SIMILAR PATTERNS OF AMINO ACIDS FOR 6B0L_B_TA1B502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 VAL A 211
ASP A 212
LEU A  67
LEU A 107
LEU A 220
 None
 1.13A 6b0lB-1aosA:
undetectable		 6b0lB-1aosA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 VAL A  32
ASP A  33
THR A 185
GLY A  14
LEU A  17
 None
NAD  A 380 (-2.7A)
None
None
None
 1.09A 6b0lB-1bxkA:
7.4		 6b0lB-1bxkA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		5 LEU A 237
ASP A 244
ARG A 323
PRO A 228
GLY A 223
 None
 0.96A 6b0lB-1drtA:
0.0		 6b0lB-1drtA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 LEU A 489
ASP A 128
PRO A 637
GLY A 606
LEU A 664
 None
 1.17A 6b0lB-1e1cA:
0.0		 6b0lB-1e1cA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.02A 6b0lB-1ehiA:
0.0		 6b0lB-1ehiA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  21
SER A 168
THR A  74
ARG A  18
GLY A  16
 None
 1.17A 6b0lB-1fn4A:
undetectable		 6b0lB-1fn4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		5 LEU A 207
LEU A 190
SER A 181
PRO A 162
LEU A 148
 None
 1.08A 6b0lB-1i2wA:
undetectable		 6b0lB-1i2wA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A  71
ASP A 256
HIS A  93
SER A  68
GLY A 415
 None
None
None
IMP  A1331 (-2.6A)
IMP  A1331 ( 3.1A)
 1.16A 6b0lB-1jr1A:
3.0		 6b0lB-1jr1A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		5 VAL A  74
ASP A 166
PRO A  70
GLY A  44
LEU A  43
 None
GOL  A 304 (-2.9A)
None
None
None
 1.15A 6b0lB-1l5xA:
3.0		 6b0lB-1l5xA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		5 VAL A 145
LEU A 201
ASP A   7
LEU A 251
SER A 179
 None
None
LLP  A 199 ( 3.7A)
None
None
 0.94A 6b0lB-1m6sA:
undetectable		 6b0lB-1m6sA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmy SIMILAR TO
THYMIDYLATE KINASE
(DTMP KINASE)

(Homo sapiens) 		PF02223
(Thymidylate_kin) 		5 VAL A  95
ASP A  96
ASP A 121
LEU A 210
GLY A  13
 None
MG  A 401 ( 4.1A)
None
None
None
 1.12A 6b0lB-1nmyA:
undetectable		 6b0lB-1nmyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		5 VAL A  84
LEU A  36
LEU A  97
SER A 107
LEU A 270
 None
 1.01A 6b0lB-1p8rA:
4.4		 6b0lB-1p8rA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 ASP A 457
LEU A 427
SER A 159
THR A 143
GLY A 415
 None
 1.20A 6b0lB-1suvA:
undetectable		 6b0lB-1suvA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 VAL A  81
LEU A  17
LEU A  97
GLY A   8
LEU A  38
 None
 0.95A 6b0lB-1tviA:
undetectable		 6b0lB-1tviA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		5 ASP A 123
LEU A  65
LEU A  39
THR A  62
GLY A  87
 None
 1.13A 6b0lB-1uj4A:
undetectable		 6b0lB-1uj4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 VAL A 987
ASP A 988
ASP A 876
GLY A 925
LEU A 914
 None
 1.19A 6b0lB-1yq2A:
undetectable		 6b0lB-1yq2A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 LEU B 207
ASP B 215
LEU B 220
THR B 205
LEU B 187
 None
 1.20A 6b0lB-2akaB:
2.3		 6b0lB-2akaB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 VAL A 158
ASP A 159
THR A 188
GLY A 183
LEU A 179
 None
 0.99A 6b0lB-2ef4A:
3.1		 6b0lB-2ef4A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		5 LEU A  60
ASP A 180
LEU A 182
PRO A  67
GLY A  65
 None
 1.16A 6b0lB-2fmlA:
undetectable		 6b0lB-2fmlA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 VAL A 114
LEU A 190
LEU A 143
GLY A 121
LEU A 122
 None
 0.95A 6b0lB-2g7gA:
undetectable		 6b0lB-2g7gA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 592
ASP A 487
THR A 602
GLY A 613
LEU A 612
 None
 1.19A 6b0lB-2hpiA:
undetectable		 6b0lB-2hpiA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 445
ASP B 460
LEU B 450
THR B 434
PRO B 496
 None
 1.09A 6b0lB-2j04B:
undetectable		 6b0lB-2j04B:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		5 LEU A  24
LEU A   6
THR A  19
PRO A 222
GLY A 194
 None
 1.19A 6b0lB-2janA:
undetectable		 6b0lB-2janA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00550
(PP-binding) 		5 VAL A   6
LEU A  68
ASP A  71
GLY A  59
LEU A  58
 None
 1.07A 6b0lB-2kr5A:
undetectable		 6b0lB-2kr5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis) 		PF06094
(GGACT)
PF13772
(AIG2_2) 		5 VAL A 148
ASP A 149
LEU A 231
LEU A 199
THR A 232
 None
 0.97A 6b0lB-2qikA:
undetectable		 6b0lB-2qikA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 ASP A2003
LEU A1900
LEU A1971
GLY A2055
LEU A2056
 None
None
NAP  A3002 (-4.7A)
None
None
 1.15A 6b0lB-2vz9A:
undetectable		 6b0lB-2vz9A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		5 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.08A 6b0lB-2w92A:
undetectable		 6b0lB-2w92A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 HIS A 189
THR A 199
PRO A 135
GLY A 137
LEU A 136
 None
 1.14A 6b0lB-2xpzA:
undetectable		 6b0lB-2xpzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 308
LEU A 322
SER A 203
GLY A 166
LEU A 165
 None
 0.96A 6b0lB-2ycbA:
undetectable		 6b0lB-2ycbA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ASP A 246
LEU A 236
LEU A 183
THR A 237
GLY A 275
 SO4  A 324 (-4.0A)
None
None
None
None
 1.15A 6b0lB-3dwiA:
undetectable		 6b0lB-3dwiA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 324
ASP A 323
LEU A 328
GLY A 315
LEU A 318
 None
 1.10A 6b0lB-3fjoA:
undetectable		 6b0lB-3fjoA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 VAL A 173
ASP A 174
LEU A 388
LEU A 113
GLY A 202
 None
 0.99A 6b0lB-3g0iA:
undetectable		 6b0lB-3g0iA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		5 VAL A  25
ASP A  24
LEU A 175
LEU A 150
GLY A 238
 None
 1.04A 6b0lB-3g10A:
undetectable		 6b0lB-3g10A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		5 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.07A 6b0lB-3gdbA:
undetectable		 6b0lB-3gdbA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 359
ASP A 358
LEU A  40
ARG A 116
GLY A 354
 None
 0.90A 6b0lB-3i6tA:
undetectable		 6b0lB-3i6tA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 366
HIS A 374
LEU A 375
THR A 364
LEU A 481
 None
 1.15A 6b0lB-3ifrA:
undetectable		 6b0lB-3ifrA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkg PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Jannaschia sp.
CCS1) 		PF07366
(SnoaL) 		5 LEU A 159
LEU A 126
THR A 157
GLY A 119
LEU A  97
 None
PGE  A 204 (-4.2A)
PEG  A 202 ( 4.7A)
None
None
 1.14A 6b0lB-3kkgA:
undetectable		 6b0lB-3kkgA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 LEU A  54
ASP A  30
LEU A  29
THR A  86
GLY A 111
 None
SAH  A 216 ( 4.7A)
None
SAH  A 216 (-4.4A)
None
 0.84A 6b0lB-3mq2A:
undetectable		 6b0lB-3mq2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii) 		PF06778
(Chlor_dismutase) 		5 ASP A 230
LEU A  95
SER A  55
GLY A  42
LEU A  43
 GOL  A 248 (-3.7A)
None
None
None
None
 1.15A 6b0lB-3nn2A:
undetectable		 6b0lB-3nn2A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 VAL A 347
ASP A 346
LEU A 351
GLY A 338
LEU A 341
 None
 1.17A 6b0lB-3qfsA:
4.5		 6b0lB-3qfsA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ASP A 279
LEU A 394
LEU A 352
GLY A 274
LEU A 273
 PO4  A   4 (-3.2A)
None
None
None
None
 1.09A 6b0lB-3qmlA:
undetectable		 6b0lB-3qmlA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis) 		PF00696
(AA_kinase) 		5 ASP A  26
LEU A 241
ASP A 236
LEU A 169
LEU A  90
 None
 0.88A 6b0lB-3qvfA:
undetectable		 6b0lB-3qvfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 VAL A  70
LEU A 296
LEU A  16
THR A 292
LEU A 285
 None
 1.06A 6b0lB-3snhA:
undetectable		 6b0lB-3snhA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 183
LEU A 119
SER A 140
THR A 179
LEU A 144
 None
 1.06A 6b0lB-3ttgA:
undetectable		 6b0lB-3ttgA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		5 ASP A 284
HIS A 124
LEU A 123
ARG A 100
GLY A 139
 GOL  A 720 (-3.0A)
None
None
GOL  A 710 (-4.0A)
GOL  A 710 ( 4.1A)
 1.03A 6b0lB-3ucqA:
undetectable		 6b0lB-3ucqA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 VAL A  75
ASP A  39
LEU A 125
ARG A 139
GLY A 180
 None
None
None
SO4  A 523 (-3.8A)
SO4  A   7 (-3.2A)
 1.06A 6b0lB-3v5rA:
undetectable		 6b0lB-3v5rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		5 VAL A 145
LEU A 201
ASP A   9
LEU A 251
SER A 179
 None
 0.99A 6b0lB-3wgcA:
undetectable		 6b0lB-3wgcA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		5 ASP A 291
SER A 318
THR A 281
GLY A 326
LEU A 278
 None
 1.08A 6b0lB-3wufA:
undetectable		 6b0lB-3wufA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 VAL A 455
LEU A 513
LEU A 479
THR A 512
GLY A 464
 None
 1.15A 6b0lB-4a1oA:
undetectable		 6b0lB-4a1oA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP B  89
ASP B 270
HIS B 111
SER B  86
GLY B 429
 None
None
None
IMP  B1527 (-2.6A)
IMP  B1527 ( 3.3A)
 1.15A 6b0lB-4af0B:
undetectable		 6b0lB-4af0B:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 VAL C 852
ASP C 853
LEU C 803
PRO C 871
LEU C 856
 None
 1.11A 6b0lB-4aq1C:
undetectable		 6b0lB-4aq1C:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 5 LEU A 254
LEU A 124
SER A 129
ARG A  83
GLY A  58
 None
CL  A1277 (-4.4A)
None
None
None
 1.00A 6b0lB-4ateA:
undetectable		 6b0lB-4ateA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a POLY(A) RIBONUCLEASE
POP2

(Saccharomyces
cerevisiae) 		PF04857
(CAF1) 		5 VAL B  19
ASP B  18
LEU B 170
LEU B 145
GLY B 248
 None
 1.02A 6b0lB-4b8aB:
undetectable		 6b0lB-4b8aB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		5 LEU B 252
HIS B 402
LEU B 405
GLY B 387
LEU B 386
 None
 1.06A 6b0lB-4ci6B:
undetectable		 6b0lB-4ci6B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 VAL A 161
LEU A 373
LEU A 149
THR A 375
GLY A 240
 None
 1.17A 6b0lB-4eyoA:
undetectable		 6b0lB-4eyoA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 VAL A  84
LEU A  36
LEU A  97
SER A 107
LEU A 270
 None
 1.01A 6b0lB-4hxqA:
undetectable		 6b0lB-4hxqA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 VAL A 475
LEU A 403
LEU A 449
THR A 401
GLY A 437
 None
 1.12A 6b0lB-4kh3A:
undetectable		 6b0lB-4kh3A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 ASP A 154
THR A 105
PRO A  51
GLY A  78
LEU A  52
 None
 1.18A 6b0lB-4kmaA:
undetectable		 6b0lB-4kmaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		5 LEU A 116
HIS A 192
LEU A 195
GLY A 185
LEU A  71
 None
 1.18A 6b0lB-4l0cA:
undetectable		 6b0lB-4l0cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 466
LEU A 460
PRO A 505
GLY A 507
LEU A 508
 None
 1.18A 6b0lB-4m7eA:
undetectable		 6b0lB-4m7eA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 VAL A 121
ASP A 118
LEU A 129
SER A 100
GLY A 153
 VAL  A 121 ( 0.6A)
ASP  A 118 ( 0.6A)
LEU  A 129 ( 0.6A)
SER  A 100 ( 0.0A)
GLY  A 153 ( 0.0A)
 1.14A 6b0lB-4mwtA:
undetectable		 6b0lB-4mwtA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A 613
LEU A 674
SER A 696
ARG A 702
LEU A 700
 None
 1.15A 6b0lB-4n5uA:
undetectable		 6b0lB-4n5uA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		5 LEU A  37
ASP A 124
LEU A 126
THR A 102
ARG A  34
 None
 1.12A 6b0lB-4yhbA:
undetectable		 6b0lB-4yhbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme)
PF01052
(FliMN_C)
PF16973
(FliN_N) 		5 LEU B  62
LEU B  21
ARG B  51
GLY B  67
LEU A  19
 None
 1.17A 6b0lB-4yxcB:
undetectable		 6b0lB-4yxcB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		5 VAL A 107
LEU A 141
LEU A  52
GLY A  92
LEU A  91
 None
 1.01A 6b0lB-5b3kA:
undetectable		 6b0lB-5b3kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU B 205
LEU B 168
PRO B  97
GLY B  99
LEU B 100
 None
 1.01A 6b0lB-5c24B:
undetectable		 6b0lB-5c24B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 VAL A  70
LEU A 296
LEU A  16
THR A 292
LEU A 285
 None
 1.14A 6b0lB-5d3qA:
undetectable		 6b0lB-5d3qA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 VAL A  79
ASP A  33
LEU A 109
PRO A  49
LEU A  51
 None
 1.13A 6b0lB-5d8wA:
undetectable		 6b0lB-5d8wA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		5 LEU A 432
HIS A 442
ARG A 447
GLY A  65
LEU A  66
 None
 0.99A 6b0lB-5gviA:
undetectable		 6b0lB-5gviA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A  89
LEU A  44
SER A  95
THR A 212
GLY A  18
 None
 1.06A 6b0lB-5i68A:
undetectable		 6b0lB-5i68A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 383
LEU A 213
LEU A 255
ARG A 215
GLY A 388
 None
 1.15A 6b0lB-5ilbA:
undetectable		 6b0lB-5ilbA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 VAL A 256
LEU A 128
LEU A 216
GLY A 175
LEU A 200
 None
 1.18A 6b0lB-5iysA:
undetectable		 6b0lB-5iysA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 VAL C   9
LEU C 180
HIS C 203
LEU C 202
GLY C 236
 None
None
MN  C2002 (-3.5A)
None
None
 1.19A 6b0lB-5ks8C:
undetectable		 6b0lB-5ks8C:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 5 LEU A 397
THR A 399
ARG A 401
GLY A 323
LEU A 403
 None
 1.10A 6b0lB-5mc5A:
undetectable		 6b0lB-5mc5A:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 7 ASP A  26
LEU A 215
ASP A 224
HIS A 227
LEU A 228
PRO A 357
LEU A 360
 None
 0.92A 6b0lB-5mjsA:
57.1		 6b0lB-5mjsA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
ASP B  26
LEU B 217
ASP B 226
HIS B 229
LEU B 230
SER B 236
PRO B 360
 None
 1.07A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
ASP B  26
LEU B 217
ASP B 226
HIS B 229
LEU B 230
SER B 236
THR B 276
 None
 1.12A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
ASP B  26
LEU B 217
ASP B 226
LEU B 230
SER B 236
PRO B 360
LEU B 371
 None
 1.09A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
ASP B  26
LEU B 217
ASP B 226
LEU B 230
SER B 236
THR B 276
LEU B 371
 None
 1.19A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
ASP B 226
HIS B 229
LEU B 230
SER B 236
PRO B 360
GLY B 370
 None
 0.82A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
ASP B 226
HIS B 229
LEU B 230
SER B 236
THR B 276
GLY B 370
 None
 0.94A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
ASP B 226
LEU B 230
SER B 236
PRO B 360
GLY B 370
LEU B 371
 None
 0.92A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
ASP B 226
LEU B 230
SER B 236
THR B 276
GLY B 370
LEU B 371
 None
 1.05A 6b0lB-5n5nB:
59.5		 6b0lB-5n5nB:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU A 346
LEU A 230
PRO A 397
GLY A 401
LEU A 396
 None
 1.11A 6b0lB-5nd1A:
undetectable		 6b0lB-5nd1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 VAL A 465
LEU A 346
LEU A 230
GLY A 401
LEU A 396
 None
 1.18A 6b0lB-5nd1A:
undetectable		 6b0lB-5nd1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4u FLAGELLIN

(Pyrococcus
furiosus) 		PF01917
(Arch_flagellin) 		5 VAL A  71
LEU A 105
LEU A  96
THR A 132
GLY A 168
 None
 1.17A 6b0lB-5o4uA:
undetectable		 6b0lB-5o4uA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 VAL B 323
LEU B 259
HIS B 327
LEU B 330
SER B 298
 None
 1.15A 6b0lB-5tchB:
undetectable		 6b0lB-5tchB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 VAL A 175
ASP A 176
LEU A 292
THR A 319
GLY A 302
 None
K  A 402 (-3.4A)
None
None
None
 1.15A 6b0lB-5vi6A:
undetectable		 6b0lB-5vi6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		9 VAL B  23
ASP B  26
LEU B 215
ASP B 224
LEU B 228
THR B 274
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
None
None
TA1  B 502 (-4.7A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 0.86A 6b0lB-5w3jB:
58.6		 6b0lB-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
LEU B 215
SER B 234
THR B 274
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 0.93A 6b0lB-5w3jB:
58.6		 6b0lB-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.07A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.82A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 LEU A1056
LEU A1110
THR A1055
PRO A1073
GLY A1051
 None
 1.11A 6b0lB-5x7sA:
undetectable		 6b0lB-5x7sA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xts MACROPHAGE MANNOSE
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.82A 6b0lB-5xtsA:
undetectable		 6b0lB-5xtsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtw MACROPHAGE MANNOSE
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.84A 6b0lB-5xtwA:
undetectable		 6b0lB-5xtwA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 5 ASP A 642
LEU A 911
PRO A 741
GLY A 647
LEU A 650
 None
 1.17A 6b0lB-5zq6A:
undetectable		 6b0lB-5zq6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ans UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF06742
(DUF1214) 		5 LEU A 187
LEU A 113
THR A 104
ARG A 102
GLY A 158
 None
 0.99A 6b0lB-6ansA:
undetectable		 6b0lB-6ansA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 5 ASP A1363
LEU A1360
THR A1369
GLY A1478
LEU A1481
 None
 1.18A 6b0lB-6bq1A:
undetectable		 6b0lB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 HIS A 512
LEU A 511
PRO A 460
GLY A 458
LEU A 455
 None
 1.14A 6b0lB-6byxA:
undetectable		 6b0lB-6byxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 LEU A 306
ASP A 321
LEU A 308
PRO A 401
LEU A 400
 None
 1.17A 6b0lB-6d47A:
undetectable		 6b0lB-6d47A:
23.16