SIMILAR PATTERNS OF AMINO ACIDS FOR 6AWV_A_BEZA202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 PHE A 164
ASP A 160
LEU A 227
LYS A 231
 None
 1.45A 6awvA-1dj0A:
1.9		 6awvA-1dj0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PHE A  76
ASP A  72
LEU A  80
LYS A  75
 None
 1.25A 6awvA-1fw8A:
0.0		 6awvA-1fw8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		4 PHE A6173
ASP A6172
LEU A6177
LYS A6176
 None
 1.48A 6awvA-1koaA:
1.0		 6awvA-1koaA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly7 FRATAXIN

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		4 PHE A 120
ASP A 122
LEU A 140
LYS A 135
 None
 1.24A 6awvA-1ly7A:
0.1		 6awvA-1ly7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 PHE A 300
ASP A 299
LEU A 304
LYS A 303
 None
 1.32A 6awvA-1m2pA:
0.0		 6awvA-1m2pA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		4 PHE A 171
ASP A 168
LEU A  63
LYS A  62
 None
 1.48A 6awvA-1r4vA:
0.0		 6awvA-1r4vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tig TRANSLATION
INITIATION FACTOR 3

(Geobacillus
stearothermophilus) 		PF00707
(IF3_C) 		4 PHE A  99
ASP A  98
LEU A 140
LYS A 102
 None
 1.44A 6awvA-1tigA:
undetectable		 6awvA-1tigA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 PHE A 126
ASP A 131
LEU A 218
LYS A 184
 None
 1.31A 6awvA-1wstA:
1.5		 6awvA-1wstA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzx COG3291: FOG: PKD
REPEAT

(Ruminiclostridium
thermocellum) 		no annotation 4 PHE A  89
ASP A 174
LEU A  87
LYS A 176
 None
 1.08A 6awvA-1wzxA:
0.0		 6awvA-1wzxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 PHE A 640
ASP A 639
LEU A 644
LYS A 643
 None
 1.46A 6awvA-1xmjA:
undetectable		 6awvA-1xmjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		4 PHE A 297
ASP A 296
LEU A 301
LYS A 300
 None
 1.46A 6awvA-2basA:
undetectable		 6awvA-2basA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsr TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Streptococcus
pneumoniae) 		PF03461
(TRCF) 		4 PHE A1136
ASP A1137
LEU A1116
LYS A1122
 None
 1.40A 6awvA-2qsrA:
undetectable		 6awvA-2qsrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		4 PHE A 488
ASP A 467
LEU A 486
LYS A 465
 None
 1.38A 6awvA-2qv3A:
undetectable		 6awvA-2qv3A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		4 PHE A  13
ASP A  90
LEU A  69
LYS A  93
 None
 1.41A 6awvA-2qw8A:
undetectable		 6awvA-2qw8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE

(Aquifex
aeolicus) 		PF13419
(HAD_2) 		4 PHE A 124
ASP A 125
LEU A  90
LYS A  94
 None
 1.13A 6awvA-2yy6A:
undetectable		 6awvA-2yy6A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 PHE A 340
ASP A 260
LEU A 345
LYS A 343
 None
 1.15A 6awvA-2z87A:
undetectable		 6awvA-2z87A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		4 PHE A 198
ASP A 197
LEU A 202
LYS A 200
 None
 1.35A 6awvA-3cq0A:
undetectable		 6awvA-3cq0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 PHE A 473
ASP A 472
LEU A 477
LYS A 476
 None
 1.32A 6awvA-3f6tA:
undetectable		 6awvA-3f6tA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 PHE A 311
ASP A 310
LEU A 203
LYS A 314
 None
 1.06A 6awvA-3f70A:
undetectable		 6awvA-3f70A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 PHE A 312
ASP A 309
LEU A 300
LYS A 319
 None
 1.38A 6awvA-3oy2A:
undetectable		 6awvA-3oy2A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rui UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF) 		4 PHE A 353
ASP A 355
LEU A 369
LYS A 379
 None
 1.28A 6awvA-3ruiA:
undetectable		 6awvA-3ruiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		4 PHE A 801
ASP A 799
LEU A 815
LYS A 813
 None
 1.29A 6awvA-3ubhA:
undetectable		 6awvA-3ubhA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 PHE A 295
ASP A 305
LEU A 310
LYS A 309
 None
 1.18A 6awvA-3welA:
undetectable		 6awvA-3welA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 PHE A 256
ASP A 258
LEU A 668
LYS A 667
 None
 1.30A 6awvA-3wonA:
undetectable		 6awvA-3wonA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		4 PHE A 334
ASP A 335
LEU A 332
LYS A 351
 None
 1.11A 6awvA-4ep0A:
undetectable		 6awvA-4ep0A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 PHE A 152
ASP A 157
LEU A 244
LYS A 210
 None
 1.36A 6awvA-4je5A:
undetectable		 6awvA-4je5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		4 PHE A 185
ASP A 184
LEU A 192
LYS A 187
 None
 0.92A 6awvA-4o8sA:
undetectable		 6awvA-4o8sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01209
(Ubie_methyltran) 		4 PHE A 115
ASP A 145
LEU A 113
LYS A 191
 None
 1.30A 6awvA-4obwA:
undetectable		 6awvA-4obwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok0 PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		4 PHE A 185
ASP A 184
LEU A 192
LYS A 187
 None
 0.84A 6awvA-4ok0A:
undetectable		 6awvA-4ok0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		4 PHE A 414
ASP A 412
LEU A 331
LYS A 330
 None
 1.46A 6awvA-4q76A:
undetectable		 6awvA-4q76A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 PHE A 280
ASP A 279
LEU A 284
LYS A 283
 None
 1.14A 6awvA-4y0iA:
undetectable		 6awvA-4y0iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m38 OMPA FAMILY PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A  11
ASP A  12
LEU A  18
LYS A  19
 None
 1.26A 6awvA-5m38A:
undetectable		 6awvA-5m38A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6n BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00653
(BIR) 		4 PHE A 324
ASP A 304
LEU A 307
LYS A 299
 7H9  A1004 (-4.0A)
None
7H9  A1004 (-3.4A)
None
 1.32A 6awvA-5m6nA:
undetectable		 6awvA-5m6nA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 PHE A 248
ASP A 247
LEU A 252
LYS A 251
 None
 1.34A 6awvA-5no8A:
undetectable		 6awvA-5no8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 4 PHE A  64
ASP A  63
LEU A  68
LYS A  67
 None
 1.13A 6awvA-5vfaA:
undetectable		 6awvA-5vfaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 4 PHE X 256
ASP X 255
LEU X 260
LYS X 258
 None
 1.19A 6awvA-5vtmX:
undetectable		 6awvA-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 PHE A 439
ASP A 438
LEU A 443
LYS A 441
 None
 1.24A 6awvA-6ao5A:
undetectable		 6awvA-6ao5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 PHE A 283
ASP A 284
LEU A 236
LYS A 240
 None
 1.10A 6awvA-6dd3A:
undetectable		 6awvA-6dd3A:
undetectable