SIMILAR PATTERNS OF AMINO ACIDS FOR 6B5V_B_ECLB1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)


(Pyrococcus
woesei)
PF00382
(TFIIB)
4 ALA B1112
ILE B1146
LEU B1145
ILE B1186
None
0.89A 6b5vA-1aisB:
0.0
6b5vB-1aisB:
0.0
6b5vA-1aisB:
17.88
6b5vB-1aisB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhq CD11B

(Homo sapiens)
PF00092
(VWA)
4 PHE 1 137
ILE 1 240
PHE 1 275
ILE 1 236
None
0.86A 6b5vA-1bhq1:
undetectable
6b5vB-1bhq1:
undetectable
6b5vA-1bhq1:
13.99
6b5vB-1bhq1:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 295
ILE A 308
LEU A 284
ILE A 337
None
0.79A 6b5vA-1bvuA:
0.0
6b5vB-1bvuA:
0.0
6b5vA-1bvuA:
10.05
6b5vB-1bvuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)


(Salmonella
enterica)
PF00180
(Iso_dh)
4 ALA A   8
PHE A 102
LEU A  98
ILE A  48
None
0.89A 6b5vA-1cnzA:
0.0
6b5vB-1cnzA:
0.0
6b5vA-1cnzA:
13.02
6b5vB-1cnzA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 199
None
0.82A 6b5vA-1euzA:
0.0
6b5vB-1euzA:
0.0
6b5vA-1euzA:
10.50
6b5vB-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 338
None
0.72A 6b5vA-1euzA:
0.0
6b5vB-1euzA:
0.0
6b5vA-1euzA:
10.50
6b5vB-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanothermobacter
thermautotrophicus)
PF00296
(Bac_luciferase)
4 ILE A 311
PHE A 282
LEU A 314
ILE A  33
None
0.84A 6b5vA-1f07A:
0.0
6b5vB-1f07A:
0.0
6b5vA-1f07A:
13.75
6b5vB-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 ALA B 770
ILE B 655
PHE B 674
ILE B 414
None
0.75A 6b5vA-1ffvB:
0.0
6b5vB-1ffvB:
0.0
6b5vA-1ffvB:
6.89
6b5vB-1ffvB:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ALA A 187
ILE A 317
PHE A 305
LEU A 313
None
0.77A 6b5vA-1fotA:
0.0
6b5vB-1fotA:
0.0
6b5vA-1fotA:
13.31
6b5vB-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
4 ALA A 184
ILE A 169
LEU A 166
ILE A  95
None
0.89A 6b5vA-1gkrA:
0.0
6b5vB-1gkrA:
0.0
6b5vA-1gkrA:
10.25
6b5vB-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 296
ILE A 309
LEU A 285
ILE A 338
None
0.75A 6b5vA-1gtmA:
0.0
6b5vB-1gtmA:
0.0
6b5vA-1gtmA:
11.46
6b5vB-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
5 ALA B 120
ILE B  57
PHE B  89
LEU B  93
ILE B 161
None
1.47A 6b5vA-1gydB:
undetectable
6b5vB-1gydB:
undetectable
6b5vA-1gydB:
14.81
6b5vB-1gydB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1


(Escherichia
coli)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 ALA A 625
ILE A 446
LEU A 443
ILE A 559
None
0.86A 6b5vA-1h17A:
undetectable
6b5vB-1h17A:
undetectable
6b5vA-1h17A:
7.95
6b5vB-1h17A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli)
PF00923
(TAL_FSA)
4 ALA A 142
ILE A 175
LEU A 155
ILE A 276
None
0.84A 6b5vA-1i2oA:
0.0
6b5vB-1i2oA:
undetectable
6b5vA-1i2oA:
12.42
6b5vB-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
4 ALA A 253
PHE A 163
LEU A 160
ILE A 118
None
0.80A 6b5vA-1i7oA:
undetectable
6b5vB-1i7oA:
undetectable
6b5vA-1i7oA:
12.47
6b5vB-1i7oA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ALA A 319
PHE A 336
ILE A 341
LEU A 329
ILE A 303
None
1.40A 6b5vA-1j6uA:
undetectable
6b5vB-1j6uA:
undetectable
6b5vA-1j6uA:
9.21
6b5vB-1j6uA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae)
PF00817
(IMS)
PF11799
(IMS_C)
4 ILE A 413
PHE A 419
LEU A 416
ILE A 486
None
0.73A 6b5vA-1jihA:
undetectable
6b5vB-1jihA:
undetectable
6b5vA-1jihA:
11.02
6b5vB-1jihA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
5 ALA A 278
ILE A 304
PHE A 319
LEU A 288
ILE A 246
None
1.46A 6b5vA-1kkrA:
undetectable
6b5vB-1kkrA:
undetectable
6b5vA-1kkrA:
10.73
6b5vB-1kkrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 272
ILE A 256
LEU A 259
ILE A 315
None
0.81A 6b5vA-1lujA:
undetectable
6b5vB-1lujA:
undetectable
6b5vA-1lujA:
9.98
6b5vB-1lujA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 305
ILE A 327
LEU A 324
ILE A 256
None
0.72A 6b5vA-1lujA:
undetectable
6b5vB-1lujA:
undetectable
6b5vA-1lujA:
9.98
6b5vB-1lujA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE


(Desulfovibrio
vulgaris)
PF03063
(Prismane)
4 ALA A  68
PHE A  61
LEU A  38
ILE A 136
None
0.86A 6b5vA-1oa1A:
undetectable
6b5vB-1oa1A:
undetectable
6b5vA-1oa1A:
9.04
6b5vB-1oa1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M)
4 ALA A 912
PHE A 851
ILE A 782
PHE A 816
None
0.87A 6b5vA-1q2lA:
undetectable
6b5vB-1q2lA:
undetectable
6b5vA-1q2lA:
6.69
6b5vB-1q2lA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE


(Lachancea
kluyveri)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PHE A 340
ILE A 344
LEU A 352
ILE A 282
None
0.76A 6b5vA-1r3nA:
undetectable
6b5vB-1r3nA:
undetectable
6b5vA-1r3nA:
11.41
6b5vB-1r3nA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum)
PF00150
(Cellulase)
5 PHE A 319
ILE A 316
PHE A 273
LEU A 315
ILE A 388
None
1.35A 6b5vA-1rh9A:
undetectable
6b5vB-1rh9A:
undetectable
6b5vA-1rh9A:
11.80
6b5vB-1rh9A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3k DUAL-SPECIFICITY
TYROSINE PHOSPHATASE


(Arabidopsis
thaliana)
PF00581
(Rhodanese)
4 ALA A  25
ILE A  55
LEU A  58
ILE A   7
None
0.59A 6b5vA-1t3kA:
undetectable
6b5vB-1t3kA:
undetectable
6b5vA-1t3kA:
18.79
6b5vB-1t3kA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Arabidopsis
thaliana)
PF00903
(Glyoxalase)
4 ILE A 200
PHE A  43
LEU A  47
ILE A 346
None
0.88A 6b5vA-1tg5A:
undetectable
6b5vB-1tg5A:
undetectable
6b5vA-1tg5A:
10.86
6b5vB-1tg5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR


(Geobacillus
stearothermophilus)
PF12146
(Hydrolase_4)
4 ALA A  91
ILE A 215
PHE A 241
ILE A 196
None
0.85A 6b5vA-1tqhA:
0.0
6b5vB-1tqhA:
undetectable
6b5vA-1tqhA:
15.55
6b5vB-1tqhA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE


(Synechocystis
sp.)
PF00834
(Ribul_P_3_epim)
4 ALA A   8
PHE A  81
ILE A  89
ILE A  49
None
0.88A 6b5vA-1tqjA:
undetectable
6b5vB-1tqjA:
undetectable
6b5vA-1tqjA:
16.67
6b5vB-1tqjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4f INWARD RECTIFIER
POTASSIUM CHANNEL 2


(Mus musculus)
PF01007
(IRK)
4 ALA A 290
ILE A 248
LEU A 231
ILE A 236
None
0.75A 6b5vA-1u4fA:
undetectable
6b5vB-1u4fA:
undetectable
6b5vA-1u4fA:
14.61
6b5vB-1u4fA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
4 ALA A 142
PHE A 260
LEU A  47
ILE A  33
None
0.75A 6b5vA-1urtA:
undetectable
6b5vB-1urtA:
undetectable
6b5vA-1urtA:
12.50
6b5vB-1urtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger)
PF01764
(Lipase_3)
4 ALA A  23
ILE A  52
LEU A  53
ILE A  48
None
0.64A 6b5vA-1uswA:
undetectable
6b5vB-1uswA:
undetectable
6b5vA-1uswA:
14.62
6b5vB-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum)
PF00017
(SH2)
PF09267
(Dict-STAT-coil)
5 PHE A 651
ILE A 579
PHE A 520
LEU A 573
ILE A 623
None
1.26A 6b5vA-1uusA:
1.4
6b5vB-1uusA:
3.5
6b5vA-1uusA:
12.06
6b5vB-1uusA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
4 ALA C 478
ILE C 520
LEU C 501
ILE C 365
None
0.88A 6b5vA-1wa5C:
undetectable
6b5vB-1wa5C:
1.9
6b5vA-1wa5C:
6.35
6b5vB-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ


(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
4 PHE A  50
ILE A  48
CYH A  82
ILE A 101
None
0.86A 6b5vA-1womA:
undetectable
6b5vB-1womA:
undetectable
6b5vA-1womA:
14.73
6b5vB-1womA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1


(Arabidopsis
thaliana)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ALA A 317
ILE A 275
PHE A 309
ILE A 329
None
0.83A 6b5vA-1xj5A:
undetectable
6b5vB-1xj5A:
undetectable
6b5vA-1xj5A:
11.82
6b5vB-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major)
PF05891
(Methyltransf_PK)
4 ALA A  87
ILE A 107
LEU A 111
ILE A 193
None
SAI  A 401 (-4.9A)
None
None
0.79A 6b5vA-1xtpA:
undetectable
6b5vB-1xtpA:
undetectable
6b5vA-1xtpA:
15.48
6b5vB-1xtpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
4 ILE A 288
PHE A 436
LEU A 284
ILE A 199
None
0.85A 6b5vA-1xwiA:
0.0
6b5vB-1xwiA:
undetectable
6b5vA-1xwiA:
12.42
6b5vB-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9l LIPOPROTEIN MXIM

(Shigella
flexneri)
PF11441
(MxiM)
4 ALA A 103
PHE A  83
ILE A 128
LEU A 136
None
UND  A 150 ( 3.9A)
None
None
0.78A 6b5vA-1y9lA:
undetectable
6b5vB-1y9lA:
undetectable
6b5vA-1y9lA:
16.10
6b5vB-1y9lA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus)
PF02171
(Piwi)
PF12212
(PAZ_siRNAbind)
4 ALA A 750
PHE A 611
LEU A 762
ILE A 557
None
0.82A 6b5vA-1z26A:
undetectable
6b5vB-1z26A:
undetectable
6b5vA-1z26A:
8.05
6b5vB-1z26A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C)
4 ALA A 393
ILE A 512
LEU A 498
ILE A 528
ATP  A1001 ( 3.6A)
None
None
UGA  A1101 (-3.5A)
0.88A 6b5vA-1z7eA:
undetectable
6b5vB-1z7eA:
undetectable
6b5vA-1z7eA:
7.16
6b5vB-1z7eA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
4 ALA A  60
ILE A 268
LEU A 100
ILE A 228
None
0.83A 6b5vA-2b4vA:
undetectable
6b5vB-2b4vA:
0.8
6b5vA-2b4vA:
10.68
6b5vB-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
4 ALA A 566
ILE A 586
PHE A 612
LEU A 606
None
0.89A 6b5vA-2b5mA:
undetectable
6b5vB-2b5mA:
undetectable
6b5vA-2b5mA:
5.73
6b5vB-2b5mA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF10433
(MMS1_N)
4 ALA A 566
ILE A 586
PHE A 612
LEU A 606
None
0.80A 6b5vA-2b5nA:
undetectable
6b5vB-2b5nA:
undetectable
6b5vA-2b5nA:
12.30
6b5vB-2b5nA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527


(Shewanella
oneidensis)
PF03992
(ABM)
4 PHE A  68
ILE A  14
CYH A  16
ILE A  83
None
0.85A 6b5vA-2bbeA:
undetectable
6b5vB-2bbeA:
undetectable
6b5vA-2bbeA:
15.74
6b5vB-2bbeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea)
PF00246
(Peptidase_M14)
4 ALA A 301
ILE A  83
LEU A  86
ILE A 182
None
0.85A 6b5vA-2c1cA:
undetectable
6b5vB-2c1cA:
undetectable
6b5vA-2c1cA:
12.79
6b5vB-2c1cA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE


([Clostridium]
stercorarium)
PF00331
(Glyco_hydro_10)
5 ALA A 375
PHE A  55
ILE A  57
PHE A 366
LEU A  47
None
1.50A 6b5vA-2depA:
undetectable
6b5vB-2depA:
undetectable
6b5vA-2depA:
12.07
6b5vB-2depA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1


(Elizabethkingia
meningoseptica)
PF00704
(Glyco_hydro_18)
4 ALA A 162
ILE A 100
LEU A 155
ILE A  88
None
0.82A 6b5vA-2ebnA:
undetectable
6b5vB-2ebnA:
undetectable
6b5vA-2ebnA:
14.34
6b5vB-2ebnA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
4 ALA A 235
ILE A 371
LEU A 374
ILE A 135
None
0.78A 6b5vA-2frxA:
undetectable
6b5vB-2frxA:
undetectable
6b5vA-2frxA:
10.76
6b5vB-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A


(Homo sapiens)
no annotation 5 ALA N 413
PHE N 337
ILE N 395
LEU N 392
ILE N 322
None
1.48A 6b5vA-2gk1N:
undetectable
6b5vB-2gk1N:
undetectable
6b5vA-2gk1N:
14.83
6b5vB-2gk1N:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk4 CONSERVED
HYPOTHETICAL PROTEIN


(Streptococcus
pneumoniae)
PF04127
(DFP)
4 ALA A 199
ILE A  31
PHE A 157
LEU A  28
None
None
GOL  A 501 (-4.0A)
GOL  A 501 ( 4.7A)
0.84A 6b5vA-2gk4A:
undetectable
6b5vB-2gk4A:
undetectable
6b5vA-2gk4A:
14.59
6b5vB-2gk4A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens)
PF00147
(Fibrinogen_C)
4 ALA A 383
ILE A 472
LEU A 484
ILE A 324
None
0.82A 6b5vA-2gy7A:
undetectable
6b5vB-2gy7A:
undetectable
6b5vA-2gy7A:
15.28
6b5vB-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 PHE A 487
ILE A 490
PHE A 497
LEU A 494
ILE A 380
None
1.43A 6b5vA-2hk5A:
undetectable
6b5vB-2hk5A:
1.2
6b5vA-2hk5A:
14.81
6b5vB-2hk5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Saccharomyces
cerevisiae)
no annotation 4 ALA A  33
ILE A  51
LEU A  23
ILE A 176
None
0.85A 6b5vA-2hsmA:
undetectable
6b5vB-2hsmA:
undetectable
6b5vA-2hsmA:
17.70
6b5vB-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01019
(G_glu_transpept)
4 ALA A  16
ILE A 438
LEU A 439
ILE A 495
None
0.83A 6b5vA-2i3oA:
undetectable
6b5vB-2i3oA:
undetectable
6b5vA-2i3oA:
10.41
6b5vB-2i3oA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE


(Bacillus
subtilis)
PF08543
(Phos_pyr_kin)
4 ALA A  67
ILE A  88
LEU A  91
ILE A  20
None
0.89A 6b5vA-2i5bA:
undetectable
6b5vB-2i5bA:
undetectable
6b5vA-2i5bA:
13.60
6b5vB-2i5bA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
4 ALA A 315
PHE A  79
PHE A  14
ILE A 166
None
0.80A 6b5vA-2i9kA:
undetectable
6b5vB-2i9kA:
undetectable
6b5vA-2i9kA:
16.32
6b5vB-2i9kA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ido DNA POLYMERASE III
EPSILON SUBUNIT


(Escherichia
coli)
PF00929
(RNase_T)
4 ALA A  93
PHE A  79
ILE A  33
ILE A 118
None
0.82A 6b5vA-2idoA:
undetectable
6b5vB-2idoA:
undetectable
6b5vA-2idoA:
17.03
6b5vB-2idoA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens)
no annotation 5 PHE B 588
ILE B 591
PHE B 554
LEU B 555
CYH B 595
None
1.43A 6b5vA-2l1lB:
undetectable
6b5vB-2l1lB:
2.7
6b5vA-2l1lB:
18.11
6b5vB-2l1lB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens)
no annotation 5 PHE B 588
PHE B 554
LEU B 555
CYH B 595
ILE B 614
None
1.29A 6b5vA-2l1lB:
undetectable
6b5vB-2l1lB:
2.7
6b5vA-2l1lB:
18.11
6b5vB-2l1lB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2


(Homo sapiens)
PF00428
(Ribosomal_60s)
4 PHE A  47
ILE A  28
LEU A  31
ILE B 159
None
0.63A 6b5vA-2lbfA:
undetectable
6b5vB-2lbfA:
undetectable
6b5vA-2lbfA:
23.81
6b5vB-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1


(Saccharomyces
cerevisiae)
PF01851
(PC_rep)
4 ALA A 607
PHE A 550
ILE A 588
LEU A 585
None
0.84A 6b5vA-2n3wA:
undetectable
6b5vB-2n3wA:
undetectable
6b5vA-2n3wA:
19.70
6b5vB-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ALA A 104
PHE A  48
ILE A  85
ILE A  68
None
0.78A 6b5vA-2o5pA:
undetectable
6b5vB-2o5pA:
undetectable
6b5vA-2o5pA:
7.16
6b5vB-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE


(Staphylococcus
aureus)
PF13378
(MR_MLE_C)
5 PHE A  51
ILE A  61
PHE A   8
LEU A  32
CYH A  31
None
1.16A 6b5vA-2olaA:
0.4
6b5vB-2olaA:
undetectable
6b5vA-2olaA:
14.14
6b5vB-2olaA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
4 ALA B 299
ILE B 188
PHE B 292
ILE B 236
None
0.87A 6b5vA-2pffB:
undetectable
6b5vB-2pffB:
undetectable
6b5vA-2pffB:
2.98
6b5vB-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE


(Escherichia
virus T7)
PF00940
(RNA_pol)
PF14700
(RPOL_N)
4 ALA A 138
PHE A  89
PHE A 751
ILE A 109
None
0.88A 6b5vA-2pi5A:
undetectable
6b5vB-2pi5A:
undetectable
6b5vA-2pi5A:
7.64
6b5vB-2pi5A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae)
PF08613
(Cyclin)
4 ALA B 126
ILE B  47
LEU B 114
ILE B  75
None
None
None
MES  B 294 (-4.0A)
0.89A 6b5vA-2pk9B:
undetectable
6b5vB-2pk9B:
undetectable
6b5vA-2pk9B:
14.34
6b5vB-2pk9B:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ALA A 146
ILE A 163
LEU A 135
ILE A  39
None
0.84A 6b5vA-2q5oA:
undetectable
6b5vB-2q5oA:
undetectable
6b5vA-2q5oA:
8.85
6b5vB-2q5oA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN


(Trichormus
variabilis)
PF03022
(MRJP)
4 ALA A 203
ILE A 252
PHE A 297
ILE A 221
None
0.88A 6b5vA-2qe8A:
undetectable
6b5vB-2qe8A:
undetectable
6b5vA-2qe8A:
13.16
6b5vB-2qe8A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR


(Escherichia
coli)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
4 ALA A 163
LEU A 154
CYH A 148
ILE A  92
None
0.89A 6b5vA-2qopA:
undetectable
6b5vB-2qopA:
undetectable
6b5vA-2qopA:
15.81
6b5vB-2qopA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1


(Gallus gallus)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
4 PHE A  62
ILE A  70
LEU A  33
ILE A 177
MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
0.84A 6b5vA-2r2iA:
undetectable
6b5vB-2r2iA:
undetectable
6b5vA-2r2iA:
19.27
6b5vB-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 ALA A 686
ILE A   5
LEU A 671
ILE A 341
None
0.88A 6b5vA-2rdyA:
0.0
6b5vB-2rdyA:
undetectable
6b5vA-2rdyA:
7.45
6b5vB-2rdyA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
4 ALA G 299
ILE G 188
PHE G 292
ILE G 236
None
0.88A 6b5vA-2uv8G:
0.0
6b5vB-2uv8G:
undetectable
6b5vA-2uv8G:
3.87
6b5vB-2uv8G:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 171
ILE A 335
LEU A 340
ILE A 129
None
0.88A 6b5vA-2vcyA:
undetectable
6b5vB-2vcyA:
undetectable
6b5vA-2vcyA:
13.68
6b5vB-2vcyA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1


(Synechocystis
sp. PCC 6803)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
4 ALA A 387
ILE A 377
PHE A 440
LEU A 378
None
0.88A 6b5vA-2veaA:
undetectable
6b5vB-2veaA:
1.2
6b5vA-2veaA:
12.07
6b5vB-2veaA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 ALA A 105
ILE A 151
LEU A 121
ILE A 248
None
0.77A 6b5vA-2x58A:
undetectable
6b5vB-2x58A:
undetectable
6b5vA-2x58A:
8.88
6b5vB-2x58A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yop PROTEIN FAM3B

(Mus musculus)
PF15711
(ILEI)
4 ALA A 112
ILE A 226
LEU A  78
ILE A 179
None
0.84A 6b5vA-2yopA:
undetectable
6b5vB-2yopA:
undetectable
6b5vA-2yopA:
15.34
6b5vB-2yopA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 ALA A  97
ILE A 108
PHE A 122
LEU A 107
None
0.87A 6b5vA-2z65A:
undetectable
6b5vB-2z65A:
undetectable
6b5vA-2z65A:
17.09
6b5vB-2z65A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 ALA A 222
PHE A 246
LEU A 231
ILE A 162
None
0.88A 6b5vA-2z65A:
undetectable
6b5vB-2z65A:
undetectable
6b5vA-2z65A:
17.09
6b5vB-2z65A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 ALA A 271
ILE A 255
LEU A 258
ILE A 314
None
0.88A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable
6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 ALA A 275
ILE A 255
LEU A 258
ILE A 314
None
0.81A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable
6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 ALA A 304
ILE A 326
LEU A 323
ILE A 255
None
0.77A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable
6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 272
ILE A 256
LEU A 259
ILE A 315
None
0.82A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable
6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 276
ILE A 256
LEU A 259
ILE A 315
None
0.85A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable
6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ALA A 305
ILE A 327
LEU A 324
ILE A 256
None
0.74A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable
6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii)
PF00118
(Cpn60_TCP1)
4 ALA B 119
ILE B 436
LEU B  91
ILE B 130
None
0.89A 6b5vA-3aq1B:
undetectable
6b5vB-3aq1B:
1.8
6b5vA-3aq1B:
9.43
6b5vB-3aq1B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 ALA A 199
PHE A 224
LEU A 204
ILE A 143
None
0.75A 6b5vA-3b2dA:
undetectable
6b5vB-3b2dA:
undetectable
6b5vA-3b2dA:
9.33
6b5vB-3b2dA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234


(Pectobacterium
atrosepticum)
PF06821
(Ser_hydrolase)
5 ALA A 105
ILE A 118
PHE A 112
LEU A  85
CYH A  88
None
None
CL  A 193 (-4.7A)
None
None
1.41A 6b5vA-3bdvA:
undetectable
6b5vB-3bdvA:
undetectable
6b5vA-3bdvA:
18.12
6b5vB-3bdvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE


(Vibrio
parahaemolyticus)
PF14583
(Pectate_lyase22)
4 ILE A 377
PHE A 371
CYH A  33
ILE A   7
None
0.84A 6b5vA-3c5mA:
undetectable
6b5vB-3c5mA:
undetectable
6b5vA-3c5mA:
11.98
6b5vB-3c5mA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ALA A 143
PHE A 261
LEU A  48
ILE A  34
None
0.68A 6b5vA-3da2A:
undetectable
6b5vB-3da2A:
undetectable
6b5vA-3da2A:
17.30
6b5vB-3da2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
4 ALA A 283
ILE A  61
LEU A  60
ILE A 531
None
0.78A 6b5vA-3dh4A:
0.8
6b5vB-3dh4A:
2.4
6b5vA-3dh4A:
8.83
6b5vB-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Vibrio cholerae)
PF02350
(Epimerase_2)
4 ALA A 371
ILE A   6
LEU A  24
ILE A 112
None
0.89A 6b5vA-3dzcA:
undetectable
6b5vB-3dzcA:
undetectable
6b5vA-3dzcA:
13.20
6b5vB-3dzcA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF03061
(4HBT)
4 PHE A 126
ILE A  53
LEU A  37
ILE A  67
None
0.84A 6b5vA-3e8pA:
undetectable
6b5vB-3e8pA:
1.8
6b5vA-3e8pA:
17.68
6b5vB-3e8pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A


(Homo sapiens)
PF00620
(RhoGAP)
4 ALA A 118
ILE A 232
LEU A 195
ILE A 132
None
None
None
UNX  A 254 (-4.5A)
0.86A 6b5vA-3eapA:
undetectable
6b5vB-3eapA:
undetectable
6b5vA-3eapA:
15.72
6b5vB-3eapA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE


(Listeria
monocytogenes)
PF00682
(HMGL-like)
4 ALA X 142
ILE X 190
PHE X 183
LEU X 186
None
0.87A 6b5vA-3ewbX:
undetectable
6b5vB-3ewbX:
undetectable
6b5vA-3ewbX:
16.43
6b5vB-3ewbX:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
4 ALA A 311
ILE A  86
LEU A  85
ILE A 260
None
0.80A 6b5vA-3fcyA:
undetectable
6b5vB-3fcyA:
undetectable
6b5vA-3fcyA:
13.12
6b5vB-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
4 ALA A 229
PHE A  76
LEU A  69
ILE A 271
None
0.85A 6b5vA-3ffhA:
undetectable
6b5vB-3ffhA:
undetectable
6b5vA-3ffhA:
12.50
6b5vB-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1


(Homo sapiens)
PF00620
(RhoGAP)
4 ALA A1320
PHE A1312
LEU A1307
ILE A1261
None
0.82A 6b5vA-3fk2A:
undetectable
6b5vB-3fk2A:
undetectable
6b5vA-3fk2A:
15.57
6b5vB-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ALA A  97
ILE A 108
PHE A 122
LEU A 107
None
0.87A 6b5vA-3fxiA:
undetectable
6b5vB-3fxiA:
undetectable
6b5vA-3fxiA:
7.63
6b5vB-3fxiA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL


(Plasmodium
falciparum)
PF01180
(DHO_dh)
4 ALA A 561
ILE A 542
LEU A 546
ILE A 503
None
0.80A 6b5vA-3i6rA:
undetectable
6b5vB-3i6rA:
undetectable
6b5vA-3i6rA:
11.44
6b5vB-3i6rA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens)
PF00514
(Arm)
4 ALA A 296
ILE A 318
LEU A 315
ILE A 247
None
0.69A 6b5vA-3ifqA:
undetectable
6b5vB-3ifqA:
undetectable
6b5vA-3ifqA:
9.45
6b5vB-3ifqA:
9.45