89B-1pvdA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A  42
ARG A  41
ARG A 134
LEU A 133
 None
 1.06A 6b89B-1rblA:
undetectable		 6b89B-1rblA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 PHE A 266
ARG A  19
LEU A  18
ALA A  37
 None
 0.94A 6b89B-1y3tA:
undetectable		 6b89B-1y3tA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 PHE 1 479
ARG 1 481
ARG 1 649
LEU 1 647
 None
 0.94A 6b89B-1y791:
undetectable		 6b89B-1y791:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ARG A 293
LEU A 300
ALA A 345
GLN A 295
 None
 1.03A 6b89B-1zu4A:
2.7		 6b89B-1zu4A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 535
ARG A 533
LEU A 532
GLN A 530
 None
 1.08A 6b89B-2db3A:
3.6		 6b89B-2db3A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 ARG A 195
ARG A 196
LEU A 193
ALA A 224
 None
 0.94A 6b89B-2e7uA:
undetectable		 6b89B-2e7uA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 PHE A1856
ARG A1857
ARG A1858
ALA A1807
 None
 0.98A 6b89B-2fr1A:
2.3		 6b89B-2fr1A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		4 PHE A 233
ARG A 228
LEU A 230
ALA A   6
 None
 0.98A 6b89B-2gdfA:
undetectable		 6b89B-2gdfA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 ARG A 304
ARG A 300
LEU A 303
ALA A 368
 None
 1.09A 6b89B-2ogaA:
undetectable		 6b89B-2ogaA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 118
LEU A 117
ALA A 214
GLN A 115
 None
 1.08A 6b89B-2oi6A:
undetectable		 6b89B-2oi6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ARG A  48
LEU A  49
ALA A  68
GLN A  51
 None
 1.04A 6b89B-2rfqA:
undetectable		 6b89B-2rfqA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A  11
ARG A  13
LEU A  14
GLN A  16
 None
 0.82A 6b89B-2vk4A:
undetectable		 6b89B-2vk4A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 PHE A 286
LEU A 289
ALA A 106
GLN A 288
 None
 1.07A 6b89B-2x1cA:
undetectable		 6b89B-2x1cA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 PHE A  23
ARG A 174
ALA A 185
GLN A 173
 None
 0.99A 6b89B-2xmzA:
undetectable		 6b89B-2xmzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb6 UBIQUITIN-CONJUGATIN
G ENZYME E2 B

(Homo sapiens) 		PF00179
(UQ_con) 		4 ARG A   8
ARG A  15
LEU A  16
ALA A  38
 None
 1.06A 6b89B-2yb6A:
undetectable		 6b89B-2yb6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 PHE A  90
ARG A  88
LEU A  87
ALA A 316
 None
SAH  A 801 (-3.9A)
None
None
 1.06A 6b89B-2zwaA:
2.4		 6b89B-2zwaA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		4 PHE A 305
ARG A 294
ARG A 300
ALA A 308
 None
 1.07A 6b89B-3aqkA:
undetectable		 6b89B-3aqkA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs9 NUCLEOLYSIN TIA-1
ISOFORM P40

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG A 164
LEU A 161
ALA A 110
GLN A 165
 None
 0.94A 6b89B-3bs9A:
undetectable		 6b89B-3bs9A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		4 PHE A 151
ARG A 127
LEU A 126
ALA A 276
 None
 0.89A 6b89B-3bu7A:
undetectable		 6b89B-3bu7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE B  55
LEU B 345
ALA B 348
GLN B  24
 None
 1.04A 6b89B-3bxwB:
1.5		 6b89B-3bxwB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 ARG A  81
ARG A  82
LEU A  83
GLN A  85
 None
 0.61A 6b89B-3c0kA:
undetectable		 6b89B-3c0kA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 PHE A 128
ARG A 130
LEU A 129
ALA A 174
 None
 0.99A 6b89B-3czeA:
1.5		 6b89B-3czeA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 PHE A 231
ARG A 229
LEU A 228
ALA A 184
 None
 1.09A 6b89B-3d19A:
undetectable		 6b89B-3d19A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 PHE A 247
ARG A 258
ALA A 214
GLN A 310
 None
 1.03A 6b89B-3e7gA:
undetectable		 6b89B-3e7gA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 184
ARG A 162
LEU A 164
GLN A 190
 None
 1.07A 6b89B-3ghyA:
undetectable		 6b89B-3ghyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A1214
ARG A1175
LEU A1202
ALA A1204
 None
 1.06A 6b89B-3greA:
undetectable		 6b89B-3greA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		4 PHE A 179
LEU A 245
ALA A 174
GLN A 249
 None
HEM  A 305 (-4.8A)
HEM  A 305 (-3.5A)
None
 1.04A 6b89B-3hdlA:
undetectable		 6b89B-3hdlA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A1085
ARG A 398
ALA A 416
GLN A1083
 COA  A2001 (-3.5A)
COA  A2001 (-3.3A)
None
None
 1.09A 6b89B-3ho8A:
undetectable		 6b89B-3ho8A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 4 ARG A 111
LEU A 110
ALA A  55
GLN A 112
 None
 1.09A 6b89B-3i9wA:
undetectable		 6b89B-3i9wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 PHE A 336
ARG A 334
LEU A 339
ALA A 327
 None
 1.08A 6b89B-3jq3A:
undetectable		 6b89B-3jq3A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		4 PHE A 129
ARG A 130
ALA A  78
GLN A 134
 None
 0.85A 6b89B-3lg3A:
undetectable		 6b89B-3lg3A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		4 PHE A 129
ARG A 131
ALA A  82
GLN A 134
 None
 0.90A 6b89B-3lg3A:
undetectable		 6b89B-3lg3A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 280
ARG A 277
LEU A 279
ALA A 286
 None
 1.08A 6b89B-3lgxA:
undetectable		 6b89B-3lgxA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 PHE A 108
ARG A 115
LEU A 132
ALA A 136
 None
 1.09A 6b89B-3m1uA:
undetectable		 6b89B-3m1uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 ARG A 304
ARG A 205
LEU A 301
ALA A 316
 None
 1.08A 6b89B-3m7dA:
undetectable		 6b89B-3m7dA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 PHE A 382
ARG A 376
ARG A 377
LEU A 380
 None
 0.96A 6b89B-3n05A:
undetectable		 6b89B-3n05A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		4 ARG A  13
LEU A  12
ALA A  60
GLN A  10
 None
 1.06A 6b89B-3ogzA:
undetectable		 6b89B-3ogzA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orh GUANIDINOACETATE
N-METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ARG A 100
LEU A  99
ALA A  75
GLN A  97
 None
 0.96A 6b89B-3orhA:
undetectable		 6b89B-3orhA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3

(Homo sapiens) 		PF07686
(V-set) 		4 PHE B  41
ARG B 109
LEU B  19
ALA B  43
 None
 1.01A 6b89B-3pv6B:
undetectable		 6b89B-3pv6B:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 ARG A 365
LEU A 366
ALA A 318
GLN A 390
 None
 0.79A 6b89B-3swgA:
undetectable		 6b89B-3swgA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 PHE A 377
LEU A 372
ALA A 381
GLN A 358
 None
 0.99A 6b89B-3uemA:
undetectable		 6b89B-3uemA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwx GLUTATHIONE
S-TRANSFERASE 6B

(Musca domestica) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ARG A 113
LEU A 112
ALA A 173
GLN A 109
 GSH  A 500 (-2.9A)
None
None
None
 0.98A 6b89B-3vwxA:
undetectable		 6b89B-3vwxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 PHE A 346
ARG A 347
LEU A 405
GLN A 361
 None
 1.02A 6b89B-3wevA:
undetectable		 6b89B-3wevA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ARG A  97
LEU A  96
ALA A 108
GLN A  98
 None
 1.02A 6b89B-4bkmA:
undetectable		 6b89B-4bkmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el1 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 PHE A 377
LEU A 372
ALA A 381
GLN A 358
 None
 1.04A 6b89B-4el1A:
undetectable		 6b89B-4el1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		4 PHE A 324
ARG A 323
LEU A 328
ALA A 541
 None
 1.01A 6b89B-4emeA:
undetectable		 6b89B-4emeA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 162
LEU A 165
ALA A 400
GLN A 170
 None
 1.01A 6b89B-4f99A:
undetectable		 6b89B-4f99A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 PHE A  85
ARG A  83
ALA A  39
GLN A  80
 None
 1.07A 6b89B-4fgvA:
undetectable		 6b89B-4fgvA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		4 PHE A 165
ARG A 167
LEU A 168
ALA A 130
 None
 0.97A 6b89B-4kl0A:
undetectable		 6b89B-4kl0A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 4 ARG E 191
LEU E 188
ALA E 229
GLN E 190
 None
 1.08A 6b89B-4p9uE:
undetectable		 6b89B-4p9uE:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		4 ARG A  33
LEU A  35
ALA A  54
GLN A  37
 None
 1.00A 6b89B-4plsA:
undetectable		 6b89B-4plsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4png LD04004P

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ARG A  99
LEU A 100
ALA A  73
GLN A  98
 None
 0.91A 6b89B-4pngA:
undetectable		 6b89B-4pngA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdu HOMEOBOX PROTEIN
DLX-5

(Homo sapiens) 		PF00046
(Homeobox) 		4 ARG A 167
LEU A 170
ALA A 151
GLN A 178
 None
 1.07A 6b89B-4rduA:
undetectable		 6b89B-4rduA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 PHE A 227
LEU A 228
ALA A 200
GLN A 222
 None
 1.10A 6b89B-4rniA:
undetectable		 6b89B-4rniA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpu RUBREDOXIN

(Methanosarcina
acetivorans) 		PF02943
(FeThRed_B) 		4 ARG A  11
ARG A  12
LEU A  13
GLN A  15
 None
 1.08A 6b89B-4tpuA:
undetectable		 6b89B-4tpuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 ARG A 841
LEU A 842
ALA A 878
GLN A 960
 None
 1.02A 6b89B-4ts6A:
undetectable		 6b89B-4ts6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		4 PHE C 513
ARG C 514
LEU C 516
GLN C 518
 None
 1.08A 6b89B-4ui9C:
undetectable		 6b89B-4ui9C:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 ARG A 120
ARG A  63
LEU A  61
ALA A  19
 None
 0.93A 6b89B-4w97A:
undetectable		 6b89B-4w97A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn5 HYPOXIA-INDUCIBLE
FACTOR 3-ALPHA

(Homo sapiens) 		PF14598
(PAS_11) 		4 PHE A 306
ARG A 305
LEU A 314
ALA A 262
 MVC  A 402 (-2.8A)
None
None
None
 1.03A 6b89B-4wn5A:
undetectable		 6b89B-4wn5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 PHE A 462
ARG A 347
LEU A 341
ALA A 339
 None
ICS  A 602 (-3.9A)
None
None
 0.93A 6b89B-4wn9A:
undetectable		 6b89B-4wn9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG A 125
LEU A 126
ALA A 105
GLN A 128
 None
 0.96A 6b89B-4x0oA:
undetectable		 6b89B-4x0oA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 ARG A  99
LEU A 100
ALA A  73
GLN A  98
 None
 0.80A 6b89B-4yh2A:
undetectable		 6b89B-4yh2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ARG A  69
ARG A  68
LEU A  71
ALA A 194
 SO4  A 507 (-3.3A)
None
None
None
 1.03A 6b89B-4yrpA:
undetectable		 6b89B-4yrpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 521
LEU A 519
ALA A 534
GLN A 520
 None
 0.99A 6b89B-5agaA:
4.8		 6b89B-5agaA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ARG A 738
ARG A 695
LEU A 696
GLN A 740
 None
SO4  A 801 (-2.6A)
None
None
 1.07A 6b89B-5by3A:
undetectable		 6b89B-5by3A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9s RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 5 PHE B1624
ARG B1622
LEU B1627
ALA B1601
GLN B1661
 None
GOL  B1801 (-4.7A)
None
None
None
 1.33A 6b89B-5c9sB:
undetectable		 6b89B-5c9sB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 232
ARG A 230
LEU A 229
GLN A 227
 None
 0.62A 6b89B-5ci7A:
undetectable		 6b89B-5ci7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		4 PHE A  33
ARG A 129
ALA A   8
GLN A  35
 None
None
None
FAD  A 401 (-3.3A)
 1.03A 6b89B-5eowA:
undetectable		 6b89B-5eowA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		4 PHE A 103
ARG A 107
LEU A 125
ALA A 156
 None
 1.06A 6b89B-5gl6A:
2.4		 6b89B-5gl6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae) 		PF00497
(SBP_bac_3) 		4 PHE A 390
LEU A 393
ALA A 358
GLN A 395
 None
 0.98A 6b89B-5gzsA:
undetectable		 6b89B-5gzsA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hly INHIBIN BETA A CHAIN

(Homo sapiens) 		PF00019
(TGF_beta)
PF00688
(TGFb_propeptide) 		4 ARG A 229
LEU A 231
ALA A 297
GLN A 233
 None
 1.01A 6b89B-5hlyA:
undetectable		 6b89B-5hlyA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 139
ARG A 138
LEU A 144
ALA A  84
 None
 0.98A 6b89B-5jjqA:
undetectable		 6b89B-5jjqA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 PHE A 343
ARG A 348
LEU A 346
ALA A 601
 None
 1.08A 6b89B-5k3jA:
undetectable		 6b89B-5k3jA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		4 ARG A1135
LEU A1136
ALA A1105
GLN A1092
 None
 1.01A 6b89B-5ktgA:
undetectable		 6b89B-5ktgA:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		4 PHE A  90
ARG A  92
LEU A  93
ALA A 101
 None
 0.73A 6b89B-5l75A:
31.0		 6b89B-5l75A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 136
ARG A 137
LEU A 122
ALA A 162
 None
 1.04A 6b89B-5o8xA:
undetectable		 6b89B-5o8xA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgy PS1

(Escherichia
coli) 		no annotation 4 PHE A   3
LEU A   6
ALA A  56
GLN A   8
 None
7BU  A 201 (-4.0A)
7BU  A 201 (-3.2A)
None
 1.04A 6b89B-5tgyA:
undetectable		 6b89B-5tgyA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 PHE A  70
LEU A 120
ALA A 122
GLN A  75
 None
 1.07A 6b89B-5tu4A:
undetectable		 6b89B-5tu4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4q DTDP-GLUCOSE
4,6-DEHYDRATASE

(Klebsiella
pneumoniae) 		PF16363
(GDP_Man_Dehyd) 		4 PHE A 311
LEU A 305
ALA A 226
GLN A 303
 None
 1.08A 6b89B-5u4qA:
1.9		 6b89B-5u4qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v10 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 PHE A  49
LEU A  44
ALA A 136
GLN A  51
 None
 1.09A 6b89B-5v10A:
undetectable		 6b89B-5v10A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 ARG A 522
LEU A 364
ALA A 368
GLN A 357
 None
 0.98A 6b89B-5vmsA:
undetectable		 6b89B-5vmsA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 4 PHE A  41
ARG A 309
ALA A 377
GLN A  43
 None
 1.07A 6b89B-5y0qA:
undetectable		 6b89B-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ARG A  32
ARG A  50
ALA A 267
GLN A  36
 None
 1.08A 6b89B-6at7A:
2.7		 6b89B-6at7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 PHE B 441
ARG B 443
LEU B 444
ALA B 410
 None
 0.95A 6b89B-6bcqB:
undetectable		 6b89B-6bcqB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 PHE A 463
ARG A 468
LEU A 464
ALA A 425
 None
 0.96A 6b89B-6dd6A:
undetectable		 6b89B-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT

(Geobacillus
kaustophilus) 		no annotation 4 PHE A 188
LEU A 191
ALA A  58
GLN A 193
 None
 1.06A 6b89B-6f6eA:
undetectable		 6b89B-6f6eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 ARG A 542
ARG A 546
LEU A 544
ALA A 571
 None
 0.91A 6b89B-6fn1A:
21.5		 6b89B-6fn1A:
18.99