SIMILAR PATTERNS OF AMINO ACIDS FOR 6AWT_D_BEZD202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avq LAMBDA EXONUCLEASE

(Escherichia
virus Lambda) 		PF09588
(YqaJ) 		3 PHE A 142
ASP A 138
LYS A 141
 None
 0.78A 6awtD-1avqA:
0.0		 6awtD-1avqA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		3 PHE A  87
ASP A  92
LYS A 139
 None
 0.83A 6awtD-1cs1A:
1.0		 6awtD-1cs1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A  39
ASP A  38
LYS A  42
 None
 0.83A 6awtD-1d6hA:
0.0		 6awtD-1d6hA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		3 PHE A  20
ASP A  22
LYS A  25
 None
 0.89A 6awtD-1hi9A:
0.0		 6awtD-1hi9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 PHE A 267
ASP A 270
LYS A 274
 HEM  A 402 (-4.7A)
None
None
 0.86A 6awtD-1iqcA:
0.0		 6awtD-1iqcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 PHE B 378
ASP B 374
LYS B 369
 None
 0.79A 6awtD-1mhyB:
0.0		 6awtD-1mhyB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		3 PHE A  78
ASP A  74
LYS A  77
 HEM  A 150 (-4.5A)
None
None
 0.89A 6awtD-1mqvA:
undetectable		 6awtD-1mqvA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 PHE A 549
ASP A 513
LYS A 550
 None
 0.87A 6awtD-1ot5A:
0.0		 6awtD-1ot5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		3 PHE B 221
ASP B 223
LYS B 188
 None
 0.88A 6awtD-1pk6B:
0.0		 6awtD-1pk6B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 PHE A 355
ASP A 350
LYS A 352
 None
 0.84A 6awtD-1qu2A:
undetectable		 6awtD-1qu2A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		3 PHE A 483
ASP A 486
LYS A 490
 SAH  A 801 ( 4.7A)
None
None
 0.79A 6awtD-1u2zA:
undetectable		 6awtD-1u2zA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1h FIBRITIN, FIBER
PROTEIN

(Escherichia
virus T4;
Human
mastadenovirus
C) 		PF00608
(Adeno_shaft)
PF07921
(Fibritin_C) 		3 PHE A 344
ASP A 345
LYS A 358
 None
 0.86A 6awtD-1v1hA:
undetectable		 6awtD-1v1hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzx COG3291: FOG: PKD
REPEAT

(Ruminiclostridium
thermocellum) 		no annotation 3 PHE A  89
ASP A 174
LYS A 176
 None
 0.83A 6awtD-1wzxA:
undetectable		 6awtD-1wzxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 PHE A 146
ASP A 147
LYS A 158
 None
 0.74A 6awtD-1z7cA:
undetectable		 6awtD-1z7cA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 PHE A 197
ASP A 196
LYS A 200
 None
 0.77A 6awtD-2as9A:
undetectable		 6awtD-2as9A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN

(Bulinus
truncatus) 		PF02931
(Neur_chan_LBD) 		3 PHE A 170
ASP A 171
LYS A 203
 None
 0.89A 6awtD-2bj0A:
undetectable		 6awtD-2bj0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		3 PHE A 168
ASP A 167
LYS A 171
 None
 0.82A 6awtD-2c08A:
undetectable		 6awtD-2c08A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		3 PHE A 103
ASP A 104
LYS A  59
 None
 0.72A 6awtD-2c1cA:
undetectable		 6awtD-2c1cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 PHE A 449
ASP A 289
LYS A 295
 None
 0.88A 6awtD-2d7iA:
undetectable		 6awtD-2d7iA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 PHE A 284
ASP A 283
LYS A 287
 None
 0.88A 6awtD-2e5vA:
undetectable		 6awtD-2e5vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		3 PHE A 130
ASP A  84
LYS A 109
 None
 0.69A 6awtD-2hdwA:
undetectable		 6awtD-2hdwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 PHE A 236
ASP A 185
LYS A 259
 None
 0.68A 6awtD-2htvA:
undetectable		 6awtD-2htvA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		3 PHE A  52
ASP A  47
LYS A  77
 None
 0.88A 6awtD-2i0oA:
undetectable		 6awtD-2i0oA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD

(Escherichia
coli) 		PF00691
(OmpA) 		3 PHE A  38
ASP A  39
LYS A  46
 None
 0.82A 6awtD-2k1sA:
undetectable		 6awtD-2k1sA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A 234
ASP A 271
LYS A 266
 None
 0.88A 6awtD-2o14A:
undetectable		 6awtD-2o14A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 PHE A  76
ASP A  41
LYS A  46
 None
 0.88A 6awtD-2o3jA:
undetectable		 6awtD-2o3jA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		3 PHE B 192
ASP B  77
LYS B  80
 None
 0.79A 6awtD-2odrB:
undetectable		 6awtD-2odrB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 PHE A 324
ASP A 323
LYS A 327
 None
 0.87A 6awtD-2okjA:
undetectable		 6awtD-2okjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		3 PHE A1006
ASP A1005
LYS A1009
 None
 0.85A 6awtD-2p3vA:
undetectable		 6awtD-2p3vA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcs CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF06240
(COXG) 		3 PHE A 136
ASP A 135
LYS A 139
 UNL  A 161 (-4.2A)
None
None
 0.79A 6awtD-2pcsA:
13.4		 6awtD-2pcsA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qen WALKER-TYPE ATPASE

(Pyrococcus
abyssi) 		PF01637
(ATPase_2) 		3 PHE A 180
ASP A 179
LYS A 182
 None
 0.84A 6awtD-2qenA:
undetectable		 6awtD-2qenA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 PHE A 203
ASP A 202
LYS A 198
 None
 0.83A 6awtD-2r5gA:
undetectable		 6awtD-2r5gA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		3 PHE A  23
ASP A  22
LYS A  14
 None
 0.70A 6awtD-2ri6A:
undetectable		 6awtD-2ri6A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy POTENTIAL
COPPER-TRANSPORTING
ATPASE

(Bacillus
subtilis) 		PF00403
(HMA) 		3 PHE A   7
ASP A   8
LYS A  71
 None
 0.87A 6awtD-2voyA:
undetectable		 6awtD-2voyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		3 PHE A 240
ASP A 241
LYS A 244
 None
None
UPG  A1415 (-3.3A)
 0.88A 6awtD-2xa2A:
undetectable		 6awtD-2xa2A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		3 PHE A 191
ASP A 193
LYS A 124
 None
 0.62A 6awtD-2xrcA:
undetectable		 6awtD-2xrcA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		3 PHE A 269
ASP A 270
LYS A 145
 UNL  A 501 (-4.4A)
None
None
 0.85A 6awtD-3d1cA:
undetectable		 6awtD-3d1cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 PHE A 233
ASP A 229
LYS A 232
 None
 0.85A 6awtD-3f41A:
undetectable		 6awtD-3f41A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		3 PHE A   8
ASP A  40
LYS A   5
 None
 0.84A 6awtD-3g8rA:
undetectable		 6awtD-3g8rA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 PHE A  36
ASP A  37
LYS A   3
 None
 0.75A 6awtD-3i12A:
1.7		 6awtD-3i12A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		3 PHE A 993
ASP A1008
LYS A1011
 None
 0.75A 6awtD-3jbyA:
undetectable		 6awtD-3jbyA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		3 PHE A 177
ASP A 176
LYS A 180
 None
 0.85A 6awtD-3k55A:
1.4		 6awtD-3k55A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 PHE A 276
ASP A 277
LYS A 299
 None
 0.82A 6awtD-3lk6A:
undetectable		 6awtD-3lk6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		3 PHE A 197
ASP A 176
LYS A   3
 None
 0.83A 6awtD-3mr1A:
undetectable		 6awtD-3mr1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		3 PHE A  21
ASP A  20
LYS A  24
 None
 0.85A 6awtD-3ph3A:
undetectable		 6awtD-3ph3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A  92
ASP A  93
LYS A 121
 EFE  A 701 (-4.7A)
None
None
 0.77A 6awtD-3qlbA:
2.4		 6awtD-3qlbA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		3 PHE A 643
ASP A 699
LYS A 695
 None
 0.85A 6awtD-3tswA:
undetectable		 6awtD-3tswA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		3 PHE A 387
ASP A 386
LYS A 390
 None
 0.87A 6awtD-3utoA:
undetectable		 6awtD-3utoA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		3 PHE A  95
ASP A  96
LYS A 367
 None
 0.87A 6awtD-3v8dA:
undetectable		 6awtD-3v8dA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		3 PHE A 295
ASP A 305
LYS A 309
 None
 0.87A 6awtD-3welA:
undetectable		 6awtD-3welA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		3 PHE A 139
ASP A 140
LYS A 125
 None
 0.84A 6awtD-4alqA:
undetectable		 6awtD-4alqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		3 PHE A 193
ASP A 195
LYS A 184
 None
 0.80A 6awtD-4aoeA:
undetectable		 6awtD-4aoeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 PHE A 472
ASP A 683
LYS A 686
 None
 0.75A 6awtD-4btpA:
undetectable		 6awtD-4btpA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		3 PHE A 433
ASP A 435
LYS A 438
 None
 0.83A 6awtD-4c2fA:
undetectable		 6awtD-4c2fA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 PHE A 481
ASP A 480
LYS A 484
 None
 0.72A 6awtD-4cczA:
undetectable		 6awtD-4cczA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		3 PHE A 224
ASP A 223
LYS A 227
 None
 0.82A 6awtD-4drsA:
undetectable		 6awtD-4drsA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		3 PHE A 109
ASP A 111
LYS A 106
 None
 0.81A 6awtD-4f53A:
undetectable		 6awtD-4f53A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 PHE A  48
ASP A  44
LYS A  47
 None
 0.82A 6awtD-4g1pA:
3.1		 6awtD-4g1pA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		3 PHE A 384
ASP A 383
LYS A 387
 None
 0.85A 6awtD-4gkpA:
undetectable		 6awtD-4gkpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ife GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF04466
(Terminase_3)
PF17288
(Terminase_3C) 		3 PHE A 139
ASP A 113
LYS A 137
 None
 0.80A 6awtD-4ifeA:
undetectable		 6awtD-4ifeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krr WNT INHIBITOR OF
DORSAL PROTEIN

(Drosophila
melanogaster) 		PF00110
(wnt) 		3 PHE A  67
ASP A  66
LYS A  70
 None
 0.85A 6awtD-4krrA:
undetectable		 6awtD-4krrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		3 PHE A 417
ASP A 438
LYS A 442
 None
 0.86A 6awtD-4kvoA:
undetectable		 6awtD-4kvoA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A  27
ASP A  28
LYS A  47
 None
 0.68A 6awtD-4lg4A:
undetectable		 6awtD-4lg4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 PHE A 106
ASP A 108
LYS A 103
 None
 0.85A 6awtD-4mruA:
undetectable		 6awtD-4mruA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n01 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 PHE A 279
ASP A 278
LYS A 282
 None
 0.79A 6awtD-4n01A:
undetectable		 6awtD-4n01A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		3 PHE A  58
ASP A  59
LYS A  38
 None
 0.88A 6awtD-4o8sA:
undetectable		 6awtD-4o8sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		3 PHE B 665
ASP B 661
LYS B 664
 None
 0.80A 6awtD-4oavB:
undetectable		 6awtD-4oavB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok0 PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		3 PHE A 185
ASP A 184
LYS A 187
 None
 0.83A 6awtD-4ok0A:
undetectable		 6awtD-4ok0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE

(Streptomyces
melanosporofaciens) 		no annotation 3 PHE A 185
ASP A 184
LYS A 188
 None
 0.86A 6awtD-4omgA:
undetectable		 6awtD-4omgA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov1 PUTATIVE FERREDOXIN

(Rhodopseudomonas
palustris) 		PF13459
(Fer4_15) 		3 PHE A  28
ASP A  29
LYS A  39
 PHE  A  28 ( 1.3A)
ASP  A  29 ( 0.6A)
LYS  A  39 ( 0.0A)
 0.75A 6awtD-4ov1A:
undetectable		 6awtD-4ov1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		3 PHE A   5
ASP A  86
LYS A   4
 None
 0.85A 6awtD-4rhmA:
undetectable		 6awtD-4rhmA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		3 PHE A 317
ASP A 316
LYS A 320
 None
 0.88A 6awtD-4rkkA:
undetectable		 6awtD-4rkkA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		3 PHE A 304
ASP A 303
LYS A 348
 None
 0.87A 6awtD-4roaA:
undetectable		 6awtD-4roaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 PHE A 184
ASP A 186
LYS A 189
 None
 0.82A 6awtD-4u2mA:
undetectable		 6awtD-4u2mA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 PHE A 974
ASP A 976
LYS A 980
 None
 0.83A 6awtD-4uvkA:
undetectable		 6awtD-4uvkA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE

(Picrophilus
torridus) 		PF00701
(DHDPS) 		3 PHE A  62
ASP A  58
LYS A  61
 None
 0.84A 6awtD-4uxdA:
undetectable		 6awtD-4uxdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wat PFRH5

(Plasmodium
falciparum) 		no annotation 3 PHE A 450
ASP A 453
LYS A 457
 None
 0.83A 6awtD-4watA:
undetectable		 6awtD-4watA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1

(Danio rerio) 		PF05301
(Acetyltransf_16) 		3 PHE A 136
ASP A 135
LYS A 139
 None
 0.85A 6awtD-4yrhA:
undetectable		 6awtD-4yrhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 PHE A 761
ASP A 759
LYS A 701
 None
 0.85A 6awtD-4zktA:
undetectable		 6awtD-4zktA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af0 MAELSTROM

(Bombyx mori) 		PF13017
(Maelstrom) 		3 PHE A 143
ASP A 147
LYS A 150
 None
 0.84A 6awtD-5af0A:
undetectable		 6awtD-5af0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 PHE A1208
ASP A1207
LYS A1211
 None
 0.77A 6awtD-5amqA:
3.9		 6awtD-5amqA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		3 PHE O 233
ASP O 232
LYS O 236
 None
 0.88A 6awtD-5crjO:
undetectable		 6awtD-5crjO:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5x PUTATIVE
TRANSCRIPTION FACTOR

(Chaetomium
thermophilum) 		PF00447
(HSF_DNA-bind) 		3 PHE B  43
ASP B  42
LYS B  46
 None
 0.86A 6awtD-5d5xB:
undetectable		 6awtD-5d5xB:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		3 PHE A 421
ASP A 422
LYS A 451
 None
 0.82A 6awtD-5e78A:
undetectable		 6awtD-5e78A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		3 PHE A  93
ASP A  94
LYS A 113
 None
 0.80A 6awtD-5eykA:
undetectable		 6awtD-5eykA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjq UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 PHE x 159
ASP x 160
LYS x 133
 None
 0.81A 6awtD-5gjqx:
undetectable		 6awtD-5gjqx:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m38 OMPA FAMILY PROTEIN

(Escherichia
coli) 		no annotation 3 PHE A  11
ASP A  12
LYS A  19
 None
 0.88A 6awtD-5m38A:
undetectable		 6awtD-5m38A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxb CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN

(Lupinus luteus) 		no annotation 3 PHE A   5
ASP A   7
LYS A 136
 UNL  A 203 ( 3.8A)
UNL  A 213 ( 4.8A)
None
 0.53A 6awtD-5mxbA:
21.4		 6awtD-5mxbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 3 PHE A 205
ASP A 204
LYS A 208
 None
 0.62A 6awtD-5npuA:
undetectable		 6awtD-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 PHE A 331
ASP A 330
LYS A 334
 None
 0.86A 6awtD-5nqdA:
undetectable		 6awtD-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 PHE A1337
ASP A1336
LYS A1340
 None
 0.70A 6awtD-5u1sA:
undetectable		 6awtD-5u1sA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6i TMV RESISTANCE
PROTEIN Y3

(Coprinus
comatus) 		no annotation 3 PHE A  43
ASP A  41
LYS A  91
 None
 0.88A 6awtD-5v6iA:
undetectable		 6awtD-5v6iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 3 PHE A 187
ASP A 186
LYS A 190
 None
 0.79A 6awtD-5vyoA:
undetectable		 6awtD-5vyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 3 PHE A 680
ASP A 679
LYS A 683
 None
None
U  B  43 ( 2.8A)
 0.88A 6awtD-5xwyA:
undetectable		 6awtD-5xwyA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y83 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 3 PHE A  44
ASP A  45
LYS A  52
 None
 0.87A 6awtD-5y83A:
undetectable		 6awtD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 3 PHE B 224
ASP B 223
LYS B 227
 None
 0.86A 6awtD-5yk7B:
2.5		 6awtD-5yk7B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 3 PHE A 147
ASP A 143
LYS A 146
 None
CA  A 302 (-3.4A)
CA  A 302 ( 4.5A)
 0.82A 6awtD-5zdmA:
undetectable		 6awtD-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 PHE A 227
ASP A 226
LYS A 230
 None
 0.85A 6awtD-6bljA:
undetectable		 6awtD-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		no annotation 3 PHE A 153
ASP A 157
LYS A 161
 None
 0.88A 6awtD-6dclA:
undetectable		 6awtD-6dclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 PHE D 431
ASP D 433
LYS D 597
 None
 0.71A 6awtD-6eq8D:
undetectable		 6awtD-6eq8D:
undetectable