SIMILAR PATTERNS OF AMINO ACIDS FOR 6B5V_B_ECLB1001
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ais | PROTEIN(TRANSCRIPTIONINITIATION FACTORIIB) (Pyrococcuswoesei) |
PF00382(TFIIB) | 4 | ALA B1112ILE B1146LEU B1145ILE B1186 | None | 0.89A | 6b5vA-1aisB:0.06b5vB-1aisB:0.0 | 6b5vA-1aisB:17.886b5vB-1aisB:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhq | CD11B (Homo sapiens) |
PF00092(VWA) | 4 | PHE 1 137ILE 1 240PHE 1 275ILE 1 236 | None | 0.86A | 6b5vA-1bhq1:undetectable6b5vB-1bhq1:undetectable | 6b5vA-1bhq1:13.996b5vB-1bhq1:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ALA A 295ILE A 308LEU A 284ILE A 337 | None | 0.79A | 6b5vA-1bvuA:0.06b5vB-1bvuA:0.0 | 6b5vA-1bvuA:10.056b5vB-1bvuA:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 4 | ALA A 8PHE A 102LEU A 98ILE A 48 | None | 0.89A | 6b5vA-1cnzA:0.06b5vB-1cnzA:0.0 | 6b5vA-1cnzA:13.026b5vB-1cnzA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ALA A 296ILE A 309LEU A 285ILE A 199 | None | 0.82A | 6b5vA-1euzA:0.06b5vB-1euzA:0.0 | 6b5vA-1euzA:10.506b5vB-1euzA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ALA A 296ILE A 309LEU A 285ILE A 338 | None | 0.72A | 6b5vA-1euzA:0.06b5vB-1euzA:0.0 | 6b5vA-1euzA:10.506b5vB-1euzA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f07 | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanothermobacterthermautotrophicus) |
PF00296(Bac_luciferase) | 4 | ILE A 311PHE A 282LEU A 314ILE A 33 | None | 0.84A | 6b5vA-1f07A:0.06b5vB-1f07A:0.0 | 6b5vA-1f07A:13.756b5vB-1f07A:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | ALA B 770ILE B 655PHE B 674ILE B 414 | None | 0.75A | 6b5vA-1ffvB:0.06b5vB-1ffvB:0.0 | 6b5vA-1ffvB:6.896b5vB-1ffvB:6.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fot | CAMP-DEPENDENTPROTEIN KINASE TYPE1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 4 | ALA A 187ILE A 317PHE A 305LEU A 313 | None | 0.77A | 6b5vA-1fotA:0.06b5vB-1fotA:0.0 | 6b5vA-1fotA:13.316b5vB-1fotA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 4 | ALA A 184ILE A 169LEU A 166ILE A 95 | None | 0.89A | 6b5vA-1gkrA:0.06b5vB-1gkrA:0.0 | 6b5vA-1gkrA:10.256b5vB-1gkrA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ALA A 296ILE A 309LEU A 285ILE A 338 | None | 0.75A | 6b5vA-1gtmA:0.06b5vB-1gtmA:0.0 | 6b5vA-1gtmA:11.466b5vB-1gtmA:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyd | ARABINANENDO-1,5-ALPHA-L-ARABINOSIDASE A (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 5 | ALA B 120ILE B 57PHE B 89LEU B 93ILE B 161 | None | 1.47A | 6b5vA-1gydB:undetectable6b5vB-1gydB:undetectable | 6b5vA-1gydB:14.816b5vB-1gydB:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h17 | FORMATEACETYLTRANSFERASE 1 (Escherichiacoli) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | ALA A 625ILE A 446LEU A 443ILE A 559 | None | 0.86A | 6b5vA-1h17A:undetectable6b5vB-1h17A:undetectable | 6b5vA-1h17A:7.956b5vB-1h17A:7.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i2o | TRANSALDOLASE B (Escherichiacoli) |
PF00923(TAL_FSA) | 4 | ALA A 142ILE A 175LEU A 155ILE A 276 | None | 0.84A | 6b5vA-1i2oA:0.06b5vB-1i2oA:undetectable | 6b5vA-1i2oA:12.426b5vB-1i2oA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7o | 4-HYDROXYPHENYLACETATE DEGRADATIONBIFUNCTIONALISOMERASE/DECARBOXYLASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 4 | ALA A 253PHE A 163LEU A 160ILE A 118 | None | 0.80A | 6b5vA-1i7oA:undetectable6b5vB-1i7oA:undetectable | 6b5vA-1i7oA:12.476b5vB-1i7oA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6u | UDP-N-ACETYLMURAMATE-ALANINE LIGASE MURC (Thermotogamaritima) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 319PHE A 336ILE A 341LEU A 329ILE A 303 | None | 1.40A | 6b5vA-1j6uA:undetectable6b5vB-1j6uA:undetectable | 6b5vA-1j6uA:9.216b5vB-1j6uA:9.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jih | DNA POLYMERASE ETA (Saccharomycescerevisiae) |
PF00817(IMS)PF11799(IMS_C) | 4 | ILE A 413PHE A 419LEU A 416ILE A 486 | None | 0.73A | 6b5vA-1jihA:undetectable6b5vB-1jihA:undetectable | 6b5vA-1jihA:11.026b5vB-1jihA:11.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 5 | ALA A 278ILE A 304PHE A 319LEU A 288ILE A 246 | None | 1.46A | 6b5vA-1kkrA:undetectable6b5vB-1kkrA:undetectable | 6b5vA-1kkrA:10.736b5vB-1kkrA:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1luj | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 272ILE A 256LEU A 259ILE A 315 | None | 0.81A | 6b5vA-1lujA:undetectable6b5vB-1lujA:undetectable | 6b5vA-1lujA:9.986b5vB-1lujA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1luj | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 305ILE A 327LEU A 324ILE A 256 | None | 0.72A | 6b5vA-1lujA:undetectable6b5vB-1lujA:undetectable | 6b5vA-1lujA:9.986b5vB-1lujA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oa1 | HYDROXYLAMINEREDUCTASE (Desulfovibriovulgaris) |
PF03063(Prismane) | 4 | ALA A 68PHE A 61LEU A 38ILE A 136 | None | 0.86A | 6b5vA-1oa1A:undetectable6b5vB-1oa1A:undetectable | 6b5vA-1oa1A:9.046b5vB-1oa1A:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q2l | PROTEASE III (Escherichiacoli) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF16187(Peptidase_M16_M) | 4 | ALA A 912PHE A 851ILE A 782PHE A 816 | None | 0.87A | 6b5vA-1q2lA:undetectable6b5vB-1q2lA:undetectable | 6b5vA-1q2lA:6.696b5vB-1q2lA:6.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3n | BETA-ALANINESYNTHASE (Lachanceakluyveri) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | PHE A 340ILE A 344LEU A 352ILE A 282 | None | 0.76A | 6b5vA-1r3nA:undetectable6b5vB-1r3nA:undetectable | 6b5vA-1r3nA:11.416b5vB-1r3nA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rh9 | ENDO-BETA-MANNANASE (Solanumlycopersicum) |
PF00150(Cellulase) | 5 | PHE A 319ILE A 316PHE A 273LEU A 315ILE A 388 | None | 1.35A | 6b5vA-1rh9A:undetectable6b5vB-1rh9A:undetectable | 6b5vA-1rh9A:11.806b5vB-1rh9A:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3k | DUAL-SPECIFICITYTYROSINE PHOSPHATASE (Arabidopsisthaliana) |
PF00581(Rhodanese) | 4 | ALA A 25ILE A 55LEU A 58ILE A 7 | None | 0.59A | 6b5vA-1t3kA:undetectable6b5vB-1t3kA:undetectable | 6b5vA-1t3kA:18.796b5vB-1t3kA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tg5 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Arabidopsisthaliana) |
PF00903(Glyoxalase) | 4 | ILE A 200PHE A 43LEU A 47ILE A 346 | None | 0.88A | 6b5vA-1tg5A:undetectable6b5vB-1tg5A:undetectable | 6b5vA-1tg5A:10.866b5vB-1tg5A:10.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqh | CARBOXYLESTERASEPRECURSOR (Geobacillusstearothermophilus) |
PF12146(Hydrolase_4) | 4 | ALA A 91ILE A 215PHE A 241ILE A 196 | None | 0.85A | 6b5vA-1tqhA:0.06b5vB-1tqhA:undetectable | 6b5vA-1tqhA:15.556b5vB-1tqhA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqj | RIBULOSE-PHOSPHATE3-EPIMERASE (Synechocystissp.) |
PF00834(Ribul_P_3_epim) | 4 | ALA A 8PHE A 81ILE A 89ILE A 49 | None | 0.88A | 6b5vA-1tqjA:undetectable6b5vB-1tqjA:undetectable | 6b5vA-1tqjA:16.676b5vB-1tqjA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u4f | INWARD RECTIFIERPOTASSIUM CHANNEL 2 (Mus musculus) |
PF01007(IRK) | 4 | ALA A 290ILE A 248LEU A 231ILE A 236 | None | 0.75A | 6b5vA-1u4fA:undetectable6b5vB-1u4fA:undetectable | 6b5vA-1u4fA:14.616b5vB-1u4fA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urt | CARBONIC ANHYDRASE V (Mus musculus) |
PF00194(Carb_anhydrase) | 4 | ALA A 142PHE A 260LEU A 47ILE A 33 | None | 0.75A | 6b5vA-1urtA:undetectable6b5vB-1urtA:undetectable | 6b5vA-1urtA:12.506b5vB-1urtA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usw | FERULOYL ESTERASE A (Aspergillusniger) |
PF01764(Lipase_3) | 4 | ALA A 23ILE A 52LEU A 53ILE A 48 | None | 0.64A | 6b5vA-1uswA:undetectable6b5vB-1uswA:undetectable | 6b5vA-1uswA:14.626b5vB-1uswA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uus | STAT PROTEIN (Dictyosteliumdiscoideum) |
PF00017(SH2)PF09267(Dict-STAT-coil) | 5 | PHE A 651ILE A 579PHE A 520LEU A 573ILE A 623 | None | 1.26A | 6b5vA-1uusA:1.46b5vB-1uusA:3.5 | 6b5vA-1uusA:12.066b5vB-1uusA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHARE-EXPORTER (Saccharomycescerevisiae) |
PF03378(CAS_CSE1)PF03810(IBN_N)PF08506(Cse1) | 4 | ALA C 478ILE C 520LEU C 501ILE C 365 | None | 0.88A | 6b5vA-1wa5C:undetectable6b5vB-1wa5C:1.9 | 6b5vA-1wa5C:6.356b5vB-1wa5C:6.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wom | SIGMA FACTOR SIGBREGULATION PROTEINRSBQ (Bacillussubtilis) |
PF12697(Abhydrolase_6) | 4 | PHE A 50ILE A 48CYH A 82ILE A 101 | None | 0.86A | 6b5vA-1womA:undetectable6b5vB-1womA:undetectable | 6b5vA-1womA:14.736b5vB-1womA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ALA A 317ILE A 275PHE A 309ILE A 329 | None | 0.83A | 6b5vA-1xj5A:undetectable6b5vB-1xj5A:undetectable | 6b5vA-1xj5A:11.826b5vB-1xj5A:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xtp | LMAJ004091AAA (Leishmaniamajor) |
PF05891(Methyltransf_PK) | 4 | ALA A 87ILE A 107LEU A 111ILE A 193 | NoneSAI A 401 (-4.9A)NoneNone | 0.79A | 6b5vA-1xtpA:undetectable6b5vB-1xtpA:undetectable | 6b5vA-1xtpA:15.486b5vB-1xtpA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwi | SKD1 PROTEIN (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 4 | ILE A 288PHE A 436LEU A 284ILE A 199 | None | 0.85A | 6b5vA-1xwiA:0.06b5vB-1xwiA:undetectable | 6b5vA-1xwiA:12.426b5vB-1xwiA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9l | LIPOPROTEIN MXIM (Shigellaflexneri) |
PF11441(MxiM) | 4 | ALA A 103PHE A 83ILE A 128LEU A 136 | NoneUND A 150 ( 3.9A)NoneNone | 0.78A | 6b5vA-1y9lA:undetectable6b5vB-1y9lA:undetectable | 6b5vA-1y9lA:16.106b5vB-1y9lA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z26 | ARGONAUTE (Pyrococcusfuriosus) |
PF02171(Piwi)PF12212(PAZ_siRNAbind) | 4 | ALA A 750PHE A 611LEU A 762ILE A 557 | None | 0.82A | 6b5vA-1z26A:undetectable6b5vB-1z26A:undetectable | 6b5vA-1z26A:8.056b5vB-1z26A:8.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7e | PROTEIN ARNA (Escherichiacoli) |
PF00551(Formyl_trans_N)PF01370(Epimerase)PF02911(Formyl_trans_C) | 4 | ALA A 393ILE A 512LEU A 498ILE A 528 | ATP A1001 ( 3.6A)NoneNoneUGA A1101 (-3.5A) | 0.88A | 6b5vA-1z7eA:undetectable6b5vB-1z7eA:undetectable | 6b5vA-1z7eA:7.166b5vB-1z7eA:7.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4v | RNA EDITING COMPLEXPROTEIN MP57 (Trypanosomabrucei) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 4 | ALA A 60ILE A 268LEU A 100ILE A 228 | None | 0.83A | 6b5vA-2b4vA:undetectable6b5vB-2b4vA:0.8 | 6b5vA-2b4vA:10.686b5vB-2b4vA:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5m | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 4 | ALA A 566ILE A 586PHE A 612LEU A 606 | None | 0.89A | 6b5vA-2b5mA:undetectable6b5vB-2b5mA:undetectable | 6b5vA-2b5mA:5.736b5vB-2b5mA:5.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5n | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF10433(MMS1_N) | 4 | ALA A 566ILE A 586PHE A 612LEU A 606 | None | 0.80A | 6b5vA-2b5nA:undetectable6b5vB-2b5nA:undetectable | 6b5vA-2b5nA:12.306b5vB-2b5nA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bbe | HYPOTHETICAL PROTEINSO0527 (Shewanellaoneidensis) |
PF03992(ABM) | 4 | PHE A 68ILE A 14CYH A 16ILE A 83 | None | 0.85A | 6b5vA-2bbeA:undetectable6b5vB-2bbeA:undetectable | 6b5vA-2bbeA:15.746b5vB-2bbeA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 4 | ALA A 301ILE A 83LEU A 86ILE A 182 | None | 0.85A | 6b5vA-2c1cA:undetectable6b5vB-2c1cA:undetectable | 6b5vA-2c1cA:12.796b5vB-2c1cA:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dep | THERMOSTABLECELLOXYLANASE ([Clostridium]stercorarium) |
PF00331(Glyco_hydro_10) | 5 | ALA A 375PHE A 55ILE A 57PHE A 366LEU A 47 | None | 1.50A | 6b5vA-2depA:undetectable6b5vB-2depA:undetectable | 6b5vA-2depA:12.076b5vB-2depA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ebn | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F1 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 4 | ALA A 162ILE A 100LEU A 155ILE A 88 | None | 0.82A | 6b5vA-2ebnA:undetectable6b5vB-2ebnA:undetectable | 6b5vA-2ebnA:14.346b5vB-2ebnA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 4 | ALA A 235ILE A 371LEU A 374ILE A 135 | None | 0.78A | 6b5vA-2frxA:undetectable6b5vB-2frxA:undetectable | 6b5vA-2frxA:10.766b5vB-2frxA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk1 | BETA-HEXOSAMINIDASESUBUNIT BETA CHAIN A (Homo sapiens) |
no annotation | 5 | ALA N 413PHE N 337ILE N 395LEU N 392ILE N 322 | None | 1.48A | 6b5vA-2gk1N:undetectable6b5vB-2gk1N:undetectable | 6b5vA-2gk1N:14.836b5vB-2gk1N:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk4 | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF04127(DFP) | 4 | ALA A 199ILE A 31PHE A 157LEU A 28 | NoneNoneGOL A 501 (-4.0A)GOL A 501 ( 4.7A) | 0.84A | 6b5vA-2gk4A:undetectable6b5vB-2gk4A:undetectable | 6b5vA-2gk4A:14.596b5vB-2gk4A:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gy7 | ANGIOPOIETIN-2 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | ALA A 383ILE A 472LEU A 484ILE A 324 | None | 0.82A | 6b5vA-2gy7A:undetectable6b5vB-2gy7A:undetectable | 6b5vA-2gy7A:15.286b5vB-2gy7A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | PHE A 487ILE A 490PHE A 497LEU A 494ILE A 380 | None | 1.43A | 6b5vA-2hk5A:undetectable6b5vB-2hk5A:1.2 | 6b5vA-2hk5A:14.816b5vB-2hk5A:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsm | GLUTAMYL-TRNASYNTHETASE,CYTOPLASMIC (Saccharomycescerevisiae) |
no annotation | 4 | ALA A 33ILE A 51LEU A 23ILE A 176 | None | 0.85A | 6b5vA-2hsmA:undetectable6b5vB-2hsmA:undetectable | 6b5vA-2hsmA:17.706b5vB-2hsmA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3o | GAMMA-GLUTAMYLTRANSFERASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01019(G_glu_transpept) | 4 | ALA A 16ILE A 438LEU A 439ILE A 495 | None | 0.83A | 6b5vA-2i3oA:undetectable6b5vB-2i3oA:undetectable | 6b5vA-2i3oA:10.416b5vB-2i3oA:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 4 | ALA A 67ILE A 88LEU A 91ILE A 20 | None | 0.89A | 6b5vA-2i5bA:undetectable6b5vB-2i5bA:undetectable | 6b5vA-2i5bA:13.606b5vB-2i5bA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 4 | ALA A 315PHE A 79PHE A 14ILE A 166 | None | 0.80A | 6b5vA-2i9kA:undetectable6b5vB-2i9kA:undetectable | 6b5vA-2i9kA:16.326b5vB-2i9kA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ido | DNA POLYMERASE IIIEPSILON SUBUNIT (Escherichiacoli) |
PF00929(RNase_T) | 4 | ALA A 93PHE A 79ILE A 33ILE A 118 | None | 0.82A | 6b5vA-2idoA:undetectable6b5vB-2idoA:undetectable | 6b5vA-2idoA:17.036b5vB-2idoA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l1l | EXPORTIN-1 (Homo sapiens) |
no annotation | 5 | PHE B 588ILE B 591PHE B 554LEU B 555CYH B 595 | None | 1.43A | 6b5vA-2l1lB:undetectable6b5vB-2l1lB:2.7 | 6b5vA-2l1lB:18.116b5vB-2l1lB:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l1l | EXPORTIN-1 (Homo sapiens) |
no annotation | 5 | PHE B 588PHE B 554LEU B 555CYH B 595ILE B 614 | None | 1.29A | 6b5vA-2l1lB:undetectable6b5vB-2l1lB:2.7 | 6b5vA-2l1lB:18.116b5vB-2l1lB:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lbf | 60S ACIDIC RIBOSOMALPROTEIN P160S ACIDIC RIBOSOMALPROTEIN P2 (Homo sapiens) |
PF00428(Ribosomal_60s) | 4 | PHE A 47ILE A 28LEU A 31ILE B 159 | None | 0.63A | 6b5vA-2lbfA:undetectable6b5vB-2lbfA:undetectable | 6b5vA-2lbfA:23.816b5vB-2lbfA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n3w | 26S PROTEASOMEREGULATORY SUBUNITRPN1 (Saccharomycescerevisiae) |
PF01851(PC_rep) | 4 | ALA A 607PHE A 550ILE A 588LEU A 585 | None | 0.84A | 6b5vA-2n3wA:undetectable6b5vB-2n3wA:undetectable | 6b5vA-2n3wA:19.706b5vB-2n3wA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | ALA A 104PHE A 48ILE A 85ILE A 68 | None | 0.78A | 6b5vA-2o5pA:undetectable6b5vB-2o5pA:undetectable | 6b5vA-2o5pA:7.166b5vB-2o5pA:7.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ola | O-SUCCINYLBENZOICACID SYNTHETASE (Staphylococcusaureus) |
PF13378(MR_MLE_C) | 5 | PHE A 51ILE A 61PHE A 8LEU A 32CYH A 31 | None | 1.16A | 6b5vA-2olaA:0.46b5vB-2olaA:undetectable | 6b5vA-2olaA:14.146b5vB-2olaA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 4 | ALA B 299ILE B 188PHE B 292ILE B 236 | None | 0.87A | 6b5vA-2pffB:undetectable6b5vB-2pffB:undetectable | 6b5vA-2pffB:2.986b5vB-2pffB:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pi5 | DNA-DIRECTED RNAPOLYMERASE (Escherichiavirus T7) |
PF00940(RNA_pol)PF14700(RPOL_N) | 4 | ALA A 138PHE A 89PHE A 751ILE A 109 | None | 0.88A | 6b5vA-2pi5A:undetectable6b5vB-2pi5A:undetectable | 6b5vA-2pi5A:7.646b5vB-2pi5A:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk9 | PHO85 CYCLIN PHO80 (Saccharomycescerevisiae) |
PF08613(Cyclin) | 4 | ALA B 126ILE B 47LEU B 114ILE B 75 | NoneNoneNoneMES B 294 (-4.0A) | 0.89A | 6b5vA-2pk9B:undetectable6b5vB-2pk9B:undetectable | 6b5vA-2pk9B:14.346b5vB-2pk9B:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5o | PHENYLPYRUVATEDECARBOXYLASE (Azospirillumbrasilense) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | ALA A 146ILE A 163LEU A 135ILE A 39 | None | 0.84A | 6b5vA-2q5oA:undetectable6b5vB-2q5oA:undetectable | 6b5vA-2q5oA:8.856b5vB-2q5oA:8.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qe8 | UNCHARACTERIZEDPROTEIN (Trichormusvariabilis) |
PF03022(MRJP) | 4 | ALA A 203ILE A 252PHE A 297ILE A 221 | None | 0.88A | 6b5vA-2qe8A:undetectable6b5vB-2qe8A:undetectable | 6b5vA-2qe8A:13.166b5vB-2qe8A:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qop | HTH-TYPETRANSCRIPTIONALREGULATOR ACRR (Escherichiacoli) |
PF00440(TetR_N)PF08361(TetR_C_2) | 4 | ALA A 163LEU A 154CYH A 148ILE A 92 | None | 0.89A | 6b5vA-2qopA:undetectable6b5vB-2qopA:undetectable | 6b5vA-2qopA:15.816b5vB-2qopA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2i | GUANYLYLCYCLASE-ACTIVATINGPROTEIN 1 (Gallus gallus) |
PF00036(EF-hand_1)PF13499(EF-hand_7) | 4 | PHE A 62ILE A 70LEU A 33ILE A 177 | MYR A 1 ( 4.7A)MYR A 1 ( 4.7A)BME A 301 (-4.1A)MYR A 1 ( 4.6A) | 0.84A | 6b5vA-2r2iA:undetectable6b5vB-2r2iA:undetectable | 6b5vA-2r2iA:19.276b5vB-2r2iA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | ALA A 686ILE A 5LEU A 671ILE A 341 | None | 0.88A | 6b5vA-2rdyA:0.06b5vB-2rdyA:undetectable | 6b5vA-2rdyA:7.456b5vB-2rdyA:7.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 4 | ALA G 299ILE G 188PHE G 292ILE G 236 | None | 0.88A | 6b5vA-2uv8G:0.06b5vB-2uv8G:undetectable | 6b5vA-2uv8G:3.876b5vB-2uv8G:3.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcy | TRANS-2-ENOYL-COAREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ALA A 171ILE A 335LEU A 340ILE A 129 | None | 0.88A | 6b5vA-2vcyA:undetectable6b5vB-2vcyA:undetectable | 6b5vA-2vcyA:13.686b5vB-2vcyA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vea | PHYTOCHROME-LIKEPROTEIN CPH1 (Synechocystissp. PCC 6803) |
PF00360(PHY)PF01590(GAF)PF08446(PAS_2) | 4 | ALA A 387ILE A 377PHE A 440LEU A 378 | None | 0.88A | 6b5vA-2veaA:undetectable6b5vB-2veaA:1.2 | 6b5vA-2veaA:12.076b5vB-2veaA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x58 | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 4 | ALA A 105ILE A 151LEU A 121ILE A 248 | None | 0.77A | 6b5vA-2x58A:undetectable6b5vB-2x58A:undetectable | 6b5vA-2x58A:8.886b5vB-2x58A:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yop | PROTEIN FAM3B (Mus musculus) |
PF15711(ILEI) | 4 | ALA A 112ILE A 226LEU A 78ILE A 179 | None | 0.84A | 6b5vA-2yopA:undetectable6b5vB-2yopA:undetectable | 6b5vA-2yopA:15.346b5vB-2yopA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z65 | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13306(LRR_5)PF13855(LRR_8) | 4 | ALA A 97ILE A 108PHE A 122LEU A 107 | None | 0.87A | 6b5vA-2z65A:undetectable6b5vB-2z65A:undetectable | 6b5vA-2z65A:17.096b5vB-2z65A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z65 | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13306(LRR_5)PF13855(LRR_8) | 4 | ALA A 222PHE A 246LEU A 231ILE A 162 | None | 0.88A | 6b5vA-2z65A:undetectable6b5vB-2z65A:undetectable | 6b5vA-2z65A:17.096b5vB-2z65A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6g | B-CATENIN (Danio rerio) |
PF00514(Arm) | 4 | ALA A 271ILE A 255LEU A 258ILE A 314 | None | 0.88A | 6b5vA-2z6gA:undetectable6b5vB-2z6gA:undetectable | 6b5vA-2z6gA:7.396b5vB-2z6gA:7.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6g | B-CATENIN (Danio rerio) |
PF00514(Arm) | 4 | ALA A 275ILE A 255LEU A 258ILE A 314 | None | 0.81A | 6b5vA-2z6gA:undetectable6b5vB-2z6gA:undetectable | 6b5vA-2z6gA:7.396b5vB-2z6gA:7.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6g | B-CATENIN (Danio rerio) |
PF00514(Arm) | 4 | ALA A 304ILE A 326LEU A 323ILE A 255 | None | 0.77A | 6b5vA-2z6gA:undetectable6b5vB-2z6gA:undetectable | 6b5vA-2z6gA:7.396b5vB-2z6gA:7.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 272ILE A 256LEU A 259ILE A 315 | None | 0.82A | 6b5vA-2z6hA:undetectable6b5vB-2z6hA:undetectable | 6b5vA-2z6hA:8.636b5vB-2z6hA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 276ILE A 256LEU A 259ILE A 315 | None | 0.85A | 6b5vA-2z6hA:undetectable6b5vB-2z6hA:undetectable | 6b5vA-2z6hA:8.636b5vB-2z6hA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 305ILE A 327LEU A 324ILE A 256 | None | 0.74A | 6b5vA-2z6hA:undetectable6b5vB-2z6hA:undetectable | 6b5vA-2z6hA:8.636b5vB-2z6hA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq1 | THERMOSOME SUBUNIT (Methanococcoidesburtonii) |
PF00118(Cpn60_TCP1) | 4 | ALA B 119ILE B 436LEU B 91ILE B 130 | None | 0.89A | 6b5vA-3aq1B:undetectable6b5vB-3aq1B:1.8 | 6b5vA-3aq1B:9.436b5vB-3aq1B:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | ALA A 199PHE A 224LEU A 204ILE A 143 | None | 0.75A | 6b5vA-3b2dA:undetectable6b5vB-3b2dA:undetectable | 6b5vA-3b2dA:9.336b5vB-3b2dA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdv | UNCHARACTERIZEDPROTEIN DUF1234 (Pectobacteriumatrosepticum) |
PF06821(Ser_hydrolase) | 5 | ALA A 105ILE A 118PHE A 112LEU A 85CYH A 88 | NoneNone CL A 193 (-4.7A)NoneNone | 1.41A | 6b5vA-3bdvA:undetectable6b5vB-3bdvA:undetectable | 6b5vA-3bdvA:18.126b5vB-3bdvA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5m | OLIGOGALACTURONATELYASE (Vibrioparahaemolyticus) |
PF14583(Pectate_lyase22) | 4 | ILE A 377PHE A 371CYH A 33ILE A 7 | None | 0.84A | 6b5vA-3c5mA:undetectable6b5vB-3c5mA:undetectable | 6b5vA-3c5mA:11.986b5vB-3c5mA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da2 | CARBONIC ANHYDRASE13 (Homo sapiens) |
PF00194(Carb_anhydrase) | 4 | ALA A 143PHE A 261LEU A 48ILE A 34 | None | 0.68A | 6b5vA-3da2A:undetectable6b5vB-3da2A:undetectable | 6b5vA-3da2A:17.306b5vB-3da2A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh4 | SODIUM/GLUCOSECOTRANSPORTER (Vibrioparahaemolyticus) |
PF00474(SSF) | 4 | ALA A 283ILE A 61LEU A 60ILE A 531 | None | 0.78A | 6b5vA-3dh4A:0.86b5vB-3dh4A:2.4 | 6b5vA-3dh4A:8.836b5vB-3dh4A:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzc | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Vibrio cholerae) |
PF02350(Epimerase_2) | 4 | ALA A 371ILE A 6LEU A 24ILE A 112 | None | 0.89A | 6b5vA-3dzcA:undetectable6b5vB-3dzcA:undetectable | 6b5vA-3dzcA:13.206b5vB-3dzcA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8p | UNCHARACTERIZEDPROTEIN (Shewanellaoneidensis) |
PF03061(4HBT) | 4 | PHE A 126ILE A 53LEU A 37ILE A 67 | None | 0.84A | 6b5vA-3e8pA:undetectable6b5vB-3e8pA:1.8 | 6b5vA-3e8pA:17.686b5vB-3e8pA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eap | RHOGTPASE-ACTIVATINGPROTEIN 11A (Homo sapiens) |
PF00620(RhoGAP) | 4 | ALA A 118ILE A 232LEU A 195ILE A 132 | NoneNoneNoneUNX A 254 (-4.5A) | 0.86A | 6b5vA-3eapA:undetectable6b5vB-3eapA:undetectable | 6b5vA-3eapA:15.726b5vB-3eapA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewb | 2-ISOPROPYLMALATESYNTHASE (Listeriamonocytogenes) |
PF00682(HMGL-like) | 4 | ALA X 142ILE X 190PHE X 183LEU X 186 | None | 0.87A | 6b5vA-3ewbX:undetectable6b5vB-3ewbX:undetectable | 6b5vA-3ewbX:16.436b5vB-3ewbX:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcy | XYLAN ESTERASE 1 (Thermoanaerobacteriumsaccharolyticum) |
PF05448(AXE1) | 4 | ALA A 311ILE A 86LEU A 85ILE A 260 | None | 0.80A | 6b5vA-3fcyA:undetectable6b5vB-3fcyA:undetectable | 6b5vA-3fcyA:13.126b5vB-3fcyA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffh | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Listeriainnocua) |
PF00155(Aminotran_1_2) | 4 | ALA A 229PHE A 76LEU A 69ILE A 271 | None | 0.85A | 6b5vA-3ffhA:undetectable6b5vB-3ffhA:undetectable | 6b5vA-3ffhA:12.506b5vB-3ffhA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk2 | GLUCOCORTICOIDRECEPTOR DNA-BINDINGFACTOR 1 (Homo sapiens) |
PF00620(RhoGAP) | 4 | ALA A1320PHE A1312LEU A1307ILE A1261 | None | 0.82A | 6b5vA-3fk2A:undetectable6b5vB-3fk2A:undetectable | 6b5vA-3fk2A:15.576b5vB-3fk2A:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxi | TOLL-LIKE RECEPTOR 4 (Homo sapiens) |
PF13516(LRR_6)PF13855(LRR_8) | 4 | ALA A 97ILE A 108PHE A 122LEU A 107 | None | 0.87A | 6b5vA-3fxiA:undetectable6b5vB-3fxiA:undetectable | 6b5vA-3fxiA:7.636b5vB-3fxiA:7.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6r | DIHYDROOROTATEDEHYDROGENASEHOMOLOG,MITOCHONDRIAL (Plasmodiumfalciparum) |
PF01180(DHO_dh) | 4 | ALA A 561ILE A 542LEU A 546ILE A 503 | None | 0.80A | 6b5vA-3i6rA:undetectable6b5vB-3i6rA:undetectable | 6b5vA-3i6rA:11.446b5vB-3i6rA:11.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifq | PLAKOGLOBIN (Homo sapiens) |
PF00514(Arm) | 4 | ALA A 296ILE A 318LEU A 315ILE A 247 | None | 0.69A | 6b5vA-3ifqA:undetectable6b5vB-3ifqA:undetectable | 6b5vA-3ifqA:9.456b5vB-3ifqA:9.45 |