SIMILAR PATTERNS OF AMINO ACIDS FOR 6B52_A_OAQA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		5 PRO A 197
ILE A  30
LEU A 244
LEU A 121
THR A 122
 None
 1.03A 6b52A-1dmuA:
undetectable		 6b52A-1dmuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 ILE A 124
VAL A  90
VAL A  91
LEU A 120
LEU A 150
 None
 0.87A 6b52A-1dppA:
undetectable		 6b52A-1dppA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 PRO A 398
LEU A 394
VAL A  86
VAL A 362
LEU A 350
 None
 1.23A 6b52A-1fw8A:
undetectable		 6b52A-1fw8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 ILE A 355
LEU A 313
VAL A 336
LEU A 358
LEU A 371
 None
 1.08A 6b52A-1gl6A:
undetectable		 6b52A-1gl6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
 None
 1.10A 6b52A-1gz4A:
1.1		 6b52A-1gz4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 ILE A 132
VAL A 167
VAL A 168
PHE A  40
THR A   9
 None
 1.15A 6b52A-1jy5A:
undetectable		 6b52A-1jy5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 ILE A 245
VAL A 165
VAL A  99
LEU A 265
THR A 264
 None
 1.15A 6b52A-1mxfA:
0.8		 6b52A-1mxfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
 None
 1.19A 6b52A-1r47A:
undetectable		 6b52A-1r47A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 ILE A  34
VAL A  56
VAL A  57
LEU A  32
PHE A  85
 None
 0.99A 6b52A-1su1A:
undetectable		 6b52A-1su1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 105
LEU A  10
LEU A  98
SER A   9
LEU A  85
 None
 1.17A 6b52A-1vlvA:
undetectable		 6b52A-1vlvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 207
VAL A  26
MET A 108
LEU A 137
THR A 138
 None
 1.13A 6b52A-1w5fA:
1.9		 6b52A-1w5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		5 VAL A 137
VAL A 138
LEU A   3
MET A 201
LEU A 204
 None
 1.13A 6b52A-2btdA:
undetectable		 6b52A-2btdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 360
VAL A 384
PHE A 368
LEU A 406
THR A 405
 None
 1.12A 6b52A-2c7zA:
undetectable		 6b52A-2c7zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
 None
 1.02A 6b52A-2dw4A:
undetectable		 6b52A-2dw4A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 MET A   1
ILE A   3
LEU A  18
LEU A 316
THR A 315
 None
 1.22A 6b52A-2eezA:
undetectable		 6b52A-2eezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 PRO A 252
ILE A 245
VAL A 378
LEU A 422
MET A 369
 None
 1.11A 6b52A-2i2xA:
undetectable		 6b52A-2i2xA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 PRO A1719
LEU A1718
VAL A1668
VAL A1724
LEU A1916
 None
 1.23A 6b52A-2ix8A:
undetectable		 6b52A-2ix8A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1f APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN

(Mus musculus) 		PF02758
(PYRIN) 		5 ILE A  39
VAL A  57
LEU A  27
LEU A  68
THR A  69
 None
 1.20A 6b52A-2n1fA:
undetectable		 6b52A-2n1fA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naf PEPTIDYL-TRNA
HYDROLASE

(Mycolicibacterium
smegmatis) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  79
VAL A  92
VAL A   8
LEU A  55
THR A 173
 None
 1.20A 6b52A-2nafA:
2.4		 6b52A-2nafA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		5 PRO A 219
ILE A 177
VAL A 103
VAL A 104
LEU A 151
 None
 1.02A 6b52A-2o1oA:
undetectable		 6b52A-2o1oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		5 PRO A  61
ILE A  68
VAL A  65
LEU A  98
LEU A  27
 None
 1.03A 6b52A-2plwA:
undetectable		 6b52A-2plwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		5 MET C1385
ILE C1383
LEU C1381
PHE C1439
LEU C1341
 None
 1.09A 6b52A-2qkiC:
undetectable		 6b52A-2qkiC:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		5 LEU A  29
VAL A 126
MET A  89
LEU A  92
THR A  93
 None
 1.12A 6b52A-2qtnA:
undetectable		 6b52A-2qtnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 264
VAL B 326
LEU B 335
SER B 246
LEU B 283
 None
 0.85A 6b52A-2vduB:
undetectable		 6b52A-2vduB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 ILE A 297
VAL A 278
LEU A 129
PHE A 307
MET A 280
 None
 1.24A 6b52A-2w3zA:
undetectable		 6b52A-2w3zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtp GTPASE IMAP FAMILY
MEMBER 2

(Homo sapiens) 		PF04548
(AIG1) 		6 ILE A  75
LEU A 101
VAL A  28
PHE A  48
SER A  62
LEU A 144
 None
 1.36A 6b52A-2xtpA:
2.8		 6b52A-2xtpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 MET B1385
ILE B1383
LEU B1381
PHE B1439
LEU B1341
 None
 1.08A 6b52A-2xwbB:
undetectable		 6b52A-2xwbB:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 MET A 191
VAL A  94
VAL A  95
LEU A 521
THR A 508
 None
 1.23A 6b52A-2yevA:
undetectable		 6b52A-2yevA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Sulfolobus
shibatae) 		PF04406
(TP6A_N) 		5 ILE A 378
VAL A 207
LEU A 373
PHE A 222
SER A 228
 None
 1.11A 6b52A-2zbkA:
undetectable		 6b52A-2zbkA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ILE A 117
VAL A 122
LEU A 323
MET A  59
LEU A  58
 None
 1.23A 6b52A-3b9yA:
undetectable		 6b52A-3b9yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA

(Perca
flavescens) 		PF00042
(Globin) 		5 ILE A 106
VAL A  68
VAL A  71
LEU A 102
PHE A 130
 None
None
None
HEM  A 143 (-4.2A)
None
 1.08A 6b52A-3bj1A:
undetectable		 6b52A-3bj1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 PRO A 367
PHE A  81
SER A 372
MET A 388
LEU A 385
 None
 0.97A 6b52A-3ed4A:
undetectable		 6b52A-3ed4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 405
PHE A  81
SER A 372
MET A 388
LEU A 385
 None
 0.97A 6b52A-3ed4A:
undetectable		 6b52A-3ed4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		5 PRO A  61
ILE A  23
VAL A  10
LEU A  22
LEU A  75
 None
 1.22A 6b52A-3efeA:
undetectable		 6b52A-3efeA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 PRO A  42
ILE A   7
LEU A  10
VAL A  67
LEU A  62
 None
 1.02A 6b52A-3ejwA:
1.6		 6b52A-3ejwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 207
ILE A 234
PHE A 271
MET A 178
LEU A 220
 None
 1.22A 6b52A-3gdcA:
undetectable		 6b52A-3gdcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A  62
VAL A 101
LEU A 162
LEU A 174
THR A 173
 None
 1.18A 6b52A-3h3zA:
undetectable		 6b52A-3h3zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A  68
ILE A   3
VAL A  73
VAL A   6
LEU A  19
 None
 1.12A 6b52A-3hn2A:
undetectable		 6b52A-3hn2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		5 ILE A   7
VAL A  63
VAL A  64
SER A  87
LEU A  54
 None
 1.23A 6b52A-3id6A:
undetectable		 6b52A-3id6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		no annotation 5 ILE 9 299
LEU 9 257
LEU 9 297
LEU 9 286
THR 9 281
 None
 1.21A 6b52A-3j9f9:
undetectable		 6b52A-3j9f9:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 5 ILE A 298
LEU A 365
VAL A 337
VAL A 338
THR A 355
 None
 0.89A 6b52A-3kptA:
undetectable		 6b52A-3kptA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A 196
LEU A 199
VAL A 145
VAL A 146
LEU A 422
 None
 1.21A 6b52A-3krtA:
undetectable		 6b52A-3krtA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 PRO A 301
VAL A 298
VAL A 299
LEU A 246
LEU A 290
 None
 1.23A 6b52A-3m6cA:
undetectable		 6b52A-3m6cA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		5 ILE A 617
VAL A 629
LEU A 615
PHE A 663
THR A 596
 None
 1.23A 6b52A-3n3tA:
undetectable		 6b52A-3n3tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 ILE A 135
VAL A  76
LEU A 137
PHE A  25
THR A  36
 None
 1.24A 6b52A-3nnmA:
undetectable		 6b52A-3nnmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 ILE A 135
VAL A  76
PHE A  25
LEU A  37
THR A  36
 None
 1.19A 6b52A-3nnmA:
undetectable		 6b52A-3nnmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa8 TOXIN B

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		5 PRO A  94
ILE A  85
LEU A  20
PHE A  55
SER A  62
 None
 1.23A 6b52A-3pa8A:
undetectable		 6b52A-3pa8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk1 INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		5 ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
 None
 1.11A 6b52A-3pk1A:
undetectable		 6b52A-3pk1A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		5 MET A 157
ILE A 153
LEU A 149
PHE A 115
THR A  73
 None
None
HEM  A 163 (-4.1A)
HEM  A 163 ( 4.3A)
HEM  A 163 (-4.0A)
 0.99A 6b52A-3qqrA:
undetectable		 6b52A-3qqrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 283
VAL A 343
VAL A 342
LEU A 290
THR A 320
 None
 1.05A 6b52A-3u1kA:
undetectable		 6b52A-3u1kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16

(Homo sapiens) 		PF01419
(Jacalin) 		5 ILE A  49
VAL A  54
LEU A  88
SER A  73
LEU A 118
 None
 1.19A 6b52A-3vzgA:
undetectable		 6b52A-3vzgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		5 ILE A  92
VAL A  85
VAL A 111
SER A 128
THR A  12
 None
None
None
None
SO4  A 301 (-4.8A)
 1.05A 6b52A-3w5iA:
3.2		 6b52A-3w5iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyr KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL4

(Homo sapiens) 		PF00047
(ig) 		5 PRO A 180
MET A  95
ILE A  94
LEU A  26
LEU A  50
 None
 1.16A 6b52A-3wyrA:
undetectable		 6b52A-3wyrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		5 ILE A 694
LEU A 692
PHE A 702
SER A 785
LEU A 751
 None
 1.23A 6b52A-4acjA:
undetectable		 6b52A-4acjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 MET A 187
ILE A 219
VAL A 156
VAL A 157
LEU A  95
 None
 1.23A 6b52A-4bkmA:
undetectable		 6b52A-4bkmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A 268
LEU A 272
MET A 196
LEU A 197
THR A 194
 None
 1.16A 6b52A-4bziA:
undetectable		 6b52A-4bziA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 PRO A  21
ILE A 184
VAL A  34
LEU A 188
LEU A   6
 None
 1.15A 6b52A-4ed9A:
undetectable		 6b52A-4ed9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		5 ILE B 168
LEU B  26
SER B 215
LEU B 158
THR B 159
 None
 1.18A 6b52A-4ejsB:
undetectable		 6b52A-4ejsB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 PRO B1182
ILE B1204
LEU B1202
PHE B1239
LEU B1282
 None
 1.18A 6b52A-4f92B:
undetectable		 6b52A-4f92B:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 VAL A 309
LEU A 220
SER A 289
MET A 304
LEU A 280
 None
 1.20A 6b52A-4infA:
undetectable		 6b52A-4infA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 PRO A  77
LEU A  81
VAL A 114
VAL A  91
MET A 358
 None
 0.91A 6b52A-4j16A:
undetectable		 6b52A-4j16A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr ESPG5

(Mycobacterium
tuberculosis) 		PF14011
(ESX-1_EspG) 		5 ILE C 150
VAL C 119
VAL C 118
LEU C 286
LEU C  83
 None
 1.17A 6b52A-4kxrC:
undetectable		 6b52A-4kxrC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A) 		PF00947
(Pico_P2A) 		5 ILE A 123
VAL A  12
LEU A  40
SER A   7
LEU A 140
 None
 1.11A 6b52A-4mg3A:
undetectable		 6b52A-4mg3A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 PRO A  69
LEU A 119
VAL A 113
VAL A 114
MET A  51
 None
 1.19A 6b52A-4mlaA:
undetectable		 6b52A-4mlaA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 ILE A 507
VAL A 601
LEU A 483
MET A 516
LEU A 498
 None
 1.23A 6b52A-4om9A:
undetectable		 6b52A-4om9A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 PRO A 186
VAL A  15
VAL A   8
LEU A  31
THR A  61
 None
 1.14A 6b52A-4qwwA:
undetectable		 6b52A-4qwwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 VAL A  15
VAL A   8
LEU A  20
LEU A  31
THR A  61
 None
 0.97A 6b52A-4qwwA:
undetectable		 6b52A-4qwwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 ILE B 133
LEU B 279
LEU B 130
PHE B 137
THR B 148
 None
 1.03A 6b52A-4ritB:
undetectable		 6b52A-4ritB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 ILE B 133
LEU B 279
PHE B 137
LEU B 147
THR B 148
 None
 1.20A 6b52A-4ritB:
undetectable		 6b52A-4ritB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		6 PRO A 121
ILE A  43
VAL A  95
LEU A  73
PHE A  64
MET A  90
 None
 1.46A 6b52A-4wwhA:
undetectable		 6b52A-4wwhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 353
LEU A 348
VAL A 334
VAL A 333
LEU A 355
 None
 1.03A 6b52A-4xg0A:
undetectable		 6b52A-4xg0A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		5 VAL A 192
VAL A 193
PHE A 339
LEU A 168
THR A 200
 None
None
HEM  A 504 ( 3.8A)
None
None
 1.22A 6b52A-4xydA:
undetectable		 6b52A-4xydA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO A 217
ILE A 249
LEU A 216
VAL A 125
LEU A 244
 None
 1.16A 6b52A-4ywlA:
undetectable		 6b52A-4ywlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1o PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran) 		5 PRO A 114
ILE A  59
VAL A  32
LEU A  37
SER A 106
 None
 1.13A 6b52A-4z1oA:
undetectable		 6b52A-4z1oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1o PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran) 		5 PRO A 114
ILE A  59
VAL A  32
VAL A  89
SER A 106
 None
 1.20A 6b52A-4z1oA:
undetectable		 6b52A-4z1oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 ILE A 108
LEU A 102
VAL A 240
LEU A 113
LEU A 187
 None
 1.20A 6b52A-5azdA:
undetectable		 6b52A-5azdA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 11 PRO A  16
MET A  38
ILE A  42
LEU A  92
VAL A 127
VAL A 128
LEU A 147
PHE A 153
MET A 233
LEU A 236
THR A 237
 OAQ  A 302 (-4.4A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.9A)
OAQ  A 302 (-4.0A)
None
OAQ  A 302 ( 4.8A)
None
None
OAQ  A 302 (-3.8A)
 0.37A 6b52A-5bykA:
39.8		 6b52A-5bykA:
75.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cv1 P GRANULE
ABNORMALITY PROTEIN
1

(Caenorhabditis
elegans) 		no annotation 5 ILE A 482
LEU A 461
PHE A 466
SER A 465
THR A 436
 None
 1.11A 6b52A-5cv1A:
undetectable		 6b52A-5cv1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		5 ILE A 150
VAL A  78
VAL A  81
LEU A  90
THR A  73
 None
 1.12A 6b52A-5dqlA:
undetectable		 6b52A-5dqlA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezv 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Homo sapiens) 		PF04739
(AMPKBI)
PF16561
(AMPK1_CBM) 		5 ILE B 214
LEU B 210
LEU B 228
LEU B 265
THR B 264
 None
 1.21A 6b52A-5ezvB:
undetectable		 6b52A-5ezvB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		6 PRO A 282
LEU A 277
VAL A 242
LEU A 364
MET A 138
LEU A 137
 HEM  A 501 ( 4.4A)
None
None
None
None
None
 1.28A 6b52A-5gnmA:
undetectable		 6b52A-5gnmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsz KINESIN-LIKE PROTEIN
KIF19

(Mus musculus) 		PF00225
(Kinesin) 		5 LEU A 224
PHE A 247
SER A 310
LEU A 128
THR A 127
 None
 1.19A 6b52A-5gszA:
undetectable		 6b52A-5gszA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 PRO A  24
ILE A  96
LEU A 159
LEU A 112
LEU A 150
 None
 1.12A 6b52A-5h5jA:
undetectable		 6b52A-5h5jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Kluyveromyces
lactis) 		PF01048
(PNP_UDP_1) 		5 PRO A 236
LEU A 105
SER A 104
MET A  93
LEU A  80
 None
 1.23A 6b52A-5ifkA:
undetectable		 6b52A-5ifkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		5 ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
 None
 1.10A 6b52A-5jsbA:
undetectable		 6b52A-5jsbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0o RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 126
VAL A  90
VAL A  89
LEU A 159
LEU A  81
 None
 1.14A 6b52A-5l0oA:
undetectable		 6b52A-5l0oA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
 None
 0.95A 6b52A-5l3dA:
undetectable		 6b52A-5l3dA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens;
Mus musculus) 		PF00452
(Bcl-2) 		5 ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
 None
 1.16A 6b52A-5mevA:
undetectable		 6b52A-5mevA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 MET A 559
ILE A 586
LEU A 497
VAL A 449
VAL A 475
 None
 1.15A 6b52A-5neuA:
undetectable		 6b52A-5neuA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 6 PRO A 115
ILE A 162
LEU A 196
PHE A 141
SER A 145
LEU A 219
 None
 1.49A 6b52A-5ns8A:
undetectable		 6b52A-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 ILE A 365
VAL A 393
LEU A 364
LEU A 444
THR A 440
 None
 1.20A 6b52A-5odoA:
1.3		 6b52A-5odoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 ILE A 571
LEU A 592
PHE A 586
SER A 578
MET A 609
 None
 1.12A 6b52A-5ot4A:
undetectable		 6b52A-5ot4A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 6 PRO A  31
MET A  53
ILE A  57
LEU A 101
SER A 166
LEU A 265
 OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
OAQ  A 302 (-3.5A)
None
 1.44A 6b52A-5tiwA:
42.9		 6b52A-5tiwA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 12 PRO A  31
MET A  53
ILE A  57
LEU A 101
VAL A 136
VAL A 137
LEU A 156
PHE A 162
SER A 166
MET A 242
LEU A 245
THR A 246
 OAQ  A 302 (-4.7A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
None
OAQ  A 302 (-4.0A)
None
OAQ  A 302 (-4.6A)
OAQ  A 302 (-3.5A)
OAQ  A 302 ( 4.0A)
OAQ  A 302 ( 4.4A)
OAQ  A 302 (-3.5A)
 0.29A 6b52A-5tiwA:
42.9		 6b52A-5tiwA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 9 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
LEU A 232
THR A 233
 None
 0.73A 6b52A-5tizA:
35.8		 6b52A-5tizA:
60.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 9 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
 None
 0.69A 6b52A-5tizA:
35.8		 6b52A-5tizA:
60.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum) 		PF03421
(Acetyltransf_14) 		5 PRO A 183
ILE A 323
VAL A 193
VAL A 190
LEU A 326
 None
 1.19A 6b52A-5w40A:
undetectable		 6b52A-5w40A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 ILE A 159
VAL A 102
LEU A 165
PHE A 110
LEU A 171
 None
 1.18A 6b52A-5xxgA:
undetectable		 6b52A-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 5 ILE A 286
LEU A  14
VAL A 245
LEU A 250
MET A 235
 None
 1.23A 6b52A-5xzuA:
undetectable		 6b52A-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 PRO A  11
ILE A  96
SER A  42
MET A  53
LEU A  59
 FAD  A 501 (-3.4A)
None
FAD  A 501 (-3.1A)
None
None
 1.12A 6b52A-6c7sA:
undetectable		 6b52A-6c7sA:
undetectable