SIMILAR PATTERNS OF AMINO ACIDS FOR 6AZ3_1_PAR11803_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoy ARGININE REPRESSOR

(Escherichia
coli) 		PF01316
(Arg_repressor) 		3 SER A  44
LYS A  45
SER A  47
 SER  A  44 ( 0.0A)
LYS  A  45 ( 0.0A)
SER  A  47 ( 0.0A)
 0.78A 6az3P-1aoyA:
undetectable		 6az3P-1aoyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awj ITK

(Mus musculus) 		PF00018
(SH3_1) 		3 SER A  79
LYS A  78
SER A  16
 None
 0.56A 6az3P-1awjA:
undetectable		 6az3P-1awjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f97 JUNCTION ADHESION
MOLECULE

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 SER A  29
LYS A  27
SER A  52
 None
 0.82A 6az3P-1f97A:
0.4		 6az3P-1f97A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fe8 IMMUNOGLOBULIN IGG
RU5

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  19
LYS H  81
SER H  17
 None
 0.84A 6az3P-1fe8H:
0.0		 6az3P-1fe8H:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		3 SER C 105
LYS C 106
SER C 109
 None
 0.60A 6az3P-1g3nC:
undetectable		 6az3P-1g3nC:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		3 SER A   8
LYS A   9
SER A  12
 None
 0.51A 6az3P-1gcbA:
0.0		 6az3P-1gcbA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		3 SER B 593
LYS B 594
SER B 597
 None
 0.78A 6az3P-1jmuB:
0.0		 6az3P-1jmuB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		3 SER B 649
LYS B 650
SER B 653
 None
 0.66A 6az3P-1jmuB:
0.0		 6az3P-1jmuB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbm F1-ATPASE

(Bos taurus) 		PF00231
(ATP-synt) 		3 SER G 236
LYS G 237
SER G 240
 None
 0.82A 6az3P-1nbmG:
undetectable		 6az3P-1nbmG:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		3 SER A 874
LYS A 875
SER A 877
 None
 0.55A 6az3P-1q2lA:
0.0		 6az3P-1q2lA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		3 SER A  29
LYS A  30
SER A  33
 None
 0.74A 6az3P-1sznA:
0.0		 6az3P-1sznA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		3 SER A   8
LYS A   7
SER A   5
 None
 0.83A 6az3P-1ua7A:
0.0		 6az3P-1ua7A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uju SCRIBBLE

(Homo sapiens) 		PF00595
(PDZ) 		3 SER A  26
LYS A  50
SER A  49
 None
 0.70A 6az3P-1ujuA:
0.0		 6az3P-1ujuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whl CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		PF01302
(CAP_GLY) 		3 SER A   3
LYS A   1
SER A   5
 None
 0.74A 6az3P-1whlA:
undetectable		 6az3P-1whlA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 677
LYS A 676
SER A 674
 None
None
IOD  A9061 ( 3.3A)
 0.84A 6az3P-1xc6A:
undetectable		 6az3P-1xc6A:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		3 SER A 261
LYS A 262
SER A 265
 None
 0.72A 6az3P-1ycoA:
undetectable		 6az3P-1ycoA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		3 SER A 366
LYS A 365
SER A 364
 None
 0.81A 6az3P-1yf2A:
undetectable		 6az3P-1yf2A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9a RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00047
(ig)
PF00629
(MAM) 		3 SER A 107
LYS A 106
SER A 105
 None
 0.74A 6az3P-2c9aA:
undetectable		 6az3P-2c9aA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		3 SER A 536
LYS A 537
SER A 540
 None
 0.64A 6az3P-2dkdA:
undetectable		 6az3P-2dkdA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do9 NACHT-, LRR- AND
PYD-CONTAINING
PROTEIN 10

(Mus musculus) 		PF02758
(PYRIN) 		3 SER A  62
LYS A  63
SER A  66
 None
 0.85A 6az3P-2do9A:
undetectable		 6az3P-2do9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		3 SER A  15
LYS A  14
SER A  16
 GDP  A 501 (-2.7A)
GDP  A 501 (-2.7A)
GDP  A 501 (-2.9A)
 0.84A 6az3P-2dykA:
undetectable		 6az3P-2dykA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef8 PUTATIVE
TRANSCRIPTION FACTOR

(Escherichia
virus P2) 		PF13560
(HTH_31) 		3 SER A  45
LYS A  46
SER A  49
 None
 0.78A 6az3P-2ef8A:
undetectable		 6az3P-2ef8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkh IMMUNOGLOBULIN HEAVY
CHAIN FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  55
LYS H  54
SER H  53
 None
 0.79A 6az3P-2hkhH:
undetectable		 6az3P-2hkhH:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsq INVASIN IPAA

(Shigella
flexneri) 		no annotation 3 SER B 578
LYS B 579
SER B 582
 None
 0.66A 6az3P-2hsqB:
undetectable		 6az3P-2hsqB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvv DEOXYCYTIDYLATE
DEAMINASE

(Streptococcus
mutans) 		PF00383
(dCMP_cyt_deam_1) 		3 SER A  19
LYS A  20
SER A  22
 None
 0.72A 6az3P-2hvvA:
undetectable		 6az3P-2hvvA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k20 PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 SER A  48
LYS A  47
SER A  29
 None
 0.78A 6az3P-2k20A:
undetectable		 6az3P-2k20A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k32 A

(Campylobacter
jejuni) 		PF13533
(Biotin_lipoyl_2) 		3 SER A  44
LYS A  45
SER A  49
 None
 0.83A 6az3P-2k32A:
undetectable		 6az3P-2k32A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvb CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		3 SER A 648
LYS A 620
SER A 646
 None
 0.73A 6az3P-2kvbA:
undetectable		 6az3P-2kvbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mex PROTEIN PRGI

(Salmonella
enterica) 		PF09392
(T3SS_needle_F) 		3 SER A  49
LYS A  50
SER A  52
 None
 0.57A 6az3P-2mexA:
undetectable		 6az3P-2mexA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		3 SER A  62
LYS A  63
SER A  65
 None
 0.70A 6az3P-2oq2A:
undetectable		 6az3P-2oq2A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5s RAS AND EF-HAND
DOMAIN CONTAINING

(Homo sapiens) 		PF00071
(Ras) 		3 SER A 555
LYS A 554
SER A 556
 GDP  A1001 ( 2.5A)
GDP  A1001 ( 2.8A)
GDP  A1001 ( 2.6A)
 0.84A 6az3P-2p5sA:
undetectable		 6az3P-2p5sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 SER A  43
LYS A  44
SER A  47
 None
 0.67A 6az3P-2p82A:
undetectable		 6az3P-2p82A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1

(Plasmodium
falciparum) 		PF06858
(NOG1) 		3 SER A  43
LYS A  42
SER A  44
 GDP  A 229 (-2.9A)
GDP  A 229 (-2.6A)
GDP  A 229 (-2.6A)
 0.83A 6az3P-2qu8A:
undetectable		 6az3P-2qu8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		3 SER A  48
LYS A  49
SER A  69
 None
 0.82A 6az3P-2xotA:
undetectable		 6az3P-2xotA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		3 SER A  32
LYS A  31
SER A  30
 None
 0.77A 6az3P-2yjnA:
undetectable		 6az3P-2yjnA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		3 SER A 257
LYS A 258
SER A 260
 None
 0.78A 6az3P-3adrA:
undetectable		 6az3P-3adrA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		3 SER A 106
LYS A  30
SER A 104
 None
 0.84A 6az3P-3ce1A:
undetectable		 6az3P-3ce1A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clv RAB5 PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00071
(Ras)
PF08477
(Roc) 		3 SER A  21
LYS A  20
SER A  22
 GDP  A 211 (-2.6A)
GDP  A 211 (-2.8A)
GDP  A 211 (-2.7A)
 0.81A 6az3P-3clvA:
undetectable		 6az3P-3clvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 SER A1036
LYS A 836
SER A1034
 None
 0.59A 6az3P-3eh1A:
undetectable		 6az3P-3eh1A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3g N-ACETYLTRANSFERASE

(Trypanosoma
brucei) 		PF00583
(Acetyltransf_1) 		3 SER A 127
LYS A 126
SER A 124
 None
 0.80A 6az3P-3i3gA:
undetectable		 6az3P-3i3gA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis) 		PF11989
(Dsl1_C) 		3 SER C 592
LYS C 591
SER C 589
 None
 0.60A 6az3P-3k8pC:
undetectable		 6az3P-3k8pC:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254

(Thermotoga
maritima) 		PF13419
(HAD_2) 		3 SER A 168
LYS A 167
SER A 166
 SER  A 168 (-0.0A)
LYS  A 167 (-0.0A)
SER  A 166 (-0.0A)
 0.85A 6az3P-3kbbA:
undetectable		 6az3P-3kbbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbx SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		3 SER B1956
LYS B1957
SER B1960
 None
 0.67A 6az3P-3lbxB:
undetectable		 6az3P-3lbxB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		3 SER A 211
LYS A 210
SER A 209
 None
 0.77A 6az3P-3n9iA:
undetectable		 6az3P-3n9iA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nut PRECORRIN-3
METHYLASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		3 SER A 169
LYS A 168
SER A 167
 None
 0.82A 6az3P-3nutA:
undetectable		 6az3P-3nutA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 537
LYS A 536
SER A 534
 None
 0.67A 6az3P-3sunA:
undetectable		 6az3P-3sunA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		3 SER A 202
LYS A 201
SER A 200
 None
 0.76A 6az3P-3sz3A:
undetectable		 6az3P-3sz3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz COATOMER SUBUNIT
GAMMA

(Bos taurus) 		PF01602
(Adaptin_N) 		3 SER B 212
LYS B 213
SER B 216
 None
 0.74A 6az3P-3tjzB:
undetectable		 6az3P-3tjzB:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF01208
(URO-D) 		3 SER A 163
LYS A 162
SER A 160
 None
 0.70A 6az3P-4ay7A:
undetectable		 6az3P-4ay7A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 SER A 418
LYS A 417
SER A 416
 None
 0.83A 6az3P-4bh6A:
undetectable		 6az3P-4bh6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		3 SER A 251
LYS A 229
SER A 232
 None
 0.72A 6az3P-4czeA:
undetectable		 6az3P-4czeA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djm DRAB

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		3 SER A  65
LYS A  64
SER A  60
 None
 0.77A 6az3P-4djmA:
1.4		 6az3P-4djmA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 SER A 282
LYS A 281
SER A 280
 None
 0.84A 6az3P-4g25A:
undetectable		 6az3P-4g25A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 SER B  56
LYS B  57
SER B  60
 None
 0.84A 6az3P-4g6tB:
undetectable		 6az3P-4g6tB:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP4

(Foot-and-mouth
disease virus) 		PF08935
(VP4_2) 		3 SER D  69
LYS D  70
SER D  73
 None
 0.52A 6az3P-4gh4D:
undetectable		 6az3P-4gh4D:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		3 SER A 166
LYS A 167
SER A 170
 CL  A 303 (-2.7A)
None
CL  A 303 ( 4.5A)
 0.75A 6az3P-4h16A:
undetectable		 6az3P-4h16A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 SER A 579
LYS A 580
SER A 583
 None
 0.85A 6az3P-4h5yA:
undetectable		 6az3P-4h5yA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwf BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
3

(Arabidopsis
thaliana) 		PF02179
(BAG) 		3 SER A 136
LYS A 137
SER A 140
 None
 0.73A 6az3P-4hwfA:
undetectable		 6az3P-4hwfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 SER A  83
LYS A  82
SER A  80
 None
 0.44A 6az3P-4jeuA:
undetectable		 6az3P-4jeuA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lin TAIL NEEDLE PROTEIN
GP26

(Salmonella
virus P22) 		no annotation 3 SER A1030
LYS A1029
SER A1028
 None
 0.76A 6az3P-4linA:
undetectable		 6az3P-4linA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 3 SER A 452
LYS A 453
SER A 456
 None
 0.70A 6az3P-4n5aA:
undetectable		 6az3P-4n5aA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 SER A 121
LYS A 122
SER A 165
 SO4  A 707 (-2.6A)
SO4  A 707 ( 4.4A)
None
 0.84A 6az3P-4nbqA:
undetectable		 6az3P-4nbqA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psm SSDNA BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF10015
(DUF2258) 		3 SER A 126
LYS A 127
SER A 130
 None
 0.72A 6az3P-4psmA:
undetectable		 6az3P-4psmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 SER A 679
LYS A 680
SER A 836
 None
 0.72A 6az3P-4qnlA:
undetectable		 6az3P-4qnlA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		3 SER A 206
LYS A 207
SER A 209
 None
 0.61A 6az3P-4ut1A:
undetectable		 6az3P-4ut1A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 SER A 190
LYS A 194
SER A 197
 None
 0.76A 6az3P-4uvkA:
undetectable		 6az3P-4uvkA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxq TAIL NEEDLE PROTEIN
GP26

(Salmonella
virus P22) 		no annotation 3 SER A  30
LYS A  29
SER A  28
 None
 0.68A 6az3P-4zxqA:
undetectable		 6az3P-4zxqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		3 SER A 365
LYS A 366
SER A 369
 None
 0.70A 6az3P-5ch6A:
undetectable		 6az3P-5ch6A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		3 SER A 198
LYS A 197
SER A 196
 None
 0.76A 6az3P-5dzsA:
undetectable		 6az3P-5dzsA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 SER A 279
LYS A 278
SER A 276
 None
 0.72A 6az3P-5e6kA:
undetectable		 6az3P-5e6kA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 SER A 279
LYS A 278
SER A 276
 None
 0.70A 6az3P-5enyA:
undetectable		 6az3P-5enyA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		3 SER A  62
LYS A  61
SER A  59
 None
 0.74A 6az3P-5f0kA:
undetectable		 6az3P-5f0kA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 3 SER A 206
LYS A 207
SER A 210
 None
 0.34A 6az3P-5in8A:
undetectable		 6az3P-5in8A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 SER A 418
LYS A 419
SER A 422
 None
 0.77A 6az3P-5jboA:
undetectable		 6az3P-5jboA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		3 SER A 214
LYS A 215
SER A 218
 None
 0.75A 6az3P-5kvmA:
undetectable		 6az3P-5kvmA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 3 SER B 225
LYS B 226
SER B 229
 None
 0.81A 6az3P-5l22B:
undetectable		 6az3P-5l22B:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		3 SER 1 176
LYS 1 175
SER 1 177
 None
 0.83A 6az3P-5mz61:
undetectable		 6az3P-5mz61:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem O PANASIA VP4

(Foot-and-mouth
disease virus) 		PF08935
(VP4_2) 		3 SER 4  69
LYS 4  70
SER 4  73
 None
 0.71A 6az3P-5nem4:
undetectable		 6az3P-5nem4:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0D15741P

(Kluyveromyces
lactis) 		PF08202
(MIS13) 		3 SER D 390
LYS D 391
SER D 394
 None
 0.80A 6az3P-5t58D:
undetectable		 6az3P-5t58D:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8l VACUOLAR-SORTING
PROTEIN SNF7

(Saccharomyces
cerevisiae) 		PF03357
(Snf7) 		3 SER A  34
LYS A  35
SER A  38
 None
 0.67A 6az3P-5t8lA:
undetectable		 6az3P-5t8lA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 SER A 850
LYS A 851
SER A 854
 None
 0.82A 6az3P-5u1sA:
undetectable		 6az3P-5u1sA:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 SER A 182
LYS A 183
SER A 186
 None
 0.74A 6az3P-5ucmA:
undetectable		 6az3P-5ucmA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  57
LYS A  56
SER A  54
 None
 0.71A 6az3P-5uf2A:
undetectable		 6az3P-5uf2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 3 SER A 539
LYS A 540
SER A 543
 None
 0.71A 6az3P-5ukhA:
undetectable		 6az3P-5ukhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		3 SER A   9
LYS A   8
SER A   6
 None
 0.73A 6az3P-5ul4A:
undetectable		 6az3P-5ul4A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		3 SER A 199
LYS A 198
SER A 197
 None
AMP  A 401 (-4.6A)
None
 0.84A 6az3P-5v0iA:
undetectable		 6az3P-5v0iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Caldanaerobacter
subterraneus) 		no annotation 3 SER A 241
LYS A 242
SER A 245
 None
 0.82A 6az3P-5woyA:
undetectable		 6az3P-5woyA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		3 SER A 100
LYS A 101
SER A 104
 None
 0.69A 6az3P-5x62A:
undetectable		 6az3P-5x62A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 3 SER G 579
LYS G 580
SER G 583
 None
 0.79A 6az3P-5x6oG:
undetectable		 6az3P-5x6oG:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN

(Pisum sativum) 		no annotation 3 SER B 388
LYS B 389
SER B 391
 None
 0.83A 6az3P-5xnmB:
undetectable		 6az3P-5xnmB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 3 SER A 117
LYS A 120
SER A 119
 None
 0.67A 6az3P-5xu1A:
undetectable		 6az3P-5xu1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 3 SER B  89
LYS B  88
SER B  90
 MG  B 804 ( 2.1A)
BEF  B 802 ( 2.5A)
GDP  B 801 (-2.5A)
 0.83A 6az3P-5yewB:
undetectable		 6az3P-5yewB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yi0 ZINC TRANSPORT
TRANSCRIPTIONAL
REGULATOR

(Lactococcus
lactis) 		no annotation 3 SER B 135
LYS B 136
SER B 139
 None
 0.79A 6az3P-5yi0B:
undetectable		 6az3P-5yi0B:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzc GLYCOPROTEIN
F1,MEASLES VIRUS
FUSION PROTEIN

(Measles
morbillivirus) 		no annotation 3 SER B 365
LYS B 364
SER B 362
 None
 0.77A 6az3P-5yzcB:
undetectable		 6az3P-5yzcB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 3 SER A  24
LYS A  23
SER A  22
 None
 0.79A 6az3P-6bc5A:
undetectable		 6az3P-6bc5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 SER A1530
LYS A1531
SER A1534
 None
 0.84A 6az3P-6bq1A:
undetectable		 6az3P-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 3 SER A 400
LYS A 401
SER A 404
 None
 0.67A 6az3P-6bqlA:
undetectable		 6az3P-6bqlA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 3 SER A 199
LYS A 198
SER A 197
 None
 0.79A 6az3P-6dfuA:
undetectable		 6az3P-6dfuA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dku VP35

(Myotis
lucifugus) 		no annotation 3 SER A 242
LYS A 241
SER A 240
 None
 0.77A 6az3P-6dkuA:
undetectable		 6az3P-6dkuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 3 SER W  39
LYS W  40
SER W  43
 None
 0.84A 6az3P-6epdW:
undetectable		 6az3P-6epdW:
20.43