SIMILAR PATTERNS OF AMINO ACIDS FOR 6B58_A_ACTA606_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad0 ANTIBODY A5B7 (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B 148
PHE B 146
HIS B 199
THR B 110
 None
 1.17A 6b58A-1ad0B:
undetectable		 6b58A-1ad0B:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 GLU A  74
PHE A  70
ASP A  67
THR A 104
 None
None
NA  A 401 ( 2.6A)
CL  A 405 ( 3.9A)
 1.32A 6b58A-1ag9A:
1.3		 6b58A-1ag9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgx TP7 MAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 144
PHE H 142
HIS H 195
THR H 112
 None
 1.38A 6b58A-1bgxH:
0.0		 6b58A-1bgxH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egj ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 148
PHE H 146
HIS H 210
THR H 110
 None
 1.15A 6b58A-1egjH:
0.0		 6b58A-1egjH:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B 148
PHE B 146
HIS B 199
THR B 110
 None
 1.08A 6b58A-1fj1B:
undetectable		 6b58A-1fj1B:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 155
PHE H 153
HIS H 206
THR H 117
 None
 1.08A 6b58A-1kenH:
0.0		 6b58A-1kenH:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfa MONOCLONAL ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 161
PHE H 159
HIS H 212
THR H 118
 None
 1.16A 6b58A-1kfaH:
0.0		 6b58A-1kfaH:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 GLU A 510
ASP A 522
HIS A 558
THR A 549
 None
 1.45A 6b58A-1m9iA:
0.0		 6b58A-1m9iA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ncb IGG2A-KAPPA NC41 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 150
PHE H 148
HIS H 212
THR H 110
 None
 1.04A 6b58A-1ncbH:
0.3		 6b58A-1ncbH:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o51 HYPOTHETICAL PROTEIN
TM0021

(Thermotoga
maritima) 		PF02641
(DUF190) 		4 GLU A  72
ASP A  95
HIS A   0
THR A  93
 None
 1.33A 6b58A-1o51A:
undetectable		 6b58A-1o51A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s78 PERTUZUMAB FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU D 148
PHE D 146
HIS D 200
THR D 110
 None
 1.07A 6b58A-1s78D:
undetectable		 6b58A-1s78D:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd FAB FRAGMENT OF
5.11A1 ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 155
PHE H 153
HIS H 206
THR H 117
 None
 1.09A 6b58A-1yjdH:
undetectable		 6b58A-1yjdH:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis) 		no annotation 4 GLU A 194
PHE A 193
HIS A 222
THR A 197
 None
 1.38A 6b58A-2iicA:
3.0		 6b58A-2iicA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or9 MONOCLONAL
ANTI-C-MYC ANTIBODY
9E10

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.20A 6b58A-2or9H:
undetectable		 6b58A-2or9H:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 GLU A 337
ASP A 233
HIS A 235
THR A 177
 None
SR1  A 998 (-2.7A)
SR1  A 998 ( 4.7A)
None
 1.44A 6b58A-2punA:
undetectable		 6b58A-2punA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 GLU A 216
PHE A 219
ASP A 505
HIS A 302
 None
 1.19A 6b58A-2qr4A:
4.2		 6b58A-2qr4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.11A 6b58A-2r4sH:
undetectable		 6b58A-2r4sH:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 GLU X 127
PHE X 124
ASP X 145
THR X 176
 None
 1.28A 6b58A-2x27X:
undetectable		 6b58A-2x27X:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymx FAB ANTIBODY HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 159
PHE H 157
HIS H 210
THR H 121
 None
 1.11A 6b58A-2ymxH:
undetectable		 6b58A-2ymxH:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 GLU A 139
ASP A 217
HIS A 219
THR A 141
 PO4  A 272 (-2.9A)
MN  A 271 (-2.1A)
MN  A 271 ( 3.4A)
None
 1.49A 6b58A-3aamA:
undetectable		 6b58A-3aamA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU D 159
PHE D 157
HIS D 210
THR D 119
 None
 1.11A 6b58A-3bquD:
undetectable		 6b58A-3bquD:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		4 PHE A 125
ASP A 127
HIS A 126
THR A  79
 None
 1.45A 6b58A-3bsfA:
undetectable		 6b58A-3bsfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsf FAB FRAGMENT OF
ANTI-OSTEOPONTIN
ANTIBODY 23C3, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 151
PHE H 149
HIS H 202
THR H 113
 None
 1.12A 6b58A-3dsfH:
undetectable		 6b58A-3dsfH:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		4 GLU A 226
ASP A 195
HIS A 324
THR A 251
 IMD  A 438 (-2.6A)
ZN  A 435 ( 2.3A)
ZN  A 435 ( 3.2A)
None
 1.20A 6b58A-3k9tA:
undetectable		 6b58A-3k9tA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 GLU A 391
PHE A 388
ASP A 368
THR A 372
 None
None
GOL  A 401 (-2.8A)
None
 1.33A 6b58A-3m8yA:
undetectable		 6b58A-3m8yA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A  66
ASP A  83
HIS A  87
THR A 571
 None
 1.32A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A  66
ASP A  83
HIS A  87
THR A 572
 None
 0.39A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 GLU A 148
ASP A 102
HIS A 104
THR A 258
 SO4  A 346 ( 4.1A)
None
None
None
 1.30A 6b58A-3qr3A:
undetectable		 6b58A-3qr3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 PHE A  26
ASP A  73
HIS A  74
THR A 226
 None
ZN  A 302 (-2.8A)
ZN  A 302 (-3.4A)
None
 1.11A 6b58A-3rpcA:
undetectable		 6b58A-3rpcA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujt AB-52 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.10A 6b58A-3ujtH:
undetectable		 6b58A-3ujtH:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.14A 6b58A-3v0wH:
undetectable		 6b58A-3v0wH:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvn NIMP.M7 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU C 155
PHE C 153
HIS C 206
THR C 117
 None
 1.20A 6b58A-4lvnC:
undetectable		 6b58A-4lvnC:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onf 3D6 FAB ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 154
PHE H 152
HIS H 205
THR H 116
 None
 1.07A 6b58A-4onfH:
undetectable		 6b58A-4onfH:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj 8G12 HEAVY CHAIN

(Mus musculus) 		no annotation 4 GLU H 158
PHE H 156
HIS H 209
THR H 118
 None
 1.15A 6b58A-4pljH:
undetectable		 6b58A-4pljH:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		4 GLU A 229
ASP A 206
HIS A 205
THR A 150
 None
None
None
GOL  A 402 (-3.7A)
 1.44A 6b58A-4r72A:
undetectable		 6b58A-4r72A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF00223
(PsaA_PsaB) 		4 GLU B 673
PHE A 562
HIS A 597
THR B 677
 None
 1.21A 6b58A-4rkuB:
1.6		 6b58A-4rkuB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uok FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU A 369
PHE A 367
HIS A 421
THR A 331
 None
 1.06A 6b58A-4uokA:
undetectable		 6b58A-4uokA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5r ANTI-IFN-A ANTIBODY
RONTALIZUMAB HEAVY
CHAIN MODULES VH AND
CH1 (FAB)

(Homo sapiens) 		no annotation 4 GLU K 148
PHE K 146
HIS K 200
THR K 110
 None
 1.11A 6b58A-4z5rK:
undetectable		 6b58A-4z5rK:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 PHE L 410
ASP L 412
HIS L 459
THR L 400
 None
 1.43A 6b58A-5a7dL:
2.8		 6b58A-5a7dL:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 GLU A  71
PHE A  76
HIS A  64
THR C  29
 None
 1.49A 6b58A-5aa5A:
undetectable		 6b58A-5aa5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z D4-10 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU D 163
PHE D 161
HIS D 215
THR D 125
 None
 1.23A 6b58A-5d1zD:
undetectable		 6b58A-5d1zD:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		4 GLU A 164
ASP A 118
HIS A 120
THR A 275
 None
 1.30A 6b58A-5d8wA:
undetectable		 6b58A-5d8wA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLU B 276
ASP B 261
HIS B 265
THR B 258
 None
 1.35A 6b58A-5e6sB:
undetectable		 6b58A-5e6sB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 GLU H 148
PHE H 146
HIS H 200
THR H 110
 None
 1.20A 6b58A-5f89H:
undetectable		 6b58A-5f89H:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B 148
PHE B 146
HIS B 200
THR B 110
 None
 1.09A 6b58A-5f9wB:
undetectable		 6b58A-5f9wB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 156
PHE H 154
HIS H 208
THR H 118
 None
 1.16A 6b58A-5fuzH:
undetectable		 6b58A-5fuzH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 GLU A 162
PHE A 439
ASP A 553
THR A 441
 None
 1.29A 6b58A-5hmpA:
0.3		 6b58A-5hmpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		4 GLU B 178
ASP B 169
HIS B 126
THR B 167
 None
 1.42A 6b58A-5lnbB:
undetectable		 6b58A-5lnbB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		4 GLU A 362
PHE A 363
ASP A 377
THR A 383
 None
 1.33A 6b58A-5sy5A:
undetectable		 6b58A-5sy5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t51 KLLA0E05809P

(Kluyveromyces
lactis) 		PF03980
(Nnf1) 		4 GLU B  87
PHE B  81
ASP B  78
HIS B  82
 None
 1.21A 6b58A-5t51B:
2.9		 6b58A-5t51B:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6m HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A3

(Oryctolagus
cuniculus) 		no annotation 4 GLU H 144
PHE H 142
HIS H 196
THR H 106
 None
 1.11A 6b58A-5v6mH:
undetectable		 6b58A-5v6mH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob FAB 8I21 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 157
PHE H 155
HIS H 209
THR H 119
 None
 1.15A 6b58A-5vobH:
undetectable		 6b58A-5vobH:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqm PA41 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 GLU H 154
PHE H 152
HIS H 206
THR H 116
 None
 1.01A 6b58A-5vqmH:
undetectable		 6b58A-5vqmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w42 -

(-) 		no annotation 4 GLU H 148
PHE H 146
HIS H 200
THR H 110
 None
 1.21A 6b58A-5w42H:
undetectable		 6b58A-5w42H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN

(Mus musculus) 		no annotation 4 GLU A 170
PHE A 168
HIS A 221
THR A 132
 None
 1.13A 6b58A-5x0tA:
undetectable		 6b58A-5x0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 GLU A 593
ASP A 550
HIS A 552
THR A 548
 None
 1.02A 6b58A-5x7hA:
undetectable		 6b58A-5x7hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Bos taurus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		4 GLU B 362
PHE B 363
ASP B 377
THR B 383
 None
 1.37A 6b58A-5y7yB:
undetectable		 6b58A-5y7yB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9c HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
A12A3

(Mus musculus) 		no annotation 4 GLU H 154
PHE H 152
HIS H 205
THR H 117
 None
 1.10A 6b58A-5y9cH:
undetectable		 6b58A-5y9cH:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN

(Mus musculus) 		no annotation 4 GLU G 155
PHE G 153
HIS G 206
THR G 117
 None
 1.13A 6b58A-6cnkG:
undetectable		 6b58A-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE BETA
SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 GLU B 216
PHE B 215
ASP B 151
THR B 213
 None
 1.41A 6b58A-6co9B:
undetectable		 6b58A-6co9B:
undetectable