SIMILAR PATTERNS OF AMINO ACIDS FOR 6B0I_B_TA1B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 LEU A 291
ASP A 331
LEU A 330
ALA A 328
LEU A 233
 None
 1.09A 6b0iB-1c7tA:
undetectable		 6b0iB-1c7tA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 ASP A 185
ASP A 278
ALA A 121
SER A 117
GLY A 138
 None
 1.06A 6b0iB-1dlmA:
undetectable		 6b0iB-1dlmA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 LEU A  88
LEU A 123
ALA A 127
GLY A 106
LEU A 107
 None
 1.00A 6b0iB-1gq7A:
undetectable		 6b0iB-1gq7A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU F 324
LEU F 344
ALA F 475
ARG F 329
GLY F 458
 None
 1.04A 6b0iB-1htjF:
undetectable		 6b0iB-1htjF:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 VAL A 485
ALA A 524
SER A 528
GLY A 543
LEU A 546
 None
 1.01A 6b0iB-1j1wA:
2.1		 6b0iB-1j1wA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mek PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin) 		5 LEU A  10
HIS A  24
LEU A  27
GLY A  57
LEU A  53
 None
 1.05A 6b0iB-1mekA:
undetectable		 6b0iB-1mekA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 VAL A 683
LEU A 622
ALA A 642
PRO A 671
GLY A 661
 None
 0.93A 6b0iB-1n11A:
undetectable		 6b0iB-1n11A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmy SIMILAR TO
THYMIDYLATE KINASE
(DTMP KINASE)

(Homo sapiens) 		PF02223
(Thymidylate_kin) 		5 VAL A  95
ASP A  96
ASP A 121
LEU A 210
GLY A  13
 None
MG  A 401 ( 4.1A)
None
None
None
 1.05A 6b0iB-1nmyA:
undetectable		 6b0iB-1nmyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38) 		5 LEU A 297
ALA A 300
PRO A 264
GLY A 266
LEU A 267
 None
 1.03A 6b0iB-1o7dA:
undetectable		 6b0iB-1o7dA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 LEU A 193
ALA A 190
PRO A 172
GLY A 137
LEU A 138
 None
None
None
MET  A5001 ( 3.8A)
None
 1.04A 6b0iB-1p1mA:
undetectable		 6b0iB-1p1mA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		5 VAL A  84
LEU A  36
LEU A  97
SER A 107
LEU A 270
 None
 1.08A 6b0iB-1p8rA:
2.9		 6b0iB-1p8rA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 ASP A 122
LEU A 132
ALA A 128
PRO A 120
LEU A 163
 None
 1.08A 6b0iB-1s2jA:
undetectable		 6b0iB-1s2jA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 ASP A 122
LEU A 132
ALA A 128
PRO A 120
LEU A 163
 None
 1.07A 6b0iB-1sxrA:
undetectable		 6b0iB-1sxrA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 VAL A  81
LEU A  17
LEU A  97
GLY A   8
LEU A  38
 None
 0.83A 6b0iB-1tviA:
undetectable		 6b0iB-1tviA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 VAL A 481
ALA A 520
SER A 524
GLY A 539
LEU A 542
 None
 1.03A 6b0iB-2b0tA:
undetectable		 6b0iB-2b0tA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A 140
LEU A 173
ALA A 132
GLY A   7
LEU A  78
 None
 1.04A 6b0iB-2ew2A:
undetectable		 6b0iB-2ew2A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 VAL A 114
LEU A 190
LEU A 143
GLY A 121
LEU A 122
 None
 1.02A 6b0iB-2g7gA:
undetectable		 6b0iB-2g7gA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 ASP A  44
LEU A 213
ALA A  73
PRO A 195
LEU A 196
 None
 1.10A 6b0iB-2goyA:
2.2		 6b0iB-2goyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 124
LEU A  66
LEU A 151
GLY A  47
LEU A 170
 None
 1.08A 6b0iB-2hivA:
undetectable		 6b0iB-2hivA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 VAL A 135
LEU A 158
ALA A 143
GLY A  57
LEU A 116
 None
 1.07A 6b0iB-2jg5A:
3.4		 6b0iB-2jg5A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 VAL A  13
LEU A 291
LEU A 247
ALA A 250
SER A 253
 None
 1.00A 6b0iB-2o0xA:
undetectable		 6b0iB-2o0xA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		5 LEU A  28
LEU A 245
ALA A 244
GLY A 230
LEU A 229
 None
 1.03A 6b0iB-2pcqA:
undetectable		 6b0iB-2pcqA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 ASP A  50
ALA A  99
SER A 103
PRO A  63
LEU A   4
 None
 1.10A 6b0iB-2pk3A:
6.6		 6b0iB-2pk3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 LEU A  88
ASP A 216
LEU A 220
ALA A 224
LEU A   3
 None
 1.03A 6b0iB-2q8nA:
3.2		 6b0iB-2q8nA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 ASP A 364
LEU A 446
SER A 124
PRO A  92
GLY A  93
 None
 1.02A 6b0iB-2qneA:
undetectable		 6b0iB-2qneA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 LEU A  47
ASP A  80
LEU A  84
ALA A  87
SER A  90
 None
 1.05A 6b0iB-2qpmA:
undetectable		 6b0iB-2qpmA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		5 ASP A 361
LEU A 295
SER A 368
GLY A 358
LEU A 357
 None
HBI  A 500 (-4.2A)
HBI  A 500 ( 4.1A)
None
None
 1.04A 6b0iB-2tohA:
undetectable		 6b0iB-2tohA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A  54
LEU A  63
ALA A  67
GLY A 151
LEU A 152
 None
 0.93A 6b0iB-2vdaA:
2.0		 6b0iB-2vdaA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		6 VAL A 299
LEU A 192
LEU A 159
ALA A 162
SER A 165
LEU A 263
 None
 1.47A 6b0iB-2vwqA:
undetectable		 6b0iB-2vwqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 LEU B 226
ASP B 198
LEU B 200
ALA B 237
GLY B 233
 None
 1.10A 6b0iB-2vzkB:
undetectable		 6b0iB-2vzkB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		5 LEU A 184
ASP A 305
ALA A  34
PRO A  68
LEU A  67
 None
 1.10A 6b0iB-2wbpA:
undetectable		 6b0iB-2wbpA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		5 VAL A  77
ASP A  76
ASP A 155
ALA A  82
GLY A  14
 None
None
None
None
GOL  A1196 (-4.2A)
 1.09A 6b0iB-2we9A:
undetectable		 6b0iB-2we9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 LEU A 359
LEU A 335
ALA A 380
GLY A 308
LEU A 307
 None
 1.07A 6b0iB-2wk8A:
undetectable		 6b0iB-2wk8A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 LEU A 171
LEU A  54
ALA A  51
SER A  79
GLY A   8
 None
None
None
None
C  A1261 (-3.0A)
 0.94A 6b0iB-2x63A:
undetectable		 6b0iB-2x63A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 308
LEU A 322
SER A 203
GLY A 166
LEU A 165
 None
 0.84A 6b0iB-2ycbA:
undetectable		 6b0iB-2ycbA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ASP A 247
LEU A 208
LEU A 195
ALA A 222
PRO A 242
 None
 1.06A 6b0iB-2z65A:
undetectable		 6b0iB-2z65A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  83
ALA A  95
PRO A 122
GLY A 100
LEU A 123
 None
 1.09A 6b0iB-2z81A:
undetectable		 6b0iB-2z81A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 VAL A 732
LEU A 777
LEU A 851
ALA A 854
SER A 857
 None
 0.92A 6b0iB-3a6pA:
undetectable		 6b0iB-3a6pA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ASP A 534
ASP A 426
LEU A 430
ALA A 433
LEU A 581
 None
FAD  A 616 (-3.8A)
None
None
None
 1.02A 6b0iB-3b96A:
undetectable		 6b0iB-3b96A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		5 LEU A 195
LEU A 109
ALA A 108
GLY A 167
LEU A 168
 None
 1.10A 6b0iB-3c7jA:
undetectable		 6b0iB-3c7jA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 LEU A  50
LEU A  97
ALA A 128
GLY A 165
LEU A 166
 None
NHE  A 195 (-3.8A)
NHE  A 195 ( 4.5A)
None
None
 1.10A 6b0iB-3cggA:
undetectable		 6b0iB-3cggA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		5 VAL A 126
LEU A 302
LEU A 284
ALA A 123
GLY A 309
 None
 1.03A 6b0iB-3fgwA:
undetectable		 6b0iB-3fgwA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 VAL A 173
ASP A 174
LEU A 388
LEU A 113
GLY A 202
 None
 0.92A 6b0iB-3g0iA:
undetectable		 6b0iB-3g0iA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		5 VAL A  25
ASP A  24
LEU A 175
LEU A 150
GLY A 238
 None
 1.05A 6b0iB-3g10A:
undetectable		 6b0iB-3g10A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		5 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.10A 6b0iB-3gdbA:
undetectable		 6b0iB-3gdbA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		6 ASP A 336
ASP A 247
LEU A 246
PRO A 121
GLY A 123
LEU A 122
 None
 1.35A 6b0iB-3htxA:
undetectable		 6b0iB-3htxA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 359
ASP A 358
LEU A  40
ARG A 116
GLY A 354
 None
 0.99A 6b0iB-3i6tA:
undetectable		 6b0iB-3i6tA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ASP A 249
LEU A 425
LEU A 235
SER A 260
GLY A 224
 None
 1.10A 6b0iB-3khkA:
undetectable		 6b0iB-3khkA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 VAL A 264
ASP A 263
LEU A 251
ALA A 254
GLY A 314
 None
 1.08A 6b0iB-3l0oA:
2.7		 6b0iB-3l0oA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ASP A 151
LEU A 154
ARG A 144
GLY A  89
LEU A 111
 None
None
TRS  A 383 ( 3.4A)
EDO  A 387 (-3.7A)
None
 0.90A 6b0iB-3llxA:
undetectable		 6b0iB-3llxA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 411
LEU A 364
ALA A 367
SER A 371
GLY A 333
 None
 0.92A 6b0iB-3lscA:
undetectable		 6b0iB-3lscA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 ASP A 279
LEU A 394
LEU A 352
GLY A 274
LEU A 273
 PO4  A   4 (-3.2A)
None
None
None
None
 1.04A 6b0iB-3qmlA:
undetectable		 6b0iB-3qmlA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 VAL A   4
LEU A 246
LEU A 276
ARG A 242
GLY A   9
 None
None
None
FAD  A 501 (-4.2A)
FAD  A 501 (-4.5A)
 1.02A 6b0iB-3r9uA:
undetectable		 6b0iB-3r9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 VAL A 105
ASP A 104
ALA A  85
SER A  80
GLY A 101
 None
 1.07A 6b0iB-3syjA:
undetectable		 6b0iB-3syjA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 VAL A  75
ASP A  39
LEU A 125
ARG A 139
GLY A 180
 None
None
None
SO4  A 523 (-3.8A)
SO4  A   7 (-3.2A)
 1.06A 6b0iB-3v5rA:
undetectable		 6b0iB-3v5rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		5 VAL A 258
ASP A 256
LEU A  13
GLY A 233
LEU A 234
 None
 1.00A 6b0iB-3w9uA:
3.5		 6b0iB-3w9uA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A 551
ASP A 550
ASP A  82
GLY A 485
LEU A 482
 None
 1.08A 6b0iB-4acqA:
undetectable		 6b0iB-4acqA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 VAL C 852
ASP C 853
LEU C 803
PRO C 871
LEU C 856
 None
 1.07A 6b0iB-4aq1C:
undetectable		 6b0iB-4aq1C:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 5 LEU A 254
LEU A 124
SER A 129
ARG A  83
GLY A  58
 None
CL  A1277 (-4.4A)
None
None
None
 1.01A 6b0iB-4ateA:
undetectable		 6b0iB-4ateA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 VAL A  49
LEU A 194
ASP A  23
LEU A  19
ALA A  16
 None
 0.94A 6b0iB-4b45A:
29.8		 6b0iB-4b45A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a POLY(A) RIBONUCLEASE
POP2

(Saccharomyces
cerevisiae) 		PF04857
(CAF1) 		5 VAL B  19
ASP B  18
LEU B 170
LEU B 145
GLY B 248
 None
 1.07A 6b0iB-4b8aB:
undetectable		 6b0iB-4b8aB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 VAL A 293
ASP A 292
ASP A 268
GLY A 287
LEU A 279
 None
 1.08A 6b0iB-4bpsA:
undetectable		 6b0iB-4bpsA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni INTERLEUKIN-6

(Homo sapiens) 		PF00489
(IL6) 		5 ASP C  71
LEU C  33
LEU C 178
GLY C  90
LEU C  91
 None
 0.93A 6b0iB-4cniC:
undetectable		 6b0iB-4cniC:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 VAL A  61
ASP A  53
HIS A  57
ARG A 106
GLY A 111
 None
 0.98A 6b0iB-4e0tA:
undetectable		 6b0iB-4e0tA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 VAL A 132
ASP A 131
ALA A  71
GLY A 179
LEU A 178
 None
 0.99A 6b0iB-4fp4A:
undetectable		 6b0iB-4fp4A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh5 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 VAL A 104
LEU A  47
ASP A  54
ALA A 121
LEU A  98
 None
 1.02A 6b0iB-4hh5A:
undetectable		 6b0iB-4hh5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 VAL A  84
LEU A  36
LEU A  97
SER A 107
LEU A 270
 None
 1.06A 6b0iB-4hxqA:
4.4		 6b0iB-4hxqA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		5 VAL D 733
LEU D 675
ALA D 743
ARG D 693
LEU D 715
 None
 1.06A 6b0iB-4j3oD:
undetectable		 6b0iB-4j3oD:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 VAL B  23
ALA B 100
SER B 104
GLY B  77
LEU B 118
 None
 1.02A 6b0iB-4k7gB:
undetectable		 6b0iB-4k7gB:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m98 PILIN GLYCOSYLATION
PROTEIN

(Neisseria
gonorrhoeae) 		PF00132
(Hexapep) 		6 ASP A 231
LEU A 230
ALA A 203
PRO A 286
GLY A 304
LEU A 285
 None
 1.30A 6b0iB-4m98A:
undetectable		 6b0iB-4m98A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A 613
LEU A 674
SER A 696
ARG A 702
LEU A 700
 None
 1.04A 6b0iB-4n5uA:
undetectable		 6b0iB-4n5uA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 LEU A 258
LEU A 239
ALA A 244
GLY A 176
LEU A 179
 None
 1.03A 6b0iB-4rk1A:
3.6		 6b0iB-4rk1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		5 VAL A  92
LEU A 147
HIS A 238
LEU A 166
LEU A 183
 None
 1.01A 6b0iB-4rpcA:
undetectable		 6b0iB-4rpcA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 VAL A 166
ASP A 155
LEU A 152
PRO A 169
LEU A 229
 None
 1.07A 6b0iB-4s2uA:
6.0		 6b0iB-4s2uA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		5 LEU A 239
LEU A 275
ALA A 278
SER A 281
GLY A 141
 None
 0.99A 6b0iB-4wd2A:
undetectable		 6b0iB-4wd2A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		5 ASP A 149
LEU A 137
ALA A 144
ARG A  50
GLY A 154
 None
 1.06A 6b0iB-4xjnA:
undetectable		 6b0iB-4xjnA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		5 VAL A 162
LEU A 106
ALA A 110
PRO A 206
LEU A 236
 None
 0.95A 6b0iB-4yamA:
undetectable		 6b0iB-4yamA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		5 VAL A 107
LEU A 141
LEU A  52
GLY A  92
LEU A  91
 None
 0.86A 6b0iB-5b3kA:
undetectable		 6b0iB-5b3kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03170
(BcsB)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		5 LEU A  56
ALA A  72
SER A  74
GLY B 699
LEU B 698
 None
 1.00A 6b0iB-5ej1A:
undetectable		 6b0iB-5ej1A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 VAL A 352
LEU A 301
ASP A 338
GLY A 478
LEU A 479
 None
 1.08A 6b0iB-5jcfA:
undetectable		 6b0iB-5jcfA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		5 LEU A  54
LEU A  63
ALA A  67
GLY A 151
LEU A 152
 None
 0.92A 6b0iB-5k9tA:
undetectable		 6b0iB-5k9tA:
9.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 8 ASP A  26
LEU A 215
ASP A 224
HIS A 227
LEU A 228
ALA A 231
PRO A 357
LEU A 360
 None
 0.98A 6b0iB-5mjsA:
57.7		 6b0iB-5mjsA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
ASP B  26
LEU B 217
ASP B 226
HIS B 229
LEU B 230
ALA B 233
SER B 236
LEU B 371
 None
 0.97A 6b0iB-5n5nB:
59.9		 6b0iB-5n5nB:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
LEU B 217
ASP B 226
HIS B 229
LEU B 230
ALA B 233
SER B 236
PRO B 360
GLY B 370
LEU B 371
 None
 0.73A 6b0iB-5n5nB:
59.9		 6b0iB-5n5nB:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 5 VAL A 218
LEU A 327
LEU A 208
SER A 245
GLY A 225
 None
8Q2  A 501 (-4.9A)
None
None
None
 1.04A 6b0iB-5n81A:
undetectable		 6b0iB-5n81A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU A 346
LEU A 230
PRO A 397
GLY A 401
LEU A 396
 None
 1.01A 6b0iB-5nd1A:
undetectable		 6b0iB-5nd1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 VAL A 215
LEU A 179
ALA A 211
GLY A 252
LEU A 251
 None
 0.97A 6b0iB-5nuxA:
4.3		 6b0iB-5nuxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		5 ASP A 307
LEU A 369
ALA A 368
GLY A  26
LEU A  50
 None
 1.08A 6b0iB-5tf2A:
undetectable		 6b0iB-5tf2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 VAL A 287
LEU A 108
LEU A 306
ALA A 309
GLY A  11
 None
None
None
None
FAD  A 402 (-3.2A)
 1.06A 6b0iB-5tukA:
undetectable		 6b0iB-5tukA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8

(Homo sapiens) 		PF00004
(AAA) 		5 ASP C 394
LEU C 338
LEU C 344
ALA C 348
GLY C 361
 None
 0.99A 6b0iB-5vhjC:
undetectable		 6b0iB-5vhjC:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 5 LEU A  20
HIS A  61
ALA A  65
GLY A  26
LEU A  27
 None
 0.99A 6b0iB-5vtoA:
3.8		 6b0iB-5vtoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
LEU B 215
ASP B 224
HIS B 227
LEU B 228
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
None
TA1  B 502 (-4.3A)
None
 1.23A 6b0iB-5w3jB:
59.6		 6b0iB-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		8 VAL B  23
ASP B  26
LEU B 215
ASP B 224
LEU B 228
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
None
None
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 0.73A 6b0iB-5w3jB:
59.6		 6b0iB-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
LEU B 215
SER B 234
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 0.72A 6b0iB-5w3jB:
59.6		 6b0iB-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.06A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.92A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xts MACROPHAGE MANNOSE
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.86A 6b0iB-5xtsA:
undetectable		 6b0iB-5xtsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtw MACROPHAGE MANNOSE
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.90A 6b0iB-5xtwA:
undetectable		 6b0iB-5xtwA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 462
LEU 2 991
ASP 2 988
ALA 2 459
GLY 21025
 None
 1.04A 6b0iB-5zvs2:
undetectable		 6b0iB-5zvs2:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 5 ASP A 311
LEU A 359
ALA A 347
GLY A 271
LEU A 250
 None
 1.05A 6b0iB-6ehnA:
undetectable		 6b0iB-6ehnA:
18.09