SIMILAR PATTERNS OF AMINO ACIDS FOR 6AP9_A_ACTA304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 142
GLN A 147
ILE A 148
ARG A 186
 None
 0.55A 6ap9A-1lbkA:
36.0		 6ap9A-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 140
GLN A 145
ILE A 146
ARG A 184
 None
 0.57A 6ap9A-2gsrA:
35.7		 6ap9A-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 142
GLN A 147
ILE A 148
ARG A 186
 None
 0.22A 6ap9A-3o76A:
36.4		 6ap9A-3o76A:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PHE A 135
GLN A 136
ILE A 142
ARG A  72
 None
 1.38A 6ap9A-4b9yA:
0.0		 6ap9A-4b9yA:
13.72