SIMILAR PATTERNS OF AMINO ACIDS FOR 6B58_A_ACTA607

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		4 GLY A 119
ARG A 158
ASN A 155
LEU A 156
 None
 1.25A 6b58A-1f6dA:
4.3		 6b58A-1f6dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A 204
ARG A 102
ASN A 203
LEU A   9
 None
 1.24A 6b58A-1fheA:
0.0		 6b58A-1fheA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ic8 HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		4 GLY A 255
ARG A 244
ASN A 257
LEU A 258
 None
 1.41A 6b58A-1ic8A:
0.1		 6b58A-1ic8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 GLY A 322
ARG A 372
ASN A 325
LEU A 321
 None
 1.36A 6b58A-1irxA:
0.1		 6b58A-1irxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 GLY A 290
ARG A 285
ASN A 289
LEU A 254
 None
 1.24A 6b58A-1js6A:
0.0		 6b58A-1js6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  43
ARG A  49
ASN A  45
LEU A  47
 None
 1.32A 6b58A-1ma1A:
0.0		 6b58A-1ma1A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 GLY A 163
ARG A 230
ASN A 165
LEU A 157
 None
 1.20A 6b58A-1pznA:
undetectable		 6b58A-1pznA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 GLY A 274
ARG A 237
ASN A 248
LEU A 250
 None
PEP  A8002 (-3.9A)
None
None
 1.18A 6b58A-1rzmA:
undetectable		 6b58A-1rzmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 315
ARG A 185
ASN A 317
LEU A 286
 None
 1.50A 6b58A-1smkA:
3.6		 6b58A-1smkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		4 GLY A 232
ARG A 133
ASN A 233
LEU A 238
 SAM  A 301 (-3.2A)
None
None
None
 1.27A 6b58A-1x7pA:
2.5		 6b58A-1x7pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 GLY A 260
ARG A 142
ASN A 262
LEU A 281
 None
 1.08A 6b58A-1y3nA:
2.7		 6b58A-1y3nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 GLY X 142
ARG X 147
ASN X 143
LEU X 145
 None
 1.50A 6b58A-2de0X:
5.8		 6b58A-2de0X:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 GLY A  85
ARG A 166
ASN A 163
LEU A 164
 None
 1.24A 6b58A-2djzA:
undetectable		 6b58A-2djzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 381
ARG A  14
ASN A 382
LEU A 396
 None
 0.97A 6b58A-2dzdA:
3.4		 6b58A-2dzdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed7 NETRIN RECEPTOR DCC

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A  79
ARG A  64
ASN A  80
LEU A  81
 None
 1.25A 6b58A-2ed7A:
undetectable		 6b58A-2ed7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A 435
ARG A 180
ASN A 432
LEU A 436
 None
 1.23A 6b58A-2f2aA:
undetectable		 6b58A-2f2aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 435
ARG A 477
ASN A 516
LEU A 515
 None
CAC  A 705 ( 3.0A)
CAC  A 705 (-4.1A)
None
 1.42A 6b58A-2i0kA:
undetectable		 6b58A-2i0kA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 795
ARG A 801
ASN A 783
LEU A 785
 None
 1.10A 6b58A-2ogvA:
undetectable		 6b58A-2ogvA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 292
ARG A 148
ASN A 315
LEU A 145
 None
 1.45A 6b58A-2omeA:
undetectable		 6b58A-2omeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtw FIBER PROTEIN 2

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		4 GLY A 390
ARG A 265
ASN A 389
LEU A 347
 None
 1.13A 6b58A-2vtwA:
undetectable		 6b58A-2vtwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 GLY A 120
ARG A 183
ASN A 119
LEU A 121
 None
 1.41A 6b58A-2w3pA:
undetectable		 6b58A-2w3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLY A 199
ARG A 273
ASN A 195
LEU A 198
 None
 1.13A 6b58A-2wm4A:
undetectable		 6b58A-2wm4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 GLY A 115
ARG A  88
ASN A 116
LEU A 111
 None
 1.42A 6b58A-2xpiA:
4.2		 6b58A-2xpiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywk PUTATIVE RNA-BINDING
PROTEIN 11

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A  15
ARG A  78
ASN A  16
LEU A  17
 None
 1.45A 6b58A-2ywkA:
undetectable		 6b58A-2ywkA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 GLY A 419
ARG A 167
ASN A 416
LEU A 420
 None
 1.25A 6b58A-3al0A:
undetectable		 6b58A-3al0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Francisella
tularensis) 		PF02540
(NAD_synthase) 		4 GLY A 195
ARG A 124
ASN A  66
LEU A 196
 None
AMP  A3001 (-3.8A)
AMP  A3001 ( 3.7A)
None
 1.32A 6b58A-3fiuA:
undetectable		 6b58A-3fiuA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 GLY A 428
ARG A 173
ASN A 425
LEU A 429
 None
 1.13A 6b58A-3h0lA:
undetectable		 6b58A-3h0lA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2t BASEPLATE STRUCTURAL
PROTEIN GP6

(Escherichia
virus T4) 		no annotation 4 GLY A 637
ARG A 486
ASN A 412
LEU A 639
 None
 1.16A 6b58A-3h2tA:
undetectable		 6b58A-3h2tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 322
ARG A 282
ASN A 324
LEU A 325
 None
 1.30A 6b58A-3iwaA:
12.3		 6b58A-3iwaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLY E 417
ARG E 167
ASN E 414
LEU E 418
 None
 1.16A 6b58A-3kfuE:
undetectable		 6b58A-3kfuE:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqg HPY188I

(Helicobacter
pylori) 		no annotation 4 GLY A  91
ARG A  84
ASN A 105
LEU A 109
 None
 1.14A 6b58A-3oqgA:
undetectable		 6b58A-3oqgA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 GLY A 274
ARG A 237
ASN A 248
LEU A 250
 None
 1.18A 6b58A-3pg8A:
undetectable		 6b58A-3pg8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 GLY A 290
ARG A 285
ASN A 289
LEU A 254
 None
 1.30A 6b58A-3rblA:
undetectable		 6b58A-3rblA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 GLY A 159
ARG A 417
ASN A 116
LEU A 158
 None
 1.46A 6b58A-3ua4A:
3.1		 6b58A-3ua4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 GLY A 890
ARG A 619
ASN A 889
LEU A 891
 None
 1.22A 6b58A-3zqjA:
3.0		 6b58A-3zqjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLY A 101
ARG A 329
ASN A  12
LEU A  99
 None
 1.31A 6b58A-3zzuA:
undetectable		 6b58A-3zzuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		4 GLY A 137
ARG A  40
ASN A 136
LEU A  47
 None
 0.84A 6b58A-4dipA:
undetectable		 6b58A-4dipA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7f AGAP005208-PA

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 GLY A  30
ARG A  14
ASN A  29
LEU A  31
 None
PG6  A 202 (-3.9A)
None
None
 1.43A 6b58A-4f7fA:
undetectable		 6b58A-4f7fA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 GLY A 712
ARG A  37
ASN A  76
LEU A  29
 None
 1.38A 6b58A-4fyeA:
5.8		 6b58A-4fyeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 GLY A 282
ARG A 259
ASN A 229
LEU A 283
 EDO  A 805 (-3.5A)
None
None
None
 1.30A 6b58A-4hizA:
undetectable		 6b58A-4hizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  49
ARG H  64
ASN H  57
LEU H  69
 None
 1.07A 6b58A-4i3rH:
undetectable		 6b58A-4i3rH:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 GLY A 315
ARG A 307
ASN A 311
LEU A 314
 None
 1.41A 6b58A-4kbmA:
undetectable		 6b58A-4kbmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqb THYMIDYLATE KINASE

(Staphylococcus
aureus) 		PF02223
(Thymidylate_kin) 		4 GLY A 122
ARG A  71
ASN A 121
LEU A 123
 None
 1.38A 6b58A-4mqbA:
undetectable		 6b58A-4mqbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		4 GLY A 118
ARG A  21
ASN A 117
LEU A  28
 None
 0.88A 6b58A-4mspA:
undetectable		 6b58A-4mspA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLY A 836
ARG A 639
ASN A 603
LEU A 880
 None
 1.09A 6b58A-4n3nA:
undetectable		 6b58A-4n3nA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLY A 718
ARG A 521
ASN A 485
LEU A 762
 None
 1.03A 6b58A-4n3sA:
undetectable		 6b58A-4n3sA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLY A 448
ARG A 624
ASN A 446
LEU A 445
 None
 1.36A 6b58A-4ppmA:
undetectable		 6b58A-4ppmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLY A 180
ARG A 228
ASN A 225
LEU A 226
 None
None
EDO  A 406 (-3.7A)
None
 1.27A 6b58A-4rnwA:
undetectable		 6b58A-4rnwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLY A 329
ARG A 377
ASN A 374
LEU A 375
 None
 1.23A 6b58A-4rnxA:
undetectable		 6b58A-4rnxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 GLY A 433
ARG A 178
ASN A 430
LEU A 434
 None
 1.11A 6b58A-4wj3A:
undetectable		 6b58A-4wj3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NORC-LIKE PROTEIN

(Roseobacter
denitrificans) 		PF00034
(Cytochrom_C) 		4 GLY B  80
ARG B  85
ASN B  81
LEU B 133
 None
HEC  B 201 (-3.6A)
None
None
 1.21A 6b58A-4xydB:
undetectable		 6b58A-4xydB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 GLY A  29
ARG A  24
ASN A  28
LEU A  26
 None
 1.42A 6b58A-4yaiA:
3.0		 6b58A-4yaiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLY A  81
ARG A 129
ASN A 126
LEU A 127
 None
 1.25A 6b58A-4yncA:
undetectable		 6b58A-4yncA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 GLY A 166
ARG A  69
ASN A 170
LEU A 165
 None
 1.47A 6b58A-4z11A:
undetectable		 6b58A-4z11A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmi CHI220 FAB HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  98
ARG H  94
ASN H  97
LEU H 100
 None
 1.44A 6b58A-5dmiH:
undetectable		 6b58A-5dmiH:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 GLY A 417
ARG A 181
ASN A 414
LEU A 418
 None
 1.28A 6b58A-5h6sA:
undetectable		 6b58A-5h6sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 GLY A 260
ARG A 142
ASN A 262
LEU A 281
 None
 1.15A 6b58A-5h71A:
undetectable		 6b58A-5h71A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		4 GLY A 294
ARG A 242
ASN A 290
LEU A 292
 None
 1.33A 6b58A-5ijxA:
undetectable		 6b58A-5ijxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		4 GLY A 461
ARG A 185
ASN A 460
LEU A 464
 None
None
GDP  A 601 ( 4.8A)
None
 1.16A 6b58A-5kx6A:
undetectable		 6b58A-5kx6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		4 GLY A 113
ARG A 120
ASN A 110
LEU A 109
 None
 1.38A 6b58A-5l7vA:
undetectable		 6b58A-5l7vA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 HEAVY CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  49
ARG H  64
ASN H  58
LEU H  69
 None
 0.99A 6b58A-5te6H:
undetectable		 6b58A-5te6H:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 374
ARG A   9
ASN A 375
LEU A 389
 None
 0.95A 6b58A-5vywA:
undetectable		 6b58A-5vywA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 GLY C 594
ARG C1087
ASN C 593
LEU C1080
 None
 1.20A 6b58A-5y3rC:
undetectable		 6b58A-5y3rC:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf4 -

(-) 		no annotation 4 GLY A  83
ARG A 126
ASN A  82
LEU A  81
 None
 1.17A 6b58A-5yf4A:
2.6		 6b58A-5yf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 GLY A1009
ARG A 996
ASN A1006
LEU A1005
 None
 1.45A 6b58A-5zalA:
undetectable		 6b58A-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 GLY A 259
ARG A 256
ASN A 310
LEU A 307
 None
 1.31A 6b58A-6b2wA:
undetectable		 6b58A-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 GLY A 311
ARG A 256
ASN A 310
LEU A 307
 AG2  A 401 ( 4.1A)
None
None
None
 1.36A 6b58A-6b2wA:
undetectable		 6b58A-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpd MONOCLONAL ANTIBODY
10B12 FAB HEAVY
CHAIN

(Mus musculus) 		no annotation 4 GLY A  68
ARG A  84
ASN A  78
LEU A  89
 None
 1.17A 6b58A-6bpdA:
undetectable		 6b58A-6bpdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 4 GLY A 194
ARG A  78
ASN A 193
LEU A 174
 None
 1.31A 6b58A-6bqwA:
undetectable		 6b58A-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT

(Rhodothermus
marinus;
Rhodothermus
marinus) 		no annotation
no annotation 		4 GLY B 126
ARG E  71
ASN B 127
LEU B 112
 None
 1.33A 6b58A-6f0kB:
undetectable		 6b58A-6f0kB:
undetectable