SIMILAR PATTERNS OF AMINO ACIDS FOR 6B5V_C_ECLC1001_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ILE A 308LEU A 284ILE A 337ALA A 295 | None | 0.84A | 6b5vC-1bvuA:0.06b5vD-1bvuA:0.0 | 6b5vC-1bvuA:10.056b5vD-1bvuA:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ILE A 309LEU A 285ILE A 199ALA A 296 | None | 0.84A | 6b5vC-1euzA:0.06b5vD-1euzA:0.0 | 6b5vC-1euzA:10.506b5vD-1euzA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ILE A 309LEU A 285ILE A 338ALA A 296 | None | 0.74A | 6b5vC-1euzA:0.06b5vD-1euzA:0.0 | 6b5vC-1euzA:10.506b5vD-1euzA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f07 | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanothermobacterthermautotrophicus) |
PF00296(Bac_luciferase) | 4 | ILE A 311PHE A 282LEU A 314ILE A 33 | None | 0.83A | 6b5vC-1f07A:0.06b5vD-1f07A:0.0 | 6b5vC-1f07A:13.756b5vD-1f07A:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | ILE B 655PHE B 674ILE B 414ALA B 770 | None | 0.77A | 6b5vC-1ffvB:undetectable6b5vD-1ffvB:0.0 | 6b5vC-1ffvB:6.896b5vD-1ffvB:6.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fot | CAMP-DEPENDENTPROTEIN KINASE TYPE1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 4 | ILE A 317PHE A 305LEU A 313ALA A 187 | None | 0.82A | 6b5vC-1fotA:undetectable6b5vD-1fotA:undetectable | 6b5vC-1fotA:13.316b5vD-1fotA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 4 | ILE A 169LEU A 166ILE A 95ALA A 184 | None | 0.85A | 6b5vC-1gkrA:0.06b5vD-1gkrA:0.0 | 6b5vC-1gkrA:10.256b5vD-1gkrA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ILE A 309LEU A 285ILE A 338ALA A 296 | None | 0.79A | 6b5vC-1gtmA:0.06b5vD-1gtmA:undetectable | 6b5vC-1gtmA:11.466b5vD-1gtmA:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i2o | TRANSALDOLASE B (Escherichiacoli) |
PF00923(TAL_FSA) | 4 | ILE A 175LEU A 155ILE A 276ALA A 142 | None | 0.84A | 6b5vC-1i2oA:0.06b5vD-1i2oA:0.0 | 6b5vC-1i2oA:12.426b5vD-1i2oA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1luj | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ILE A 256LEU A 259ILE A 315ALA A 272 | None | 0.83A | 6b5vC-1lujA:0.06b5vD-1lujA:0.0 | 6b5vC-1lujA:9.986b5vD-1lujA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3k | DUAL-SPECIFICITYTYROSINE PHOSPHATASE (Arabidopsisthaliana) |
PF00581(Rhodanese) | 4 | ILE A 55LEU A 58ILE A 7ALA A 25 | None | 0.57A | 6b5vC-1t3kA:undetectable6b5vD-1t3kA:undetectable | 6b5vC-1t3kA:18.796b5vD-1t3kA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urt | CARBONIC ANHYDRASE V (Mus musculus) |
PF00194(Carb_anhydrase) | 4 | PHE A 260LEU A 47ILE A 33ALA A 142 | None | 0.77A | 6b5vC-1urtA:undetectable6b5vD-1urtA:undetectable | 6b5vC-1urtA:12.506b5vD-1urtA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usw | FERULOYL ESTERASE A (Aspergillusniger) |
PF01764(Lipase_3) | 4 | ILE A 52LEU A 53ILE A 48ALA A 23 | None | 0.68A | 6b5vC-1uswA:undetectable6b5vD-1uswA:undetectable | 6b5vC-1uswA:14.626b5vD-1uswA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz2 | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 4 | ILE A 63LEU A 744ILE A 677ALA A 756 | None | 0.87A | 6b5vC-1wz2A:undetectable6b5vD-1wz2A:undetectable | 6b5vC-1wz2A:5.586b5vD-1wz2A:5.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ILE A 275PHE A 309ILE A 329ALA A 317 | None | 0.85A | 6b5vC-1xj5A:undetectable6b5vD-1xj5A:undetectable | 6b5vC-1xj5A:11.826b5vD-1xj5A:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwi | SKD1 PROTEIN (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 4 | ILE A 288PHE A 436LEU A 284ILE A 199 | None | 0.85A | 6b5vC-1xwiA:undetectable6b5vD-1xwiA:undetectable | 6b5vC-1xwiA:12.426b5vD-1xwiA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9l | LIPOPROTEIN MXIM (Shigellaflexneri) |
PF11441(MxiM) | 4 | PHE A 83ILE A 128LEU A 136ALA A 103 | UND A 150 ( 3.9A)NoneNoneNone | 0.78A | 6b5vC-1y9lA:undetectable6b5vD-1y9lA:undetectable | 6b5vC-1y9lA:16.106b5vD-1y9lA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4v | RNA EDITING COMPLEXPROTEIN MP57 (Trypanosomabrucei) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 4 | ILE A 268LEU A 100ILE A 228ALA A 60 | None | 0.80A | 6b5vC-2b4vA:0.06b5vD-2b4vA:undetectable | 6b5vC-2b4vA:10.686b5vD-2b4vA:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bbe | HYPOTHETICAL PROTEINSO0527 (Shewanellaoneidensis) |
PF03992(ABM) | 4 | PHE A 68ILE A 14CYH A 16ILE A 83 | None | 0.85A | 6b5vC-2bbeA:undetectable6b5vD-2bbeA:undetectable | 6b5vC-2bbeA:15.746b5vD-2bbeA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 4 | ILE A 83LEU A 86ILE A 182ALA A 301 | None | 0.87A | 6b5vC-2c1cA:undetectable6b5vD-2c1cA:undetectable | 6b5vC-2c1cA:12.796b5vD-2c1cA:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 4 | ILE A 371LEU A 374ILE A 135ALA A 235 | None | 0.81A | 6b5vC-2frxA:undetectable6b5vD-2frxA:undetectable | 6b5vC-2frxA:10.766b5vD-2frxA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gy7 | ANGIOPOIETIN-2 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | ILE A 472LEU A 484ILE A 324ALA A 383 | None | 0.82A | 6b5vC-2gy7A:undetectable6b5vD-2gy7A:undetectable | 6b5vC-2gy7A:15.286b5vD-2gy7A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsm | GLUTAMYL-TRNASYNTHETASE,CYTOPLASMIC (Saccharomycescerevisiae) |
no annotation | 4 | ILE A 51LEU A 23ILE A 176ALA A 33 | None | 0.81A | 6b5vC-2hsmA:undetectable6b5vD-2hsmA:undetectable | 6b5vC-2hsmA:17.706b5vD-2hsmA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j49 | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 5 (Saccharomycescerevisiae) |
PF04494(TFIID_NTD2) | 4 | PHE A 208ILE A 216LEU A 219ILE A 181 | None | 0.84A | 6b5vC-2j49A:0.16b5vD-2j49A:undetectable | 6b5vC-2j49A:19.316b5vD-2j49A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lbf | 60S ACIDIC RIBOSOMALPROTEIN P160S ACIDIC RIBOSOMALPROTEIN P2 (Homo sapiens) |
PF00428(Ribosomal_60s) | 4 | PHE A 47ILE A 28LEU A 31ILE B 159 | None | 0.63A | 6b5vC-2lbfA:undetectable6b5vD-2lbfA:undetectable | 6b5vC-2lbfA:23.816b5vD-2lbfA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n3w | 26S PROTEASOMEREGULATORY SUBUNITRPN1 (Saccharomycescerevisiae) |
PF01851(PC_rep) | 4 | PHE A 550ILE A 588LEU A 585ALA A 607 | None | 0.82A | 6b5vC-2n3wA:undetectable6b5vD-2n3wA:undetectable | 6b5vC-2n3wA:19.706b5vD-2n3wA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | PHE A 48ILE A 85ILE A 68ALA A 104 | None | 0.77A | 6b5vC-2o5pA:undetectable6b5vD-2o5pA:undetectable | 6b5vC-2o5pA:7.166b5vD-2o5pA:7.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 4 | ILE B 188PHE B 292ILE B 236ALA B 299 | None | 0.87A | 6b5vC-2pffB:undetectable6b5vD-2pffB:undetectable | 6b5vC-2pffB:2.986b5vD-2pffB:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2i | GUANYLYLCYCLASE-ACTIVATINGPROTEIN 1 (Gallus gallus) |
PF00036(EF-hand_1)PF13499(EF-hand_7) | 4 | PHE A 62ILE A 70LEU A 33ILE A 177 | MYR A 1 ( 4.7A)MYR A 1 ( 4.7A)BME A 301 (-4.1A)MYR A 1 ( 4.6A) | 0.84A | 6b5vC-2r2iA:undetectable6b5vD-2r2iA:undetectable | 6b5vC-2r2iA:19.276b5vD-2r2iA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 4 | ILE G 188PHE G 292ILE G 236ALA G 299 | None | 0.87A | 6b5vC-2uv8G:undetectable6b5vD-2uv8G:0.0 | 6b5vC-2uv8G:3.876b5vD-2uv8G:3.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6g | B-CATENIN (Danio rerio) |
PF00514(Arm) | 4 | ILE A 255LEU A 258ILE A 314ALA A 275 | None | 0.79A | 6b5vC-2z6gA:undetectable6b5vD-2z6gA:undetectable | 6b5vC-2z6gA:7.396b5vD-2z6gA:7.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ILE A 256LEU A 259ILE A 315ALA A 272 | None | 0.85A | 6b5vC-2z6hA:undetectable6b5vD-2z6hA:undetectable | 6b5vC-2z6hA:8.636b5vD-2z6hA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ILE A 256LEU A 259ILE A 315ALA A 276 | None | 0.83A | 6b5vC-2z6hA:undetectable6b5vD-2z6hA:undetectable | 6b5vC-2z6hA:8.636b5vD-2z6hA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | PHE A 224LEU A 204ILE A 143ALA A 199 | None | 0.73A | 6b5vC-3b2dA:undetectable6b5vD-3b2dA:undetectable | 6b5vC-3b2dA:9.336b5vD-3b2dA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da2 | CARBONIC ANHYDRASE13 (Homo sapiens) |
PF00194(Carb_anhydrase) | 4 | PHE A 261LEU A 48ILE A 34ALA A 143 | None | 0.71A | 6b5vC-3da2A:undetectable6b5vD-3da2A:undetectable | 6b5vC-3da2A:17.306b5vD-3da2A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh4 | SODIUM/GLUCOSECOTRANSPORTER (Vibrioparahaemolyticus) |
PF00474(SSF) | 4 | ILE A 61LEU A 60ILE A 531ALA A 283 | None | 0.79A | 6b5vC-3dh4A:0.06b5vD-3dh4A:0.1 | 6b5vC-3dh4A:8.836b5vD-3dh4A:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8p | UNCHARACTERIZEDPROTEIN (Shewanellaoneidensis) |
PF03061(4HBT) | 4 | PHE A 126ILE A 53LEU A 37ILE A 67 | None | 0.85A | 6b5vC-3e8pA:undetectable6b5vD-3e8pA:undetectable | 6b5vC-3e8pA:17.686b5vD-3e8pA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcy | XYLAN ESTERASE 1 (Thermoanaerobacteriumsaccharolyticum) |
PF05448(AXE1) | 4 | ILE A 86LEU A 85ILE A 260ALA A 311 | None | 0.80A | 6b5vC-3fcyA:undetectable6b5vD-3fcyA:undetectable | 6b5vC-3fcyA:13.126b5vD-3fcyA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffh | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Listeriainnocua) |
PF00155(Aminotran_1_2) | 4 | PHE A 76LEU A 69ILE A 271ALA A 229 | None | 0.88A | 6b5vC-3ffhA:undetectable6b5vD-3ffhA:undetectable | 6b5vC-3ffhA:12.506b5vD-3ffhA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk2 | GLUCOCORTICOIDRECEPTOR DNA-BINDINGFACTOR 1 (Homo sapiens) |
PF00620(RhoGAP) | 4 | PHE A1312LEU A1307ILE A1261ALA A1320 | None | 0.79A | 6b5vC-3fk2A:undetectable6b5vD-3fk2A:undetectable | 6b5vC-3fk2A:15.576b5vD-3fk2A:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifq | PLAKOGLOBIN (Homo sapiens) |
PF00514(Arm) | 4 | ILE A 247LEU A 250ILE A 306ALA A 267 | None | 0.86A | 6b5vC-3ifqA:0.56b5vD-3ifqA:undetectable | 6b5vC-3ifqA:9.456b5vD-3ifqA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 4 | PHE A 84LEU A 80ILE A 333ALA A 382 | None | 0.86A | 6b5vC-3j3iA:undetectable6b5vD-3j3iA:undetectable | 6b5vC-3j3iA:6.216b5vD-3j3iA:6.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jz3 | SENSOR PROTEIN QSEC (Escherichiacoli) |
PF00512(HisKA)PF02518(HATPase_c) | 4 | ILE A 384PHE A 435ILE A 344ALA A 426 | None | 0.87A | 6b5vC-3jz3A:undetectable6b5vD-3jz3A:undetectable | 6b5vC-3jz3A:19.766b5vD-3jz3A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1n | HTH-TYPETRANSCRIPTIONALREGULATOR BENM (Acinetobactersp. ADP1) |
PF00126(HTH_1)PF03466(LysR_substrate) | 4 | PHE A 211ILE A 210ILE A 240ALA A 245 | None | 0.85A | 6b5vC-3k1nA:undetectable6b5vD-3k1nA:undetectable | 6b5vC-3k1nA:19.756b5vD-3k1nA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6a | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 4 | PHE A 157ILE A 121PHE A 85LEU A 124 | MES A 362 (-4.8A)NoneNoneNone | 0.85A | 6b5vC-3l6aA:1.56b5vD-3l6aA:1.9 | 6b5vC-3l6aA:13.236b5vD-3l6aA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx4 | PUTATIVEOXIDOREDUCTASE (Salmonellaenterica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ILE A 5LEU A 6ILE A 323ALA A 307 | None | 0.84A | 6b5vC-3nx4A:undetectable6b5vD-3nx4A:undetectable | 6b5vC-3nx4A:14.246b5vD-3nx4A:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozq | SERPIN48 (Tenebriomolitor) |
PF00079(Serpin) | 4 | ILE A 73PHE A 31LEU A 77ILE A 125 | None | 0.77A | 6b5vC-3ozqA:undetectable6b5vD-3ozqA:undetectable | 6b5vC-3ozqA:13.916b5vD-3ozqA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 4 | PHE A 34ILE A 71PHE A 81LEU A 68 | None | 0.80A | 6b5vC-3q1yA:undetectable6b5vD-3q1yA:undetectable | 6b5vC-3q1yA:14.766b5vD-3q1yA:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qhy | BETA-LACTAMASE (Bacillusanthracis) |
PF13354(Beta-lactamase2) | 4 | ILE A 186LEU A 190ILE A 279ALA A 232 | None | 0.88A | 6b5vC-3qhyA:undetectable6b5vD-3qhyA:undetectable | 6b5vC-3qhyA:14.946b5vD-3qhyA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rio | PTSGHI OPERONANTITERMINATOR (Bacillussubtilis) |
PF00874(PRD)PF03123(CAT_RBD) | 4 | PHE A 52ILE A 29ILE A 85ALA A 106 | None | 0.84A | 6b5vC-3rioA:undetectable6b5vD-3rioA:undetectable | 6b5vC-3rioA:18.086b5vD-3rioA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swe | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Haemophilusinfluenzae) |
PF00275(EPSP_synthase) | 4 | ILE A 96LEU A 99ILE A 160ALA A 136 | None | 0.68A | 6b5vC-3sweA:undetectable6b5vD-3sweA:undetectable | 6b5vC-3sweA:11.866b5vD-3sweA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uon | HUMAN M2 MUSCARINICACETYLCHOLINE,RECEPTOR T4 LYSOZYMEFUSION PROTEIN (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | ILE A 48LEU A 54ILE A 392ALA A 445 | None | 0.83A | 6b5vC-3uonA:0.06b5vD-3uonA:undetectable | 6b5vC-3uonA:15.126b5vD-3uonA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uyk | NDP-RHAMNOSYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 4 | ILE A 306LEU A 283ILE A 349ALA A 255 | None | 0.75A | 6b5vC-3uykA:undetectable6b5vD-3uykA:undetectable | 6b5vC-3uykA:12.776b5vD-3uykA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 4 | ILE A 19LEU A 23ILE A 168ALA A 224 | NAD A 401 (-4.1A)NoneNoneNone | 0.80A | 6b5vC-3vpsA:undetectable6b5vD-3vpsA:undetectable | 6b5vC-3vpsA:14.336b5vD-3vpsA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w25 | GLYCOSIDE HYDROLASEFAMILY 10 (Thermoanaerobacteriumsaccharolyticum) |
PF00331(Glyco_hydro_10) | 5 | PHE A 17ILE A 19PHE A 310LEU A 9ALA A 319 | None | 1.39A | 6b5vC-3w25A:undetectable6b5vD-3w25A:undetectable | 6b5vC-3w25A:12.206b5vD-3w25A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bug | ANCILLARY PROTEIN 1 (Streptococcuspyogenes) |
PF08341(TED) | 4 | PHE A 362ILE A 360ILE A 336ALA A 310 | None | 0.88A | 6b5vC-4bugA:undetectable6b5vD-4bugA:undetectable | 6b5vC-4bugA:10.076b5vD-4bugA:10.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3e | MAOC DOMAIN PROTEINDEHYDRATASE (Chloroflexusaurantiacus) |
PF01575(MaoC_dehydratas) | 4 | ILE A 72LEU A 106ILE A 275ALA A 98 | None | 0.88A | 6b5vC-4e3eA:undetectable6b5vD-4e3eA:undetectable | 6b5vC-4e3eA:13.216b5vD-4e3eA:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exq | UROPORPHYRINOGENDECARBOXYLASE (Burkholderiathailandensis) |
PF01208(URO-D) | 4 | PHE A 92LEU A 90ILE A 118ALA A 51 | None | 0.81A | 6b5vC-4exqA:undetectable6b5vD-4exqA:undetectable | 6b5vC-4exqA:15.036b5vD-4exqA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jzy | CRYPTOCHROME-1 (Drosophilamelanogaster) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | ILE A 91LEU A 95ILE A 106ALA A 6 | None | 0.85A | 6b5vC-4jzyA:undetectable6b5vD-4jzyA:0.4 | 6b5vC-4jzyA:10.256b5vD-4jzyA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lis | UDP-GLUCOSE4-EPIMERASE (Aspergillusnidulans) |
PF16363(GDP_Man_Dehyd) | 4 | ILE A 82PHE A 68ILE A 47ALA A 58 | None | 0.87A | 6b5vC-4lisA:undetectable6b5vD-4lisA:undetectable | 6b5vC-4lisA:13.926b5vD-4lisA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk3 | UDP-GLUCURONIC ACIDDECARBOXYLASE 1 (Homo sapiens) |
PF16363(GDP_Man_Dehyd) | 4 | ILE A 258LEU A 323ILE A 93ALA A 311 | NAD A 501 (-3.9A)NoneNoneNone | 0.80A | 6b5vC-4lk3A:undetectable6b5vD-4lk3A:undetectable | 6b5vC-4lk3A:15.976b5vD-4lk3A:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lnv | THIOESTER-CONTAININGPROTEIN I (Anophelesgambiae) |
PF00207(A2M)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | PHE A1193ILE A1315LEU A 796ALA A 854 | None | 0.87A | 6b5vC-4lnvA:undetectable6b5vD-4lnvA:undetectable | 6b5vC-4lnvA:5.746b5vD-4lnvA:5.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me9 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Bacillus cereus) |
PF00440(TetR_N)PF16295(TetR_C_10) | 5 | PHE A 71ILE A 67PHE A 99LEU A 88ILE A 77 | None | 1.30A | 6b5vC-4me9A:undetectable6b5vD-4me9A:undetectable | 6b5vC-4me9A:16.936b5vD-4me9A:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pys | BETA-N-ACETYLHEXOSAMINIDASE (Bacteroidesfragilis) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 4 | ILE A 320LEU A 325ILE A 270ALA A 337 | None | 0.57A | 6b5vC-4pysA:undetectable6b5vD-4pysA:undetectable | 6b5vC-4pysA:9.466b5vD-4pysA:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3l | MGS-M2 (unidentified) |
PF00561(Abhydrolase_1) | 4 | ILE A 102LEU A 79ILE A 209ALA A 91 | None | 0.84A | 6b5vC-4q3lA:undetectable6b5vD-4q3lA:undetectable | 6b5vC-4q3lA:12.766b5vD-4q3lA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9t | NUCLEOPORIN NUP133 (Vanderwaltozymapolyspora) |
PF08801(Nucleoporin_N) | 5 | PHE A 83LEU A 81CYH A 486ILE A 494ALA A 110 | None | 1.18A | 6b5vC-4q9tA:undetectable6b5vD-4q9tA:undetectable | 6b5vC-4q9tA:8.196b5vD-4q9tA:8.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qbu | ZMAA (Bacillus cereus) |
PF00698(Acyl_transf_1) | 4 | PHE A 97LEU A 201CYH A 200ILE A 130 | None | 0.69A | 6b5vC-4qbuA:undetectable6b5vD-4qbuA:0.0 | 6b5vC-4qbuA:10.516b5vD-4qbuA:10.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgk | FATTY ALDEHYDEDEHYDROGENASE (Homo sapiens) |
PF00171(Aldedh) | 4 | PHE A 178ILE A 181ILE A 163ALA A 110 | None | 0.72A | 6b5vC-4qgkA:0.06b5vD-4qgkA:undetectable | 6b5vC-4qgkA:11.286b5vD-4qgkA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qk3 | CARBONIC ANHYDRASE 2 (Homo sapiens) |
PF00194(Carb_anhydrase) | 4 | PHE A 249LEU A 47ILE A 33ALA A 142 | None | 0.74A | 6b5vC-4qk3A:undetectable6b5vD-4qk3A:undetectable | 6b5vC-4qk3A:16.066b5vD-4qk3A:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7l | LEUCINE-RICH REPEATSANDIMMUNOGLOBULIN-LIKEDOMAINS PROTEIN 1 (Homo sapiens) |
PF01463(LRRCT)PF13855(LRR_8) | 4 | PHE A 386LEU A 371ILE A 303ALA A 361 | None | 0.87A | 6b5vC-4u7lA:undetectable6b5vD-4u7lA:undetectable | 6b5vC-4u7lA:8.776b5vD-4u7lA:8.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | ILE A 592LEU A 454ILE A 508ALA A 540 | None | 0.85A | 6b5vC-4um8A:undetectable6b5vD-4um8A:undetectable | 6b5vC-4um8A:9.716b5vD-4um8A:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5z | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18) | 4 | ILE A 90LEU A 92ILE A 113ALA A 99 | ACT A 410 (-4.8A)NoneNoneNone | 0.76A | 6b5vC-4w5zA:undetectable6b5vD-4w5zA:undetectable | 6b5vC-4w5zA:12.206b5vD-4w5zA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpz | CYTOCHROME P450 (Streptomycesavermitilis) |
PF00067(p450) | 4 | ILE A 153LEU A 156ILE A 230ALA A 107 | None | 0.88A | 6b5vC-4wpzA:undetectable6b5vD-4wpzA:undetectable | 6b5vC-4wpzA:12.236b5vD-4wpzA:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Drosophilamelanogaster) |
PF13191(AAA_16)PF14630(ORC5_C) | 4 | ILE E 4LEU E 8ILE E 37ALA E 49 | None | 0.85A | 6b5vC-4xgcE:undetectable6b5vD-4xgcE:0.0 | 6b5vC-4xgcE:11.336b5vD-4xgcE:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zch | TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B (Homo sapiens) |
PF00229(TNF) | 4 | PHE A 353LEU A 56ILE A 158ALA A 256 | NoneNone144 A 501 ( 4.2A)None | 0.78A | 6b5vC-4zchA:undetectable6b5vD-4zchA:undetectable | 6b5vC-4zchA:10.806b5vD-4zchA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zk3 | SERPIN B3 (Homo sapiens) |
PF00079(Serpin) | 5 | PHE A 19ILE A 27PHE A 287ILE A 34ALA A 343 | None | 1.49A | 6b5vC-4zk3A:undetectable6b5vD-4zk3A:undetectable | 6b5vC-4zk3A:12.746b5vD-4zk3A:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoy | SQT1 (Chaetomiumthermophilum) |
PF00400(WD40) | 4 | PHE A 296ILE A 370LEU A 371ALA A 312 | None | 0.73A | 6b5vC-4zoyA:undetectable6b5vD-4zoyA:undetectable | 6b5vC-4zoyA:8.416b5vD-4zoyA:8.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 4 | ILE A 451LEU A 454ILE A 251ALA A 445 | None | 0.88A | 6b5vC-4zxiA:undetectable6b5vD-4zxiA:undetectable | 6b5vC-4zxiA:6.926b5vD-4zxiA:6.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aex | AMMONIUM TRANSPORTERMEP2 (Saccharomycescerevisiae) |
PF00909(Ammonium_transp) | 5 | PHE A 107ILE A 123LEU A 124ILE A 77ALA A 38 | None | 1.46A | 6b5vC-5aexA:undetectable6b5vD-5aexA:undetectable | 6b5vC-5aexA:9.566b5vD-5aexA:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ao0 | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Homo sapiens) |
PF01966(HD) | 4 | ILE A 448LEU A 445ILE A 499ALA A 393 | None | 0.84A | 6b5vC-5ao0A:undetectable6b5vD-5ao0A:undetectable | 6b5vC-5ao0A:9.306b5vD-5ao0A:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayn | SOLUTE CARRIERFAMILY 39(IRON-REGULATEDTRANSPORTER) (Bdellovibriobacteriovorus) |
PF06963(FPN1) | 4 | ILE A 243PHE A 420LEU A 246ILE A 135 | None | 0.72A | 6b5vC-5aynA:undetectable6b5vD-5aynA:0.0 | 6b5vC-5aynA:10.576b5vD-5aynA:10.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwc | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 4 | ILE A 63LEU A 62CYH A 66ALA A 134 | None | 0.73A | 6b5vC-5cwcA:undetectable6b5vD-5cwcA:0.3 | 6b5vC-5cwcA:16.586b5vD-5cwcA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyx | PROTEIN CDHR2 (Mus musculus) |
PF00028(Cadherin) | 5 | PHE A 157ILE A 143PHE A 104LEU A 184ILE A 113 | None | 1.49A | 6b5vC-5cyxA:undetectable6b5vD-5cyxA:undetectable | 6b5vC-5cyxA:12.166b5vD-5cyxA:12.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6o | HOMOSERINEO-ACETYLTRANSFERASE (Corynebacteriumglutamicum) |
PF00561(Abhydrolase_1) | 4 | ILE A 70LEU A 76ILE A 86ALA A 163 | None | 0.71A | 6b5vC-5d6oA:0.06b5vD-5d6oA:undetectable | 6b5vC-5d6oA:14.416b5vD-5d6oA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8m | METAGENOMIC CARBOXYLESTERASE MGS0156 (unculturedorganism) |
no annotation | 4 | ILE A 405LEU A 401ILE A 359ALA A 371 | None | 0.82A | 6b5vC-5d8mA:undetectable6b5vD-5d8mA:undetectable | 6b5vC-5d8mA:11.806b5vD-5d8mA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7p | CELL DIVISIONCONTROL PROTEINCDC48 (Mycolicibacteriumsmegmatis) |
PF00004(AAA)PF02359(CDC48_N) | 4 | ILE A 587LEU A 590ILE A 617ALA A 566 | None | 0.84A | 6b5vC-5e7pA:undetectable6b5vD-5e7pA:undetectable | 6b5vC-5e7pA:6.716b5vD-5e7pA:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g1n | CAD PROTEIN (Homo sapiens) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | ILE A2132LEU A2167ILE A2075ALA A2201 | None | 0.86A | 6b5vC-5g1nA:undetectable6b5vD-5g1nA:undetectable | 6b5vC-5g1nA:14.066b5vD-5g1nA:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gpl | PUTATIVE NUCLEOSOMEASSEMBLY PROTEINC36B7.08C (Schizosaccharomycespombe) |
PF00956(NAP) | 4 | PHE A 161ILE A 65ILE A 79ALA A 200 | None | 0.88A | 6b5vC-5gplA:undetectable6b5vD-5gplA:undetectable | 6b5vC-5gplA:17.326b5vD-5gplA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw4 | T-COMPLEX PROTEIN 1SUBUNIT GAMMA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 4 | ILE g 122LEU g 521ILE g 437ALA g 108 | None | 0.86A | 6b5vC-5gw4g:undetectable6b5vD-5gw4g:undetectable | 6b5vC-5gw4g:9.366b5vD-5gw4g:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2v | IMPORTIN SUBUNITBETA-3 (Saccharomycescerevisiae) |
PF13513(HEAT_EZ) | 4 | ILE A 406LEU A 410ILE A 486ALA A 454 | None | 0.79A | 6b5vC-5h2vA:undetectable6b5vD-5h2vA:0.2 | 6b5vC-5h2vA:7.156b5vD-5h2vA:7.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h60 | TRANSFERASE (Escherichiacoli) |
no annotation | 4 | ILE A 78LEU A 75ILE A 119ALA A 105 | None | 0.88A | 6b5vC-5h60A:undetectable6b5vD-5h60A:undetectable | 6b5vC-5h60A:22.356b5vD-5h60A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb3 | NUCLEOPORIN NIC96 (Chaetomiumthermophilum) |
PF04097(Nic96) | 4 | ILE A1008LEU A1005CYH A1004ILE A 916 | None | 0.84A | 6b5vC-5hb3A:0.06b5vD-5hb3A:undetectable | 6b5vC-5hb3A:8.676b5vD-5hb3A:8.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4f | UNCHARACTERIZEDPROTEIN (Helicobacterpylori) |
no annotation | 4 | PHE A 59ILE A 57PHE A 12ILE A 48 | None | 0.70A | 6b5vC-5j4fA:undetectable6b5vD-5j4fA:undetectable | 6b5vC-5j4fA:17.506b5vD-5j4fA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mso | CARBOXYLIC ACIDREDUCTASE (Mycobacteriummarinum) |
PF07993(NAD_binding_4) | 4 | ILE A1006PHE A1098LEU A1009ILE A1069 | None | 0.77A | 6b5vC-5msoA:undetectable6b5vD-5msoA:undetectable | 6b5vC-5msoA:5.426b5vD-5msoA:5.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5unc | PHOSPHOENOLPYRUVATEPHOSPHOMUTASE (Streptomycesplatensis) |
PF13714(PEP_mutase) | 4 | ILE A 201LEU A 200ILE A 234ALA A 250 | NoneNoneNoneTLA A 401 (-3.5A) | 0.86A | 6b5vC-5uncA:undetectable6b5vD-5uncA:undetectable | 6b5vC-5uncA:14.646b5vD-5uncA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usx | THIOREDOXINREDUCTASE (Vibriovulnificus) |
PF07992(Pyr_redox_2) | 4 | ILE A 110PHE A 90LEU A 109ILE A 80 | None | 0.86A | 6b5vC-5usxA:undetectable6b5vD-5usxA:undetectable | 6b5vC-5usxA:12.596b5vD-5usxA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm9 | PROTEIN ARGONAUTE-3 (Homo sapiens) |
no annotation | 4 | ILE A 520PHE A 506ILE A 467ALA A 496 | None | 0.76A | 6b5vC-5vm9A:undetectable6b5vD-5vm9A:undetectable | 6b5vC-5vm9A:6.716b5vD-5vm9A:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apj | ALPHA-N-ACETYLGALACTOSAMINIDEALPHA-2,6-SIALYLTRANSFERASE 2 (Homo sapiens) |
no annotation | 4 | PHE A 325ILE A 326LEU A 353ALA A 349 | None | 0.76A | 6b5vC-6apjA:undetectable6b5vD-6apjA:undetectable | 6b5vC-6apjA:22.836b5vD-6apjA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bo0 | MDBA PROTEIN (Corynebacteriummatruchotii) |
no annotation | 4 | PHE A 51ILE A 180ILE A 165ALA A 192 | None | 0.85A | 6b5vC-6bo0A:undetectable6b5vD-6bo0A:undetectable | 6b5vC-6bo0A:20.486b5vD-6bo0A:20.48 |