SIMILAR PATTERNS OF AMINO ACIDS FOR 6B58_A_ACTA608_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		3 GLY A 194
THR A 196
GLU A 213
 None
 0.51A 6b58A-1a2oA:
undetectable		 6b58A-1a2oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bht HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle) 		3 GLY A 146
THR A 143
GLU A 199
 None
 0.65A 6b58A-1bhtA:
undetectable		 6b58A-1bhtA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		3 GLY A 194
THR A 196
GLU A 213
 None
 0.50A 6b58A-1chdA:
undetectable		 6b58A-1chdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		3 GLY A 209
THR A 207
GLU A 202
 None
 0.61A 6b58A-1evqA:
0.9		 6b58A-1evqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		3 GLY A 223
THR A 256
GLU A 253
 None
 0.65A 6b58A-1f7cA:
undetectable		 6b58A-1f7cA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz2 OVOCLEIDIN-17

(Gallus gallus) 		PF00059
(Lectin_C) 		3 GLY A  14
THR A  12
GLU A  50
 None
 0.47A 6b58A-1gz2A:
undetectable		 6b58A-1gz2A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 GLY A 463
THR A 465
GLU A 466
 None
 0.59A 6b58A-1hxjA:
undetectable		 6b58A-1hxjA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLY A 451
THR A 394
GLU A 395
 None
 0.66A 6b58A-1jr1A:
undetectable		 6b58A-1jr1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 GLY A 151
THR A 167
GLU A 148
 None
 0.64A 6b58A-1mpoA:
undetectable		 6b58A-1mpoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		3 GLY A 106
THR A 135
GLU A 134
 None
 0.32A 6b58A-1ne2A:
3.3		 6b58A-1ne2A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 GLY A 562
THR A 564
GLU A 567
 None
 0.62A 6b58A-1ogyA:
undetectable		 6b58A-1ogyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		3 GLY A 432
THR A 430
GLU A 174
 None
 0.49A 6b58A-1ohfA:
undetectable		 6b58A-1ohfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 GLY A 296
THR A 298
GLU A 299
 None
 0.50A 6b58A-1ot5A:
2.2		 6b58A-1ot5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 GLY A 307
THR A 309
GLU A 422
 None
 0.65A 6b58A-1pgjA:
3.1		 6b58A-1pgjA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 GLY A 607
THR A 576
GLU A 574
 None
 0.54A 6b58A-1qb4A:
3.5		 6b58A-1qb4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 GLY D 492
THR D 495
GLU D 496
 None
 0.65A 6b58A-1r20D:
undetectable		 6b58A-1r20D:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		3 GLY A  93
THR A  49
GLU A  51
 None
 0.60A 6b58A-1rqgA:
6.1		 6b58A-1rqgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgo PROTEIN C14ORF129

(Homo sapiens) 		PF05303
(DUF727) 		3 GLY A  84
THR A  81
GLU A  82
 None
 0.45A 6b58A-1sgoA:
undetectable		 6b58A-1sgoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tn3 TETRANECTIN

(Homo sapiens) 		PF00059
(Lectin_C) 		3 GLY A 147
THR A 149
GLU A 150
 CA  A 182 ( 4.1A)
None
CA  A 183 ( 3.1A)
 0.54A 6b58A-1tn3A:
undetectable		 6b58A-1tn3A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		3 GLY A 464
THR A 466
GLU A 467
 None
 0.59A 6b58A-1v02A:
undetectable		 6b58A-1v02A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 GLY A 279
THR A 283
GLU A 284
 None
 0.58A 6b58A-1vkzA:
3.8		 6b58A-1vkzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		3 GLY A 143
THR A 152
GLU A 154
 None
None
NAG  A1782 ( 4.3A)
 0.58A 6b58A-1w7cA:
undetectable		 6b58A-1w7cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we1 HEME OXYGENASE 1

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		3 GLY A 151
THR A 153
GLU A 157
 None
 0.65A 6b58A-1we1A:
undetectable		 6b58A-1we1A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLY A 425
THR A 389
GLU A 380
 None
 0.60A 6b58A-1zfjA:
undetectable		 6b58A-1zfjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 GLY E 181
THR E 178
GLU E 179
 None
 0.57A 6b58A-2bg9E:
5.9		 6b58A-2bg9E:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 GLY A 295
THR A  50
GLU A  49
 None
 0.47A 6b58A-2bi7A:
8.0		 6b58A-2bi7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 GLY A 663
THR A 650
GLU A 699
 None
 0.57A 6b58A-2cbzA:
undetectable		 6b58A-2cbzA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq2 HYPOTHETICAL PROTEIN
LOC91801

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLY A 102
THR A 114
GLU A 104
 None
 0.66A 6b58A-2cq2A:
undetectable		 6b58A-2cq2A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		3 GLY A 240
THR A 297
GLU A 296
 None
 0.65A 6b58A-2d1gA:
undetectable		 6b58A-2d1gA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		3 GLY A 368
THR A 370
GLU A 373
 None
 0.60A 6b58A-2dkjA:
undetectable		 6b58A-2dkjA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl0 SAM AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF07647
(SAM_2) 		3 GLY A  65
THR A  67
GLU A  68
 None
 0.57A 6b58A-2dl0A:
undetectable		 6b58A-2dl0A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLY X 181
THR X 161
GLU X 159
 PTR  X 160 ( 4.9A)
PTR  X 160 ( 4.1A)
PTR  X 160 ( 4.6A)
 0.51A 6b58A-2dq7X:
undetectable		 6b58A-2dq7X:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLY A 415
THR A 395
GLU A 393
 None
 0.50A 6b58A-2hk5A:
undetectable		 6b58A-2hk5A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki0 DS119

(-) 		no annotation 3 GLY A  11
THR A  13
GLU A  16
 None
 0.57A 6b58A-2ki0A:
undetectable		 6b58A-2ki0A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		3 GLY A 151
THR A 167
GLU A 148
 None
 0.61A 6b58A-2mprA:
undetectable		 6b58A-2mprA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		3 GLY A 288
THR A 290
GLU A 294
 None
 0.62A 6b58A-2ps3A:
undetectable		 6b58A-2ps3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		3 GLY B 388
THR B 392
GLU B 396
 None
 0.54A 6b58A-2q2eB:
undetectable		 6b58A-2q2eB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		3 GLY A 142
THR A 144
GLU A 145
 None
CL  A1293 ( 3.9A)
None
 0.66A 6b58A-2vd3A:
undetectable		 6b58A-2vd3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		3 GLY A 222
THR A 267
GLU A 268
 None
 0.62A 6b58A-2vdtA:
undetectable		 6b58A-2vdtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 GLY A 116
THR A 136
GLU A 114
 None
 0.61A 6b58A-2xn1A:
undetectable		 6b58A-2xn1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 GLY A  21
THR A  23
GLU A  40
 None
 0.63A 6b58A-2xr1A:
undetectable		 6b58A-2xr1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 3 GLY A   2
THR A   4
GLU A   7
 None
 0.64A 6b58A-2y0oA:
undetectable		 6b58A-2y0oA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		3 GLY A  85
THR A  87
GLU A 188
 None
 0.59A 6b58A-2z1pA:
undetectable		 6b58A-2z1pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 GLY A  68
THR A 101
GLU A 100
 None
 0.64A 6b58A-3a9sA:
undetectable		 6b58A-3a9sA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3but UNCHARACTERIZED
PROTEIN AF_0446

(Archaeoglobus
fulgidus) 		PF03168
(LEA_2) 		3 GLY A  36
THR A 101
GLU A 103
 None
 0.59A 6b58A-3butA:
undetectable		 6b58A-3butA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Shewanella
oneidensis) 		PF03702
(AnmK) 		3 GLY A  70
THR A 120
GLU A 124
 None
 0.60A 6b58A-3cqyA:
undetectable		 6b58A-3cqyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLY A 854
THR A 856
GLU A 832
 None
 0.43A 6b58A-3ddrA:
undetectable		 6b58A-3ddrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		3 GLY A 198
THR A 200
GLU A 201
 None
 0.48A 6b58A-3exsA:
undetectable		 6b58A-3exsA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		3 GLY A  70
THR A  72
GLU A  73
 None
 0.58A 6b58A-3hm7A:
undetectable		 6b58A-3hm7A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 GLY E  73
THR E  71
GLU E  91
 None
 0.64A 6b58A-3kfuE:
undetectable		 6b58A-3kfuE:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		3 GLY A 270
THR A 273
GLU A  50
 None
 0.62A 6b58A-3lhlA:
undetectable		 6b58A-3lhlA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		3 GLY A 362
THR A 378
GLU A 377
 None
None
SO4  A 404 (-4.1A)
 0.60A 6b58A-3os6A:
undetectable		 6b58A-3os6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLY B 325
THR B 322
GLU B 323
 None
 0.31A 6b58A-3prxB:
undetectable		 6b58A-3prxB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE

(Toxoplasma
gondii) 		no annotation 3 GLY A  86
THR A  90
GLU A  94
 None
 0.65A 6b58A-3qyqA:
undetectable		 6b58A-3qyqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE

(Rhipicephalus
microplus) 		PF00121
(TIM) 		3 GLY A 137
THR A 139
GLU A 140
 None
 0.56A 6b58A-3th6A:
undetectable		 6b58A-3th6A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		3 GLY B 119
THR B  40
GLU B  68
 None
 0.42A 6b58A-3tu5B:
undetectable		 6b58A-3tu5B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 GLY A 399
THR A 397
GLU A 427
 None
 0.62A 6b58A-3u2pA:
undetectable		 6b58A-3u2pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		3 GLY A 115
THR A  93
GLU A  82
 None
 0.52A 6b58A-3w9rA:
undetectable		 6b58A-3w9rA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 GLY A  22
THR A  24
GLU A  25
 None
 0.56A 6b58A-3zheA:
4.7		 6b58A-3zheA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 336
THR A 334
GLU A 312
 NAP  A1447 ( 4.1A)
None
None
 0.46A 6b58A-4a0sA:
2.8		 6b58A-4a0sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		3 GLY A 192
THR A 196
GLU A 200
 None
 0.66A 6b58A-4axvA:
undetectable		 6b58A-4axvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 GLY A  61
THR A  94
GLU A  93
 None
 0.65A 6b58A-4c22A:
undetectable		 6b58A-4c22A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  57
THR A 119
GLU A 120
 None
 0.64A 6b58A-4c2kA:
undetectable		 6b58A-4c2kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 GLY A 663
THR A 650
GLU A 699
 None
 0.55A 6b58A-4c3zA:
undetectable		 6b58A-4c3zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 246
THR A 249
GLU A 242
 None
 0.63A 6b58A-4cpdA:
4.5		 6b58A-4cpdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  54
THR A 115
GLU A 116
 None
 0.64A 6b58A-4e1lA:
undetectable		 6b58A-4e1lA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		3 GLY A 126
THR A 128
GLU A 129
 None
 0.63A 6b58A-4eelA:
undetectable		 6b58A-4eelA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE

(Homarus
americanus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 GLY 1   7
THR 1  95
GLU 1  93
 None
 0.66A 6b58A-4gpd1:
2.6		 6b58A-4gpd1:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h40 PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF15415
(Mfa_like_2) 		3 GLY A 298
THR A 217
GLU A 219
 None
 0.64A 6b58A-4h40A:
undetectable		 6b58A-4h40A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		3 GLY B 122
THR B 152
GLU B 150
 None
 0.45A 6b58A-4hxeB:
undetectable		 6b58A-4hxeB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		3 GLY A 169
THR A 188
GLU A 171
 None
 0.54A 6b58A-4napA:
undetectable		 6b58A-4napA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 GLY A 713
THR A 715
GLU A 716
 None
 0.66A 6b58A-4om9A:
undetectable		 6b58A-4om9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		3 GLY A 229
THR A 231
GLU A 285
 ADP  A 601 (-3.4A)
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.4A)
 0.66A 6b58A-4px9A:
undetectable		 6b58A-4px9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb1 XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6) 		3 GLY A  87
THR A 120
GLU A  54
 None
 0.66A 6b58A-4qb1A:
undetectable		 6b58A-4qb1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM) 		3 GLY A 112
THR A 106
GLU A 177
 None
 0.63A 6b58A-4qrmA:
undetectable		 6b58A-4qrmA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		3 GLY A 130
THR A 109
GLU A  77
 None
 0.46A 6b58A-4umlA:
undetectable		 6b58A-4umlA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw0 TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		PF11612
(T2SSJ) 		3 GLY A 117
THR A 119
GLU A 121
 None
 0.62A 6b58A-5bw0A:
undetectable		 6b58A-5bw0A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		3 GLY B 386
THR B 388
GLU B 389
 None
 0.65A 6b58A-5cscB:
undetectable		 6b58A-5cscB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 GLY A 689
THR A 692
GLU A 693
 None
 0.60A 6b58A-5d4wA:
2.5		 6b58A-5d4wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 GLY A  46
THR A  48
GLU A  51
 None
EDO  A 402 (-2.9A)
None
 0.58A 6b58A-5dmuA:
undetectable		 6b58A-5dmuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLY A 229
THR A 231
GLU A 285
 AMP  A 801 (-3.2A)
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.5A)
 0.66A 6b58A-5e7jA:
undetectable		 6b58A-5e7jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		3 GLY B 122
THR B 119
GLU B 116
 SAM  B 401 (-3.9A)
None
None
 0.65A 6b58A-5ergB:
2.9		 6b58A-5ergB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		3 GLY A 355
THR A 311
GLU A 313
 None
 0.57A 6b58A-5gl7A:
5.3		 6b58A-5gl7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		3 GLY A 372
THR A 374
GLU A 375
 None
 0.57A 6b58A-5ijgA:
undetectable		 6b58A-5ijgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ird UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01883
(FeS_assembly_P) 		3 GLY A 108
THR A 105
GLU A 106
 None
 0.55A 6b58A-5irdA:
undetectable		 6b58A-5irdA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		3 GLY A  58
THR A  32
GLU A  34
 None
 0.66A 6b58A-5kvkA:
undetectable		 6b58A-5kvkA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		3 GLY C 303
THR C 305
GLU C 308
 None
 0.59A 6b58A-5mdxC:
2.5		 6b58A-5mdxC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		3 GLY A 900
THR A 902
GLU A 903
 None
 0.64A 6b58A-5n8oA:
undetectable		 6b58A-5n8oA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		no annotation 3 GLY W 117
THR W 119
GLU W 121
 None
 0.63A 6b58A-5vtmW:
undetectable		 6b58A-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu3 COMPETENCE
DAMAGE-INDUCIBLE
PROTEIN A

(Enterobacter
cloacae) 		PF02464
(CinA) 		3 GLY A  59
THR A  33
GLU A  35
 None
 0.63A 6b58A-5vu3A:
undetectable		 6b58A-5vu3A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		3 GLY A 332
THR A 344
GLU A 475
 None
MN  A 602 (-4.8A)
MN  A 602 (-2.4A)
 0.61A 6b58A-5x49A:
undetectable		 6b58A-5x49A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 3 GLY A  28
THR A 181
GLU A 472
 None
 0.63A 6b58A-5y6rA:
undetectable		 6b58A-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 3 GLY A 158
THR A 155
GLU A 156
 None
 0.61A 6b58A-5ybaA:
undetectable		 6b58A-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 3 GLY A 152
THR A 150
GLU A 186
 None
 0.65A 6b58A-5yp3A:
undetectable		 6b58A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 3 GLY A  58
THR A 119
GLU A 120
 None
 0.63A 6b58A-6arrA:
undetectable		 6b58A-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 3 GLY A 396
THR A 400
GLU A 403
 None
 0.65A 6b58A-6bdzA:
undetectable		 6b58A-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 3 GLY A  94
THR A  86
GLU A  72
 None
 0.52A 6b58A-6bogA:
4.7		 6b58A-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgs HISTONE
ACETYLTRANSFERASE
P300,TUMOR PROTEIN
P73

(Homo sapiens) 		no annotation 3 GLY A 110
THR A 112
GLU A 115
 None
 0.64A 6b58A-6fgsA:
undetectable		 6b58A-6fgsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 3 GLY A 161
THR A 137
GLU A 138
 None
 0.66A 6b58A-6fhsA:
undetectable		 6b58A-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 3 GLY A 435
THR A 247
GLU A 251
 None
 0.56A 6b58A-6gneA:
2.0		 6b58A-6gneA:
undetectable