SIMILAR PATTERNS OF AMINO ACIDS FOR 6B5V_A_ECLA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A 308
LEU A 284
ILE A 337
ALA A 295
None
0.82A 6b5vA-1bvuA:
0.0
6b5vC-1bvuA:
0.0
6b5vA-1bvuA:
10.05
6b5vC-1bvuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A 309
LEU A 285
ILE A 199
ALA A 296
None
0.84A 6b5vA-1euzA:
0.0
6b5vC-1euzA:
0.0
6b5vA-1euzA:
10.50
6b5vC-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A 309
LEU A 285
ILE A 338
ALA A 296
None
0.73A 6b5vA-1euzA:
0.0
6b5vC-1euzA:
0.0
6b5vA-1euzA:
10.50
6b5vC-1euzA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanothermobacter
thermautotrophicus)
PF00296
(Bac_luciferase)
4 ILE A 311
PHE A 282
LEU A 314
ILE A  33
None
0.84A 6b5vA-1f07A:
0.0
6b5vC-1f07A:
0.0
6b5vA-1f07A:
13.75
6b5vC-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 ILE B 655
PHE B 674
ILE B 414
ALA B 770
None
0.76A 6b5vA-1ffvB:
0.0
6b5vC-1ffvB:
undetectable
6b5vA-1ffvB:
6.89
6b5vC-1ffvB:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ILE A 317
PHE A 305
LEU A 313
ALA A 187
None
0.81A 6b5vA-1fotA:
undetectable
6b5vC-1fotA:
undetectable
6b5vA-1fotA:
13.31
6b5vC-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
4 ILE A 169
LEU A 166
ILE A  95
ALA A 184
None
0.86A 6b5vA-1gkrA:
0.0
6b5vC-1gkrA:
0.0
6b5vA-1gkrA:
10.25
6b5vC-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A 309
LEU A 285
ILE A 338
ALA A 296
None
0.78A 6b5vA-1gtmA:
0.0
6b5vC-1gtmA:
0.0
6b5vA-1gtmA:
11.46
6b5vC-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli)
PF00923
(TAL_FSA)
4 ILE A 175
LEU A 155
ILE A 276
ALA A 142
None
0.84A 6b5vA-1i2oA:
0.0
6b5vC-1i2oA:
0.0
6b5vA-1i2oA:
12.42
6b5vC-1i2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ILE A 256
LEU A 259
ILE A 315
ALA A 272
None
0.82A 6b5vA-1lujA:
0.0
6b5vC-1lujA:
0.0
6b5vA-1lujA:
9.98
6b5vC-1lujA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3k DUAL-SPECIFICITY
TYROSINE PHOSPHATASE


(Arabidopsis
thaliana)
PF00581
(Rhodanese)
4 ILE A  55
LEU A  58
ILE A   7
ALA A  25
None
0.57A 6b5vA-1t3kA:
undetectable
6b5vC-1t3kA:
undetectable
6b5vA-1t3kA:
18.79
6b5vC-1t3kA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
4 PHE A 260
LEU A  47
ILE A  33
ALA A 142
None
0.77A 6b5vA-1urtA:
undetectable
6b5vC-1urtA:
undetectable
6b5vA-1urtA:
12.50
6b5vC-1urtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger)
PF01764
(Lipase_3)
4 ILE A  52
LEU A  53
ILE A  48
ALA A  23
None
0.66A 6b5vA-1uswA:
undetectable
6b5vC-1uswA:
undetectable
6b5vA-1uswA:
14.62
6b5vC-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
4 ILE C 520
LEU C 501
ILE C 365
ALA C 478
None
0.88A 6b5vA-1wa5C:
undetectable
6b5vC-1wa5C:
undetectable
6b5vA-1wa5C:
6.35
6b5vC-1wa5C:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
4 ILE A  63
LEU A 744
ILE A 677
ALA A 756
None
0.87A 6b5vA-1wz2A:
1.0
6b5vC-1wz2A:
undetectable
6b5vA-1wz2A:
5.58
6b5vC-1wz2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1


(Arabidopsis
thaliana)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ILE A 275
PHE A 309
ILE A 329
ALA A 317
None
0.85A 6b5vA-1xj5A:
undetectable
6b5vC-1xj5A:
undetectable
6b5vA-1xj5A:
11.82
6b5vC-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
4 ILE A 288
PHE A 436
LEU A 284
ILE A 199
None
0.85A 6b5vA-1xwiA:
undetectable
6b5vC-1xwiA:
undetectable
6b5vA-1xwiA:
12.42
6b5vC-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9l LIPOPROTEIN MXIM

(Shigella
flexneri)
PF11441
(MxiM)
4 PHE A  83
ILE A 128
LEU A 136
ALA A 103
UND  A 150 ( 3.9A)
None
None
None
0.78A 6b5vA-1y9lA:
undetectable
6b5vC-1y9lA:
undetectable
6b5vA-1y9lA:
16.10
6b5vC-1y9lA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
4 ILE A 268
LEU A 100
ILE A 228
ALA A  60
None
0.80A 6b5vA-2b4vA:
undetectable
6b5vC-2b4vA:
0.0
6b5vA-2b4vA:
10.68
6b5vC-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527


(Shewanella
oneidensis)
PF03992
(ABM)
4 PHE A  68
ILE A  14
CYH A  16
ILE A  83
None
0.85A 6b5vA-2bbeA:
undetectable
6b5vC-2bbeA:
undetectable
6b5vA-2bbeA:
15.74
6b5vC-2bbeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea)
PF00246
(Peptidase_M14)
4 ILE A  83
LEU A  86
ILE A 182
ALA A 301
None
0.87A 6b5vA-2c1cA:
undetectable
6b5vC-2c1cA:
undetectable
6b5vA-2c1cA:
12.79
6b5vC-2c1cA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
4 ILE A 371
LEU A 374
ILE A 135
ALA A 235
None
0.80A 6b5vA-2frxA:
undetectable
6b5vC-2frxA:
undetectable
6b5vA-2frxA:
10.76
6b5vC-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens)
PF00147
(Fibrinogen_C)
4 ILE A 472
LEU A 484
ILE A 324
ALA A 383
None
0.81A 6b5vA-2gy7A:
undetectable
6b5vC-2gy7A:
undetectable
6b5vA-2gy7A:
15.28
6b5vC-2gy7A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Saccharomyces
cerevisiae)
no annotation 4 ILE A  51
LEU A  23
ILE A 176
ALA A  33
None
0.81A 6b5vA-2hsmA:
undetectable
6b5vC-2hsmA:
undetectable
6b5vA-2hsmA:
17.70
6b5vC-2hsmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5


(Saccharomyces
cerevisiae)
PF04494
(TFIID_NTD2)
4 PHE A 208
ILE A 216
LEU A 219
ILE A 181
None
0.83A 6b5vA-2j49A:
undetectable
6b5vC-2j49A:
0.1
6b5vA-2j49A:
19.31
6b5vC-2j49A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2


(Homo sapiens)
PF00428
(Ribosomal_60s)
4 PHE A  47
ILE A  28
LEU A  31
ILE B 159
None
0.63A 6b5vA-2lbfA:
undetectable
6b5vC-2lbfA:
undetectable
6b5vA-2lbfA:
23.81
6b5vC-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1


(Saccharomyces
cerevisiae)
PF01851
(PC_rep)
4 PHE A 550
ILE A 588
LEU A 585
ALA A 607
None
0.82A 6b5vA-2n3wA:
undetectable
6b5vC-2n3wA:
undetectable
6b5vA-2n3wA:
19.70
6b5vC-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 PHE A  48
ILE A  85
ILE A  68
ALA A 104
None
0.77A 6b5vA-2o5pA:
undetectable
6b5vC-2o5pA:
undetectable
6b5vA-2o5pA:
7.16
6b5vC-2o5pA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
4 ILE B 188
PHE B 292
ILE B 236
ALA B 299
None
0.87A 6b5vA-2pffB:
undetectable
6b5vC-2pffB:
undetectable
6b5vA-2pffB:
2.98
6b5vC-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1


(Gallus gallus)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
4 PHE A  62
ILE A  70
LEU A  33
ILE A 177
MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
0.84A 6b5vA-2r2iA:
undetectable
6b5vC-2r2iA:
undetectable
6b5vA-2r2iA:
19.27
6b5vC-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
4 ILE G 188
PHE G 292
ILE G 236
ALA G 299
None
0.87A 6b5vA-2uv8G:
0.0
6b5vC-2uv8G:
undetectable
6b5vA-2uv8G:
3.87
6b5vC-2uv8G:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 ILE A 255
LEU A 258
ILE A 314
ALA A 275
None
0.80A 6b5vA-2z6gA:
undetectable
6b5vC-2z6gA:
undetectable
6b5vA-2z6gA:
7.39
6b5vC-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ILE A 256
LEU A 259
ILE A 315
ALA A 272
None
0.83A 6b5vA-2z6hA:
undetectable
6b5vC-2z6hA:
undetectable
6b5vA-2z6hA:
8.63
6b5vC-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 ILE A 256
LEU A 259
ILE A 315
ALA A 276
None
0.84A 6b5vA-2z6hA:
undetectable
6b5vC-2z6hA:
undetectable
6b5vA-2z6hA:
8.63
6b5vC-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 PHE A 224
LEU A 204
ILE A 143
ALA A 199
None
0.73A 6b5vA-3b2dA:
undetectable
6b5vC-3b2dA:
undetectable
6b5vA-3b2dA:
9.33
6b5vC-3b2dA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
4 PHE A 261
LEU A  48
ILE A  34
ALA A 143
None
0.71A 6b5vA-3da2A:
undetectable
6b5vC-3da2A:
undetectable
6b5vA-3da2A:
17.30
6b5vC-3da2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
4 ILE A  61
LEU A  60
ILE A 531
ALA A 283
None
0.79A 6b5vA-3dh4A:
0.8
6b5vC-3dh4A:
0.0
6b5vA-3dh4A:
8.83
6b5vC-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF03061
(4HBT)
4 PHE A 126
ILE A  53
LEU A  37
ILE A  67
None
0.85A 6b5vA-3e8pA:
undetectable
6b5vC-3e8pA:
undetectable
6b5vA-3e8pA:
17.68
6b5vC-3e8pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
4 ILE A  86
LEU A  85
ILE A 260
ALA A 311
None
0.80A 6b5vA-3fcyA:
undetectable
6b5vC-3fcyA:
undetectable
6b5vA-3fcyA:
13.12
6b5vC-3fcyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
4 PHE A  76
LEU A  69
ILE A 271
ALA A 229
None
0.87A 6b5vA-3ffhA:
undetectable
6b5vC-3ffhA:
undetectable
6b5vA-3ffhA:
12.50
6b5vC-3ffhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1


(Homo sapiens)
PF00620
(RhoGAP)
4 PHE A1312
LEU A1307
ILE A1261
ALA A1320
None
0.80A 6b5vA-3fk2A:
undetectable
6b5vC-3fk2A:
0.0
6b5vA-3fk2A:
15.57
6b5vC-3fk2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens)
PF00514
(Arm)
4 ILE A 247
LEU A 250
ILE A 306
ALA A 267
None
0.87A 6b5vA-3ifqA:
undetectable
6b5vC-3ifqA:
0.5
6b5vA-3ifqA:
9.45
6b5vC-3ifqA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 4 PHE A  84
LEU A  80
ILE A 333
ALA A 382
None
0.86A 6b5vA-3j3iA:
undetectable
6b5vC-3j3iA:
undetectable
6b5vA-3j3iA:
6.21
6b5vC-3j3iA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz3 SENSOR PROTEIN QSEC

(Escherichia
coli)
PF00512
(HisKA)
PF02518
(HATPase_c)
4 ILE A 384
PHE A 435
ILE A 344
ALA A 426
None
0.87A 6b5vA-3jz3A:
undetectable
6b5vC-3jz3A:
undetectable
6b5vA-3jz3A:
19.76
6b5vC-3jz3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM


(Acinetobacter
sp. ADP1)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
4 PHE A 211
ILE A 210
ILE A 240
ALA A 245
None
0.86A 6b5vA-3k1nA:
undetectable
6b5vC-3k1nA:
undetectable
6b5vA-3k1nA:
19.75
6b5vC-3k1nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
4 PHE A 157
ILE A 121
PHE A  85
LEU A 124
MES  A 362 (-4.8A)
None
None
None
0.86A 6b5vA-3l6aA:
undetectable
6b5vC-3l6aA:
1.5
6b5vA-3l6aA:
13.23
6b5vC-3l6aA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE


(Salmonella
enterica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ILE A   5
LEU A   6
ILE A 323
ALA A 307
None
0.84A 6b5vA-3nx4A:
undetectable
6b5vC-3nx4A:
undetectable
6b5vA-3nx4A:
14.24
6b5vC-3nx4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor)
PF00079
(Serpin)
4 ILE A  73
PHE A  31
LEU A  77
ILE A 125
None
0.77A 6b5vA-3ozqA:
undetectable
6b5vC-3ozqA:
undetectable
6b5vA-3ozqA:
13.91
6b5vC-3ozqA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
4 PHE A  34
ILE A  71
PHE A  81
LEU A  68
None
0.80A 6b5vA-3q1yA:
undetectable
6b5vC-3q1yA:
undetectable
6b5vA-3q1yA:
14.76
6b5vC-3q1yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR


(Bacillus
subtilis)
PF00874
(PRD)
PF03123
(CAT_RBD)
4 PHE A  52
ILE A  29
ILE A  85
ALA A 106
None
0.84A 6b5vA-3rioA:
undetectable
6b5vC-3rioA:
undetectable
6b5vA-3rioA:
18.08
6b5vC-3rioA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Haemophilus
influenzae)
PF00275
(EPSP_synthase)
4 ILE A  96
LEU A  99
ILE A 160
ALA A 136
None
0.67A 6b5vA-3sweA:
undetectable
6b5vC-3sweA:
undetectable
6b5vA-3sweA:
11.86
6b5vC-3sweA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
4 ILE A  48
LEU A  54
ILE A 392
ALA A 445
None
0.83A 6b5vA-3uonA:
1.2
6b5vC-3uonA:
0.0
6b5vA-3uonA:
15.12
6b5vC-3uonA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
4 ILE A 306
LEU A 283
ILE A 349
ALA A 255
None
0.75A 6b5vA-3uykA:
undetectable
6b5vC-3uykA:
undetectable
6b5vA-3uykA:
12.77
6b5vC-3uykA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Streptomyces
chartreusis)
PF01370
(Epimerase)
4 ILE A  19
LEU A  23
ILE A 168
ALA A 224
NAD  A 401 (-4.1A)
None
None
None
0.80A 6b5vA-3vpsA:
undetectable
6b5vC-3vpsA:
undetectable
6b5vA-3vpsA:
14.33
6b5vC-3vpsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
5 PHE A  17
ILE A  19
PHE A 310
LEU A   9
ALA A 319
None
1.40A 6b5vA-3w25A:
undetectable
6b5vC-3w25A:
undetectable
6b5vA-3w25A:
12.20
6b5vC-3w25A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae)
PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T)
4 ILE A 202
LEU A 204
ILE A 310
ALA A 330
None
0.77A 6b5vA-4ae0A:
undetectable
6b5vC-4ae0A:
undetectable
6b5vA-4ae0A:
11.50
6b5vC-4ae0A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE


(Chloroflexus
aurantiacus)
PF01575
(MaoC_dehydratas)
4 ILE A  72
LEU A 106
ILE A 275
ALA A  98
None
0.88A 6b5vA-4e3eA:
undetectable
6b5vC-4e3eA:
undetectable
6b5vA-4e3eA:
13.21
6b5vC-4e3eA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE


(Burkholderia
thailandensis)
PF01208
(URO-D)
4 PHE A  92
LEU A  90
ILE A 118
ALA A  51
None
0.80A 6b5vA-4exqA:
undetectable
6b5vC-4exqA:
undetectable
6b5vA-4exqA:
15.03
6b5vC-4exqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ILE A  91
LEU A  95
ILE A 106
ALA A   6
None
0.84A 6b5vA-4jzyA:
undetectable
6b5vC-4jzyA:
undetectable
6b5vA-4jzyA:
10.25
6b5vC-4jzyA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE


(Aspergillus
nidulans)
PF16363
(GDP_Man_Dehyd)
4 ILE A  82
PHE A  68
ILE A  47
ALA A  58
None
0.86A 6b5vA-4lisA:
undetectable
6b5vC-4lisA:
undetectable
6b5vA-4lisA:
13.92
6b5vC-4lisA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1


(Homo sapiens)
PF16363
(GDP_Man_Dehyd)
4 ILE A 258
LEU A 323
ILE A  93
ALA A 311
NAD  A 501 (-3.9A)
None
None
None
0.80A 6b5vA-4lk3A:
undetectable
6b5vC-4lk3A:
undetectable
6b5vA-4lk3A:
15.97
6b5vC-4lk3A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I


(Anopheles
gambiae)
PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 PHE A1193
ILE A1315
LEU A 796
ALA A 854
None
0.87A 6b5vA-4lnvA:
0.3
6b5vC-4lnvA:
undetectable
6b5vA-4lnvA:
5.74
6b5vC-4lnvA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me9 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Bacillus cereus)
PF00440
(TetR_N)
PF16295
(TetR_C_10)
5 PHE A  71
ILE A  67
PHE A  99
LEU A  88
ILE A  77
None
1.30A 6b5vA-4me9A:
undetectable
6b5vC-4me9A:
undetectable
6b5vA-4me9A:
16.93
6b5vC-4me9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE


(Bacteroides
fragilis)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
4 ILE A 320
LEU A 325
ILE A 270
ALA A 337
None
0.56A 6b5vA-4pysA:
undetectable
6b5vC-4pysA:
undetectable
6b5vA-4pysA:
9.46
6b5vC-4pysA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified)
PF00561
(Abhydrolase_1)
4 ILE A 102
LEU A  79
ILE A 209
ALA A  91
None
0.84A 6b5vA-4q3lA:
undetectable
6b5vC-4q3lA:
undetectable
6b5vA-4q3lA:
12.76
6b5vC-4q3lA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora)
PF08801
(Nucleoporin_N)
5 PHE A  83
LEU A  81
CYH A 486
ILE A 494
ALA A 110
None
1.18A 6b5vA-4q9tA:
undetectable
6b5vC-4q9tA:
undetectable
6b5vA-4q9tA:
8.19
6b5vC-4q9tA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus)
PF00698
(Acyl_transf_1)
4 PHE A  97
LEU A 201
CYH A 200
ILE A 130
None
0.69A 6b5vA-4qbuA:
0.0
6b5vC-4qbuA:
undetectable
6b5vA-4qbuA:
10.51
6b5vC-4qbuA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE


(Homo sapiens)
PF00171
(Aldedh)
4 PHE A 178
ILE A 181
ILE A 163
ALA A 110
None
0.72A 6b5vA-4qgkA:
undetectable
6b5vC-4qgkA:
undetectable
6b5vA-4qgkA:
11.28
6b5vC-4qgkA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
4 PHE A 249
LEU A  47
ILE A  33
ALA A 142
None
0.74A 6b5vA-4qk3A:
undetectable
6b5vC-4qk3A:
undetectable
6b5vA-4qk3A:
16.06
6b5vC-4qk3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 PHE A 386
LEU A 371
ILE A 303
ALA A 361
None
0.86A 6b5vA-4u7lA:
undetectable
6b5vC-4u7lA:
undetectable
6b5vA-4u7lA:
8.77
6b5vC-4u7lA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 ILE A 592
LEU A 454
ILE A 508
ALA A 540
None
0.84A 6b5vA-4um8A:
undetectable
6b5vC-4um8A:
undetectable
6b5vA-4um8A:
9.71
6b5vC-4um8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ILE A  90
LEU A  92
ILE A 113
ALA A  99
ACT  A 410 (-4.8A)
None
None
None
0.75A 6b5vA-4w5zA:
undetectable
6b5vC-4w5zA:
undetectable
6b5vA-4w5zA:
12.20
6b5vC-4w5zA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis)
PF00067
(p450)
4 ILE A 153
LEU A 156
ILE A 230
ALA A 107
None
0.88A 6b5vA-4wpzA:
undetectable
6b5vC-4wpzA:
undetectable
6b5vA-4wpzA:
12.23
6b5vC-4wpzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5


(Drosophila
melanogaster)
PF13191
(AAA_16)
PF14630
(ORC5_C)
4 ILE E   4
LEU E   8
ILE E  37
ALA E  49
None
0.85A 6b5vA-4xgcE:
undetectable
6b5vC-4xgcE:
undetectable
6b5vA-4xgcE:
11.33
6b5vC-4xgcE:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
4 PHE A 353
LEU A  56
ILE A 158
ALA A 256
None
None
144  A 501 ( 4.2A)
None
0.78A 6b5vA-4zchA:
undetectable
6b5vC-4zchA:
undetectable
6b5vA-4zchA:
10.80
6b5vC-4zchA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens)
PF00079
(Serpin)
5 PHE A  19
ILE A  27
PHE A 287
ILE A  34
ALA A 343
None
1.49A 6b5vA-4zk3A:
undetectable
6b5vC-4zk3A:
undetectable
6b5vA-4zk3A:
12.74
6b5vC-4zk3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum)
PF00400
(WD40)
4 PHE A 296
ILE A 370
LEU A 371
ALA A 312
None
0.73A 6b5vA-4zoyA:
undetectable
6b5vC-4zoyA:
undetectable
6b5vA-4zoyA:
8.41
6b5vC-4zoyA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
4 ILE A 451
LEU A 454
ILE A 251
ALA A 445
None
0.88A 6b5vA-4zxiA:
undetectable
6b5vC-4zxiA:
undetectable
6b5vA-4zxiA:
6.92
6b5vC-4zxiA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 PHE A 107
ILE A 123
LEU A 124
ILE A  77
ALA A  38
None
1.46A 6b5vA-5aexA:
undetectable
6b5vC-5aexA:
undetectable
6b5vA-5aexA:
9.56
6b5vC-5aexA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 ILE A 448
LEU A 445
ILE A 499
ALA A 393
None
0.83A 6b5vA-5ao0A:
undetectable
6b5vC-5ao0A:
undetectable
6b5vA-5ao0A:
9.30
6b5vC-5ao0A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)


(Bdellovibrio
bacteriovorus)
PF06963
(FPN1)
4 ILE A 243
PHE A 420
LEU A 246
ILE A 135
None
0.72A 6b5vA-5aynA:
undetectable
6b5vC-5aynA:
undetectable
6b5vA-5aynA:
10.57
6b5vC-5aynA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 4 ILE A  63
LEU A  62
CYH A  66
ALA A 134
None
0.72A 6b5vA-5cwcA:
undetectable
6b5vC-5cwcA:
undetectable
6b5vA-5cwcA:
16.58
6b5vC-5cwcA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus)
PF00028
(Cadherin)
5 PHE A 157
ILE A 143
PHE A 104
LEU A 184
ILE A 113
None
1.49A 6b5vA-5cyxA:
undetectable
6b5vC-5cyxA:
undetectable
6b5vA-5cyxA:
12.16
6b5vC-5cyxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE


(Corynebacterium
glutamicum)
PF00561
(Abhydrolase_1)
4 ILE A  70
LEU A  76
ILE A  86
ALA A 163
None
0.71A 6b5vA-5d6oA:
0.0
6b5vC-5d6oA:
0.0
6b5vA-5d6oA:
14.41
6b5vC-5d6oA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156


(uncultured
organism)
no annotation 4 ILE A 405
LEU A 401
ILE A 359
ALA A 371
None
0.82A 6b5vA-5d8mA:
undetectable
6b5vC-5d8mA:
undetectable
6b5vA-5d8mA:
11.80
6b5vC-5d8mA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
4 ILE A 587
LEU A 590
ILE A 617
ALA A 566
None
0.84A 6b5vA-5e7pA:
undetectable
6b5vC-5e7pA:
undetectable
6b5vA-5e7pA:
6.71
6b5vC-5e7pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1n CAD PROTEIN

(Homo sapiens)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 ILE A2132
LEU A2167
ILE A2075
ALA A2201
None
0.85A 6b5vA-5g1nA:
undetectable
6b5vC-5g1nA:
undetectable
6b5vA-5g1nA:
14.06
6b5vC-5g1nA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C


(Schizosaccharomyces
pombe)
PF00956
(NAP)
4 PHE A 161
ILE A  65
ILE A  79
ALA A 200
None
0.87A 6b5vA-5gplA:
undetectable
6b5vC-5gplA:
undetectable
6b5vA-5gplA:
17.32
6b5vC-5gplA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
4 ILE g 122
LEU g 521
ILE g 437
ALA g 108
None
0.86A 6b5vA-5gw4g:
undetectable
6b5vC-5gw4g:
undetectable
6b5vA-5gw4g:
9.36
6b5vC-5gw4g:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
4 ILE A 406
LEU A 410
ILE A 486
ALA A 454
None
0.78A 6b5vA-5h2vA:
undetectable
6b5vC-5h2vA:
undetectable
6b5vA-5h2vA:
7.15
6b5vC-5h2vA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum)
PF04097
(Nic96)
4 ILE A1008
LEU A1005
CYH A1004
ILE A 916
None
0.84A 6b5vA-5hb3A:
undetectable
6b5vC-5hb3A:
0.0
6b5vA-5hb3A:
8.67
6b5vC-5hb3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4f UNCHARACTERIZED
PROTEIN


(Helicobacter
pylori)
no annotation 4 PHE A  59
ILE A  57
PHE A  12
ILE A  48
None
0.70A 6b5vA-5j4fA:
undetectable
6b5vC-5j4fA:
undetectable
6b5vA-5j4fA:
17.50
6b5vC-5j4fA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE


(Mycobacterium
marinum)
PF07993
(NAD_binding_4)
4 ILE A1006
PHE A1098
LEU A1009
ILE A1069
None
0.77A 6b5vA-5msoA:
undetectable
6b5vC-5msoA:
undetectable
6b5vA-5msoA:
5.42
6b5vC-5msoA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
4 ILE A 377
LEU A 344
ILE A 598
ALA A 328
None
0.84A 6b5vA-5n6uA:
undetectable
6b5vC-5n6uA:
undetectable
6b5vA-5n6uA:
6.93
6b5vC-5n6uA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE


(Streptomyces
platensis)
PF13714
(PEP_mutase)
4 ILE A 201
LEU A 200
ILE A 234
ALA A 250
None
None
None
TLA  A 401 (-3.5A)
0.86A 6b5vA-5uncA:
undetectable
6b5vC-5uncA:
undetectable
6b5vA-5uncA:
14.64
6b5vC-5uncA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE


(Vibrio
vulnificus)
PF07992
(Pyr_redox_2)
4 ILE A 110
PHE A  90
LEU A 109
ILE A  80
None
0.86A 6b5vA-5usxA:
undetectable
6b5vC-5usxA:
undetectable
6b5vA-5usxA:
12.59
6b5vC-5usxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 4 ILE A 520
PHE A 506
ILE A 467
ALA A 496
None
0.77A 6b5vA-5vm9A:
undetectable
6b5vC-5vm9A:
undetectable
6b5vA-5vm9A:
6.71
6b5vC-5vm9A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2


(Homo sapiens)
no annotation 4 PHE A 325
ILE A 326
LEU A 353
ALA A 349
None
0.76A 6b5vA-6apjA:
undetectable
6b5vC-6apjA:
undetectable
6b5vA-6apjA:
22.83
6b5vC-6apjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo0 MDBA PROTEIN

(Corynebacterium
matruchotii)
no annotation 4 PHE A  51
ILE A 180
ILE A 165
ALA A 192
None
0.85A 6b5vA-6bo0A:
undetectable
6b5vC-6bo0A:
undetectable
6b5vA-6bo0A:
20.48
6b5vC-6bo0A:
20.48