SIMILAR PATTERNS OF AMINO ACIDS FOR 6AUU_A_ACTA804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 GLN A 233
TRP A 246
VAL A 243
 None
 1.08A 6auuA-1aj8A:
0.0		 6auuA-1aj8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLN A 453
TRP A 380
VAL A 460
 None
 0.81A 6auuA-1e8cA:
0.0		 6auuA-1e8cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 GLN A 224
TRP A 331
VAL A 230
 None
 0.64A 6auuA-1gpmA:
0.0		 6auuA-1gpmA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itv MMP9

(Homo sapiens) 		PF00045
(Hemopexin) 		3 GLN A 163
TRP A 168
VAL A 145
 None
 1.15A 6auuA-1itvA:
0.0		 6auuA-1itvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 GLN A  89
TRP A  86
VAL A  81
 None
 1.15A 6auuA-1j3uA:
0.0		 6auuA-1j3uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 GLN A 141
TRP A 114
VAL A 110
 None
 0.87A 6auuA-1l0wA:
0.0		 6auuA-1l0wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 GLN A 300
TRP A  43
VAL A 308
 None
 0.66A 6auuA-1lgfA:
0.0		 6auuA-1lgfA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		3 GLN A 420
TRP A 587
VAL A 649
 None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
 0.11A 6auuA-1lzxA:
63.0		 6auuA-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 GLN A 189
TRP A 356
VAL A 418
 None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
 0.09A 6auuA-1m9qA:
59.2		 6auuA-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 GLN A  29
TRP A 305
VAL A 331
 None
 0.68A 6auuA-1mpoA:
undetectable		 6auuA-1mpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 GLN A 197
TRP A 110
VAL A 173
 None
 1.03A 6auuA-1poiA:
undetectable		 6auuA-1poiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 GLN A 784
TRP A 792
VAL A 787
 None
 1.14A 6auuA-1qb4A:
3.4		 6auuA-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE

(Thuja plicata) 		PF05368
(NmrA) 		3 GLN A 242
TRP A 236
VAL A 313
 None
 0.87A 6auuA-1qydA:
undetectable		 6auuA-1qydA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 GLN A 189
TRP A  16
VAL A 141
 None
 1.07A 6auuA-1rw9A:
3.3		 6auuA-1rw9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		3 GLN A  41
TRP A  67
VAL A  66
 None
 1.16A 6auuA-1sgfA:
undetectable		 6auuA-1sgfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 GLN A 455
TRP A 162
VAL A 446
 None
 1.09A 6auuA-1si8A:
undetectable		 6auuA-1si8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 GLN A 309
TRP A  56
VAL A 317
 None
 0.90A 6auuA-1uedA:
undetectable		 6auuA-1uedA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		3 GLN A 167
TRP A 163
VAL A 204
 None
 1.18A 6auuA-1xqsA:
undetectable		 6auuA-1xqsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		3 GLN A 197
TRP A  22
VAL A 309
 None
 0.99A 6auuA-2ejaA:
undetectable		 6auuA-2ejaA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho0 REPRESSOR PROTEIN
CI101-229DM-K192A

(Escherichia
coli) 		PF00717
(Peptidase_S24) 		3 GLN A 229
TRP A 142
VAL A 105
 None
 1.14A 6auuA-2ho0A:
undetectable		 6auuA-2ho0A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 GLN A 137
TRP A 133
VAL A 144
 None
 0.82A 6auuA-2if6A:
undetectable		 6auuA-2if6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 GLN A 464
TRP A 164
VAL A 455
 None
 0.99A 6auuA-2iqfA:
undetectable		 6auuA-2iqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kln PROBABLE
SULPHATE-TRANSPORT
TRANSMEMBRANE
PROTEIN, COG0659

(Mycobacterium
bovis) 		PF01740
(STAS) 		3 GLN A  43
TRP A  50
VAL A  82
 None
 1.06A 6auuA-2klnA:
undetectable		 6auuA-2klnA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt9 PROBABLE 30S
RIBOSOMAL PROTEIN
PSRP-3

(Synechocystis
sp. PCC 6803) 		PF04839
(PSRP-3_Ycf65) 		3 GLN A  81
TRP A  42
VAL A  21
 None
 1.12A 6auuA-2kt9A:
undetectable		 6auuA-2kt9A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLN A  30
TRP A  29
VAL A  47
 None
 0.81A 6auuA-2m7sA:
undetectable		 6auuA-2m7sA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		3 GLN A  29
TRP A 315
VAL A 341
 None
 0.79A 6auuA-2mprA:
undetectable		 6auuA-2mprA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		3 GLN A 245
TRP A 201
VAL A 182
 None
 0.71A 6auuA-2pkeA:
2.4		 6auuA-2pkeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		3 GLN A 232
TRP A 245
VAL A 242
 None
 1.06A 6auuA-2r26A:
undetectable		 6auuA-2r26A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		3 GLN A  47
TRP A  77
VAL A  68
 None
 0.98A 6auuA-2w68A:
undetectable		 6auuA-2w68A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 GLN A  60
TRP A 121
VAL A 119
 None
 1.00A 6auuA-2x05A:
undetectable		 6auuA-2x05A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 3 GLN A 503
TRP A 468
VAL A 485
 None
 1.14A 6auuA-2zuxA:
undetectable		 6auuA-2zuxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		3 GLN X 278
TRP X 277
VAL X 359
 None
 0.74A 6auuA-3brkX:
undetectable		 6auuA-3brkX:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 GLN A 156
TRP A 163
VAL A 129
 None
 1.03A 6auuA-3e6eA:
undetectable		 6auuA-3e6eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 624
TRP A 591
VAL A 613
 None
 1.07A 6auuA-3fzpA:
undetectable		 6auuA-3fzpA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli) 		no annotation 3 GLN O 241
TRP O 240
VAL O 272
 None
 0.93A 6auuA-3gkfO:
undetectable		 6auuA-3gkfO:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7h TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF03439
(Spt5-NGN) 		3 GLN B 232
TRP B 180
VAL B 227
 None
 0.72A 6auuA-3h7hB:
undetectable		 6auuA-3h7hB:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz2 BETA/GAMA CRYSTALLIN
FAMILY PROTEIN

(Methanosarcina
acetivorans) 		PF00030
(Crystall) 		3 GLN A  83
TRP A  45
VAL A  40
 None
 1.16A 6auuA-3hz2A:
undetectable		 6auuA-3hz2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		3 GLN C 179
TRP C 175
VAL C 196
 None
 1.16A 6auuA-3j7aC:
undetectable		 6auuA-3j7aC:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 GLN B 303
TRP B 334
VAL B 322
 None
 0.60A 6auuA-3jcmB:
undetectable		 6auuA-3jcmB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzm DNA POLYMERASE III
SUBUNIT ALPHA

(Synechocystis
sp. PCC 6803) 		no annotation 3 GLN A  46
TRP A  47
VAL A  22
 None
 0.98A 6auuA-3nzmA:
undetectable		 6auuA-3nzmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		3 GLN A  11
TRP A  47
VAL A  35
 None
 0.67A 6auuA-3ow8A:
undetectable		 6auuA-3ow8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN B1511
TRP B1584
VAL B1523
 None
 0.88A 6auuA-3prxB:
undetectable		 6auuA-3prxB:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLN A 308
TRP A 408
VAL A 502
 None
 1.08A 6auuA-3pvcA:
undetectable		 6auuA-3pvcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLN A 474
TRP A 445
VAL A 461
 None
 1.14A 6auuA-3pvcA:
undetectable		 6auuA-3pvcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 GLN A 427
TRP A 440
VAL A 418
 None
 0.91A 6auuA-3rh9A:
1.1		 6auuA-3rh9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		3 GLN A 170
TRP A 257
VAL A 255
 None
 0.87A 6auuA-3wjsA:
0.6		 6auuA-3wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 GLN A 458
TRP A 163
VAL A 450
 None
 1.16A 6auuA-4e37A:
undetectable		 6auuA-4e37A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fab IGG2A-KAPPA 4-4-20
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN H 196
TRP H 193
VAL H 188
 None
 1.10A 6auuA-4fabH:
undetectable		 6auuA-4fabH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzs SORTING NEXIN-1

(Homo sapiens) 		PF09325
(Vps5) 		3 GLN A 421
TRP A 420
VAL A 460
 None
 1.10A 6auuA-4fzsA:
2.3		 6auuA-4fzsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		3 GLN A 133
TRP A 308
VAL A 371
 BES  A 702 (-3.2A)
None
None
 0.94A 6auuA-4gaaA:
undetectable		 6auuA-4gaaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 3 GLN B 197
TRP B 195
VAL B 101
 None
 1.15A 6auuA-4gt2B:
undetectable		 6auuA-4gt2B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 GLN A 106
TRP A 101
VAL A  43
 None
 1.16A 6auuA-4hmwA:
undetectable		 6auuA-4hmwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		3 GLN A  11
TRP A 221
VAL A 182
 EDO  A 504 (-3.8A)
EDO  A 504 (-4.1A)
EDO  A 504 (-4.8A)
 0.89A 6auuA-4iusA:
undetectable		 6auuA-4iusA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4s NUCLEOCAPSID PROTEIN

(SFTS
phlebovirus) 		PF05733
(Tenui_N) 		3 GLN A 174
TRP A 173
VAL A 128
 None
 1.12A 6auuA-4j4sA:
undetectable		 6auuA-4j4sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		3 GLN A 174
TRP A 477
VAL A 436
 None
 1.08A 6auuA-4k70A:
undetectable		 6auuA-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		3 GLN A 380
TRP A  57
VAL A  77
 None
 1.07A 6auuA-4kbmA:
undetectable		 6auuA-4kbmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd6 ENOYL-COA
HYDRATASE/ISOMERASE

(Paraburkholderia
graminis) 		PF00378
(ECH_1) 		3 GLN A  65
TRP A  81
VAL A  82
 None
 1.14A 6auuA-4kd6A:
0.6		 6auuA-4kd6A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 3 GLN B 195
TRP B 153
VAL B 108
 None
 0.74A 6auuA-4kncB:
undetectable		 6auuA-4kncB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN A 900
TRP A 198
VAL A 216
 None
 1.00A 6auuA-4lnvA:
undetectable		 6auuA-4lnvA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		3 GLN A  26
TRP A 122
VAL A  59
 None
 1.16A 6auuA-4okoA:
undetectable		 6auuA-4okoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 GLN A 300
TRP A  48
VAL A 308
 None
 0.89A 6auuA-4oqrA:
undetectable		 6auuA-4oqrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 GLN A 300
TRP A  48
VAL A 308
 None
 0.87A 6auuA-4oqsA:
undetectable		 6auuA-4oqsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxw DESIGNED CISK-PX
DOMAIN

(synthetic
construct) 		PF00787
(PX) 		3 GLN A 109
TRP A  36
VAL A  38
 None
 1.15A 6auuA-4oxwA:
undetectable		 6auuA-4oxwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 GLN A 493
TRP A 562
VAL A 624
 None
 1.14A 6auuA-4q9zA:
undetectable		 6auuA-4q9zA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 GLN A 143
TRP A 309
VAL A 313
 None
 1.05A 6auuA-4r6lA:
undetectable		 6auuA-4r6lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		3 GLN A 206
TRP A  24
VAL A 323
 None
 1.07A 6auuA-4wshA:
undetectable		 6auuA-4wshA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		3 GLN A 207
TRP A 206
VAL A 237
 None
 1.10A 6auuA-4ycoA:
undetectable		 6auuA-4ycoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		3 GLN A 179
TRP A 134
VAL A 146
 None
 1.17A 6auuA-4yt9A:
undetectable		 6auuA-4yt9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 GLN A 399
TRP A 441
VAL A 444
 None
 1.06A 6auuA-4z2aA:
undetectable		 6auuA-4z2aA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 3 GLN A 193
TRP A 180
VAL A 179
 None
 1.09A 6auuA-4zoxA:
undetectable		 6auuA-4zoxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		3 GLN A 205
TRP A  24
VAL A 325
 None
 1.07A 6auuA-4zr8A:
undetectable		 6auuA-4zr8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 3 GLN A 193
TRP A 180
VAL A 179
 None
 1.08A 6auuA-5amsA:
undetectable		 6auuA-5amsA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 GLN A 234
TRP A  56
VAL A  59
 None
 1.08A 6auuA-5bv9A:
undetectable		 6auuA-5bv9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c22 CHROMOSOMAL
HEMOLYSIN D

(Escherichia
coli) 		PF13437
(HlyD_3) 		3 GLN A 199
TRP A 198
VAL A 292
 None
 0.85A 6auuA-5c22A:
2.4		 6auuA-5c22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cov NAEGLERIA GRUBERI
RNA LIGASE

(Naegleria
gruberi) 		PF09414
(RNA_ligase) 		3 GLN A  92
TRP A  32
VAL A  29
 None
 0.99A 6auuA-5covA:
undetectable		 6auuA-5covA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		3 GLN A 392
TRP A 371
VAL A 383
 None
 1.09A 6auuA-5e3xA:
undetectable		 6auuA-5e3xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e52 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		3 GLN A 802
TRP A 741
VAL A 742
 None
 1.15A 6auuA-5e52A:
undetectable		 6auuA-5e52A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 3 GLN C 300
TRP C  43
VAL C 308
 None
 0.72A 6auuA-5ex6C:
2.1		 6auuA-5ex6C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		3 GLN A 296
TRP A  49
VAL A 304
 None
 0.74A 6auuA-5ex8A:
undetectable		 6auuA-5ex8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 GLN A 266
TRP A 317
VAL A 296
 None
 1.17A 6auuA-5h7jA:
undetectable		 6auuA-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 GLN A 266
TRP A 317
VAL A 296
 None
 1.16A 6auuA-5h7kA:
undetectable		 6auuA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		3 GLN A 185
TRP A 170
VAL B 370
 None
 0.87A 6auuA-5hftA:
undetectable		 6auuA-5hftA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 GLN A 731
TRP A 331
VAL A 334
 None
 1.16A 6auuA-5iq6A:
undetectable		 6auuA-5iq6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		3 GLN A 241
TRP A 258
VAL A 256
 None
 0.75A 6auuA-5j7zA:
0.6		 6auuA-5j7zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbl PROHEAD CORE PROTEIN
PROTEASE

(Escherichia
virus T4) 		PF03420
(Peptidase_S77) 		3 GLN A  46
TRP A  11
VAL A 139
 None
 0.87A 6auuA-5jblA:
undetectable		 6auuA-5jblA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 GLN A 731
TRP A 331
VAL A 334
 None
 1.14A 6auuA-5jjrA:
undetectable		 6auuA-5jjrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 GLN A 201
TRP A 234
VAL A 236
 None
 1.17A 6auuA-5kzhA:
undetectable		 6auuA-5kzhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7s SECRETED RXLR
EFFECTOR PEPTIDE
PROTEIN

(Phytophthora
infestans) 		no annotation 3 GLN A 137
TRP A 106
VAL A 105
 None
 1.16A 6auuA-5l7sA:
undetectable		 6auuA-5l7sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 GLN A 316
TRP A  52
VAL A 324
 None
 0.87A 6auuA-5li8A:
0.9		 6auuA-5li8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		3 GLN A 197
TRP A 195
VAL A 101
 None
 1.15A 6auuA-5mapA:
undetectable		 6auuA-5mapA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		3 GLN A 186
TRP A 222
VAL A 219
 None
 1.05A 6auuA-5muaA:
undetectable		 6auuA-5muaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 GLN A  52
TRP A  75
VAL A  24
 None
 1.11A 6auuA-5mvhA:
undetectable		 6auuA-5mvhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		3 GLN Z 232
TRP Z 180
VAL Z 227
 None
 0.70A 6auuA-5oikZ:
undetectable		 6auuA-5oikZ:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 GLN A 214
TRP A 321
VAL A 220
 None
 0.71A 6auuA-5tw7A:
undetectable		 6auuA-5tw7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 GLN A 163
TRP A 228
VAL A 254
 None
 0.83A 6auuA-5volA:
undetectable		 6auuA-5volA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vz4 GDNF FAMILY RECEPTOR
ALPHA-LIKE

(Homo sapiens) 		PF02351
(GDNF) 		3 GLN B 184
TRP B 129
VAL B 134
 None
 1.12A 6auuA-5vz4B:
undetectable		 6auuA-5vz4B:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		3 GLN A  36
TRP A 277
VAL A 283
 None
 0.87A 6auuA-6aziA:
undetectable		 6auuA-6aziA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 GLN A  73
TRP A 103
VAL A  94
 None
 0.89A 6auuA-6eksA:
undetectable		 6auuA-6eksA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 3 GLN A 340
TRP A 468
VAL A 403
 None
 1.12A 6auuA-6eoqA:
0.8		 6auuA-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 GLN B  92
TRP B  56
VAL B  85
 None
 1.02A 6auuA-6g72B:
undetectable		 6auuA-6g72B:
undetectable