SIMILAR PATTERNS OF AMINO ACIDS FOR 6B58_C_ACTC608

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN

(Homo sapiens) 		PF16681
(Ig_5) 		4 TYR A  15
LYS A  12
GLN A  30
TYR A  31
 None
 1.35A 6b58C-1xiwA:
0.0		 6b58C-1xiwA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens) 		PF05153
(MIOX) 		4 TYR A 197
LYS A  59
GLN A  62
TYR A  68
 None
 1.47A 6b58C-2ibnA:
0.0		 6b58C-2ibnA:
17.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 TYR A 266
LYS A 289
GLN A 292
HIS A 296
TYR A 466
 None
 0.71A 6b58C-3p4sA:
63.6		 6b58C-3p4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 TYR A 108
GLN A  70
HIS A  87
TYR A  86
 None
 1.45A 6b58C-4g5eA:
0.0		 6b58C-4g5eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 293
GLN A 290
HIS A 425
TYR A 402
 None
 1.45A 6b58C-4rbnA:
0.7		 6b58C-4rbnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4s TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
2,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
1,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1

(Homo sapiens) 		no annotation 4 TYR A 173
LYS A 188
GLN A 172
TYR A   3
 None
 1.25A 6b58C-5m4sA:
0.4		 6b58C-5m4sA:
undetectable