SIMILAR PATTERNS OF AMINO ACIDS FOR 6B0C_D_TA1D502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 VAL A 300
GLU A 301
LEU A 157
LEU A 262
THR A 263
 None
 0.82A 6b0cD-1bqbA:
undetectable		 6b0cD-1bqbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buy PROTEIN
(ERYTHROPOIETIN)

(Homo sapiens) 		PF00758
(EPO_TPO) 		5 LEU A 112
ALA A 118
SER A 120
GLY A  66
LEU A  67
 None
 0.77A 6b0cD-1buyA:
undetectable		 6b0cD-1buyA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		6 VAL A 200
GLU A 199
HIS A 206
THR A 252
GLY A 283
LEU A 284
 None
 1.38A 6b0cD-1epxA:
undetectable		 6b0cD-1epxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 VAL A 330
LEU A 487
LEU A 451
LEU A 492
GLY A 335
 None
 0.93A 6b0cD-1f0iA:
undetectable		 6b0cD-1f0iA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU A  55
SER A 123
LEU A  26
THR A  25
GLY A  46
 None
None
None
None
FES  A 602 ( 3.1A)
 0.98A 6b0cD-1fiqA:
undetectable		 6b0cD-1fiqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  55
SER A 123
LEU A  26
THR A  25
GLY A  46
 None
None
None
None
FES  A3002 ( 3.1A)
 1.01A 6b0cD-1n5xA:
undetectable		 6b0cD-1n5xA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 330
LEU A 404
LEU A 372
THR A 373
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
 0.90A 6b0cD-1n5xA:
undetectable		 6b0cD-1n5xA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 VAL A 107
LEU A 185
LEU A  52
THR A  53
GLY A  71
 None
 0.87A 6b0cD-1nqzA:
undetectable		 6b0cD-1nqzA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		6 VAL A 172
LEU A  75
LEU A  16
LEU A  73
GLY A 145
LEU A 125
 None
 1.33A 6b0cD-1pgjA:
3.4		 6b0cD-1pgjA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 714
LEU A 698
LEU A 739
THR A 738
GLY A 683
 None
 1.00A 6b0cD-1rw9A:
undetectable		 6b0cD-1rw9A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		6 VAL A 112
GLU A 111
LEU A 129
ALA A 132
LEU A 171
THR A 168
 None
 1.40A 6b0cD-1s4eA:
undetectable		 6b0cD-1s4eA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uww ENDOGLUCANASE

(Bacillus akibai) 		PF03424
(CBM_17_28) 		5 LEU A  53
LEU A  74
LEU A  42
THR A  43
GLY A 179
 None
 0.96A 6b0cD-1uwwA:
undetectable		 6b0cD-1uwwA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		6 GLU A 158
LEU A  16
ALA A 191
LEU A  20
GLY A 176
LEU A 173
 None
 1.26A 6b0cD-1v5xA:
undetectable		 6b0cD-1v5xA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 SER A 270
LEU A 186
THR A 183
GLY A  61
LEU A  59
 None
 0.93A 6b0cD-1w27A:
undetectable		 6b0cD-1w27A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 LEU A 256
ALA A 239
LEU A 166
THR A 165
GLY A 174
 None
NAD  A 600 (-3.6A)
None
None
NAD  A 600 (-4.0A)
 0.94A 6b0cD-1x87A:
undetectable		 6b0cD-1x87A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 LEU A 256
LEU A 243
LEU A 166
THR A 165
GLY A 174
 None
None
None
None
NAD  A 600 (-4.0A)
 0.93A 6b0cD-1x87A:
undetectable		 6b0cD-1x87A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpv HYPOTHETICAL PROTEIN
XCC2852

(Xanthomonas
campestris) 		PF05768
(DUF836) 		5 LEU A  51
LEU A  72
ALA A  75
LEU A   3
THR A   4
 None
 0.91A 6b0cD-1xpvA:
undetectable		 6b0cD-1xpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 LEU A  96
LEU A  91
LEU A 103
GLY A 131
LEU A 132
 None
 0.95A 6b0cD-1xr4A:
3.3		 6b0cD-1xr4A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS28

(Saccharomyces
cerevisiae) 		PF03997
(VPS28) 		5 LEU A 181
LEU A 230
ALA A 233
SER A 236
LEU A 184
 None
 0.90A 6b0cD-2g3kA:
undetectable		 6b0cD-2g3kA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 124
LEU A  66
LEU A 151
GLY A  47
LEU A 170
 None
 0.97A 6b0cD-2hivA:
undetectable		 6b0cD-2hivA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 VAL A  47
LEU A 111
ALA A 114
LEU A 170
GLY A  20
 None
 0.98A 6b0cD-2l6gA:
undetectable		 6b0cD-2l6gA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		6 LEU A 253
LEU A 278
ALA A 277
LEU A 216
THR A 217
GLY A 258
 None
 1.18A 6b0cD-2o5vA:
undetectable		 6b0cD-2o5vA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 LEU A 719
LEU A 483
SER A 659
LEU A 712
GLY A 539
 None
 0.83A 6b0cD-2odpA:
4.0		 6b0cD-2odpA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 VAL A   6
LEU A 152
LEU A 122
ALA A 120
LEU A 164
 None
 0.98A 6b0cD-2p6pA:
5.8		 6b0cD-2p6pA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbj PROSTAGLANDIN E
SYNTHASE 2

(Macaca
fascicularis) 		PF13417
(GST_N_3) 		5 LEU A 151
LEU A 172
LEU A 102
THR A 103
GLY A 156
 None
 1.00A 6b0cD-2pbjA:
undetectable		 6b0cD-2pbjA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 VAL A  72
LEU A  76
ALA A  74
LEU A 289
GLY A  28
 None
 1.00A 6b0cD-2pn1A:
undetectable		 6b0cD-2pn1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		6 LEU A  10
HIS A  36
ALA A 110
SER A 112
LEU A 154
LEU A  85
 None
NAP  A1300 (-4.7A)
NAP  A1300 (-3.7A)
NAP  A1300 (-4.1A)
None
None
 1.48A 6b0cD-2qhxA:
7.7		 6b0cD-2qhxA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 GLU A 256
LEU A  36
LEU A 264
ALA A 260
LEU A  26
 None
 0.92A 6b0cD-2rkbA:
undetectable		 6b0cD-2rkbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		5 ALA A 377
SER A 358
LEU A 435
GLY A  20
LEU A  23
 None
 1.00A 6b0cD-2vc2A:
undetectable		 6b0cD-2vc2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		5 ALA A 305
SER A 308
LEU A  53
THR A  54
GLY A  17
 FAD  A 400 ( 3.8A)
None
FAD  A 400 (-4.0A)
None
FAD  A 400 (-3.3A)
 0.92A 6b0cD-2whdA:
undetectable		 6b0cD-2whdA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		5 LEU A 373
LEU A  50
LEU A 309
GLY A 321
LEU A 320
 None
 0.89A 6b0cD-2x8uA:
3.0		 6b0cD-2x8uA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 VAL D 369
GLU D 375
SER D 378
GLY D 327
LEU D 349
 None
 1.00A 6b0cD-2ynmD:
undetectable		 6b0cD-2ynmD:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		5 GLU A 238
LEU A  36
LEU A  24
LEU A   9
GLY A 219
 None
 1.00A 6b0cD-2yvtA:
undetectable		 6b0cD-2yvtA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 LEU A 369
LEU A 200
LEU A 228
THR A 224
LEU A 357
 None
 1.00A 6b0cD-2ywbA:
2.2		 6b0cD-2ywbA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 253
LEU A 232
ALA A 287
LEU A 213
GLY A 226
 None
 0.97A 6b0cD-2yxzA:
undetectable		 6b0cD-2yxzA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 VAL A  94
LEU A  73
LEU A  58
LEU A  84
GLY A 140
 None
 0.75A 6b0cD-2z00A:
undetectable		 6b0cD-2z00A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
LEU B 372
THR B 373
GLY B 296
 None
FAD  B 606 (-4.6A)
None
None
None
 0.91A 6b0cD-3b9jB:
undetectable		 6b0cD-3b9jB:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs6 INNER MEMBRANE
PROTEIN OXAA

(Escherichia
coli) 		PF14849
(YidC_periplas) 		5 LEU A 167
SER A 305
LEU A  70
THR A  71
GLY A  76
 None
 0.99A 6b0cD-3bs6A:
undetectable		 6b0cD-3bs6A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Brucella
melitensis) 		PF01613
(Flavin_Reduct) 		5 LEU A  46
HIS A 142
LEU A  63
LEU A  44
THR A  45
 FMN  A 200 (-3.8A)
None
FMN  A 200 (-4.8A)
FMN  A 200 (-4.3A)
FMN  A 200 (-4.4A)
 1.00A 6b0cD-3cb0A:
undetectable		 6b0cD-3cb0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A 357
LEU A 307
LEU A 326
LEU A 301
THR A 302
 None
 0.84A 6b0cD-3d1jA:
3.1		 6b0cD-3d1jA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 VAL A 100
LEU A  22
LEU A  96
LEU A  18
LEU A  66
 None
 0.99A 6b0cD-3d9wA:
undetectable		 6b0cD-3d9wA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 VAL A 242
ALA A 220
LEU A 281
THR A 282
GLY A 249
 None
 0.94A 6b0cD-3e3xA:
undetectable		 6b0cD-3e3xA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 6 GLU A 128
LEU A 143
LEU A 136
ALA A 132
SER A  97
LEU A 116
 None
 1.10A 6b0cD-3gozA:
2.3		 6b0cD-3gozA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		5 LEU A 341
ALA A 344
LEU A 241
ARG A 330
GLY A 288
 None
 0.83A 6b0cD-3hl0A:
2.8		 6b0cD-3hl0A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  32
LEU A  72
LEU A 108
GLY A  50
LEU A  49
 None
 0.89A 6b0cD-3ibrA:
undetectable		 6b0cD-3ibrA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kev GALIERIA SULFURARIA
DCUN1
DOMAIN-CONTAINING
PROTEIN

(Galdieria
sulphuraria) 		PF03556
(Cullin_binding) 		5 LEU A  84
LEU A  48
THR A  45
GLY A  28
LEU A  29
 None
None
None
None
CSO  A  58 ( 4.2A)
 0.94A 6b0cD-3kevA:
undetectable		 6b0cD-3kevA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 LEU A 126
LEU A  97
ALA A  92
LEU A  40
GLY A  45
 None
 0.98A 6b0cD-3mggA:
2.9		 6b0cD-3mggA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 LEU A  23
HIS A  43
LEU A  40
LEU A  12
THR A  11
 None
 0.85A 6b0cD-3msuA:
undetectable		 6b0cD-3msuA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
LEU B 372
THR B 373
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
 0.91A 6b0cD-3ns1B:
undetectable		 6b0cD-3ns1B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU A  55
SER A 123
LEU A  26
THR A  25
GLY A  46
 None
None
None
None
FES  A 602 ( 3.2A)
 0.95A 6b0cD-3nvyA:
undetectable		 6b0cD-3nvyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU B 466
LEU B 428
SER B 451
LEU B 457
THR B 458
 None
 0.84A 6b0cD-3ol2B:
undetectable		 6b0cD-3ol2B:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00378
(ECH_1) 		6 GLU A 129
LEU A  88
LEU A 217
ALA A 139
ARG A 116
GLY A 106
 None
 1.42A 6b0cD-3ot6A:
undetectable		 6b0cD-3ot6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 VAL B  45
LEU B 232
ALA B  91
ARG B 240
GLY B 126
 None
 0.91A 6b0cD-3pcoB:
undetectable		 6b0cD-3pcoB:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwn GENE 9 PROTEIN

(Shigella virus
Sf6) 		PF16532
(Phage_tail_NK) 		6 LEU A 218
LEU A 201
SER A 145
LEU A 163
THR A 263
GLY A 259
 None
 1.20A 6b0cD-3rwnA:
undetectable		 6b0cD-3rwnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 LEU A 287
LEU A 320
SER A 412
LEU A 304
GLY A 435
 None
 0.94A 6b0cD-3tp9A:
undetectable		 6b0cD-3tp9A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU E 142
LEU E 128
LEU E 144
GLY E 181
LEU E 177
 None
 0.86A 6b0cD-3tsrE:
undetectable		 6b0cD-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 LEU B 443
LEU B 497
ALA B 495
LEU B 463
LEU B 467
 None
 0.84A 6b0cD-3v65B:
undetectable		 6b0cD-3v65B:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 470
LEU A 433
LEU A 546
GLY A 516
LEU A 515
 None
 0.93A 6b0cD-3vlyA:
undetectable		 6b0cD-3vlyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		5 LEU A 138
LEU A 166
LEU A 142
GLY A  30
LEU A  31
 None
HG  A 301 ( 3.9A)
None
None
None
 0.88A 6b0cD-3wa8A:
undetectable		 6b0cD-3wa8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 5 LEU A 318
LEU A 334
ALA A 344
LEU A 316
ARG A 294
 None
 0.93A 6b0cD-3wnbA:
undetectable		 6b0cD-3wnbA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 LEU A 361
ALA A 363
LEU A  33
THR A  39
LEU A 240
 None
 0.79A 6b0cD-3wrtA:
undetectable		 6b0cD-3wrtA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		5 VAL A  26
LEU A 126
ALA A 125
LEU A  48
GLY A  81
 None
 1.00A 6b0cD-4ao7A:
4.1		 6b0cD-4ao7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		5 GLU A 443
LEU A 469
LEU A 419
GLY A 409
LEU A 412
 None
 0.91A 6b0cD-4bmdA:
undetectable		 6b0cD-4bmdA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 190
ALA A  40
LEU A 294
THR A 295
LEU A 285
 None
 0.93A 6b0cD-4btpA:
undetectable		 6b0cD-4btpA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		6 VAL A 127
LEU A 197
LEU A 272
ALA A 269
LEU A 193
GLY A 184
 None
 1.19A 6b0cD-4bziA:
3.9		 6b0cD-4bziA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		5 GLU A 224
LEU A   6
LEU A 183
LEU A 564
GLY A 559
 None
 0.92A 6b0cD-4ccaA:
undetectable		 6b0cD-4ccaA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 GLU A 738
LEU A 822
ALA A 742
LEU A 771
THR A 772
 None
 0.94A 6b0cD-4cvuA:
2.9		 6b0cD-4cvuA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 LEU A 148
LEU A 130
ALA A 133
LEU A 146
GLY A  19
 None
 0.88A 6b0cD-4ei8A:
20.7		 6b0cD-4ei8A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 VAL D 374
LEU D 343
LEU D 484
GLY D 316
LEU D 315
 None
 0.98A 6b0cD-4em6D:
undetectable		 6b0cD-4em6D:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 VAL A1050
LEU A 980
LEU A1033
LEU A 984
LEU A 934
 None
 0.97A 6b0cD-4fwtA:
3.6		 6b0cD-4fwtA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		6 LEU A 172
LEU A 114
ALA A 141
LEU A 189
THR A 188
LEU A 129
 None
 1.33A 6b0cD-4gr5A:
undetectable		 6b0cD-4gr5A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 LEU A 359
LEU A 350
LEU A 327
THR A 326
GLY A 383
 None
 0.93A 6b0cD-4hehA:
4.0		 6b0cD-4hehA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 LEU A 359
LEU A 350
LEU A 327
THR A 326
GLY A 383
 None
 0.95A 6b0cD-4hh1A:
4.0		 6b0cD-4hh1A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpl POLYCOMB GROUP RING
FINGER PROTEIN 1

(Homo sapiens) 		PF16207
(RAWUL) 		5 LEU B 250
LEU B 203
ALA B 198
LEU B 171
ARG B 240
 None
 0.79A 6b0cD-4hplB:
undetectable		 6b0cD-4hplB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00619
(CARD) 		5 VAL A  26
GLU A  27
LEU A  46
THR A  43
GLY A  74
 None
 0.79A 6b0cD-4jupA:
undetectable		 6b0cD-4jupA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 VAL B  23
ALA B 100
SER B 104
GLY B  77
LEU B 118
 None
 0.97A 6b0cD-4k7gB:
undetectable		 6b0cD-4k7gB:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans)
PF01239
(PPTA) 		6 VAL B 251
LEU B 319
ALA B 318
LEU B 341
THR B 340
GLY A 205
 None
 1.34A 6b0cD-4mbgB:
undetectable		 6b0cD-4mbgB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		5 VAL A 114
LEU A  96
ALA A 126
GLY A 141
LEU A 142
 None
 0.99A 6b0cD-4mouA:
undetectable		 6b0cD-4mouA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 756
HIS A 777
LEU A 778
SER A 784
LEU A 754
 None
 0.99A 6b0cD-4pd3A:
undetectable		 6b0cD-4pd3A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 LEU B 227
LEU B 214
LEU B 229
GLY B 267
LEU B 263
 None
 0.99A 6b0cD-4peqB:
undetectable		 6b0cD-4peqB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		6 GLU A  93
LEU A 172
ALA A 486
SER A 488
ARG A 108
GLY A 237
 None
 1.35A 6b0cD-4qs9A:
undetectable		 6b0cD-4qs9A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm7 ACYL-COA
DEHYDROGENASE

(Slackia
heliotrinireducens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  13
LEU A   5
ALA A   0
LEU A  72
LEU A 251
 None
 0.96A 6b0cD-4rm7A:
undetectable		 6b0cD-4rm7A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		5 ALA A  27
SER A  29
LEU A 106
GLY A 146
LEU A 147
 None
None
BFS  A 173 (-4.5A)
None
None
 0.95A 6b0cD-4stdA:
undetectable		 6b0cD-4stdA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		6 GLU A1389
LEU A1377
LEU A1422
ALA A1425
SER A1428
ARG A1363
 None
 1.49A 6b0cD-4u48A:
undetectable		 6b0cD-4u48A:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 LEU A  52
HIS A  31
ALA A  34
LEU A 103
GLY A 334
 None
 0.88A 6b0cD-4u4eA:
undetectable		 6b0cD-4u4eA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpm MRNA EXPORT PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 136
SER A 121
LEU A 158
GLY A 105
LEU A 171
 None
 0.98A 6b0cD-4wpmA:
undetectable		 6b0cD-4wpmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		6 LEU A  56
LEU A  72
SER A 154
LEU A  52
THR A  55
LEU A 390
 None
 1.40A 6b0cD-4y9lA:
undetectable		 6b0cD-4y9lA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 329
LEU A 403
LEU A 371
THR A 372
GLY A 295
 None
FAD  A3004 (-4.7A)
None
None
None
 0.86A 6b0cD-4yswA:
undetectable		 6b0cD-4yswA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU A 466
LEU A 428
SER A 451
LEU A 457
THR A 458
 None
 0.78A 6b0cD-5b4wA:
undetectable		 6b0cD-5b4wA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		5 GLU A  69
LEU A  65
ALA A  67
LEU A 116
THR A 115
 None
 0.97A 6b0cD-5bpxA:
undetectable		 6b0cD-5bpxA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		5 GLU A 215
LEU A 241
LEU A 299
LEU A 230
GLY A 208
 None
 0.98A 6b0cD-5c5sA:
undetectable		 6b0cD-5c5sA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 GLU A  49
LEU A 308
ALA A 128
GLY A 106
LEU A 107
 None
 0.95A 6b0cD-5ez3A:
undetectable		 6b0cD-5ez3A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		5 LEU A 319
LEU A 270
ALA A 331
LEU A 323
LEU A 302
 None
 1.00A 6b0cD-5fb3A:
2.5		 6b0cD-5fb3A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 GLU A  96
LEU A  40
LEU A  79
LEU A 112
GLY A  59
 None
 0.97A 6b0cD-5i5lA:
undetectable		 6b0cD-5i5lA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		5 VAL B  90
LEU B  37
LEU B  58
LEU B 137
LEU B 144
 None
 0.93A 6b0cD-5ivaB:
undetectable		 6b0cD-5ivaB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 POLYCOMB GROUP RING
FINGER PROTEIN 1

(Homo sapiens) 		PF16207
(RAWUL) 		5 LEU C 250
LEU C 203
ALA C 198
LEU C 171
ARG C 240
 None
 0.91A 6b0cD-5jh5C:
undetectable		 6b0cD-5jh5C:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 LEU A 205
LEU A 191
LEU A 200
GLY A 154
LEU A 150
 None
NAD  A 401 ( 4.4A)
None
None
None
 0.99A 6b0cD-5jlaA:
5.7		 6b0cD-5jlaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 VAL A1112
LEU A1105
LEU A1152
GLY A1123
LEU A1124
 None
 0.97A 6b0cD-5jqeA:
undetectable		 6b0cD-5jqeA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		6 LEU A 591
HIS A 552
LEU A 668
LEU A 670
GLY A 612
LEU A 611
 None
 1.49A 6b0cD-5k7lA:
undetectable		 6b0cD-5k7lA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		5 LEU A  54
LEU A  63
ALA A  67
GLY A 151
LEU A 152
 None
 0.96A 6b0cD-5k9tA:
undetectable		 6b0cD-5k9tA:
9.87