SIMILAR PATTERNS OF AMINO ACIDS FOR 6AV6_B_H4BB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		4 TRP A 242
PHE A 239
GLU A 241
ARG A 123
 None
 1.41A 6av6A-1dvkA:
undetectable
6av6B-1dvkA:
0.0		 6av6A-1dvkA:
21.60
6av6B-1dvkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 TRP A 325
PHE A  39
VAL A  63
ARG A  35
 None
 1.31A 6av6A-1gzvA:
0.0
6av6B-1gzvA:
0.0		 6av6A-1gzvA:
8.47
6av6B-1gzvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 TRP A 155
PHE A 156
GLU A 154
ARG A 340
 None
 1.30A 6av6A-1l5jA:
0.0
6av6B-1l5jA:
0.0		 6av6A-1l5jA:
7.08
6av6B-1l5jA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.17A 6av6A-1lzxA:
58.4
6av6B-1lzxA:
59.6		 6av6A-1lzxA:
10.19
6av6B-1lzxA:
10.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.12A 6av6A-1m9qA:
61.5
6av6B-1m9qA:
63.1		 6av6A-1m9qA:
100.00
6av6B-1m9qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.28A 6av6A-1qw5A:
45.8
6av6B-1qw5A:
56.8		 6av6A-1qw5A:
12.12
6av6B-1qw5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.14A 6av6A-1y4jA:
0.0
6av6B-1y4jA:
0.0		 6av6A-1y4jA:
13.38
6av6B-1y4jA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		4 PHE A 123
GLU A  30
VAL A  27
TRP A  15
 None
 1.34A 6av6A-2d9jA:
undetectable
6av6B-2d9jA:
undetectable		 6av6A-2d9jA:
18.31
6av6B-2d9jA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.27A 6av6A-2hi8X:
0.0
6av6B-2hi8X:
0.0		 6av6A-2hi8X:
13.64
6av6B-2hi8X:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 PHE A  29
GLU A  27
VAL A  23
ARG A 116
 None
 1.25A 6av6A-2incA:
0.0
6av6B-2incA:
undetectable		 6av6A-2incA:
8.09
6av6B-2incA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		4 TRP A 166
TRP A 236
GLU A 235
TRP A 234
 None
 1.27A 6av6A-2q17A:
undetectable
6av6B-2q17A:
undetectable		 6av6A-2q17A:
11.56
6av6B-2q17A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.12A 6av6A-2rdyA:
undetectable
6av6B-2rdyA:
undetectable		 6av6A-2rdyA:
6.76
6av6B-2rdyA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 PHE A  41
GLU A  38
VAL A  37
TRP A  22
 None
 1.40A 6av6A-2rttA:
undetectable
6av6B-2rttA:
undetectable		 6av6A-2rttA:
22.61
6av6B-2rttA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqx ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		4 TRP A 840
PHE A 816
GLU A 826
VAL A 811
 None
 1.49A 6av6A-2xqxA:
undetectable
6av6B-2xqxA:
undetectable		 6av6A-2xqxA:
18.37
6av6B-2xqxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.33A 6av6A-3a2fA:
0.0
6av6B-3a2fA:
undetectable		 6av6A-3a2fA:
6.60
6av6B-3a2fA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 TRP A 485
PHE A 489
GLU A 484
ARG A 437
 None
 0.99A 6av6A-3ckbA:
undetectable
6av6B-3ckbA:
0.0		 6av6A-3ckbA:
11.08
6av6B-3ckbA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.21A 6av6A-3e7gA:
42.7
6av6B-3e7gA:
55.7		 6av6A-3e7gA:
11.57
6av6B-3e7gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 6av6A-3g1nA:
undetectable
6av6B-3g1nA:
undetectable		 6av6A-3g1nA:
10.57
6av6B-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.92A 6av6A-3k25A:
undetectable
6av6B-3k25A:
undetectable		 6av6A-3k25A:
17.86
6av6B-3k25A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 PHE A 133
GLU A 122
VAL A 120
ARG A  69
 None
 1.32A 6av6A-3lccA:
undetectable
6av6B-3lccA:
undetectable		 6av6A-3lccA:
17.06
6av6B-3lccA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 PHE A  67
GLU A  73
VAL A  72
TRP A  71
 None
None
None
PVG  A 201 (-3.6A)
 1.05A 6av6A-3vv4A:
undetectable
6av6B-3vv4A:
undetectable		 6av6A-3vv4A:
15.14
6av6B-3vv4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.31A 6av6A-4fcsA:
undetectable
6av6B-4fcsA:
undetectable		 6av6A-4fcsA:
14.92
6av6B-4fcsA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		4 TRP A 107
PHE A  90
GLU A 133
VAL A 130
 None
 1.50A 6av6A-4gf8A:
undetectable
6av6B-4gf8A:
0.0		 6av6A-4gf8A:
10.10
6av6B-4gf8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TRP A   9
GLU A 421
VAL A 420
TRP A 183
 None
 1.47A 6av6A-4gi2A:
undetectable
6av6B-4gi2A:
undetectable		 6av6A-4gi2A:
11.92
6av6B-4gi2A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.33A 6av6A-4j3qA:
undetectable
6av6B-4j3qA:
undetectable		 6av6A-4j3qA:
12.50
6av6B-4j3qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 TRP A 218
PHE A 286
ARG A 385
TRP A 387
 None
 1.35A 6av6A-4mh1A:
undetectable
6av6B-4mh1A:
undetectable		 6av6A-4mh1A:
12.15
6av6B-4mh1A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 PHE A  28
GLU A  25
VAL A  71
ARG A  58
 None
 1.14A 6av6A-4o6xA:
undetectable
6av6B-4o6xA:
undetectable		 6av6A-4o6xA:
16.24
6av6B-4o6xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 TRP A 428
PHE A 431
GLU A 429
ARG A   9
 None
 1.50A 6av6A-4qbuA:
undetectable
6av6B-4qbuA:
undetectable		 6av6A-4qbuA:
10.38
6av6B-4qbuA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 6av6A-4u3vA:
undetectable
6av6B-4u3vA:
undetectable		 6av6A-4u3vA:
13.10
6av6B-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.12A 6av6A-4x8dA:
undetectable
6av6B-4x8dA:
0.0		 6av6A-4x8dA:
10.88
6av6B-4x8dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 TRP A 288
PHE A  13
GLU A  33
VAL A  36
 None
 1.43A 6av6A-5ft6A:
0.0
6av6B-5ft6A:
undetectable		 6av6A-5ft6A:
12.37
6av6B-5ft6A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 6av6A-5gn5A:
undetectable
6av6B-5gn5A:
undetectable		 6av6A-5gn5A:
11.27
6av6B-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		4 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.50A 6av6A-5i2uA:
undetectable
6av6B-5i2uA:
undetectable		 6av6A-5i2uA:
11.87
6av6B-5i2uA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 347
PHE A 290
VAL A 341
TRP A 323
 None
 1.13A 6av6A-5jseA:
undetectable
6av6B-5jseA:
undetectable		 6av6A-5jseA:
7.63
6av6B-5jseA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.33A 6av6A-5k1hB:
undetectable
6av6B-5k1hB:
undetectable		 6av6A-5k1hB:
8.87
6av6B-5k1hB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.36A 6av6A-5l46A:
undetectable
6av6B-5l46A:
undetectable		 6av6A-5l46A:
6.53
6av6B-5l46A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.20A 6av6A-5lp8B:
undetectable
6av6B-5lp8B:
undetectable		 6av6A-5lp8B:
10.22
6av6B-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 6av6A-5m8tA:
undetectable
6av6B-5m8tA:
undetectable		 6av6A-5m8tA:
10.72
6av6B-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 TRP A 599
PHE A 606
VAL A 538
ARG A 205
 None
 1.43A 6av6A-5no8A:
undetectable
6av6B-5no8A:
undetectable		 6av6A-5no8A:
8.38
6av6B-5no8A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.13A 6av6A-5nyyA:
undetectable
6av6B-5nyyA:
undetectable		 6av6A-5nyyA:
14.72
6av6B-5nyyA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.37A 6av6A-5or4A:
undetectable
6av6B-5or4A:
undetectable		 6av6A-5or4A:
22.47
6av6B-5or4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 PHE A  49
GLU A  54
VAL A  57
TRP A  56
 None
 0.98A 6av6A-5vyoA:
0.0
6av6B-5vyoA:
undetectable		 6av6A-5vyoA:
22.22
6av6B-5vyoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 4 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.32A 6av6A-6gk6A:
0.0
6av6B-6gk6A:
undetectable		 6av6A-6gk6A:
undetectable
6av6B-6gk6A:
undetectable