SIMILAR PATTERNS OF AMINO ACIDS FOR 6B5V_D_ECLD1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 295
ILE A 308
LEU A 284
ILE A 337
None
0.83A 6b5vB-1bvuA:
0.0
6b5vD-1bvuA:
0.0
6b5vB-1bvuA:
10.05
6b5vD-1bvuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 199
None
0.84A 6b5vB-1euzA:
0.0
6b5vD-1euzA:
0.0
6b5vB-1euzA:
10.50
6b5vD-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 338
None
0.73A 6b5vB-1euzA:
0.0
6b5vD-1euzA:
0.0
6b5vB-1euzA:
10.50
6b5vD-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanothermobacter
thermautotrophicus)
PF00296
(Bac_luciferase)
4 ILE A 311
PHE A 282
LEU A 314
ILE A  33
None
0.84A 6b5vB-1f07A:
0.0
6b5vD-1f07A:
0.0
6b5vB-1f07A:
13.75
6b5vD-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 ALA B 770
ILE B 655
PHE B 674
ILE B 414
None
0.76A 6b5vB-1ffvB:
undetectable
6b5vD-1ffvB:
0.0
6b5vB-1ffvB:
6.89
6b5vD-1ffvB:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ALA A 187
ILE A 317
PHE A 305
LEU A 313
None
0.82A 6b5vB-1fotA:
0.0
6b5vD-1fotA:
undetectable
6b5vB-1fotA:
13.31
6b5vD-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
4 ALA A 184
ILE A 169
LEU A 166
ILE A  95
None
0.86A 6b5vB-1gkrA:
0.0
6b5vD-1gkrA:
0.0
6b5vB-1gkrA:
10.25
6b5vD-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 338
None
0.78A 6b5vB-1gtmA:
undetectable
6b5vD-1gtmA:
undetectable
6b5vB-1gtmA:
11.46
6b5vD-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli)
PF00923
(TAL_FSA)
4 ALA A 142
ILE A 175
LEU A 155
ILE A 276
None
0.84A 6b5vB-1i2oA:
0.0
6b5vD-1i2oA:
0.0
6b5vB-1i2oA:
12.42
6b5vD-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 272
ILE A 256
LEU A 259
ILE A 315
None
0.81A 6b5vB-1lujA:
0.0
6b5vD-1lujA:
0.0
6b5vB-1lujA:
9.98
6b5vD-1lujA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3k DUAL-SPECIFICITY
TYROSINE PHOSPHATASE


(Arabidopsis
thaliana)
PF00581
(Rhodanese)
4 ALA A  25
ILE A  55
LEU A  58
ILE A   7
None
0.57A 6b5vB-1t3kA:
undetectable
6b5vD-1t3kA:
undetectable
6b5vB-1t3kA:
18.79
6b5vD-1t3kA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
4 ALA A 142
PHE A 260
LEU A  47
ILE A  33
None
0.78A 6b5vB-1urtA:
undetectable
6b5vD-1urtA:
undetectable
6b5vB-1urtA:
12.50
6b5vD-1urtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger)
PF01764
(Lipase_3)
4 ALA A  23
ILE A  52
LEU A  53
ILE A  48
None
0.66A 6b5vB-1uswA:
undetectable
6b5vD-1uswA:
undetectable
6b5vB-1uswA:
14.62
6b5vD-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
4 ALA C 478
ILE C 520
LEU C 501
ILE C 365
None
0.87A 6b5vB-1wa5C:
1.7
6b5vD-1wa5C:
0.7
6b5vB-1wa5C:
6.35
6b5vD-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
4 ALA A 756
ILE A  63
LEU A 744
ILE A 677
None
0.87A 6b5vB-1wz2A:
undetectable
6b5vD-1wz2A:
undetectable
6b5vB-1wz2A:
5.58
6b5vD-1wz2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1


(Arabidopsis
thaliana)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ALA A 317
ILE A 275
PHE A 309
ILE A 329
None
0.86A 6b5vB-1xj5A:
undetectable
6b5vD-1xj5A:
undetectable
6b5vB-1xj5A:
11.82
6b5vD-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
4 ILE A 288
PHE A 436
LEU A 284
ILE A 199
None
0.86A 6b5vB-1xwiA:
undetectable
6b5vD-1xwiA:
undetectable
6b5vB-1xwiA:
12.42
6b5vD-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9l LIPOPROTEIN MXIM

(Shigella
flexneri)
PF11441
(MxiM)
4 ALA A 103
PHE A  83
ILE A 128
LEU A 136
None
UND  A 150 ( 3.9A)
None
None
0.78A 6b5vB-1y9lA:
undetectable
6b5vD-1y9lA:
undetectable
6b5vB-1y9lA:
16.10
6b5vD-1y9lA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
4 ALA A  60
ILE A 268
LEU A 100
ILE A 228
None
0.80A 6b5vB-2b4vA:
undetectable
6b5vD-2b4vA:
undetectable
6b5vB-2b4vA:
10.68
6b5vD-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527


(Shewanella
oneidensis)
PF03992
(ABM)
4 PHE A  68
ILE A  14
CYH A  16
ILE A  83
None
0.85A 6b5vB-2bbeA:
undetectable
6b5vD-2bbeA:
undetectable
6b5vB-2bbeA:
15.74
6b5vD-2bbeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM


(Acinetobacter
baylyi)
PF03466
(LysR_substrate)
4 ALA A 245
PHE A 211
ILE A 210
ILE A 240
None
0.88A 6b5vB-2f6gA:
undetectable
6b5vD-2f6gA:
undetectable
6b5vB-2f6gA:
20.25
6b5vD-2f6gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
4 ALA A 235
ILE A 371
LEU A 374
ILE A 135
None
0.80A 6b5vB-2frxA:
undetectable
6b5vD-2frxA:
undetectable
6b5vB-2frxA:
10.76
6b5vD-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens)
PF00147
(Fibrinogen_C)
4 ALA A 383
ILE A 472
LEU A 484
ILE A 324
None
0.81A 6b5vB-2gy7A:
undetectable
6b5vD-2gy7A:
undetectable
6b5vB-2gy7A:
15.28
6b5vD-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Saccharomyces
cerevisiae)
no annotation 4 ALA A  33
ILE A  51
LEU A  23
ILE A 176
None
0.81A 6b5vB-2hsmA:
undetectable
6b5vD-2hsmA:
undetectable
6b5vB-2hsmA:
17.70
6b5vD-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5


(Saccharomyces
cerevisiae)
PF04494
(TFIID_NTD2)
4 PHE A 208
ILE A 216
LEU A 219
ILE A 181
None
0.83A 6b5vB-2j49A:
2.3
6b5vD-2j49A:
undetectable
6b5vB-2j49A:
19.31
6b5vD-2j49A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2


(Homo sapiens)
PF00428
(Ribosomal_60s)
4 PHE A  47
ILE A  28
LEU A  31
ILE B 159
None
0.63A 6b5vB-2lbfA:
undetectable
6b5vD-2lbfA:
undetectable
6b5vB-2lbfA:
23.81
6b5vD-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1


(Saccharomyces
cerevisiae)
PF01851
(PC_rep)
4 ALA A 607
PHE A 550
ILE A 588
LEU A 585
None
0.81A 6b5vB-2n3wA:
undetectable
6b5vD-2n3wA:
undetectable
6b5vB-2n3wA:
19.70
6b5vD-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ALA A 104
PHE A  48
ILE A  85
ILE A  68
None
0.77A 6b5vB-2o5pA:
undetectable
6b5vD-2o5pA:
undetectable
6b5vB-2o5pA:
7.16
6b5vD-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
4 ALA B 299
ILE B 188
PHE B 292
ILE B 236
None
0.88A 6b5vB-2pffB:
undetectable
6b5vD-2pffB:
undetectable
6b5vB-2pffB:
2.98
6b5vD-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1


(Gallus gallus)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
4 PHE A  62
ILE A  70
LEU A  33
ILE A 177
MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
0.84A 6b5vB-2r2iA:
undetectable
6b5vD-2r2iA:
undetectable
6b5vB-2r2iA:
19.27
6b5vD-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 ALA A 686
ILE A   5
LEU A 671
ILE A 341
None
0.88A 6b5vB-2rdyA:
undetectable
6b5vD-2rdyA:
0.5
6b5vB-2rdyA:
7.45
6b5vD-2rdyA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 ALA A 275
ILE A 255
LEU A 258
ILE A 314
None
0.80A 6b5vB-2z6gA:
undetectable
6b5vD-2z6gA:
undetectable
6b5vB-2z6gA:
7.39
6b5vD-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 272
ILE A 256
LEU A 259
ILE A 315
None
0.83A 6b5vB-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable
6b5vB-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 276
ILE A 256
LEU A 259
ILE A 315
None
0.85A 6b5vB-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable
6b5vB-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 ALA A 199
PHE A 224
LEU A 204
ILE A 143
None
0.74A 6b5vB-3b2dA:
undetectable
6b5vD-3b2dA:
undetectable
6b5vB-3b2dA:
9.33
6b5vD-3b2dA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ALA A 143
PHE A 261
LEU A  48
ILE A  34
None
0.72A 6b5vB-3da2A:
undetectable
6b5vD-3da2A:
undetectable
6b5vB-3da2A:
17.30
6b5vD-3da2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
4 ALA A 283
ILE A  61
LEU A  60
ILE A 531
None
0.80A 6b5vB-3dh4A:
2.4
6b5vD-3dh4A:
0.1
6b5vB-3dh4A:
8.83
6b5vD-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF03061
(4HBT)
4 PHE A 126
ILE A  53
LEU A  37
ILE A  67
None
0.85A 6b5vB-3e8pA:
undetectable
6b5vD-3e8pA:
undetectable
6b5vB-3e8pA:
17.68
6b5vD-3e8pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
4 ALA A 311
ILE A  86
LEU A  85
ILE A 260
None
0.81A 6b5vB-3fcyA:
undetectable
6b5vD-3fcyA:
undetectable
6b5vB-3fcyA:
13.12
6b5vD-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
4 ALA A 229
PHE A  76
LEU A  69
ILE A 271
None
0.87A 6b5vB-3ffhA:
undetectable
6b5vD-3ffhA:
undetectable
6b5vB-3ffhA:
12.50
6b5vD-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1


(Homo sapiens)
PF00620
(RhoGAP)
4 ALA A1320
PHE A1312
LEU A1307
ILE A1261
None
0.81A 6b5vB-3fk2A:
undetectable
6b5vD-3fk2A:
undetectable
6b5vB-3fk2A:
15.57
6b5vD-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens)
PF00514
(Arm)
4 ALA A 267
ILE A 247
LEU A 250
ILE A 306
None
0.88A 6b5vB-3ifqA:
undetectable
6b5vD-3ifqA:
undetectable
6b5vB-3ifqA:
9.45
6b5vD-3ifqA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 4 ALA A 382
PHE A  84
LEU A  80
ILE A 333
None
0.85A 6b5vB-3j3iA:
undetectable
6b5vD-3j3iA:
undetectable
6b5vB-3j3iA:
6.21
6b5vD-3j3iA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz3 SENSOR PROTEIN QSEC

(Escherichia
coli)
PF00512
(HisKA)
PF02518
(HATPase_c)
4 ALA A 426
ILE A 384
PHE A 435
ILE A 344
None
0.88A 6b5vB-3jz3A:
undetectable
6b5vD-3jz3A:
undetectable
6b5vB-3jz3A:
19.76
6b5vD-3jz3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM


(Acinetobacter
sp. ADP1)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
4 ALA A 245
PHE A 211
ILE A 210
ILE A 240
None
0.85A 6b5vB-3k1nA:
undetectable
6b5vD-3k1nA:
undetectable
6b5vB-3k1nA:
19.75
6b5vD-3k1nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
4 PHE A 157
ILE A 121
PHE A  85
LEU A 124
MES  A 362 (-4.8A)
None
None
None
0.86A 6b5vB-3l6aA:
2.9
6b5vD-3l6aA:
1.9
6b5vB-3l6aA:
13.23
6b5vD-3l6aA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE


(Salmonella
enterica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 307
ILE A   5
LEU A   6
ILE A 323
None
0.85A 6b5vB-3nx4A:
undetectable
6b5vD-3nx4A:
undetectable
6b5vB-3nx4A:
14.24
6b5vD-3nx4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor)
PF00079
(Serpin)
4 ILE A  73
PHE A  31
LEU A  77
ILE A 125
None
0.76A 6b5vB-3ozqA:
undetectable
6b5vD-3ozqA:
undetectable
6b5vB-3ozqA:
13.91
6b5vD-3ozqA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
4 PHE A  34
ILE A  71
PHE A  81
LEU A  68
None
0.81A 6b5vB-3q1yA:
undetectable
6b5vD-3q1yA:
undetectable
6b5vB-3q1yA:
14.76
6b5vD-3q1yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis)
PF13354
(Beta-lactamase2)
4 ALA A 232
ILE A 186
LEU A 190
ILE A 279
None
0.88A 6b5vB-3qhyA:
undetectable
6b5vD-3qhyA:
undetectable
6b5vB-3qhyA:
14.94
6b5vD-3qhyA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR


(Bacillus
subtilis)
PF00874
(PRD)
PF03123
(CAT_RBD)
4 ALA A 106
PHE A  52
ILE A  29
ILE A  85
None
0.84A 6b5vB-3rioA:
2.2
6b5vD-3rioA:
undetectable
6b5vB-3rioA:
18.08
6b5vD-3rioA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Haemophilus
influenzae)
PF00275
(EPSP_synthase)
4 ALA A 136
ILE A  96
LEU A  99
ILE A 160
None
0.67A 6b5vB-3sweA:
undetectable
6b5vD-3sweA:
undetectable
6b5vB-3sweA:
11.86
6b5vD-3sweA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
4 ALA A 445
ILE A  48
LEU A  54
ILE A 392
None
0.83A 6b5vB-3uonA:
undetectable
6b5vD-3uonA:
undetectable
6b5vB-3uonA:
15.12
6b5vD-3uonA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
4 ALA A 255
ILE A 306
LEU A 283
ILE A 349
None
0.74A 6b5vB-3uykA:
undetectable
6b5vD-3uykA:
undetectable
6b5vB-3uykA:
12.77
6b5vD-3uykA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Streptomyces
chartreusis)
PF01370
(Epimerase)
4 ALA A 224
ILE A  19
LEU A  23
ILE A 168
None
NAD  A 401 (-4.1A)
None
None
0.80A 6b5vB-3vpsA:
undetectable
6b5vD-3vpsA:
undetectable
6b5vB-3vpsA:
14.33
6b5vD-3vpsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
5 ALA A 319
PHE A  17
ILE A  19
PHE A 310
LEU A   9
None
1.40A 6b5vB-3w25A:
undetectable
6b5vD-3w25A:
undetectable
6b5vB-3w25A:
12.20
6b5vD-3w25A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes)
PF08341
(TED)
4 ALA A 310
PHE A 362
ILE A 360
ILE A 336
None
0.88A 6b5vB-4bugA:
undetectable
6b5vD-4bugA:
undetectable
6b5vB-4bugA:
10.07
6b5vD-4bugA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE


(Burkholderia
thailandensis)
PF01208
(URO-D)
4 ALA A  51
PHE A  92
LEU A  90
ILE A 118
None
0.80A 6b5vB-4exqA:
undetectable
6b5vD-4exqA:
undetectable
6b5vB-4exqA:
15.03
6b5vD-4exqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ALA A   6
ILE A  91
LEU A  95
ILE A 106
None
0.84A 6b5vB-4jzyA:
undetectable
6b5vD-4jzyA:
0.4
6b5vB-4jzyA:
10.25
6b5vD-4jzyA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE


(Aspergillus
nidulans)
PF16363
(GDP_Man_Dehyd)
4 ALA A  58
ILE A  82
PHE A  68
ILE A  47
None
0.85A 6b5vB-4lisA:
undetectable
6b5vD-4lisA:
undetectable
6b5vB-4lisA:
13.92
6b5vD-4lisA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1


(Homo sapiens)
PF16363
(GDP_Man_Dehyd)
4 ALA A 311
ILE A 258
LEU A 323
ILE A  93
None
NAD  A 501 (-3.9A)
None
None
0.78A 6b5vB-4lk3A:
undetectable
6b5vD-4lk3A:
undetectable
6b5vB-4lk3A:
15.97
6b5vD-4lk3A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I


(Anopheles
gambiae)
PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 ALA A 854
PHE A1193
ILE A1315
LEU A 796
None
0.87A 6b5vB-4lnvA:
undetectable
6b5vD-4lnvA:
undetectable
6b5vB-4lnvA:
5.74
6b5vD-4lnvA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me9 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Bacillus cereus)
PF00440
(TetR_N)
PF16295
(TetR_C_10)
5 PHE A  71
ILE A  67
PHE A  99
LEU A  88
ILE A  77
None
1.30A 6b5vB-4me9A:
undetectable
6b5vD-4me9A:
undetectable
6b5vB-4me9A:
16.93
6b5vD-4me9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE


(Bacteroides
fragilis)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
4 ALA A 337
ILE A 320
LEU A 325
ILE A 270
None
0.56A 6b5vB-4pysA:
undetectable
6b5vD-4pysA:
undetectable
6b5vB-4pysA:
9.46
6b5vD-4pysA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified)
PF00561
(Abhydrolase_1)
4 ALA A  91
ILE A 102
LEU A  79
ILE A 209
None
0.85A 6b5vB-4q3lA:
undetectable
6b5vD-4q3lA:
undetectable
6b5vB-4q3lA:
12.76
6b5vD-4q3lA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora)
PF08801
(Nucleoporin_N)
5 ALA A 110
PHE A  83
LEU A  81
CYH A 486
ILE A 494
None
1.19A 6b5vB-4q9tA:
undetectable
6b5vD-4q9tA:
undetectable
6b5vB-4q9tA:
8.19
6b5vD-4q9tA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus)
PF00698
(Acyl_transf_1)
4 PHE A  97
LEU A 201
CYH A 200
ILE A 130
None
0.70A 6b5vB-4qbuA:
undetectable
6b5vD-4qbuA:
0.0
6b5vB-4qbuA:
10.51
6b5vD-4qbuA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE


(Homo sapiens)
PF00171
(Aldedh)
4 ALA A 110
PHE A 178
ILE A 181
ILE A 163
None
0.72A 6b5vB-4qgkA:
undetectable
6b5vD-4qgkA:
undetectable
6b5vB-4qgkA:
11.28
6b5vD-4qgkA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ALA A 142
PHE A 249
LEU A  47
ILE A  33
None
0.75A 6b5vB-4qk3A:
undetectable
6b5vD-4qk3A:
undetectable
6b5vB-4qk3A:
16.06
6b5vD-4qk3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 ALA A 361
PHE A 386
LEU A 371
ILE A 303
None
0.86A 6b5vB-4u7lA:
undetectable
6b5vD-4u7lA:
undetectable
6b5vB-4u7lA:
8.77
6b5vD-4u7lA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 ALA A 540
ILE A 592
LEU A 454
ILE A 508
None
0.83A 6b5vB-4um8A:
undetectable
6b5vD-4um8A:
undetectable
6b5vB-4um8A:
9.71
6b5vD-4um8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ALA A  99
ILE A  90
LEU A  92
ILE A 113
None
ACT  A 410 (-4.8A)
None
None
0.75A 6b5vB-4w5zA:
undetectable
6b5vD-4w5zA:
undetectable
6b5vB-4w5zA:
12.20
6b5vD-4w5zA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis)
PF00067
(p450)
4 ALA A 107
ILE A 153
LEU A 156
ILE A 230
None
0.88A 6b5vB-4wpzA:
undetectable
6b5vD-4wpzA:
undetectable
6b5vB-4wpzA:
12.23
6b5vD-4wpzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1


(Azotobacter
vinelandii)
PF00142
(Fer4_NifH)
4 ALA E 200
ILE E 147
LEU E 179
ILE E  13
None
0.88A 6b5vB-4wzbE:
undetectable
6b5vD-4wzbE:
undetectable
6b5vB-4wzbE:
18.41
6b5vD-4wzbE:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5


(Drosophila
melanogaster)
PF13191
(AAA_16)
PF14630
(ORC5_C)
4 ALA E  49
ILE E   4
LEU E   8
ILE E  37
None
0.86A 6b5vB-4xgcE:
undetectable
6b5vD-4xgcE:
0.0
6b5vB-4xgcE:
11.33
6b5vD-4xgcE:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
4 ALA A 256
PHE A 353
LEU A  56
ILE A 158
None
None
None
144  A 501 ( 4.2A)
0.80A 6b5vB-4zchA:
undetectable
6b5vD-4zchA:
undetectable
6b5vB-4zchA:
10.80
6b5vD-4zchA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum)
PF00400
(WD40)
4 ALA A 312
PHE A 296
ILE A 370
LEU A 371
None
0.72A 6b5vB-4zoyA:
undetectable
6b5vD-4zoyA:
undetectable
6b5vB-4zoyA:
8.41
6b5vD-4zoyA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
4 ALA A 445
ILE A 451
LEU A 454
ILE A 251
None
0.88A 6b5vB-4zxiA:
undetectable
6b5vD-4zxiA:
undetectable
6b5vB-4zxiA:
6.92
6b5vD-4zxiA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 ALA A  38
PHE A 107
ILE A 123
LEU A 124
ILE A  77
None
1.46A 6b5vB-5aexA:
undetectable
6b5vD-5aexA:
undetectable
6b5vB-5aexA:
9.56
6b5vD-5aexA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 ALA A 393
ILE A 448
LEU A 445
ILE A 499
None
0.83A 6b5vB-5ao0A:
undetectable
6b5vD-5ao0A:
undetectable
6b5vB-5ao0A:
9.30
6b5vD-5ao0A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)


(Bdellovibrio
bacteriovorus)
PF06963
(FPN1)
4 ILE A 243
PHE A 420
LEU A 246
ILE A 135
None
0.73A 6b5vB-5aynA:
2.1
6b5vD-5aynA:
0.0
6b5vB-5aynA:
10.57
6b5vD-5aynA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 4 ALA A 134
ILE A  63
LEU A  62
CYH A  66
None
0.72A 6b5vB-5cwcA:
undetectable
6b5vD-5cwcA:
undetectable
6b5vB-5cwcA:
16.58
6b5vD-5cwcA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus)
PF00028
(Cadherin)
5 PHE A 157
ILE A 143
PHE A 104
LEU A 184
ILE A 113
None
1.50A 6b5vB-5cyxA:
undetectable
6b5vD-5cyxA:
undetectable
6b5vB-5cyxA:
12.16
6b5vD-5cyxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE


(Corynebacterium
glutamicum)
PF00561
(Abhydrolase_1)
4 ALA A 163
ILE A  70
LEU A  76
ILE A  86
None
0.68A 6b5vB-5d6oA:
undetectable
6b5vD-5d6oA:
undetectable
6b5vB-5d6oA:
14.41
6b5vD-5d6oA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156


(uncultured
organism)
no annotation 4 ALA A 371
ILE A 405
LEU A 401
ILE A 359
None
0.82A 6b5vB-5d8mA:
undetectable
6b5vD-5d8mA:
undetectable
6b5vB-5d8mA:
11.80
6b5vD-5d8mA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
4 ALA A 566
ILE A 587
LEU A 590
ILE A 617
None
0.84A 6b5vB-5e7pA:
undetectable
6b5vD-5e7pA:
undetectable
6b5vB-5e7pA:
6.71
6b5vD-5e7pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1n CAD PROTEIN

(Homo sapiens)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 ALA A2201
ILE A2132
LEU A2167
ILE A2075
None
0.85A 6b5vB-5g1nA:
undetectable
6b5vD-5g1nA:
undetectable
6b5vB-5g1nA:
14.06
6b5vD-5g1nA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C


(Schizosaccharomyces
pombe)
PF00956
(NAP)
4 ALA A 200
PHE A 161
ILE A  65
ILE A  79
None
0.87A 6b5vB-5gplA:
undetectable
6b5vD-5gplA:
undetectable
6b5vB-5gplA:
17.32
6b5vD-5gplA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
4 ALA g 108
ILE g 122
LEU g 521
ILE g 437
None
0.86A 6b5vB-5gw4g:
0.9
6b5vD-5gw4g:
undetectable
6b5vB-5gw4g:
9.36
6b5vD-5gw4g:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
4 ALA A 454
ILE A 406
LEU A 410
ILE A 486
None
0.77A 6b5vB-5h2vA:
undetectable
6b5vD-5h2vA:
0.2
6b5vB-5h2vA:
7.15
6b5vD-5h2vA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum)
PF04097
(Nic96)
4 ILE A1008
LEU A1005
CYH A1004
ILE A 916
None
0.84A 6b5vB-5hb3A:
2.3
6b5vD-5hb3A:
undetectable
6b5vB-5hb3A:
8.67
6b5vD-5hb3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4f UNCHARACTERIZED
PROTEIN


(Helicobacter
pylori)
no annotation 4 PHE A  59
ILE A  57
PHE A  12
ILE A  48
None
0.71A 6b5vB-5j4fA:
undetectable
6b5vD-5j4fA:
undetectable
6b5vB-5j4fA:
17.50
6b5vD-5j4fA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE


(Mycobacterium
marinum)
PF07993
(NAD_binding_4)
4 ILE A1006
PHE A1098
LEU A1009
ILE A1069
None
0.78A 6b5vB-5msoA:
undetectable
6b5vD-5msoA:
undetectable
6b5vB-5msoA:
5.42
6b5vD-5msoA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE


(Streptomyces
platensis)
PF13714
(PEP_mutase)
4 ALA A 250
ILE A 201
LEU A 200
ILE A 234
TLA  A 401 (-3.5A)
None
None
None
0.86A 6b5vB-5uncA:
undetectable
6b5vD-5uncA:
undetectable
6b5vB-5uncA:
14.64
6b5vD-5uncA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE


(Vibrio
vulnificus)
PF07992
(Pyr_redox_2)
4 ILE A 110
PHE A  90
LEU A 109
ILE A  80
None
0.87A 6b5vB-5usxA:
undetectable
6b5vD-5usxA:
undetectable
6b5vB-5usxA:
12.59
6b5vD-5usxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 4 ALA A 496
ILE A 520
PHE A 506
ILE A 467
None
0.79A 6b5vB-5vm9A:
undetectable
6b5vD-5vm9A:
undetectable
6b5vB-5vm9A:
6.71
6b5vD-5vm9A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2


(Homo sapiens)
no annotation 4 ALA A 349
PHE A 325
ILE A 326
LEU A 353
None
0.76A 6b5vB-6apjA:
undetectable
6b5vD-6apjA:
undetectable
6b5vB-6apjA:
22.83
6b5vD-6apjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo0 MDBA PROTEIN

(Corynebacterium
matruchotii)
no annotation 4 ALA A 192
PHE A  51
ILE A 180
ILE A 165
None
0.85A 6b5vB-6bo0A:
undetectable
6b5vD-6bo0A:
undetectable
6b5vB-6bo0A:
20.48
6b5vD-6bo0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33


(Homo sapiens)
no annotation 4 ALA A1225
ILE B  64
LEU B  67
ILE A1186
None
0.87A 6b5vB-6f9nA:
undetectable
6b5vD-6f9nA:
undetectable
6b5vB-6f9nA:
22.09
6b5vD-6f9nA:
22.09