SIMILAR PATTERNS OF AMINO ACIDS FOR 6B58_C_ACTC609_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLU A 651
PHE A 649
ASP A 285
HIS A 286
 None
 1.39A 6b58C-1a2vA:
0.0		 6b58C-1a2vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		4 PHE A 101
GLU A  98
ASP A  59
HIS A 102
 None
 1.48A 6b58C-1fueA:
0.3		 6b58C-1fueA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wel RNA-BINDING PROTEIN
12

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A 430
GLU A 477
PHE A 478
ASP A 483
 None
 1.40A 6b58C-1welA:
0.0		 6b58C-1welA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwa KINASE A INHIBITOR

(Bacillus
subtilis) 		PF02682
(CT_C_D) 		4 GLU A  66
PHE A  45
ASP A  85
HIS A  70
 None
 1.37A 6b58C-2kwaA:
undetectable		 6b58C-2kwaA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 GLU A 216
PHE A 219
ASP A 505
HIS A 302
 None
 1.09A 6b58C-2qr4A:
0.0		 6b58C-2qr4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		4 PHE A 272
PHE A 273
ASP A 128
HIS A 271
 None
None
None
FAH  A 501 (-4.0A)
 1.39A 6b58C-3b12A:
0.0		 6b58C-3b12A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A  62
PHE A  66
ASP A  83
HIS A  87
 None
 0.28A 6b58C-3p4sA:
63.6		 6b58C-3p4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN

([Eubacterium]
rectale) 		PF16472
(DUF5050) 		4 PHE A 309
GLU A 293
PHE A 294
ASP A 308
 None
 0.99A 6b58C-3s25A:
1.1		 6b58C-3s25A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 PHE A  94
GLU A  97
ASP A  90
HIS A  59
 None
None
None
LYS  A 401 (-3.8A)
 1.49A 6b58C-4fhaA:
0.0		 6b58C-4fhaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4f TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18

(Otolemur
garnettii) 		no annotation 4 GLU A  89
PHE A  90
ASP A  94
HIS A  91
 None
 1.15A 6b58C-4g4fA:
undetectable		 6b58C-4g4fA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 PHE A 292
GLU A 270
ASP A 264
HIS A 262
 None
 1.41A 6b58C-4lu6A:
9.7		 6b58C-4lu6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PHE A 685
PHE A 687
ASP A 648
HIS A 701
 None
None
MG  A 805 (-2.5A)
MG  A 805 ( 4.9A)
 1.02A 6b58C-4zo6A:
0.2		 6b58C-4zo6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		4 GLU A 180
PHE A  52
ASP A  19
HIS A 113
 None
 1.28A 6b58C-5e59A:
0.3		 6b58C-5e59A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 GLU A 349
PHE A 350
ASP A 245
HIS A 353
 None
 1.16A 6b58C-5ejyA:
0.0		 6b58C-5ejyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t51 KLLA0E05809P

(Kluyveromyces
lactis) 		PF03980
(Nnf1) 		4 GLU B  87
PHE B  81
ASP B  78
HIS B  82
 None
 1.27A 6b58C-5t51B:
0.8		 6b58C-5t51B:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 4 PHE A 144
GLU A 179
ASP A  97
HIS A 101
 None
 1.36A 6b58C-5ve8A:
2.5		 6b58C-5ve8A:
19.70