SIMILAR PATTERNS OF AMINO ACIDS FOR 6AZ3_1_PAR11802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		3 ARG A 172
LYS A 408
ARG A 135
 3PG  A 423 (-3.4A)
None
3PG  A 423 (-2.8A)
 1.39A 6az3C-13pkA:
0.0
6az3L-13pkA:
0.0
6az3M-13pkA:
0.0		 6az3C-13pkA:
11.90
6az3L-13pkA:
13.69
6az3M-13pkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A 446
LYS A 408
ARG A  15
 None
 1.06A 6az3C-1atiA:
0.0
6az3L-1atiA:
0.0
6az3M-1atiA:
0.0		 6az3C-1atiA:
10.64
6az3L-1atiA:
7.72
6az3M-1atiA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		3 ARG A  99
LYS A 207
ARG A 107
 None
GKR  A 499 (-3.1A)
None
 1.40A 6az3C-1jctA:
0.0
6az3L-1jctA:
0.0
6az3M-1jctA:
undetectable		 6az3C-1jctA:
9.86
6az3L-1jctA:
10.02
6az3M-1jctA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima) 		PF00731
(AIRC) 		3 ARG A 146
LYS A 119
ARG A 149
 None
 1.11A 6az3C-1o4vA:
0.0
6az3L-1o4vA:
0.0
6az3M-1o4vA:
undetectable		 6az3C-1o4vA:
20.28
6az3L-1o4vA:
18.02
6az3M-1o4vA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ARG A 410
LYS A 210
ARG A 413
 RFP  A   1 ( 4.2A)
RFP  A   1 (-3.5A)
None
 1.29A 6az3C-1skxA:
0.0
6az3L-1skxA:
0.0
6az3M-1skxA:
undetectable		 6az3C-1skxA:
10.53
6az3L-1skxA:
13.85
6az3M-1skxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A1266
LYS A1162
ARG A1243
 None
 1.38A 6az3C-1wufA:
0.0
6az3L-1wufA:
0.0
6az3M-1wufA:
undetectable		 6az3C-1wufA:
11.52
6az3L-1wufA:
11.14
6az3M-1wufA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		3 ARG A 145
LYS A 203
ARG A 148
 None
 1.43A 6az3C-2cycA:
0.0
6az3L-2cycA:
0.0
6az3M-2cycA:
undetectable		 6az3C-2cycA:
11.35
6az3L-2cycA:
11.35
6az3M-2cycA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		3 ARG A 154
LYS A 174
ARG A 269
 None
 1.29A 6az3C-2dh4A:
0.0
6az3L-2dh4A:
0.0
6az3M-2dh4A:
undetectable		 6az3C-2dh4A:
11.95
6az3L-2dh4A:
11.47
6az3M-2dh4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		3 ARG A 415
LYS A 385
ARG A  39
 None
 1.43A 6az3C-2fiqA:
0.0
6az3L-2fiqA:
0.0
6az3M-2fiqA:
0.0		 6az3C-2fiqA:
10.92
6az3L-2fiqA:
9.88
6az3M-2fiqA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		3 ARG A 535
LYS A 328
ARG A 539
 None
 1.47A 6az3C-2hroA:
undetectable
6az3L-2hroA:
undetectable
6az3M-2hroA:
undetectable		 6az3C-2hroA:
9.83
6az3L-2hroA:
8.86
6az3M-2hroA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti) 		PF00881
(Nitroreductase) 		3 ARG A 124
LYS A 175
ARG A 134
 None
 1.43A 6az3C-2isjA:
undetectable
6az3L-2isjA:
undetectable
6az3M-2isjA:
0.0		 6az3C-2isjA:
15.65
6az3L-2isjA:
10.86
6az3M-2isjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ARG A 739
LYS A 478
ARG A 762
 None
 1.47A 6az3C-2iukA:
undetectable
6az3L-2iukA:
undetectable
6az3M-2iukA:
0.0		 6az3C-2iukA:
6.57
6az3L-2iukA:
8.05
6az3M-2iukA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 ARG A  46
LYS A  61
ARG A 327
 None
 1.37A 6az3C-2p3xA:
undetectable
6az3L-2p3xA:
undetectable
6az3M-2p3xA:
undetectable		 6az3C-2p3xA:
12.93
6az3L-2p3xA:
13.44
6az3M-2p3xA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 ARG A 133
LYS A 151
ARG A 237
 None
GRG  A 500 (-2.8A)
None
 1.25A 6az3C-2q80A:
undetectable
6az3L-2q80A:
undetectable
6az3M-2q80A:
undetectable		 6az3C-2q80A:
13.60
6az3L-2q80A:
13.06
6az3M-2q80A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ARG A 301
LYS A 246
ARG A 270
 None
 1.25A 6az3C-2r66A:
undetectable
6az3L-2r66A:
undetectable
6az3M-2r66A:
undetectable		 6az3C-2r66A:
9.45
6az3L-2r66A:
9.22
6az3M-2r66A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		3 ARG A 172
LYS A 217
ARG A 114
 None
 1.47A 6az3C-2zu0A:
undetectable
6az3L-2zu0A:
undetectable
6az3M-2zu0A:
undetectable		 6az3C-2zu0A:
11.78
6az3L-2zu0A:
11.11
6az3M-2zu0A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		3 ARG A   7
LYS A 133
ARG A 232
 IPE  A 701 (-3.9A)
None
None
 1.38A 6az3C-3b05A:
undetectable
6az3L-3b05A:
undetectable
6az3M-3b05A:
undetectable		 6az3C-3b05A:
12.46
6az3L-3b05A:
12.53
6az3M-3b05A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ARG A 248
LYS A 327
ARG A 200
 None
 1.32A 6az3C-3ilvA:
undetectable
6az3L-3ilvA:
undetectable
6az3M-3ilvA:
undetectable		 6az3C-3ilvA:
7.94
6az3L-3ilvA:
7.96
6az3M-3ilvA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ARG A  75
LYS A 441
ARG A  29
 None
 1.30A 6az3C-3juxA:
0.4
6az3L-3juxA:
undetectable
6az3M-3juxA:
undetectable		 6az3C-3juxA:
6.87
6az3L-3juxA:
7.39
6az3M-3juxA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		3 ARG A 281
LYS A   4
ARG A 284
 None
 1.47A 6az3C-3jzdA:
undetectable
6az3L-3jzdA:
undetectable
6az3M-3jzdA:
undetectable		 6az3C-3jzdA:
13.13
6az3L-3jzdA:
11.82
6az3M-3jzdA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		3 ARG A 329
LYS A 249
ARG A 324
 None
 1.43A 6az3C-3lvvA:
undetectable
6az3L-3lvvA:
undetectable
6az3M-3lvvA:
undetectable		 6az3C-3lvvA:
9.26
6az3L-3lvvA:
8.16
6az3M-3lvvA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		3 ARG A 193
LYS A  86
ARG A 212
 None
TPO  A  85 ( 2.9A)
None
 1.45A 6az3C-3m8yA:
undetectable
6az3L-3m8yA:
undetectable
6az3M-3m8yA:
undetectable		 6az3C-3m8yA:
11.02
6az3L-3m8yA:
10.70
6az3M-3m8yA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2n 3,6-ANHYDRO-ALPHA-L-
GALACTOSIDASE

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		3 ARG A 159
LYS A 215
ARG A 136
 None
 1.39A 6az3C-3p2nA:
undetectable
6az3L-3p2nA:
undetectable
6az3M-3p2nA:
undetectable		 6az3C-3p2nA:
10.80
6az3L-3p2nA:
10.88
6az3M-3p2nA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A1032
LYS A 868
ARG A1066
 None
 1.40A 6az3C-3vidA:
undetectable
6az3L-3vidA:
undetectable
6az3M-3vidA:
undetectable		 6az3C-3vidA:
13.50
6az3L-3vidA:
12.72
6az3M-3vidA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		3 ARG A 303
LYS A 310
ARG A 321
 None
 1.37A 6az3C-3wvoA:
1.1
6az3L-3wvoA:
undetectable
6az3M-3wvoA:
undetectable		 6az3C-3wvoA:
8.78
6az3L-3wvoA:
8.66
6az3M-3wvoA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 ARG A 195
LYS A 184
ARG A 199
 None
 1.48A 6az3C-3zdpA:
undetectable
6az3L-3zdpA:
undetectable
6az3M-3zdpA:
undetectable		 6az3C-3zdpA:
12.94
6az3L-3zdpA:
10.07
6az3M-3zdpA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		3 ARG A 767
LYS A 561
ARG A 753
 SO4  A1970 (-4.0A)
None
None
 1.49A 6az3C-3zgbA:
0.2
6az3L-3zgbA:
undetectable
6az3M-3zgbA:
undetectable		 6az3C-3zgbA:
6.95
6az3L-3zgbA:
5.68
6az3M-3zgbA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		3 ARG A 152
LYS A 208
ARG A 129
 None
 1.46A 6az3C-4ak5A:
undetectable
6az3L-4ak5A:
undetectable
6az3M-4ak5A:
undetectable		 6az3C-4ak5A:
13.44
6az3L-4ak5A:
10.64
6az3M-4ak5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		3 ARG A 408
LYS A 195
ARG A 347
 None
CSX  A 194 ( 3.0A)
None
 1.31A 6az3C-4d3yA:
undetectable
6az3L-4d3yA:
undetectable
6az3M-4d3yA:
undetectable		 6az3C-4d3yA:
12.13
6az3L-4d3yA:
9.07
6az3M-4d3yA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		3 ARG A1295
LYS A1181
ARG A1481
 None
 1.28A 6az3C-4guaA:
undetectable
6az3L-4guaA:
undetectable
6az3M-4guaA:
undetectable		 6az3C-4guaA:
9.14
6az3L-4guaA:
7.44
6az3M-4guaA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber) 		PF01048
(PNP_UDP_1) 		3 ARG A 136
LYS A  53
ARG A 135
 None
MG  A 501 ( 4.9A)
None
 1.40A 6az3C-4m3nA:
undetectable
6az3L-4m3nA:
undetectable
6az3M-4m3nA:
undetectable		 6az3C-4m3nA:
17.52
6az3L-4m3nA:
18.27
6az3M-4m3nA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 ARG A 360
LYS A 500
ARG A 346
 None
CA  A 601 ( 4.1A)
None
 1.01A 6az3C-4ovdA:
undetectable
6az3L-4ovdA:
undetectable
6az3M-4ovdA:
undetectable		 6az3C-4ovdA:
11.68
6az3L-4ovdA:
8.13
6az3M-4ovdA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psx HISTONE H4

(Saccharomyces
cerevisiae) 		no annotation 3 ARG C  36
LYS C  20
ARG C  35
 None
 1.14A 6az3C-4psxC:
undetectable
6az3L-4psxC:
undetectable
6az3M-4psxC:
undetectable		 6az3C-4psxC:
24.29
6az3L-4psxC:
25.00
6az3M-4psxC:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 ARG A2506
LYS A1584
ARG A2539
 None
 1.20A 6az3C-4rlvA:
undetectable
6az3L-4rlvA:
undetectable
6az3M-4rlvA:
undetectable		 6az3C-4rlvA:
7.03
6az3L-4rlvA:
6.66
6az3M-4rlvA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 ARG A  29
LYS A 115
ARG A  22
 None
 1.31A 6az3C-4txdA:
undetectable
6az3L-4txdA:
undetectable
6az3M-4txdA:
undetectable		 6az3C-4txdA:
11.57
6az3L-4txdA:
10.05
6az3M-4txdA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 277
LYS A 294
ARG A 123
 ADP  A 801 (-3.8A)
None
ADP  A 801 ( 3.9A)
 1.44A 6az3C-4woeA:
0.1
6az3L-4woeA:
undetectable
6az3M-4woeA:
undetectable		 6az3C-4woeA:
8.01
6az3L-4woeA:
7.72
6az3M-4woeA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 501
LYS A 477
ARG A  81
 LGC  A 602 ( 2.8A)
LGC  A 603 ( 4.9A)
None
 1.30A 6az3C-4ynuA:
undetectable
6az3L-4ynuA:
undetectable
6az3M-4ynuA:
undetectable		 6az3C-4ynuA:
10.04
6az3L-4ynuA:
8.17
6az3M-4ynuA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ARG B 371
LYS B 296
ARG B 471
 None
 1.07A 6az3C-5b3gB:
undetectable
6az3L-5b3gB:
undetectable
6az3M-5b3gB:
undetectable		 6az3C-5b3gB:
10.32
6az3L-5b3gB:
9.50
6az3M-5b3gB:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCOP1
CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT II

(Pseudomonas
stutzeri) 		PF02433
(FixO)
PF13442
(Cytochrome_CBB3)
PF14715
(FixP_N) 		3 ARG B  82
LYS C 290
ARG B 104
 None
 1.01A 6az3C-5djqB:
undetectable
6az3L-5djqB:
undetectable
6az3M-5djqB:
undetectable		 6az3C-5djqB:
17.17
6az3L-5djqB:
13.93
6az3M-5djqB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ARG A 819
LYS A 283
ARG A 822
 None
 1.40A 6az3C-5dllA:
undetectable
6az3L-5dllA:
undetectable
6az3M-5dllA:
undetectable		 6az3C-5dllA:
6.93
6az3L-5dllA:
7.28
6az3M-5dllA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 3 ARG A 524
LYS A 451
ARG A 523
 None
 1.45A 6az3C-5dn7A:
undetectable
6az3L-5dn7A:
undetectable
6az3M-5dn7A:
undetectable		 6az3C-5dn7A:
14.43
6az3L-5dn7A:
13.41
6az3M-5dn7A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q CONTACT-DEPENDENT
INHIBITOR A
CONTACT-DEPENDENT
INHIBITOR I

(Escherichia
coli) 		no annotation 3 ARG B  85
LYS A 194
ARG A 222
 None
 1.27A 6az3C-5i4qB:
undetectable
6az3L-5i4qB:
undetectable
6az3M-5i4qB:
undetectable		 6az3C-5i4qB:
20.00
6az3L-5i4qB:
16.94
6az3M-5i4qB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 ARG A 770
LYS A 719
ARG A 856
 None
 1.44A 6az3C-5jjrA:
undetectable
6az3L-5jjrA:
undetectable
6az3M-5jjrA:
undetectable		 6az3C-5jjrA:
7.15
6az3L-5jjrA:
6.78
6az3M-5jjrA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 ARG A 770
LYS A 719
ARG A 856
 None
 1.42A 6az3C-5k5mA:
undetectable
6az3L-5k5mA:
undetectable
6az3M-5k5mA:
undetectable		 6az3C-5k5mA:
9.17
6az3L-5k5mA:
10.14
6az3M-5k5mA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ARG A 644
LYS A 297
ARG A 647
 None
ATP  A 703 (-2.8A)
None
 1.13A 6az3C-5k8fA:
undetectable
6az3L-5k8fA:
undetectable
6az3M-5k8fA:
undetectable		 6az3C-5k8fA:
8.17
6az3L-5k8fA:
7.33
6az3M-5k8fA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		3 ARG A 683
LYS A 273
ARG A 354
 None
 1.04A 6az3C-5l9wA:
0.8
6az3L-5l9wA:
undetectable
6az3M-5l9wA:
undetectable		 6az3C-5l9wA:
9.25
6az3L-5l9wA:
8.24
6az3M-5l9wA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		3 ARG A 261
LYS A 249
ARG A 221
 None
 1.36A 6az3C-5m7oA:
undetectable
6az3L-5m7oA:
undetectable
6az3M-5m7oA:
undetectable		 6az3C-5m7oA:
11.85
6az3L-5m7oA:
8.54
6az3M-5m7oA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		3 ARG A 152
LYS A 208
ARG A 129
 None
 1.37A 6az3C-5ta9A:
undetectable
6az3L-5ta9A:
undetectable
6az3M-5ta9A:
undetectable		 6az3C-5ta9A:
11.34
6az3L-5ta9A:
12.01
6az3M-5ta9A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		3 ARG A 410
LYS A 457
ARG A 379
 None
 1.29A 6az3C-5vbfA:
0.3
6az3L-5vbfA:
undetectable
6az3M-5vbfA:
undetectable		 6az3C-5vbfA:
10.40
6az3L-5vbfA:
10.85
6az3M-5vbfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		3 ARG A 175
LYS A 469
ARG A 176
 None
 1.38A 6az3C-5w94A:
1.8
6az3L-5w94A:
undetectable
6az3M-5w94A:
undetectable		 6az3C-5w94A:
9.55
6az3L-5w94A:
9.48
6az3M-5w94A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00238
(Ribosomal_L14)
PF01245
(Ribosomal_L19) 		3 ARG L  78
LYS L   1
ARG Q 182
 A  A1701 ( 4.7A)
A  A1701 ( 3.8A)
G  A2702 ( 3.1A)
 1.14A 6az3C-5x8tL:
undetectable
6az3L-5x8tL:
undetectable
6az3M-5x8tL:
undetectable		 6az3C-5x8tL:
21.85
6az3L-5x8tL:
15.57
6az3M-5x8tL:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 3 ARG A 616
LYS A 647
ARG A 598
 None
 1.40A 6az3C-5xipA:
undetectable
6az3L-5xipA:
undetectable
6az3M-5xipA:
undetectable		 6az3C-5xipA:
13.41
6az3L-5xipA:
19.57
6az3M-5xipA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 3 ARG A 300
LYS A 264
ARG A 303
 None
 1.34A 6az3C-5xncA:
undetectable
6az3L-5xncA:
undetectable
6az3M-5xncA:
undetectable		 6az3C-5xncA:
undetectable
6az3L-5xncA:
undetectable
6az3M-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		3 ARG A1026
LYS A 323
ARG A1027
 None
 1.41A 6az3C-5xsyA:
2.1
6az3L-5xsyA:
undetectable
6az3M-5xsyA:
undetectable		 6az3C-5xsyA:
3.92
6az3L-5xsyA:
3.49
6az3M-5xsyA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 3 ARG A 416
LYS A 533
ARG A 466
 None
 1.38A 6az3C-6cipA:
undetectable
6az3L-6cipA:
undetectable
6az3M-6cipA:
undetectable		 6az3C-6cipA:
20.22
6az3L-6cipA:
14.77
6az3M-6cipA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A1591
LYS A1553
ARG A1545
 None
 1.41A 6az3C-6emkA:
undetectable
6az3L-6emkA:
undetectable
6az3M-6emkA:
undetectable		 6az3C-6emkA:
18.29
6az3L-6emkA:
21.84
6az3M-6emkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj MRNA
3'-END-PROCESSING
PROTEIN YTH1
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG B  31
LYS A1030
ARG B  20
 None
 1.18A 6az3C-6eojB:
undetectable
6az3L-6eojB:
undetectable
6az3M-6eojB:
undetectable		 6az3C-6eojB:
16.35
6az3L-6eojB:
17.00
6az3M-6eojB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 3 ARG C 110
LYS F 338
ARG C 112
 None
 1.31A 6az3C-6f0kC:
undetectable
6az3L-6f0kC:
undetectable
6az3M-6f0kC:
undetectable		 6az3C-6f0kC:
22.62
6az3L-6f0kC:
15.66
6az3M-6f0kC:
21.95