SIMILAR PATTERNS OF AMINO ACIDS FOR 6B54_A_OAQA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		5 ILE A 121
LEU A  67
LEU A 136
PHE A 117
MET A 157
 None
 1.22A 6b54A-1ad3A:
1.0		 6b54A-1ad3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 ASP A 138
LEU A 137
LEU A 125
PHE A 175
THR A 179
 None
 1.17A 6b54A-1epxA:
undetectable		 6b54A-1epxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 ILE A 355
LEU A 313
VAL A 336
LEU A 358
LEU A 403
 None
 1.12A 6b54A-1gl6A:
undetectable		 6b54A-1gl6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 ILE A 240
VAL A 233
LEU A 248
THR A  87
LEU A 288
 None
 1.25A 6b54A-1ir6A:
undetectable		 6b54A-1ir6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		5 ILE A 442
LEU A 469
VAL A 476
LEU A 433
LEU A 421
 None
 1.24A 6b54A-1jqkA:
2.1		 6b54A-1jqkA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN
POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B;
Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv)
PF00073
(Rhv) 		5 LEU B 123
VAL C  52
LEU A 254
THR B 183
THR A 271
 None
 1.15A 6b54A-1mqtB:
undetectable		 6b54A-1mqtB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		6 MET A  78
ILE A  74
LEU A  27
ASP A  35
LEU A  70
THR A  38
 None
 1.34A 6b54A-1q6wA:
undetectable		 6b54A-1q6wA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 MET A  78
ILE A  74
LEU A  27
LEU A  70
THR A  34
 None
 1.12A 6b54A-1q6wA:
undetectable		 6b54A-1q6wA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE

(Streptomyces
venezuelae) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 256
LEU A 261
VAL A 308
LEU A 248
LEU A 246
 None
 1.23A 6b54A-1r66A:
2.1		 6b54A-1r66A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 VAL A 170
ASP A 196
LEU A 197
THR A 246
LEU A 249
 None
CA  A1290 (-2.2A)
None
None
None
 1.21A 6b54A-1s2nA:
undetectable		 6b54A-1s2nA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 ILE A 286
LEU A 305
VAL A 216
LEU A 266
LEU A 276
 None
 1.20A 6b54A-1xfiA:
undetectable		 6b54A-1xfiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 5 MET B 264
ILE B 259
VAL B 383
LEU B 257
LEU B 320
 None
 1.14A 6b54A-1xnjB:
6.6		 6b54A-1xnjB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 LEU A 259
LEU A 342
PHE A 337
THR A 347
LEU A 346
 SAM  A1201 (-4.5A)
None
SAM  A1201 (-4.2A)
None
None
 1.12A 6b54A-2b9eA:
undetectable		 6b54A-2b9eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		5 ILE A  82
VAL A  69
LEU A  81
THR A  37
LEU A  36
 None
 1.07A 6b54A-2bv6A:
undetectable		 6b54A-2bv6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 6 ILE A  94
LEU A 491
LEU A 150
PHE A 285
THR A 296
LEU A 297
 None
 1.43A 6b54A-2d4yA:
undetectable		 6b54A-2d4yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 221
VAL A 212
LEU A 111
THR A 104
LEU A 107
 None
NAP  A 401 ( 4.1A)
None
NAP  A 401 (-3.2A)
None
 1.07A 6b54A-2dbrA:
undetectable		 6b54A-2dbrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 LEU A 524
VAL A 495
LEU A 399
THR A 430
LEU A 433
 None
 1.10A 6b54A-2et6A:
1.6		 6b54A-2et6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		5 ILE A 121
VAL A  95
LEU A 144
THR A 113
LEU A 114
 None
 1.16A 6b54A-2htmA:
undetectable		 6b54A-2htmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9b MRNA
3'-END-PROCESSING
PROTEIN RNA15
MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF05843
(Suf) 		5 ILE A 165
VAL A 154
LEU A 169
THR A 159
LEU B 638
 None
 1.15A 6b54A-2l9bA:
undetectable		 6b54A-2l9bA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		5 ILE A  71
LEU A 146
VAL A 109
LEU A 304
LEU A 309
 None
 1.19A 6b54A-2oqcA:
undetectable		 6b54A-2oqcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 ILE A 189
LEU A 288
LEU A 161
PHE A  93
LEU A 135
 None
UNX  A1009 ( 4.2A)
None
COA  A 401 ( 3.8A)
None
 1.02A 6b54A-2pfrA:
undetectable		 6b54A-2pfrA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 ILE A  63
LEU A  81
LEU A  29
THR A  39
LEU A  33
 HEM  A 143 ( 4.6A)
None
None
HEM  A 143 ( 4.3A)
None
 1.15A 6b54A-2r1hA:
undetectable		 6b54A-2r1hA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 ILE A  52
LEU A  28
LEU A  49
PHE A  75
LEU A  86
 None
 1.17A 6b54A-2vl8A:
undetectable		 6b54A-2vl8A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU B 237
VAL B 228
LEU B 124
THR B 117
LEU B 120
 None
 1.05A 6b54A-2w2kB:
undetectable		 6b54A-2w2kB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wws COAT PROTEIN

(Physalis mottle
virus) 		PF00983
(Tymo_coat) 		5 ILE A  60
LEU A 154
LEU A  63
PHE A  38
LEU A  34
 None
 0.90A 6b54A-2wwsA:
undetectable		 6b54A-2wwsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 499
ASP A 468
LEU A 517
THR A 545
LEU A 543
 None
 1.17A 6b54A-2x40A:
2.1		 6b54A-2x40A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus) 		PF00963
(Cohesin) 		5 ILE A  36
VAL A 143
LEU A  38
THR A 147
LEU A 130
 None
 1.05A 6b54A-2xdhA:
undetectable		 6b54A-2xdhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		5 ILE A   3
ASP A  29
VAL A  60
LEU A   6
LEU A  42
 None
 1.21A 6b54A-2ywqA:
undetectable		 6b54A-2ywqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		6 MET A   1
ILE A   3
ASP A  29
LEU A  36
LEU A   6
LEU A  42
 None
 1.48A 6b54A-2ywqA:
undetectable		 6b54A-2ywqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus;
Thermosynechococcus
vulcanus) 		PF00421
(PSII)
PF00124
(Photo_RC) 		5 ILE C 459
LEU C 467
VAL D 247
PHE D 223
THR D 217
 None
None
None
None
PQ9  D1042 (-2.8A)
 1.08A 6b54A-3a0hC:
undetectable		 6b54A-3a0hC:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 ILE A 119
VAL A 165
LEU A 176
THR A 105
LEU A 109
 None
 1.15A 6b54A-3bjbA:
undetectable		 6b54A-3bjbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceg BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00179
(UQ_con) 		5 ILE A4703
LEU A4769
VAL A4708
THR A4619
LEU A4617
 None
 1.24A 6b54A-3cegA:
undetectable		 6b54A-3cegA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ILE A 206
LEU A 195
THR A 236
THR A 161
LEU A 165
 None
 1.25A 6b54A-3eluA:
undetectable		 6b54A-3eluA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		5 ILE A  52
VAL A 118
LEU A  50
MET A 134
LEU A 114
 None
 1.25A 6b54A-3fbkA:
undetectable		 6b54A-3fbkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		5 ILE A 293
VAL A 372
LEU A 352
THR A 318
LEU A  27
 None
None
None
EDO  A 388 (-4.6A)
None
 1.17A 6b54A-3fdbA:
undetectable		 6b54A-3fdbA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A  99
ASP A 146
LEU A 147
THR A 284
LEU A 283
 None
 0.95A 6b54A-3fzvA:
undetectable		 6b54A-3fzvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		6 ILE A 111
LEU A  63
VAL A  61
LEU A 130
THR A 212
LEU A  98
 None
 1.39A 6b54A-3gocA:
undetectable		 6b54A-3gocA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Vibrio
parahaemolyticus) 		PF00106
(adh_short) 		5 ILE A   2
LEU A 205
VAL A 124
LEU A   1
LEU A  67
 None
 1.23A 6b54A-3guyA:
1.9		 6b54A-3guyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ILE A 248
VAL A 265
LEU A 202
THR A 359
LEU A 189
 None
 1.22A 6b54A-3h8fA:
undetectable		 6b54A-3h8fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		5 ILE A 116
LEU A 105
VAL A  37
LEU A  47
THR A  59
 None
 1.08A 6b54A-3iclA:
undetectable		 6b54A-3iclA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 LEU A 213
VAL A 200
LEU A 345
THR A 338
LEU A 341
 None
 1.13A 6b54A-3if9A:
undetectable		 6b54A-3if9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 ILE A 136
LEU A  61
VAL A 115
LEU A 134
PHE A 151
 None
 1.12A 6b54A-3j31A:
undetectable		 6b54A-3j31A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ILE A 260
ASP A 194
LEU A 263
THR A 280
LEU A 278
 None
None
None
GOL  A 404 (-4.2A)
None
 1.23A 6b54A-3ju1A:
undetectable		 6b54A-3ju1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 MET A 243
ILE A 245
LEU A 240
THR A 164
LEU A 254
 None
 1.20A 6b54A-3k6kA:
undetectable		 6b54A-3k6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljf IRON SUPEROXIDE
DISMUTASE

(Pseudoalteromonas
haloplanktis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A  18
LEU A 175
VAL A 156
LEU A  23
LEU A   7
 None
 0.82A 6b54A-3ljfA:
undetectable		 6b54A-3ljfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ILE A 217
LEU A 197
LEU A 241
PHE A 222
LEU A 262
 None
 1.23A 6b54A-3o6nA:
undetectable		 6b54A-3o6nA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 ILE B 217
LEU B 197
LEU B 241
PHE B 222
LEU B 262
 None
 1.19A 6b54A-3ojaB:
undetectable		 6b54A-3ojaB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		5 MET A 157
ILE A 153
LEU A 149
PHE A 115
THR A  73
 None
None
HEM  A 163 (-4.1A)
HEM  A 163 ( 4.3A)
HEM  A 163 (-4.0A)
 0.95A 6b54A-3qqrA:
undetectable		 6b54A-3qqrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A  50
ILE A  54
VAL A  10
LEU A  97
LEU A  28
 None
 1.19A 6b54A-3rcyA:
undetectable		 6b54A-3rcyA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		5 ILE A 252
VAL A 140
LEU A 248
PHE A  82
LEU A 135
 None
 1.24A 6b54A-3rkxA:
undetectable		 6b54A-3rkxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		5 ILE A 266
ASP A 300
VAL A 215
LEU A 264
LEU A 258
 None
 1.08A 6b54A-3s7iA:
undetectable		 6b54A-3s7iA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 ILE A  40
LEU A  53
VAL A 120
LEU A  64
LEU A 131
 None
 1.18A 6b54A-3sutA:
undetectable		 6b54A-3sutA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		5 MET A 260
ILE A 393
PHE A 230
THR A 234
LEU A 354
 None
None
None
None
HEM  A 501 (-3.9A)
 1.21A 6b54A-3vxiA:
undetectable		 6b54A-3vxiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 238
LEU A 225
VAL A 251
LEU A 264
LEU A 439
 None
 1.05A 6b54A-4a0sA:
undetectable		 6b54A-4a0sA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 ASP A 192
LEU A 193
VAL A 110
LEU A 203
LEU A  89
 None
 1.17A 6b54A-4blpA:
undetectable		 6b54A-4blpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 ILE B  74
LEU B 117
LEU B  72
THR B 255
LEU B 258
 None
 1.24A 6b54A-4f6tB:
undetectable		 6b54A-4f6tB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		5 ILE A  95
LEU A  89
LEU A  98
THR A 201
LEU A 204
 None
 1.19A 6b54A-4jb3A:
undetectable		 6b54A-4jb3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		5 ILE A 101
ASP A 190
LEU A 114
THR A 199
LEU A 200
 None
 1.17A 6b54A-4l0cA:
undetectable		 6b54A-4l0cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 285
LEU A 186
LEU A 218
THR A 272
LEU A 271
 None
 1.26A 6b54A-4ld8A:
undetectable		 6b54A-4ld8A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 102
LEU A 184
VAL A 188
LEU A 100
LEU A 162
 None
 1.20A 6b54A-4m38A:
undetectable		 6b54A-4m38A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A 338
LEU A  49
VAL A 242
LEU A 379
LEU A 373
 None
 1.22A 6b54A-4mafA:
undetectable		 6b54A-4mafA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 5 ILE A 242
LEU A 250
VAL A 226
LEU A 168
LEU A 172
 None
 0.98A 6b54A-4mc0A:
undetectable		 6b54A-4mc0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A  25
LEU A  20
THR A 207
THR A  16
LEU A  14
 None
 1.25A 6b54A-4nf2A:
undetectable		 6b54A-4nf2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 ILE A 217
LEU A 260
LEU A 214
THR A 174
LEU A 177
 None
 1.24A 6b54A-4q22A:
undetectable		 6b54A-4q22A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmf KRR1 SMALL SUBUNIT
PROCESSOME COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 5 MET D 121
ILE D 116
ASP D 120
LEU D 100
LEU D  64
 None
 1.19A 6b54A-4qmfD:
undetectable		 6b54A-4qmfD:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		5 ILE A 448
VAL A 397
LEU A 348
THR A 486
LEU A 490
 None
 1.23A 6b54A-4r3iA:
undetectable		 6b54A-4r3iA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 ILE A 250
LEU A 217
VAL A 186
LEU A 253
LEU A 196
 None
 1.26A 6b54A-4r9oA:
undetectable		 6b54A-4r9oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tt6 ATPASE FAMILY AAA
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 ASP A1030
LEU A1031
ASP A1039
LEU A1040
THR A 997
 None
 1.17A 6b54A-4tt6A:
undetectable		 6b54A-4tt6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuy VACUOLAR MEMBRANE
PROTEIN PEP3

(Saccharomyces
cerevisiae) 		PF05131
(Pep3_Vps18) 		5 ILE A 168
VAL A 244
LEU A 161
THR A 212
LEU A 221
 None
 1.06A 6b54A-4uuyA:
undetectable		 6b54A-4uuyA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 ILE A 240
LEU A 220
LEU A 244
THR A 265
LEU A 266
 None
 1.23A 6b54A-4uvkA:
undetectable		 6b54A-4uvkA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 ILE C 576
LEU C 569
VAL C 463
LEU C 491
LEU C 474
 None
 1.18A 6b54A-4xgcC:
undetectable		 6b54A-4xgcC:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 ILE A 280
VAL A  42
LEU A  57
THR A  50
LEU A  53
 None
 1.24A 6b54A-4yn5A:
undetectable		 6b54A-4yn5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		5 MET A  64
LEU A  60
PHE A  35
THR A 123
THR A 102
 None
 1.24A 6b54A-4zi5A:
undetectable		 6b54A-4zi5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 LEU A 351
VAL A 389
LEU A 337
MET A 316
LEU A 323
 None
 1.24A 6b54A-5aqaA:
undetectable		 6b54A-5aqaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP3

(Enterovirus D) 		PF00073
(Rhv) 		5 ILE C  71
VAL C 202
LEU C 129
PHE C 119
THR C 198
 None
 1.24A 6b54A-5bnnC:
undetectable		 6b54A-5bnnC:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 12 MET A  38
ILE A  42
ASP A  91
LEU A  92
VAL A 128
ASP A 144
LEU A 147
PHE A 153
THR A 157
MET A 233
THR A 237
LEU A 240
 OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-2.7A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-3.3A)
None
OAQ  A 302 ( 4.8A)
OAQ  A 302 (-2.6A)
None
OAQ  A 302 (-3.8A)
None
 0.46A 6b54A-5bykA:
39.3		 6b54A-5bykA:
75.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 ILE A 492
LEU A 533
VAL A 543
LEU A 490
THR A 454
 None
 1.21A 6b54A-5dllA:
undetectable		 6b54A-5dllA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 MET A 246
LEU A 486
VAL A 476
LEU A 430
PHE A 492
 None
 1.23A 6b54A-5e6tA:
undetectable		 6b54A-5e6tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ILE A1055
VAL A 915
LEU A1052
THR A 898
LEU A1044
 None
 1.18A 6b54A-5eawA:
undetectable		 6b54A-5eawA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 102
LEU A 184
VAL A 188
LEU A 100
LEU A 162
 SAH  A 401 (-4.9A)
None
None
None
None
 1.09A 6b54A-5ekuA:
undetectable		 6b54A-5ekuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 ILE A 761
LEU A 798
LEU A 758
THR A 712
LEU A 715
 None
 1.16A 6b54A-5gzuA:
undetectable		 6b54A-5gzuA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
 None
 1.13A 6b54A-5hdtA:
undetectable		 6b54A-5hdtA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
betaherpesvirus
5) 		PF03325
(Herpes_PAP) 		5 MET A 116
ILE A 114
LEU A  99
PHE A  90
THR A  94
 None
 1.23A 6b54A-5iwdA:
undetectable		 6b54A-5iwdA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		5 LEU B 525
VAL B  15
LEU B 470
THR B 545
LEU B 466
 None
 1.18A 6b54A-5k1bB:
undetectable		 6b54A-5k1bB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		5 ILE A 232
LEU A 228
LEU A 103
THR A 450
LEU A 451
 None
 1.02A 6b54A-5mf1A:
undetectable		 6b54A-5mf1A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		5 ILE A  19
LEU A  24
LEU A 372
PHE A 376
LEU A 366
 C8E  A 513 ( 3.8A)
None
C8E  A 513 ( 4.7A)
None
C8E  A 513 ( 4.7A)
 1.03A 6b54A-5sytA:
undetectable		 6b54A-5sytA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 11 MET A  53
ILE A  57
ASP A 100
LEU A 101
VAL A 137
ASP A 153
LEU A 156
PHE A 162
MET A 242
THR A 246
LEU A 249
 OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-2.5A)
OAQ  A 302 ( 4.1A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-3.1A)
None
OAQ  A 302 (-4.6A)
OAQ  A 302 ( 4.0A)
OAQ  A 302 (-3.5A)
None
 0.36A 6b54A-5tiwA:
42.6		 6b54A-5tiwA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 9 MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
LEU A 143
PHE A 149
THR A 233
LEU A 236
 None
 0.72A 6b54A-5tizA:
35.5		 6b54A-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		5 MET A 194
ILE A 192
ASP A 195
THR A 292
THR A 333
 None
 1.08A 6b54A-5uamA:
undetectable		 6b54A-5uamA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		5 MET A 294
ILE A 304
LEU A 308
THR A 359
LEU A 246
 None
 1.25A 6b54A-5w94A:
undetectable		 6b54A-5w94A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 ILE B 145
VAL B  78
LEU B  40
PHE B  44
LEU B  98
 None
 1.10A 6b54A-5x2oB:
undetectable		 6b54A-5x2oB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 VAL D 768
LEU D 796
THR D 808
THR D 776
LEU D 779
 None
 1.13A 6b54A-5xbkD:
undetectable		 6b54A-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 5 ILE A 122
LEU A 123
PHE A 240
THR A 161
LEU A 158
 None
 1.21A 6b54A-5yf0A:
undetectable		 6b54A-5yf0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 ILE A 122
LEU A 172
LEU A 137
PHE A 159
LEU A 141
 None
 1.22A 6b54A-5z06A:
undetectable		 6b54A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 5 ILE A  30
LEU A 107
VAL A  95
ASP A  47
LEU A  43
 None
 1.12A 6b54A-6cjqA:
undetectable		 6b54A-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 ILE A 256
LEU A 249
PHE A 287
THR A 314
LEU A 315
 None
 1.19A 6b54A-6en4A:
undetectable		 6b54A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyn -

(-) 		no annotation 5 ASP H  44
LEU H  83
PHE H  64
THR H  87
LEU H  86
 None
None
EDO  H 304 (-4.1A)
None
None
 1.08A 6b54A-6eynH:
undetectable		 6b54A-6eynH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 MET A 155
ILE A 151
LEU A 192
LEU A 147
LEU A 129
 None
 1.25A 6b54A-6ez8A:
undetectable		 6b54A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 5 ILE A 139
VAL A 161
LEU A 119
THR A 188
LEU A  74
 None
 1.18A 6b54A-6fi2A:
undetectable		 6b54A-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 5 MET F  60
ILE F  56
LEU F  65
VAL F 230
THR F  45
 None
 1.17A 6b54A-6g2jF:
undetectable		 6b54A-6g2jF:
undetectable