SIMILAR PATTERNS OF AMINO ACIDS FOR 6AY6_A_VORA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jov	HI1317 (Haemophilus influenzae)	PF01263 (Aldose_epim)	5	ALA A 40 THR A 151 LEU A 55 CYH A 133 LEU A 57	None	1.48A	6ay6A-1jovA: undetectable	6ay6A-1jovA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ngr	P75 LOW AFFINITY NEUROTROPHIN RECEPTOR (Rattus norvegicus)	PF00531 (Death)	5	TYR A 366 ALA A 402 ALA A 398 THR A 395 LEU A 385	None	1.46A	6ay6A-1ngrA: undetectable	6ay6A-1ngrA: 12.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1x8v	CYTOCHROME P450 51 (Mycobacterium tuberculosis)	PF00067 (p450)	6	TYR A 76 PHE A 83 ALA A 256 THR A 260 LEU A 321 CYH A 394	ESL A 471 ( 3.8A) None ESL A 471 ( 3.4A) HEM A 470 (-3.6A) HEM A 470 (-4.1A) HEM A 470 (-2.4A)	0.94A	6ay6A-1x8vA: 41.4	6ay6A-1x8vA: 32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yii	ANNEXIN A5 (Gallus gallus)	PF00191 (Annexin)	5	ALA A 23 ALA A 27 THR A 33 LEU A 73 LEU A 39	None None CA A 401 ( 4.8A) None None	1.42A	6ay6A-1yiiA: undetectable	6ay6A-1yiiA: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2afb	2-KETO-3-DEOXYGLUCON ATE KINASE (Thermotoga maritima)	PF00294 (PfkB)	5	TYR A 31 PHE A 317 ALA A 40 THR A 53 LEU A 55	None	1.29A	6ay6A-2afbA: undetectable	6ay6A-2afbA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bvt	BETA-1,4-MANNANASE (Cellulomonas fimi)	PF02156 (Glyco_hydro_26)	5	TYR A 197 TYR A 193 ALA A 177 THR A 281 LEU A 243	None	1.41A	6ay6A-2bvtA: undetectable	6ay6A-2bvtA: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qa1	POLYKETIDE OXYGENASE PGAE (Streptomyces sp. PGA64)	PF01494 (FAD_binding_3)	5	ALA A 467 ALA A 469 THR A 455 LEU A 452 LEU A 417	None	1.39A	6ay6A-2qa1A: undetectable	6ay6A-2qa1A: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2rdy	BH0842 PROTEIN (Bacillus halodurans)	PF14498 (Glyco_hyd_65N_2)	5	ALA A 686 ALA A 688 THR A 384 LEU A 720 LEU A 694	None	1.41A	6ay6A-2rdyA: undetectable	6ay6A-2rdyA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	PF02278 (Lyase_8) PF02884 (Lyase_8_C) PF08124 (Lyase_8_N)	5	TYR A 91 ALA A 173 ALA A 169 LEU A 162 LEU A 208	None	1.27A	6ay6A-2wdaA: undetectable	6ay6A-2wdaA: 18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ec2	DNA REPLICATION PROTEIN DNAC (Aquifex aeolicus)	PF01695 (IstB_IS21)	5	TYR A 53 ALA A 98 ALA A 96 THR A 180 LEU A 218	ADP A 222 (-3.4A) None None None None	1.36A	6ay6A-3ec2A: undetectable	6ay6A-3ec2A: 19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ksw	STEROL 14-ALPHA DEMETHYLASE (Trypanosoma cruzi)	PF00067 (p450)	5	TYR A 103 ALA A 287 ALA A 291 LEU A 356 CYH A 422	None VNF A 490 ( 3.9A) VNF A 490 ( 4.0A) None HEM A 488 (-2.2A)	0.96A	6ay6A-3kswA: 32.5	6ay6A-3kswA: 36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ksw	STEROL 14-ALPHA DEMETHYLASE (Trypanosoma cruzi)	PF00067 (p450)	6	TYR A 103 PHE A 110 ALA A 287 ALA A 291 THR A 295 CYH A 422	None None VNF A 490 ( 3.9A) VNF A 490 ( 4.0A) VNF A 490 ( 4.0A) HEM A 488 (-2.2A)	0.82A	6ay6A-3kswA: 32.5	6ay6A-3kswA: 36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3l4d	STEROL 14-ALPHA DEMETHYLASE (Leishmania infantum)	PF00067 (p450)	8	TYR A 102 PHE A 109 TYR A 115 ALA A 286 ALA A 290 THR A 294 LEU A 355 CYH A 422	HEM A 481 (-4.7A) TPF A 490 (-4.5A) HEM A 481 ( 4.9A) TPF A 490 (-3.4A) TPF A 490 ( 3.4A) TPF A 490 ( 3.5A) TPF A 490 (-4.4A) HEM A 481 (-2.2A)	0.79A	6ay6A-3l4dA: 46.6	6ay6A-3l4dA: 36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lij	CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS (Cryptosporidium parvum)	PF00069 (Pkinase) PF13499 (EF-hand_7)	5	PHE A 505 THR A 437 LEU A 445 CYH A 513 LEU A 362	None	1.45A	6ay6A-3lijA: undetectable	6ay6A-3lijA: 24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lmb	UNCHARACTERIZED PROTEIN (Oleispira antarctica)	PF09500 (YiiD_C)	5	PHE A 118 ALA A 128 ALA A 160 THR A 89 LEU A 132	None	1.43A	6ay6A-3lmbA: undetectable	6ay6A-3lmbA: 15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nvn	PLEXIN-C1 (Homo sapiens)	PF01437 (PSI)	5	TYR B 248 ALA B 163 ALA B 181 LEU B 225 LEU B 223	None	1.18A	6ay6A-3nvnB: undetectable	6ay6A-3nvnB: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o4o	INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (Homo sapiens)	PF13927 (Ig_3)	5	TYR B 101 ALA B 44 ALA B 41 LEU B 29 LEU B 48	NAG B 340 (-4.0A) None None None None	1.10A	6ay6A-3o4oB: undetectable	6ay6A-3o4oB: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p0u	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2 (Homo sapiens)	PF00104 (Hormone_recep)	5	ALA A 502 ALA A 451 THR A 447 LEU A 569 LEU A 514	None	1.36A	6ay6A-3p0uA: undetectable	6ay6A-3p0uA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3vyw	MNMC2 (Aquifex aeolicus)	PF05430 (Methyltransf_30)	5	TYR A 14 PHE A 34 TYR A 10 ALA A 38 LEU A 301	None	1.32A	6ay6A-3vywA: undetectable	6ay6A-3vywA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wxo	CATALASE-PEROXIDASE (Synechococcus elongatus)	PF00141 (peroxidase)	5	TYR A 154 ALA A 109 ALA A 149 LEU A 146 LEU A 135	None	1.14A	6ay6A-3wxoA: undetectable	6ay6A-3wxoA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c60	OCHRATOXINASE (Aspergillus niger)	PF01979 (Amidohydro_1)	5	TYR A 363 ALA A 403 ALA A 406 LEU A 325 CYH A 110	None	1.38A	6ay6A-4c60A: undetectable	6ay6A-4c60A: 20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4g3j	STEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei)	PF00067 (p450)	6	PHE A 110 TYR A 103 ALA A 287 ALA A 291 THR A 295 CYH A 422	VNT A 502 (-4.4A) VNT A 502 ( 4.8A) VNT A 502 ( 3.9A) HEM A 501 ( 3.5A) VNT A 502 ( 3.2A) HEM A 501 (-2.3A)	1.18A	6ay6A-4g3jA: 46.4	6ay6A-4g3jA: 36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4g3j	STEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei)	PF00067 (p450)	7	PHE A 110 TYR A 116 ALA A 287 ALA A 291 THR A 295 LEU A 356 CYH A 422	VNT A 502 (-4.4A) HEM A 501 ( 4.5A) VNT A 502 ( 3.9A) HEM A 501 ( 3.5A) VNT A 502 ( 3.2A) VNT A 502 ( 4.5A) HEM A 501 (-2.3A)	0.73A	6ay6A-4g3jA: 46.4	6ay6A-4g3jA: 36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4g3j	STEROL 14-ALPHA-DEMETHYLASE (Trypanosoma brucei)	PF00067 (p450)	5	TYR A 103 TYR A 116 THR A 295 LEU A 356 CYH A 422	VNT A 502 ( 4.8A) HEM A 501 ( 4.5A) VNT A 502 ( 3.2A) VNT A 502 ( 4.5A) HEM A 501 (-2.3A)	0.99A	6ay6A-4g3jA: 46.4	6ay6A-4g3jA: 36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4imp	POLYKETIDE SYNTHASE EXTENDER MODULES 3-4 (Saccharopolyspora spinosa)	PF08659 (KR)	5	ALA A 428 ALA A 424 THR A 376 LEU A 373 LEU A 167	None	1.15A	6ay6A-4impA: undetectable	6ay6A-4impA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4l4x	AMPHI (Streptomyces nodosus)	PF08659 (KR)	5	ALA A 143 ALA A 89 LEU A 111 CYH A 117 LEU A 86	None	1.35A	6ay6A-4l4xA: undetectable	6ay6A-4l4xA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mxw	LYMPHOTOXIN-BETA (Homo sapiens)	no annotation	5	TYR Y 136 ALA Y 89 THR Y 117 LEU Y 125 LEU Y 213	None	0.93A	6ay6A-4mxwY: undetectable	6ay6A-4mxwY: 17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4uhi	STEROL 14-ALPHA DEMETHYLASE (Homo sapiens)	PF00067 (p450)	6	TYR A 131 PHE A 139 TYR A 145 ALA A 311 THR A 315 CYH A 449	VFV A 580 (-4.1A) VFV A 580 (-4.2A) HEM A 540 (-4.5A) HEM A 540 ( 3.4A) HEM A 540 (-3.6A) HEM A 540 (-2.3A)	0.71A	6ay6A-4uhiA: 48.2	6ay6A-4uhiA: 39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4uym	14-ALPHA STEROL DEMETHYLASE (Aspergillus fumigatus)	PF00067 (p450)	6	TYR A 122 PHE A 130 TYR A 136 ALA A 303 ALA A 307 CYH A 463	VOR A 590 (-3.8A) VOR A 590 (-4.6A) HEM A 580 (-4.6A) VOR A 590 ( 4.4A) VOR A 590 ( 4.0A) HEM A 580 (-2.3A)	0.81A	6ay6A-4uymA: 43.9	6ay6A-4uymA: 35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xkz	VALINE-TRNA LIGASE (Pseudomonas aeruginosa)	PF08264 (Anticodon_1)	5	TYR A 713 TYR A 709 ALA A 646 THR A 658 LEU A 721	None	1.39A	6ay6A-4xkzA: undetectable	6ay6A-4xkzA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cu1	DMSP LYASE (Ruegeria pomeroyi)	PF16867 (DMSP_lyase)	5	TYR A 98 ALA A 71 ALA A 68 LEU A 139 LEU A 57	None	1.41A	6ay6A-5cu1A: undetectable	6ay6A-5cu1A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5e9g	ISOCITRATE LYASE (Magnaporthe oryzae)	PF00463 (ICL)	5	ALA A 251 ALA A 401 LEU A 68 CYH A 462 LEU A 247	None	1.43A	6ay6A-5e9gA: undetectable	6ay6A-5e9gA: 22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5fsa	CYP51 VARIANT1 (Candida albicans)	PF00067 (p450)	6	TYR A 118 PHE A 126 TYR A 132 THR A 311 LEU A 376 CYH A 470	X2N A 590 ( 4.0A) X2N A 590 (-4.8A) HEM A 580 (-4.1A) HEM A 580 (-3.6A) X2N A 590 (-4.3A) HEM A 580 (-2.2A)	0.73A	6ay6A-5fsaA: 43.5	6ay6A-5fsaA: 36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5hs1	LANOSTEROL 14-ALPHA DEMETHYLASE (Saccharomyces cerevisiae)	PF00067 (p450)	6	TYR A 126 PHE A 134 TYR A 140 THR A 318 LEU A 380 CYH A 470	VOR A 602 ( 3.8A) VOR A 602 (-4.7A) HEM A 601 (-4.3A) HEM A 601 (-3.4A) VOR A 602 (-4.0A) HEM A 601 (-2.4A)	0.49A	6ay6A-5hs1A: 42.6	6ay6A-5hs1A: 32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5jlc	LANOSTEROL 14-ALPHA DEMETHYLASE ([Candida] glabrata)	PF00067 (p450)	6	TYR A 127 PHE A 135 TYR A 141 THR A 319 LEU A 381 CYH A 472	1YN A 602 ( 3.8A) 1YN A 602 ( 4.6A) HEM A 601 (-4.2A) HEM A 601 ( 3.5A) 1YN A 602 ( 4.7A) HEM A 601 (-2.3A)	0.50A	6ay6A-5jlcA: 42.2	6ay6A-5jlcA: 32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ks8	PYRUVATE CARBOXYLASE SUBUNIT ALPHA (Methylobacillus flagellatus)	PF00289 (Biotin_carb_N) PF02785 (Biotin_carb_C) PF02786 (CPSase_L_D2)	5	TYR A 59 ALA A 14 ALA A 30 LEU A 68 LEU A 77	None	1.18A	6ay6A-5ks8A: undetectable	6ay6A-5ks8A: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5nva	PUTATIVE SODIUM:SOLUTE SYMPORTER (Proteus mirabilis)	no annotation	5	TYR A 169 ALA A 338 ALA A 340 THR A 140 LEU A 161	None	1.49A	6ay6A-5nvaA: undetectable	6ay6A-5nvaA: 10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6all	FE(3+)-CITRATE-BINDI NG PROTEIN YFMC (Bacillus anthracis)	PF01497 (Peripla_BP_2)	5	TYR A 294 ALA A 202 ALA A 200 THR A 234 LEU A 231	None	1.35A	6ay6A-6allA: undetectable	6ay6A-6allA: 22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6ay4	CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri)	no annotation	8	TYR A 107 PHE A 114 ALA A 289 ALA A 293 THR A 297 LEU A 358 CYH A 430 LEU A 467	TPF A 506 (-4.2A) TPF A 506 (-4.4A) TPF A 506 (-3.5A) TPF A 506 ( 3.2A) HEM A 501 (-3.4A) TPF A 506 ( 4.4A) HEM A 501 ( 1.8A) EDO A 503 (-4.2A)	0.50A	6ay6A-6ay4A: 63.1	6ay6A-6ay4A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6ay4	CYP51, STEROL 14ALPHA-DEMETHYLASE (Naegleria fowleri)	no annotation	8	TYR A 107 PHE A 114 TYR A 120 ALA A 289 ALA A 293 THR A 297 LEU A 358 CYH A 430	TPF A 506 (-4.2A) TPF A 506 (-4.4A) None TPF A 506 (-3.5A) TPF A 506 ( 3.2A) HEM A 501 (-3.4A) TPF A 506 ( 4.4A) HEM A 501 ( 1.8A)	0.51A	6ay6A-6ay4A: 63.1	6ay6A-6ay4A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6c93	CYTOCHROME P450 4B1 (Oryctolagus cuniculus)	no annotation	5	TYR A 110 ALA A 310 THR A 314 CYH A 448 LEU A 485	HEM A 600 (-4.4A) HEM A 600 ( 3.2A) HEM A 600 ( 3.7A) HEM A 600 (-2.1A) OCT A 601 ( 4.9A)	0.86A	6ay6A-6c93A: 36.6	6ay6A-6c93A: 11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cf8	LYTIC TRANSGLYCOSYLASE (Campylobacter jejuni)	no annotation	5	TYR A 369 PHE A 393 ALA A 387 ALA A 385 LEU A 516	None	1.42A	6ay6A-6cf8A: undetectable	6ay6A-6cf8A: 12.65

[["6AY6_A_VORA501_1","1jov","Haemophilus influenzae","HI1317","PF01263(Aldose_epim)",5,"ALA A  40;THR A 151;LEU A  55;CYH A 133;LEU A  57","None","1.48A","6ay6A-1jovA:undetectable","6ay6A-1jovA:20.13"],["6AY6_A_VORA501_1","1ngr","Rattus norvegicus","P75 LOW AFFINITY NEUROTROPHIN RECEPTOR","PF00531(Death)",5,"TYR A 366;ALA A 402;ALA A 398;THR A 395;LEU A 385","None","1.46A","6ay6A-1ngrA:undetectable","6ay6A-1ngrA:12.11"],["6AY6_A_VORA501_1","1x8v","Mycobacterium tuberculosis","CYTOCHROME P450 51","PF00067(p450)",6,"TYR A  76;PHE A  83;ALA A 256;THR A 260;LEU A 321;CYH A 394","ESL A 471 ( 3.8A);None;ESL A 471 ( 3.4A);HEM A 470 (-3.6A);HEM A 470 (-4.1A);HEM A 470 (-2.4A)","0.94A","6ay6A-1x8vA:41.4","6ay6A-1x8vA:32.43"],["6AY6_A_VORA501_1","1yii","Gallus gallus","ANNEXIN A5","PF00191(Annexin)",5,"ALA A  23;ALA A  27;THR A  33;LEU A  73;LEU A  39","None;None; CA A 401 ( 4.8A);None;None","1.42A","6ay6A-1yiiA:undetectable","6ay6A-1yiiA:24.42"],["6AY6_A_VORA501_1","2afb","Thermotoga maritima","2-KETO-3-DEOXYGLUCONATE KINASE","PF00294(PfkB)",5,"TYR A  31;PHE A 317;ALA A  40;THR A  53;LEU A  55","None","1.29A","6ay6A-2afbA:undetectable","6ay6A-2afbA:20.73"],["6AY6_A_VORA501_1","2bvt","Cellulomonas fimi","BETA-1,4-MANNANASE","PF02156(Glyco_hydro_26)",5,"TYR A 197;TYR A 193;ALA A 177;THR A 281;LEU A 243","None","1.41A","6ay6A-2bvtA:undetectable","6ay6A-2bvtA:21.91"],["6AY6_A_VORA501_1","2qa1","Streptomyces sp. PGA64","POLYKETIDE OXYGENASE PGAE","PF01494(FAD_binding_3)",5,"ALA A 467;ALA A 469;THR A 455;LEU A 452;LEU A 417","None","1.39A","6ay6A-2qa1A:undetectable","6ay6A-2qa1A:20.96"],["6AY6_A_VORA501_1","2rdy","Bacillus halodurans","BH0842 PROTEIN","PF14498(Glyco_hyd_65N_2)",5,"ALA A 686;ALA A 688;THR A 384;LEU A 720;LEU A 694","None","1.41A","6ay6A-2rdyA:undetectable","6ay6A-2rdyA:21.13"],["6AY6_A_VORA501_1","2wda","Streptomyces violaceoruber","PUTATIVE SECRETED LYASE","PF02278(Lyase_8);PF02884(Lyase_8_C);PF08124(Lyase_8_N)",5,"TYR A  91;ALA A 173;ALA A 169;LEU A 162;LEU A 208","None","1.27A","6ay6A-2wdaA:undetectable","6ay6A-2wdaA:18.80"],["6AY6_A_VORA501_1","3ec2","Aquifex aeolicus","DNA REPLICATION PROTEIN DNAC","PF01695(IstB_IS21)",5,"TYR A  53;ALA A  98;ALA A  96;THR A 180;LEU A 218","ADP A 222 (-3.4A);None;None;None;None","1.36A","6ay6A-3ec2A:undetectable","6ay6A-3ec2A:19.00"],["6AY6_A_VORA501_1","3ksw","Trypanosoma cruzi","STEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",5,"TYR A 103;ALA A 287;ALA A 291;LEU A 356;CYH A 422","None;VNF A 490 ( 3.9A);VNF A 490 ( 4.0A);None;HEM A 488 (-2.2A)","0.96A","6ay6A-3kswA:32.5","6ay6A-3kswA:36.65"],["6AY6_A_VORA501_1","3ksw","Trypanosoma cruzi","STEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",6,"TYR A 103;PHE A 110;ALA A 287;ALA A 291;THR A 295;CYH A 422","None;None;VNF A 490 ( 3.9A);VNF A 490 ( 4.0A);VNF A 490 ( 4.0A);HEM A 488 (-2.2A)","0.82A","6ay6A-3kswA:32.5","6ay6A-3kswA:36.65"],["6AY6_A_VORA501_1","3l4d","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",8,"TYR A 102;PHE A 109;TYR A 115;ALA A 286;ALA A 290;THR A 294;LEU A 355;CYH A 422","HEM A 481 (-4.7A);TPF A 490 (-4.5A);HEM A 481 ( 4.9A);TPF A 490 (-3.4A);TPF A 490 ( 3.4A);TPF A 490 ( 3.5A);TPF A 490 (-4.4A);HEM A 481 (-2.2A)","0.79A","6ay6A-3l4dA:46.6","6ay6A-3l4dA:36.02"],["6AY6_A_VORA501_1","3lij","Cryptosporidium parvum","CALCIUM\/CALMODULIN DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS","PF00069(Pkinase);PF13499(EF-hand_7)",5,"PHE A 505;THR A 437;LEU A 445;CYH A 513;LEU A 362","None","1.45A","6ay6A-3lijA:undetectable","6ay6A-3lijA:24.77"],["6AY6_A_VORA501_1","3lmb","Oleispira antarctica","UNCHARACTERIZED PROTEIN","PF09500(YiiD_C)",5,"PHE A 118;ALA A 128;ALA A 160;THR A  89;LEU A 132","None","1.43A","6ay6A-3lmbA:undetectable","6ay6A-3lmbA:15.40"],["6AY6_A_VORA501_1","3nvn","Homo sapiens","PLEXIN-C1","PF01437(PSI)",5,"TYR B 248;ALA B 163;ALA B 181;LEU B 225;LEU B 223","None","1.18A","6ay6A-3nvnB:undetectable","6ay6A-3nvnB:20.52"],["6AY6_A_VORA501_1","3o4o","Homo sapiens","INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN","PF13927(Ig_3)",5,"TYR B 101;ALA B  44;ALA B  41;LEU B  29;LEU B  48","NAG B 340 (-4.0A);None;None;None;None","1.10A","6ay6A-3o4oB:undetectable","6ay6A-3o4oB:18.99"],["6AY6_A_VORA501_1","3p0u","Homo sapiens","NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2","PF00104(Hormone_recep)",5,"ALA A 502;ALA A 451;THR A 447;LEU A 569;LEU A 514","None","1.36A","6ay6A-3p0uA:undetectable","6ay6A-3p0uA:20.48"],["6AY6_A_VORA501_1","3vyw","Aquifex aeolicus","MNMC2","PF05430(Methyltransf_30)",5,"TYR A  14;PHE A  34;TYR A  10;ALA A  38;LEU A 301","None","1.32A","6ay6A-3vywA:undetectable","6ay6A-3vywA:21.67"],["6AY6_A_VORA501_1","3wxo","Synechococcus elongatus","CATALASE-PEROXIDASE","PF00141(peroxidase)",5,"TYR A 154;ALA A 109;ALA A 149;LEU A 146;LEU A 135","None","1.14A","6ay6A-3wxoA:undetectable","6ay6A-3wxoA:19.78"],["6AY6_A_VORA501_1","4c60","Aspergillus niger","OCHRATOXINASE","PF01979(Amidohydro_1)",5,"TYR A 363;ALA A 403;ALA A 406;LEU A 325;CYH A 110","None","1.38A","6ay6A-4c60A:undetectable","6ay6A-4c60A:20.28"],["6AY6_A_VORA501_1","4g3j","Trypanosoma brucei","STEROL 14-ALPHA-DEMETHYLASE","PF00067(p450)",6,"PHE A 110;TYR A 103;ALA A 287;ALA A 291;THR A 295;CYH A 422","VNT A 502 (-4.4A);VNT A 502 ( 4.8A);VNT A 502 ( 3.9A);HEM A 501 ( 3.5A);VNT A 502 ( 3.2A);HEM A 501 (-2.3A)","1.18A","6ay6A-4g3jA:46.4","6ay6A-4g3jA:36.32"],["6AY6_A_VORA501_1","4g3j","Trypanosoma brucei","STEROL 14-ALPHA-DEMETHYLASE","PF00067(p450)",7,"PHE A 110;TYR A 116;ALA A 287;ALA A 291;THR A 295;LEU A 356;CYH A 422","VNT A 502 (-4.4A);HEM A 501 ( 4.5A);VNT A 502 ( 3.9A);HEM A 501 ( 3.5A);VNT A 502 ( 3.2A);VNT A 502 ( 4.5A);HEM A 501 (-2.3A)","0.73A","6ay6A-4g3jA:46.4","6ay6A-4g3jA:36.32"],["6AY6_A_VORA501_1","4g3j","Trypanosoma brucei","STEROL 14-ALPHA-DEMETHYLASE","PF00067(p450)",5,"TYR A 103;TYR A 116;THR A 295;LEU A 356;CYH A 422","VNT A 502 ( 4.8A);HEM A 501 ( 4.5A);VNT A 502 ( 3.2A);VNT A 502 ( 4.5A);HEM A 501 (-2.3A)","0.99A","6ay6A-4g3jA:46.4","6ay6A-4g3jA:36.32"],["6AY6_A_VORA501_1","4imp","Saccharopolyspora spinosa","POLYKETIDE SYNTHASE EXTENDER MODULES 3-4","PF08659(KR)",5,"ALA A 428;ALA A 424;THR A 376;LEU A 373;LEU A 167","None","1.15A","6ay6A-4impA:undetectable","6ay6A-4impA:21.75"],["6AY6_A_VORA501_1","4l4x","Streptomyces nodosus","AMPHI","PF08659(KR)",5,"ALA A 143;ALA A  89;LEU A 111;CYH A 117;LEU A  86","None","1.35A","6ay6A-4l4xA:undetectable","6ay6A-4l4xA:21.37"],["6AY6_A_VORA501_1","4mxw","Homo sapiens","LYMPHOTOXIN-BETA","no annotation",5,"TYR Y 136;ALA Y  89;THR Y 117;LEU Y 125;LEU Y 213","None","0.93A","6ay6A-4mxwY:undetectable","6ay6A-4mxwY:17.38"],["6AY6_A_VORA501_1","4uhi","Homo sapiens","STEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",6,"TYR A 131;PHE A 139;TYR A 145;ALA A 311;THR A 315;CYH A 449","VFV A 580 (-4.1A);VFV A 580 (-4.2A);HEM A 540 (-4.5A);HEM A 540 ( 3.4A);HEM A 540 (-3.6A);HEM A 540 (-2.3A)","0.71A","6ay6A-4uhiA:48.2","6ay6A-4uhiA:39.74"],["6AY6_A_VORA501_1","4uym","Aspergillus fumigatus","14-ALPHA STEROL DEMETHYLASE","PF00067(p450)",6,"TYR A 122;PHE A 130;TYR A 136;ALA A 303;ALA A 307;CYH A 463","VOR A 590 (-3.8A);VOR A 590 (-4.6A);HEM A 580 (-4.6A);VOR A 590 ( 4.4A);VOR A 590 ( 4.0A);HEM A 580 (-2.3A)","0.81A","6ay6A-4uymA:43.9","6ay6A-4uymA:35.33"],["6AY6_A_VORA501_1","4xkz","Pseudomonas aeruginosa","VALINE-TRNA LIGASE","PF08264(Anticodon_1)",5,"TYR A 713;TYR A 709;ALA A 646;THR A 658;LEU A 721","None","1.39A","6ay6A-4xkzA:undetectable","6ay6A-4xkzA:19.57"],["6AY6_A_VORA501_1","5cu1","Ruegeria pomeroyi","DMSP LYASE","PF16867(DMSP_lyase)",5,"TYR A  98;ALA A  71;ALA A  68;LEU A 139;LEU A  57","None","1.41A","6ay6A-5cu1A:undetectable","6ay6A-5cu1A:18.57"],["6AY6_A_VORA501_1","5e9g","Magnaporthe oryzae","ISOCITRATE LYASE","PF00463(ICL)",5,"ALA A 251;ALA A 401;LEU A  68;CYH A 462;LEU A 247","None","1.43A","6ay6A-5e9gA:undetectable","6ay6A-5e9gA:22.63"],["6AY6_A_VORA501_1","5fsa","Candida albicans","CYP51 VARIANT1","PF00067(p450)",6,"TYR A 118;PHE A 126;TYR A 132;THR A 311;LEU A 376;CYH A 470","X2N A 590 ( 4.0A);X2N A 590 (-4.8A);HEM A 580 (-4.1A);HEM A 580 (-3.6A);X2N A 590 (-4.3A);HEM A 580 (-2.2A)","0.73A","6ay6A-5fsaA:43.5","6ay6A-5fsaA:36.91"],["6AY6_A_VORA501_1","5hs1","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",6,"TYR A 126;PHE A 134;TYR A 140;THR A 318;LEU A 380;CYH A 470","VOR A 602 ( 3.8A);VOR A 602 (-4.7A);HEM A 601 (-4.3A);HEM A 601 (-3.4A);VOR A 602 (-4.0A);HEM A 601 (-2.4A)","0.49A","6ay6A-5hs1A:42.6","6ay6A-5hs1A:32.59"],["6AY6_A_VORA501_1","5jlc","[Candida] glabrata","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",6,"TYR A 127;PHE A 135;TYR A 141;THR A 319;LEU A 381;CYH A 472","1YN A 602 ( 3.8A);1YN A 602 ( 4.6A);HEM A 601 (-4.2A);HEM A 601 ( 3.5A);1YN A 602 ( 4.7A);HEM A 601 (-2.3A)","0.50A","6ay6A-5jlcA:42.2","6ay6A-5jlcA:32.26"],["6AY6_A_VORA501_1","5ks8","Methylobacillus flagellatus","PYRUVATE CARBOXYLASE SUBUNIT ALPHA","PF00289(Biotin_carb_N);PF02785(Biotin_carb_C);PF02786(CPSase_L_D2)",5,"TYR A  59;ALA A  14;ALA A  30;LEU A  68;LEU A  77","None","1.18A","6ay6A-5ks8A:undetectable","6ay6A-5ks8A:21.03"],["6AY6_A_VORA501_1","5nva","Proteus mirabilis","PUTATIVE SODIUM:SOLUTE SYMPORTER","no annotation",5,"TYR A 169;ALA A 338;ALA A 340;THR A 140;LEU A 161","None","1.49A","6ay6A-5nvaA:undetectable","6ay6A-5nvaA:10.24"],["6AY6_A_VORA501_1","6all","Bacillus anthracis","FE(3+)-CITRATE-BINDING PROTEIN YFMC","PF01497(Peripla_BP_2)",5,"TYR A 294;ALA A 202;ALA A 200;THR A 234;LEU A 231","None","1.35A","6ay6A-6allA:undetectable","6ay6A-6allA:22.65"],["6AY6_A_VORA501_1","6ay4","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","no annotation",8,"TYR A 107;PHE A 114;ALA A 289;ALA A 293;THR A 297;LEU A 358;CYH A 430;LEU A 467","TPF A 506 (-4.2A);TPF A 506 (-4.4A);TPF A 506 (-3.5A);TPF A 506 ( 3.2A);HEM A 501 (-3.4A);TPF A 506 ( 4.4A);HEM A 501 ( 1.8A);EDO A 503 (-4.2A)","0.50A","6ay6A-6ay4A:63.1","6ay6A-6ay4A:100.00"],["6AY6_A_VORA501_1","6ay4","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","no annotation",8,"TYR A 107;PHE A 114;TYR A 120;ALA A 289;ALA A 293;THR A 297;LEU A 358;CYH A 430","TPF A 506 (-4.2A);TPF A 506 (-4.4A);None;TPF A 506 (-3.5A);TPF A 506 ( 3.2A);HEM A 501 (-3.4A);TPF A 506 ( 4.4A);HEM A 501 ( 1.8A)","0.51A","6ay6A-6ay4A:63.1","6ay6A-6ay4A:100.00"],["6AY6_A_VORA501_1","6c93","Oryctolagus cuniculus","CYTOCHROME P450 4B1","no annotation",5,"TYR A 110;ALA A 310;THR A 314;CYH A 448;LEU A 485","HEM A 600 (-4.4A);HEM A 600 ( 3.2A);HEM A 600 ( 3.7A);HEM A 600 (-2.1A);OCT A 601 ( 4.9A)","0.86A","6ay6A-6c93A:36.6","6ay6A-6c93A:11.18"],["6AY6_A_VORA501_1","6cf8","Campylobacter jejuni","LYTIC TRANSGLYCOSYLASE","no annotation",5,"TYR A 369;PHE A 393;ALA A 387;ALA A 385;LEU A 516","None","1.42A","6ay6A-6cf8A:undetectable","6ay6A-6cf8A:12.65"]]