SIMILAR PATTERNS OF AMINO ACIDS FOR 6AV2_A_H4BA802_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | VAL A 667TRP A 673PHE A 681GLU A 649 | None | 1.36A | 6av2A-1c4kA:0.06av2B-1c4kA:0.0 | 6av2A-1c4kA:7.306av2B-1c4kA:7.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dvk | PRP18 (Saccharomycescerevisiae) |
PF02840(Prp18) | 4 | ARG A 123TRP A 242PHE A 239GLU A 241 | None | 1.46A | 6av2A-1dvkA:1.66av2B-1dvkA:1.5 | 6av2A-1dvkA:19.086av2B-1dvkA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | VAL A 41TRP A 521PHE A 501GLU A 519 | None | 1.30A | 6av2A-1flgA:0.06av2B-1flgA:0.0 | 6av2A-1flgA:9.396av2B-1flgA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 4 | MET C 291VAL C 216PHE C 360GLU C 353 | None | 1.38A | 6av2A-1h2tC:0.06av2B-1h2tC:0.0 | 6av2A-1h2tC:6.656av2B-1h2tC:6.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3j | PEROXIDASE (Coprinopsiscinerea) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | MET A 268VAL A 177TRP A 258PHE A 211 | NoneNoneNoneHSO A 183 ( 3.5A) | 1.31A | 6av2A-1h3jA:0.06av2B-1h3jA:0.7 | 6av2A-1h3jA:12.426av2B-1h3jA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kex | NEUROPILIN-1 (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | ARG A 130TRP A 97PHE A 131GLU A 95 | None | 1.46A | 6av2A-1kexA:undetectable6av2B-1kexA:undetectable | 6av2A-1kexA:17.726av2B-1kexA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | ARG A 282VAL A 226PHE A 220GLU A 222 | None | 1.32A | 6av2A-1kh2A:0.26av2B-1kh2A:0.1 | 6av2A-1kh2A:10.756av2B-1kh2A:10.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 4 | MET A 336ARG A 596VAL A 677TRP A 678 | H4B A 760 ( 3.8A)H4B A 760 (-3.5A)H4B A 760 (-4.6A)H4B A 760 ( 3.6A) | 0.28A | 6av2A-1lzxA:61.96av2B-1lzxA:62.6 | 6av2A-1lzxA:91.036av2B-1lzxA:91.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 4 | VAL D 28TRP D 31PHE D 35GLU D 132 | None | 1.39A | 6av2A-1mhzD:0.06av2B-1mhzD:0.0 | 6av2A-1mhzD:9.796av2B-1mhzD:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | ARG A 69VAL A 54PHE A 79GLU A 36 | None | 1.02A | 6av2A-1mzbA:undetectable6av2B-1mzbA:undetectable | 6av2A-1mzbA:18.716av2B-1mzbA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdu | NUCLEAR HORMONERECEPTOR HR38 (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 4 | MET A 440VAL A 401TRP A 435PHE A 432 | None | 0.90A | 6av2A-1pduA:undetectable6av2B-1pduA:undetectable | 6av2A-1pduA:13.916av2B-1pduA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1j | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF09152(DUF1937) | 4 | ARG A 2VAL A 28TRP A 110PHE A 117 | None | 1.50A | 6av2A-1t1jA:undetectable6av2B-1t1jA:undetectable | 6av2A-1t1jA:21.376av2B-1t1jA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 122TRP A 277PHE A 254GLU A 250 | None | 1.50A | 6av2A-1tkiA:undetectable6av2B-1tkiA:undetectable | 6av2A-1tkiA:13.386av2B-1tkiA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmk | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermotogamaritima) |
PF01048(PNP_UDP_1) | 4 | VAL A 221TRP A 162PHE A 265GLU A 161 | None | 1.45A | 6av2A-1vmkA:undetectable6av2B-1vmkA:undetectable | 6av2A-1vmkA:12.136av2B-1vmkA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wf0 | TAR DNA-BINDINGPROTEIN-43 (Homo sapiens) |
PF00076(RRM_1) | 4 | MET A 17VAL A 35PHE A 26GLU A 21 | None | 1.20A | 6av2A-1wf0A:undetectable6av2B-1wf0A:undetectable | 6av2A-1wf0A:17.076av2B-1wf0A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | ARG B 156VAL B 128PHE B 163GLU B 26 | None | 1.14A | 6av2A-1wqlB:undetectable6av2B-1wqlB:undetectable | 6av2A-1wqlB:17.846av2B-1wqlB:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | ARG A 708VAL A1424PHE A 722GLU A 693 | None | 1.06A | 6av2A-2b39A:undetectable6av2B-2b39A:undetectable | 6av2A-2b39A:3.676av2B-2b39A:3.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT AADENYLYLSULFATEREDUCTASE, SUBUNIT B (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 62VAL A 367TRP B 788GLU A 360 | None | 1.35A | 6av2A-2fjaA:0.56av2B-2fjaA:undetectable | 6av2A-2fjaA:7.876av2B-2fjaA:7.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glf | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Thermotogamaritima) |
PF02127(Peptidase_M18) | 4 | ARG A 261VAL A 443PHE A 21GLU A 17 | None | 1.25A | 6av2A-2glfA:undetectable6av2B-2glfA:undetectable | 6av2A-2glfA:10.836av2B-2glfA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | MET A 31ARG A 53VAL A 70GLU A 34 | None | 1.50A | 6av2A-2vdaA:undetectable6av2B-2vdaA:undetectable | 6av2A-2vdaA:6.706av2B-2vdaA:6.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vy0 | ENDO-BETA-1,3-GLUCANASE (Pyrococcusfuriosus) |
PF00722(Glyco_hydro_16) | 4 | VAL A 245TRP A 252PHE A 254GLU A 251 | NoneNoneNoneMRD A1301 (-4.3A) | 1.42A | 6av2A-2vy0A:undetectable6av2B-2vy0A:undetectable | 6av2A-2vy0A:15.736av2B-2vy0A:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 4 | ARG A 278VAL A 269TRP A 266PHE A 261 | None | 1.43A | 6av2A-2w4oA:undetectable6av2B-2w4oA:undetectable | 6av2A-2w4oA:15.366av2B-2w4oA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhy | 6-PHOSPHO-BETA-GLUCOSIDASE BGLA (Escherichiacoli) |
PF00232(Glyco_hydro_1) | 4 | ARG A 159VAL A 164PHE A 98GLU A 108 | None | 1.48A | 6av2A-2xhyA:undetectable6av2B-2xhyA:undetectable | 6av2A-2xhyA:11.066av2B-2xhyA:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | ARG A 211VAL A 239PHE A 309GLU A 305 | None | 1.31A | 6av2A-2ywbA:undetectable6av2B-2ywbA:undetectable | 6av2A-2ywbA:9.246av2B-2ywbA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z11 | RIBOSOMAL-PROTEIN-ALANINEACETYLTRANSFERASE (Thermusthermophilus) |
PF13302(Acetyltransf_3) | 4 | VAL A 64TRP A 66PHE A 4GLU A 6 | None | 1.44A | 6av2A-2z11A:undetectable6av2B-2z11A:undetectable | 6av2A-2z11A:17.036av2B-2z11A:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zf8 | COMPONENT OFSODIUM-DRIVEN POLARFLAGELLAR MOTOR (Vibrioalginolyticus) |
PF00691(OmpA) | 4 | MET A 17TRP A 15PHE A 137GLU A 16 | None | 1.29A | 6av2A-2zf8A:undetectable6av2B-2zf8A:undetectable | 6av2A-2zf8A:14.346av2B-2zf8A:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | VAL A 314TRP A 293TRP A 374GLU A 372 | NoneNoneNoneEDO A 404 ( 3.8A) | 1.42A | 6av2A-3b7fA:undetectable6av2B-3b7fA:undetectable | 6av2A-3b7fA:11.896av2B-3b7fA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bit | FACT COMPLEX SUBUNITSPT16 (Saccharomycescerevisiae) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 4 | ARG A 105VAL A 35TRP A 147PHE A 117 | None | 1.50A | 6av2A-3bitA:undetectable6av2B-3bitA:undetectable | 6av2A-3bitA:10.436av2B-3bitA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2w | TAR DNA-BINDINGPROTEIN 43 (Mus musculus) |
PF00076(RRM_1) | 4 | MET A 202VAL A 220PHE A 211GLU A 206 | None | 1.00A | 6av2A-3d2wA:undetectable6av2B-3d2wA:undetectable | 6av2A-3d2wA:17.656av2B-3d2wA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddl | XANTHORHODOPSIN (Salinibacterruber) |
PF01036(Bac_rhodopsin) | 4 | VAL A 16TRP A 70PHE A 88GLU A 71 | None | 1.49A | 6av2A-3ddlA:undetectable6av2B-3ddlA:undetectable | 6av2A-3ddlA:11.366av2B-3ddlA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 66VAL A 387TRP B 88GLU A 380 | None | 1.29A | 6av2A-3gyxA:undetectable6av2B-3gyxA:undetectable | 6av2A-3gyxA:8.726av2B-3gyxA:8.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzp | NTF2-LIKE PROTEIN OFUNKNOWN FUNCTION (Prochlorococcusmarinus) |
PF12707(DUF3804) | 4 | MET A 20ARG A 118TRP A 51PHE A 34 | 1PE A 131 ( 3.8A)1PE A 131 (-3.7A)None1PE A 131 (-4.5A) | 1.36A | 6av2A-3hzpA:undetectable6av2B-3hzpA:undetectable | 6av2A-3hzpA:21.436av2B-3hzpA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3p | IPAH9.8 (Shigellaflexneri) |
PF14496(NEL) | 4 | VAL A 258TRP A 261TRP A 274GLU A 314 | None | 1.36A | 6av2A-3l3pA:undetectable6av2B-3l3pA:undetectable | 6av2A-3l3pA:12.596av2B-3l3pA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | ARG A 269VAL A 260TRP A 257PHE A 252 | None | 1.42A | 6av2A-3ma6A:undetectable6av2B-3ma6A:undetectable | 6av2A-3ma6A:12.756av2B-3ma6A:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3k | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Homo sapiens) |
PF00443(UCH) | 4 | ARG A 944TRP A1001PHE A 946GLU A 908 | None | 1.47A | 6av2A-3n3kA:undetectable6av2B-3n3kA:undetectable | 6av2A-3n3kA:11.116av2B-3n3kA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ner | CYTOCHROME B5 TYPE B (Homo sapiens) |
PF00173(Cyt-b5) | 4 | ARG A 68VAL A 61PHE A 58GLU A 56 | NoneHEM A 201 (-4.5A)HEM A 201 (-4.7A)None | 1.49A | 6av2A-3nerA:undetectable6av2B-3nerA:undetectable | 6av2A-3nerA:25.006av2B-3nerA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | ARG A 175VAL A 92PHE A 121GLU A 119 | None | 1.23A | 6av2A-3owcA:1.56av2B-3owcA:0.0 | 6av2A-3owcA:14.926av2B-3owcA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | MET A 259VAL A 169TRP A 249PHE A 203 | None | 1.33A | 6av2A-3q3uA:undetectable6av2B-3q3uA:undetectable | 6av2A-3q3uA:14.716av2B-3q3uA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q63 | MLL2253 PROTEIN (Mesorhizobiumjaponicum) |
PF08327(AHSA1) | 4 | MET A 108TRP A 128PHE A 113GLU A 109 | None | 1.26A | 6av2A-3q63A:undetectable6av2B-3q63A:undetectable | 6av2A-3q63A:19.856av2B-3q63A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | VAL A 149TRP A 146PHE A 162GLU A 187 | None | 1.30A | 6av2A-3rjyA:1.46av2B-3rjyA:1.4 | 6av2A-3rjyA:13.756av2B-3rjyA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | VAL A 240TRP A 239PHE A 305GLU A 265 | None | 1.46A | 6av2A-3ti8A:undetectable6av2B-3ti8A:undetectable | 6av2A-3ti8A:11.396av2B-3ti8A:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tix | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
no annotation | 4 | ARG B 924VAL B 944PHE B 953GLU B 951 | None | 1.27A | 6av2A-3tixB:undetectable6av2B-3tixB:undetectable | 6av2A-3tixB:11.356av2B-3tixB:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqu | NON-CANONICAL PURINENTP PYROPHOSPHATASE (Coxiellaburnetii) |
PF01725(Ham1p_like) | 4 | VAL A 162TRP A 140PHE A 118GLU A 141 | None | 1.27A | 6av2A-3tquA:undetectable6av2B-3tquA:undetectable | 6av2A-3tquA:15.426av2B-3tquA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxm | THYMIDYLATE KINASE (Pseudomonasaeruginosa) |
PF02223(Thymidylate_kin) | 4 | ARG A 109VAL A 166PHE A 162GLU A 156 | NoneNoneNone MG A 213 (-3.2A) | 1.33A | 6av2A-3uxmA:undetectable6av2B-3uxmA:undetectable | 6av2A-3uxmA:15.176av2B-3uxmA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgd | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT) | 4 | VAL C2274TRP C2314PHE C2329GLU C2310 | None | 1.32A | 6av2A-4bgdC:undetectable6av2B-4bgdC:undetectable | 6av2A-4bgdC:13.496av2B-4bgdC:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d8o | ANKYRIN-2 (Homo sapiens) |
PF00531(Death)PF00791(ZU5) | 4 | ARG A1065VAL A1046PHE A1118GLU A1032 | None | 1.38A | 6av2A-4d8oA:undetectable6av2B-4d8oA:undetectable | 6av2A-4d8oA:10.236av2B-4d8oA:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 4 | MET A 258VAL A 265TRP A 62PHE A 85 | None | 1.32A | 6av2A-4g76A:undetectable6av2B-4g76A:undetectable | 6av2A-4g76A:10.696av2B-4g76A:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmv | GLUTATHIONETRANSFERASE (Phanerochaetechrysosporium) |
PF13417(GST_N_3) | 4 | ARG A 29VAL A 73PHE A 7GLU A 42 | NoneFLC A 300 (-4.1A)NoneNone | 1.11A | 6av2A-4lmvA:undetectable6av2B-4lmvA:undetectable | 6av2A-4lmvA:14.696av2B-4lmvA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mln | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | MET A 180VAL A 9PHE A 93GLU A 183 | None | 1.23A | 6av2A-4mlnA:undetectable6av2B-4mlnA:undetectable | 6av2A-4mlnA:18.186av2B-4mlnA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6w | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | MET A 180VAL A 9PHE A 93GLU A 183 | None | 1.31A | 6av2A-4n6wA:undetectable6av2B-4n6wA:undetectable | 6av2A-4n6wA:14.416av2B-4n6wA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 4 | ARG A 75VAL A 79PHE A 141GLU A 162 | None | 1.35A | 6av2A-4pneA:undetectable6av2B-4pneA:undetectable | 6av2A-4pneA:11.926av2B-4pneA:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj5 | CYCLIC AMP-GMPSYNTHASE (Vibrio cholerae) |
no annotation | 4 | ARG A 280VAL A 309TRP A 267PHE A 268 | None | 1.19A | 6av2A-4xj5A:undetectable6av2B-4xj5A:undetectable | 6av2A-4xj5A:12.606av2B-4xj5A:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | ARG A 276VAL A 305PHE A 264GLU A 266 | None | 1.18A | 6av2A-4xj6A:undetectable6av2B-4xj6A:undetectable | 6av2A-4xj6A:12.206av2B-4xj6A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | VAL A 305TRP A 263PHE A 264GLU A 266 | None | 1.11A | 6av2A-4xj6A:undetectable6av2B-4xj6A:undetectable | 6av2A-4xj6A:12.206av2B-4xj6A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylr | TUBULINPOLYGLUTAMYLASETTLL7 (Homo sapiens) |
PF03133(TTL) | 4 | VAL A 288TRP A 292PHE A 277GLU A 279 | None | 1.40A | 6av2A-4ylrA:undetectable6av2B-4ylrA:undetectable | 6av2A-4ylrA:12.376av2B-4ylrA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zva | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | MET A 8VAL A 84TRP A 12GLU A 11 | None | 1.36A | 6av2A-4zvaA:undetectable6av2B-4zvaA:undetectable | 6av2A-4zvaA:20.626av2B-4zvaA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zvb | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | MET A 8VAL A 84TRP A 12GLU A 11 | None | 1.46A | 6av2A-4zvbA:undetectable6av2B-4zvbA:undetectable | 6av2A-4zvbA:19.756av2B-4zvbA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 4 | ARG A 505VAL A 736TRP A 732GLU A 731 | None | 1.37A | 6av2A-5by3A:undetectable6av2B-5by3A:undetectable | 6av2A-5by3A:7.756av2B-5by3A:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6g | AGR133CPSISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF10345(Cohesin_load)no annotation | 4 | VAL B 28TRP A 401PHE A 397GLU A 402 | None | 1.50A | 6av2A-5c6gB:undetectable6av2B-5c6gB:undetectable | 6av2A-5c6gB:13.006av2B-5c6gB:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 4 | ARG A 316VAL A 438TRP A 439GLU A 418 | BE2 A1476 (-4.0A)BE2 A1476 ( 4.3A)BE2 A1476 ( 3.7A)None | 1.32A | 6av2A-5fjnA:undetectable6av2B-5fjnA:undetectable | 6av2A-5fjnA:9.616av2B-5fjnA:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kn8 | ADENINE DNAGLYCOSYLASE (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | VAL A 92TRP A 83PHE A 61GLU A 84 | None | 1.36A | 6av2A-5kn8A:undetectable6av2B-5kn8A:undetectable | 6av2A-5kn8A:13.796av2B-5kn8A:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | ARG A 225TRP A 414PHE A 411GLU A 413 | None | 1.07A | 6av2A-5m8tA:undetectable6av2B-5m8tA:undetectable | 6av2A-5m8tA:11.576av2B-5m8tA:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wq3 | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Corynebacteriumglutamicum) |
PF03641(Lysine_decarbox) | 4 | MET A 112ARG A 155VAL A 104PHE A 159 | None | 1.46A | 6av2A-5wq3A:undetectable6av2B-5wq3A:undetectable | 6av2A-5wq3A:15.086av2B-5wq3A:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x89 | ENDA-LIKEPROTEIN,TRNA-SPLICING ENDONUCLEASE (Methanopyruskandleri) |
no annotation | 4 | MET A 249VAL A 231PHE A 258GLU A 253 | None | 1.08A | 6av2A-5x89A:undetectable6av2B-5x89A:undetectable | 6av2A-5x89A:17.446av2B-5x89A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwd | VH CHAIN OF 059-152VL CHAIN OF 059-152 (Homo sapiens) |
no annotation | 4 | MET H 105VAL D 98TRP D 91TRP H 49 | None | 1.03A | 6av2A-5xwdH:undetectable6av2B-5xwdH:undetectable | 6av2A-5xwdH:23.336av2B-5xwdH:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 4 | ARG A 331VAL A 317TRP A 316GLU A 322 | NoneUDP A 501 ( 4.8A)NoneNone | 1.30A | 6av2A-6bk1A:undetectable6av2B-6bk1A:undetectable | 6av2A-6bk1A:16.876av2B-6bk1A:16.87 |