SIMILAR PATTERNS OF AMINO ACIDS FOR 6AN0_A_HISA520_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ey1 | ANTITERMINATIONFACTOR NUSB (Escherichiacoli) |
PF01029(NusB) | 4 | GLU A 50ARG A 49GLU A 31ALA A 28 | None | 1.17A | 6an0A-1ey1A:undetectable | 6an0A-1ey1A:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f26 | NITRIC OXIDEREDUCTASE (Fusariumoxysporum) |
PF00067(p450) | 4 | GLU A 361LYS A 359GLU A 355ALA A 354 | NoneNoneNoneHEM A 501 (-3.2A) | 1.07A | 6an0A-1f26A:undetectable | 6an0A-1f26A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7h | FERREDOXIN (Escherichiacoli) |
PF00111(Fer2) | 4 | GLU A 39ARG A 109GLU A 110ALA A 108 | None | 0.99A | 6an0A-1i7hA:undetectable | 6an0A-1i7hA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lar | PROTEIN (LAR) (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | GLU A1616LYS A1618GLU A1614ALA A1612 | None | 1.05A | 6an0A-1larA:0.4 | 6an0A-1larA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lf9 | GLUCOAMYLASE (Thermoanaerobacteriumthermosaccharolyticum) |
PF00723(Glyco_hydro_15)PF09137(Glucodextran_N) | 4 | GLU A 232LYS A 182GLU A 167ALA A 226 | None | 1.11A | 6an0A-1lf9A:0.8 | 6an0A-1lf9A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtw | TRANSCRIPTIONALACTIVATOR, PUTATIVE (Pyrococcusfuriosus) |
PF03070(TENA_THI-4) | 4 | GLU A 198LYS A 130GLU A 134ALA A 135 | MP5 A1213 (-2.6A)NoneNoneNone | 1.24A | 6an0A-1rtwA:0.5 | 6an0A-1rtwA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufn | PUTATIVE NUCLEARPROTEIN HOMOLOG5830484A20RIK (Mus musculus) |
PF01342(SAND) | 4 | GLU A 58LYS A 25GLU A 45ALA A 46 | None | 1.10A | 6an0A-1ufnA:undetectable | 6an0A-1ufnA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 4 | GLU A 139GLU A 85ALA A 83LYS A 80 | None | 1.20A | 6an0A-1uioA:0.3 | 6an0A-1uioA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrn | PHOTOSYNTHETICREACTION CENTERCYTOCHROME C SUBUNIT (Blastochlorisviridis) |
PF02276(CytoC_RC) | 4 | LYS C 29ARG C 34GLU C 33ALA C 36 | None | 1.16A | 6an0A-1vrnC:undetectable | 6an0A-1vrnC:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9j | PROBABLE BUTYRATEKINASE 2 (Thermotogamaritima) |
PF00871(Acetate_kinase) | 4 | GLU A 164GLU A 334ALA A 337LYS A 336 | None | 1.02A | 6an0A-1x9jA:0.7 | 6an0A-1x9jA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a6e | RNA POLYMERASE SIGMAFACTOR RPOD (Thermusthermophilus) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2)PF04545(Sigma70_r4) | 4 | LYS F 230ARG F 104GLU F 107ALA F 103 | None | 0.80A | 6an0A-2a6eF:undetectable | 6an0A-2a6eF:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c11 | MEMBRANE COPPERAMINE OXIDASE (Homo sapiens) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 4 | GLU A 67ARG A 122GLU A 123ALA A 124 | None | 1.24A | 6an0A-2c11A:undetectable | 6an0A-2c11A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2da6 | HEPATOCYTE NUCLEARFACTOR 1-BETA (Homo sapiens) |
PF00046(Homeobox) | 4 | GLU A 35LYS A 33GLU A 37ALA A 38 | None | 1.12A | 6an0A-2da6A:undetectable | 6an0A-2da6A:10.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | LYS A 444ARG A 410GLU A 441ALA A 439 | None | 1.23A | 6an0A-2e5vA:1.8 | 6an0A-2e5vA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fel | 3-CARBOXY-CIS,CIS-MUCONATE LACTONIZINGENZYME (Agrobacteriumtumefaciens) |
PF00206(Lyase_1) | 4 | GLU A 46ARG A 218GLU A 44ALA A 45 | None | 1.16A | 6an0A-2felA:undetectable | 6an0A-2felA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqc | RHOMBOIDINTRAMEMBRANEPROTEASE (Pseudomonasaeruginosa) |
PF16733(NRho) | 4 | GLU A 68ARG A 57GLU A 60ALA A 70 | None | 1.23A | 6an0A-2gqcA:undetectable | 6an0A-2gqcA:9.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2msy | HOMEOBOX PROTEINHOX-C9 (Homo sapiens) |
PF00046(Homeobox) | 4 | GLU A 50ARG A 39GLU A 41ALA A 43 | None | 1.25A | 6an0A-2msyA:undetectable | 6an0A-2msyA:10.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov1 | PERIPLASMIC BINDINGPROTEIN COMPONENT OFAN ABC TYPE ZINCUPTAKE TRANSPORTER (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | GLU A 197GLU A 99ALA A 100LYS A 124 | None | 1.20A | 6an0A-2ov1A:undetectable | 6an0A-2ov1A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7v | RNA POLYMERASE SIGMAFACTOR RPOD (Escherichiacoli) |
PF04545(Sigma70_r4) | 4 | GLU B 555GLU B 591ALA B 594LYS B 593 | None | 0.95A | 6an0A-2p7vB:undetectable | 6an0A-2p7vB:9.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qni | UNCHARACTERIZEDPROTEIN ATU0299 (Agrobacteriumfabrum) |
PF00300(His_Phos_1) | 4 | LYS A 171GLU A 175ALA A 205LYS A 203 | None | 1.24A | 6an0A-2qniA:undetectable | 6an0A-2qniA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4s | ANTIBODY FOR BETA2ADRENOCEPTOR, LIGHTCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | GLU L 185LYS L 183ARG L 188GLU L 187 | None | 1.17A | 6an0A-2r4sL:undetectable | 6an0A-2r4sL:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reb | REC A (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A 320LYS A 322GLU A 318ALA A 316 | None | 1.20A | 6an0A-2rebA:3.0 | 6an0A-2rebA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbi | PYRUVATEDECARBOXYLASE (Acetobacterpasteurianus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | GLU A 365LYS A 508GLU A 358ALA A 359 | None | 0.83A | 6an0A-2vbiA:undetectable | 6an0A-2vbiA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbv | UNCHARACTERIZEDCONSERVED PROTEIN (Thermotogamaritima) |
PF01887(SAM_adeno_trans) | 4 | GLU A 173ARG A 44GLU A 255ALA A 175 | None | 1.05A | 6an0A-2zbvA:undetectable | 6an0A-2zbvA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 4 | GLU A 59LYS A 26GLU A 30LYS A 32 | None | 1.09A | 6an0A-3a4tA:3.9 | 6an0A-3a4tA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bey | CONSERVED PROTEINO27018 (Methanothermobacterthermautotrophicus) |
PF02627(CMD) | 4 | LYS A 37ARG A 35GLU A 34ALA A 61 | None | 1.05A | 6an0A-3beyA:undetectable | 6an0A-3beyA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bwl | SENSOR PROTEIN (Haloarculamarismortui) |
PF08448(PAS_4) | 4 | ARG A 388GLU A 387ALA A 386LYS A 389 | None | 1.10A | 6an0A-3bwlA:undetectable | 6an0A-3bwlA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4q | PREDICTEDGLYCOSYLTRANSFERASES (Corynebacteriumglutamicum) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 4 | LYS A 286ARG A 276GLU A 285ALA A 279 | None | 0.95A | 6an0A-3c4qA:3.9 | 6an0A-3c4qA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmm | UBIQUITIN-ACTIVATINGENZYME E1 1 (Saccharomycescerevisiae) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 4 | GLU A 395ARG A 288ALA A 284LYS A 285 | None | 1.17A | 6an0A-3cmmA:undetectable | 6an0A-3cmmA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A 320LYS A 322GLU A 318ALA A 316 | None | 0.97A | 6an0A-3cmtA:2.5 | 6an0A-3cmtA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A1320LYS A1322GLU A1318ALA A1316 | None | 0.97A | 6an0A-3cmtA:2.5 | 6an0A-3cmtA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A2320LYS A2322GLU A2318ALA A2316 | None | 0.98A | 6an0A-3cmtA:2.5 | 6an0A-3cmtA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A3320LYS A3322GLU A3318ALA A3316 | None | 0.97A | 6an0A-3cmtA:2.5 | 6an0A-3cmtA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A4320LYS A4322GLU A4318ALA A4316 | None | 0.97A | 6an0A-3cmtA:2.5 | 6an0A-3cmtA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A 320LYS A 322GLU A 318ALA A 316 | None | 1.18A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A1320LYS A1322GLU A1318ALA A1316 | None | 1.21A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A2320LYS A2322GLU A2318ALA A2316 | None | 1.19A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A3320LYS A3322GLU A3318ALA A3316 | None | 1.19A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A4320LYS A4322GLU A4318ALA A4316 | None | 1.19A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A5320LYS A5322GLU A5318ALA A5316 | None | 1.19A | 6an0A-3cmuA:undetectable | 6an0A-3cmuA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A 320LYS A 322GLU A 318ALA A 316 | None | 1.14A | 6an0A-3cmvA:3.0 | 6an0A-3cmvA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A2320LYS A2322GLU A2318ALA A2316 | None | 1.05A | 6an0A-3cmvA:3.0 | 6an0A-3cmvA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | GLU A3320LYS A3322GLU A3318ALA A3316 | None | 1.22A | 6an0A-3cmvA:3.0 | 6an0A-3cmvA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cuc | PROTEIN OF UNKNOWNFUNCTION WITH A FICDOMAIN (Bacteroidesthetaiotaomicron) |
PF02661(Fic) | 4 | LYS A 68GLU A 72ALA A 75LYS A 74 | None | 1.19A | 6an0A-3cucA:undetectable | 6an0A-3cucA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e57 | UNCHARACTERIZEDPROTEIN TM1382 (Thermotogamaritima) |
PF00293(NUDIX) | 4 | GLU A 49ARG A 45GLU A 47ALA A 48 | None | 1.22A | 6an0A-3e57A:undetectable | 6an0A-3e57A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fv5 | DNA TOPOISOMERASE 4SUBUNIT B (Escherichiacoli) |
PF02518(HATPase_c) | 4 | GLU A 82ARG A 93GLU A 88ALA A 86 | None | 1.21A | 6an0A-3fv5A:undetectable | 6an0A-3fv5A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvp | ADENOSYLHOMOCYSTEINASE 3 (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLU A 205ARG A 198GLU A 200ALA A 237 | None | 1.14A | 6an0A-3gvpA:3.3 | 6an0A-3gvpA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ik5 | PROTEIN NEF (Simianimmunodeficiencyvirus) |
PF00469(F-protein) | 4 | GLU A 150LYS A 148ARG A 109GLU A 147 | GLU A 150 ( 0.6A)LYS A 148 ( 0.0A)ARG A 109 ( 0.6A)GLU A 147 ( 0.6A) | 1.06A | 6an0A-3ik5A:undetectable | 6an0A-3ik5A:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2v | PREC/CORE PROTEIN (Hepatitis Bvirus) |
no annotation | 4 | GLU C 46ARG C 56GLU C 43ALA C 41 | None | 1.21A | 6an0A-3j2vC:undetectable | 6an0A-3j2vC:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kbb | PHOSPHORYLATEDCARBOHYDRATESPHOSPHATASE TM_1254 (Thermotogamaritima) |
PF13419(HAD_2) | 5 | GLU A 164LYS A 167GLU A 171ALA A 172LYS A 140 | GLU A 164 ( 0.6A)LYS A 167 (-0.0A)GLU A 171 ( 0.6A)ALA A 172 ( 0.0A)LYS A 140 (-0.0A) | 1.48A | 6an0A-3kbbA:4.2 | 6an0A-3kbbA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l5k | HALOACIDDEHALOGENASE-LIKEHYDROLASEDOMAIN-CONTAININGPROTEIN 1A (Homo sapiens) |
PF13419(HAD_2) | 4 | GLU A 175GLU A 182ALA A 183LYS A 149 | K A 229 (-3.3A)NoneNone K A 229 ( 4.2A) | 1.02A | 6an0A-3l5kA:3.8 | 6an0A-3l5kA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvl | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Trypanosomabrucei) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 4 | LYS A 240ARG A 235GLU A 236ALA A 234 | None | 0.88A | 6an0A-3nvlA:4.2 | 6an0A-3nvlA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oja | LEUCINE-RICH IMMUNEMOLECULE 1ANOPHELESPLASMODIUM-RESPONSIVE LEUCINE-RICHREPEAT PROTEIN 1 (Anophelesgambiae;Anophelesgambiae) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | GLU B 705LYS B 700ARG A 500GLU A 501 | None | 1.20A | 6an0A-3ojaB:undetectable | 6an0A-3ojaB:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdt | MYOSIN HEAVY CHAINKINASE A (Dictyosteliumdiscoideum) |
PF02816(Alpha_kinase) | 4 | ARG A 592GLU A 593ALA A 594LYS A 645 | ADP A 811 (-4.1A)NoneADP A 811 ( 3.8A)ADP A 811 (-2.7A) | 0.48A | 6an0A-3pdtA:undetectable | 6an0A-3pdtA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3quc | INORGANICPYROPHOSPHATASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 4 | GLU A 171GLU A 178ALA A 179LYS A 147 | None | 1.03A | 6an0A-3qucA:3.6 | 6an0A-3qucA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro3 | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF13424(TPR_12) | 4 | LYS A 231ARG A 235GLU A 234ALA A 237 | None | 1.03A | 6an0A-3ro3A:undetectable | 6an0A-3ro3A:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ub0 | NON-STRUCTURALPROTEIN 6, NSP6, (Alphacoronavirus1) |
PF08717(nsp8) | 4 | LYS A 46ARG A 51GLU A 50ALA A 53 | None | 1.22A | 6an0A-3ub0A:undetectable | 6an0A-3ub0A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2y | SPHINGOSINE1-PHOSPHATE RECEPTOR1, LYSOZYME CHIMERA(E.C.3.2.1.17) (Homo sapiens;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | GLU A1064GLU A1062ALA A1063LYS A1060 | None | 1.22A | 6an0A-3v2yA:undetectable | 6an0A-3v2yA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vep | UNCHARACTERIZEDPROTEINRV3413C/MT3522 (Mycobacteriumtuberculosis) |
no annotation | 4 | GLU X 32ARG X 51GLU X 29ALA X 26 | None | 1.06A | 6an0A-3vepX:undetectable | 6an0A-3vepX:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bja | PROTEIN GLB-12 (Caenorhabditiselegans) |
PF00042(Globin) | 4 | GLU A 208ARG A 211GLU A 210ALA A 212 | None | 0.93A | 6an0A-4bjaA:undetectable | 6an0A-4bjaA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgk | SECRETED 45 KDAPROTEIN (Streptococcuspneumoniae) |
PF05257(CHAP) | 4 | GLU A 227GLU A 195ALA A 198LYS A 197 | None | 0.97A | 6an0A-4cgkA:undetectable | 6an0A-4cgkA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddw | REVERSE GYRASE (Thermotogamaritima) |
PF00270(DEAD)PF01131(Topoisom_bac)PF01751(Toprim) | 4 | GLU A 808GLU A 807ALA A 806LYS A 944 | None | 0.82A | 6an0A-4ddwA:undetectable | 6an0A-4ddwA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6d | RNA POLYMERASE SIGMAFACTOR RPOD (Staphylococcusaureus) |
PF04545(Sigma70_r4) | 4 | GLU A 553GLU A 589ALA A 592LYS A 591 | None | 0.98A | 6an0A-4g6dA:undetectable | 6an0A-4g6dA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8x | RNA POLYMERASE SIGMAFACTOR RPOD (Staphylococcusaureus) |
PF04545(Sigma70_r4) | 4 | GLU A 311GLU A 347ALA A 350LYS A 349 | None | 0.86A | 6an0A-4g8xA:undetectable | 6an0A-4g8xA:8.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnr | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN-BRANCHEDCHAIN AMINO ACIDTRANSPORT (Streptococcuspneumoniae) |
PF13458(Peripla_BP_6) | 4 | GLU A 48LYS A 90GLU A 95ALA A 96 | None | 0.83A | 6an0A-4gnrA:4.4 | 6an0A-4gnrA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ied | CLASS DBETA-LACTAMASE (Fusobacteriumnucleatum) |
PF00905(Transpeptidase) | 4 | LYS A 19ARG A 24GLU A 23LYS A 25 | None | 1.23A | 6an0A-4iedA:undetectable | 6an0A-4iedA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENC2 (Yersiniaentomophaga) |
no annotation | 4 | GLU B 638ARG B 513ALA B 531LYS B 516 | None | 1.10A | 6an0A-4iglB:undetectable | 6an0A-4iglB:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inq | OXYSTEROL-BINDINGPROTEIN HOMOLOG 3 (Saccharomycescerevisiae) |
PF01237(Oxysterol_BP) | 4 | LYS A 985ARG A 983GLU A 982LYS A 978 | None | 1.24A | 6an0A-4inqA:undetectable | 6an0A-4inqA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m6t | RNA POLYMERASEII-ASSOCIATED FACTOR1 HOMOLOG, LINKER,RNAPOLYMERASE-ASSOCIATED PROTEIN LEO1 (Homo sapiens) |
PF03985(Paf1)PF04004(Leo1) | 4 | LYS A 143ARG A 151GLU A 147ALA A 18 | None | 1.14A | 6an0A-4m6tA:undetectable | 6an0A-4m6tA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovs | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Sulfurospirillumdeleyianum) |
PF03480(DctP) | 4 | GLU A 265LYS A 267GLU A 263ALA A 261 | None | 1.06A | 6an0A-4ovsA:undetectable | 6an0A-4ovsA:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qq1 | TRANSFERRIN-BINDINGPROTEIN 2 (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 4 | GLU A 179GLU A 65ALA A 57LYS A 64 | None | 1.07A | 6an0A-4qq1A:undetectable | 6an0A-4qq1A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmo | CPTN TOXIN ([Eubacterium]rectale) |
no annotation | 4 | GLU A 123LYS A 125GLU A 121ALA A 119 | None | 1.21A | 6an0A-4rmoA:undetectable | 6an0A-4rmoA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | GLU A 216LYS A 218GLU A 214ALA A 212 | None | 1.02A | 6an0A-4wsqA:undetectable | 6an0A-4wsqA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xaa | PUTATIVE OXYGENASE (Streptomycesviridochromogenes) |
PF05721(PhyH) | 4 | GLU A 83ARG A 41GLU A 40ALA A 39 | None | 1.16A | 6an0A-4xaaA:undetectable | 6an0A-4xaaA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yjw | DUF3829 FAMILYPROTEIN (Bacteroidesvulgatus) |
no annotation | 4 | GLU A 155LYS A 129GLU A 126ALA A 123 | None | 1.06A | 6an0A-4yjwA:undetectable | 6an0A-4yjwA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfa | BETA-GALACTOSIDASE (Geobacillusstearothermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | LYS A 470ARG A 468GLU A 413ALA A 412 | None | 0.98A | 6an0A-5dfaA:undetectable | 6an0A-5dfaA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyj | MYOSIN HEAVY CHAINKINASE A (Dictyosteliumdiscoideum) |
PF02816(Alpha_kinase) | 4 | ARG A 592GLU A 593ALA A 594LYS A 645 | AMP A 904 (-3.9A)NoneAMP A 904 ( 4.0A)AMP A 904 (-2.9A) | 0.46A | 6an0A-5dyjA:undetectable | 6an0A-5dyjA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e53 | CONTACTIN-1 (Gallus gallus) |
PF00041(fn3) | 4 | LYS A 761ARG A 712GLU A 713ALA A 795 | None | 1.16A | 6an0A-5e53A:undetectable | 6an0A-5e53A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4l | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Clostridium sp.) |
PF13561(adh_short_C2) | 4 | GLU A 60LYS A 62GLU A 58ALA A 56 | None | 0.98A | 6an0A-5g4lA:4.3 | 6an0A-5g4lA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrj | PROTEIN RECA (Herbaspirillumseropedicae) |
PF00154(RecA) | 4 | GLU A 327LYS A 329GLU A 325ALA A 323 | None | 1.08A | 6an0A-5jrjA:2.9 | 6an0A-5jrjA:25.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrj | PROTEIN RECA (Herbaspirillumseropedicae) |
PF00154(RecA) | 4 | LYS A 329ARG A 324GLU A 325ALA A 323 | None | 1.20A | 6an0A-5jrjA:2.9 | 6an0A-5jrjA:25.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8o | 5-NITROANTHRANILICACID AMINOHYDROLASE (Bradyrhizobiumsp.) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | GLU A 316LYS A 329GLU A 327ALA A 326 | None | 1.20A | 6an0A-5k8oA:undetectable | 6an0A-5k8oA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kis | RHS2 (Yersiniaentomophaga) |
no annotation | 4 | GLU B 637ARG B 512ALA B 530LYS B 515 | None | 1.12A | 6an0A-5kisB:undetectable | 6an0A-5kisB:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lso | SPLICING FACTOR 45 (Homo sapiens) |
PF00076(RRM_1) | 4 | GLU A 351ARG A 354GLU A 343ALA A 347 | None | 1.11A | 6an0A-5lsoA:undetectable | 6an0A-5lsoA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mp4 | PROTOPLAST SECRETEDPROTEIN 2 (Saccharomycescerevisiae) |
PF03358(FMN_red) | 4 | GLU A 185LYS A 23GLU A 27ALA A 28 | None | 0.92A | 6an0A-5mp4A:2.6 | 6an0A-5mp4A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mx2 | PHOTOSYSTEM II 12KDA EXTRINSICPROTEIN (Thermosynechococcuselongatus) |
PF06514(PsbU) | 4 | GLU U 77LYS U 72ARG U 70GLU U 69 | None | 1.16A | 6an0A-5mx2U:undetectable | 6an0A-5mx2U:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nr4 | CLIP-ASSOCIATINGPROTEIN 2 (Homo sapiens) |
no annotation | 4 | LYS A 107ARG A 100GLU A 111ALA A 112 | None | 1.23A | 6an0A-5nr4A:undetectable | 6an0A-5nr4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szp | PROTOCADHERIN GAMMAB7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | GLU A 114ARG A 172GLU A 175ALA A 174 | CA A 505 ( 2.9A) CA A 505 ( 4.8A)NoneNone | 1.16A | 6an0A-5szpA:undetectable | 6an0A-5szpA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3c | CTP SYNTHASE (Escherichiacoli) |
PF00117(GATase)PF06418(CTP_synth_N) | 4 | GLU A 517LYS A 306GLU A 310ALA A 311 | None | 1.11A | 6an0A-5u3cA:undetectable | 6an0A-5u3cA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v6b | PDZDOMAIN-CONTAININGPROTEIN GIPC1 (Mus musculus) |
PF00595(PDZ) | 4 | GLU A 179ARG A 131GLU A 213LYS A 128 | None | 1.08A | 6an0A-5v6bA:undetectable | 6an0A-5v6bA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wzk | PUMILIO HOMOLOG 23 (Arabidopsisthaliana) |
no annotation | 4 | LYS A 600ARG A 560GLU A 561ALA A 564 | None | 1.05A | 6an0A-5wzkA:undetectable | 6an0A-5wzkA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S5-B,PUTATIVE (Trichomonasvaginalis) |
PF00177(Ribosomal_S7) | 4 | LYS F 182ARG F 187GLU F 186ALA F 189 | None | 1.04A | 6an0A-5xyiF:undetectable | 6an0A-5xyiF:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y1g | NAD DEPENDENTEPIMERASE/DEHYDRATASE FAMILY (unculturedarchaeonMedDCM-OCT-S05-C57) |
no annotation | 4 | GLU A 246ARG A 200GLU A 244ALA A 242 | None | 1.01A | 6an0A-5y1gA:2.6 | 6an0A-5y1gA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zxd | - (-) |
no annotation | 4 | LYS A 258GLU A 262ALA A 265LYS A 264 | None | 1.22A | 6an0A-5zxdA:undetectable | 6an0A-5zxdA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6an0 | HISTIDINOLDEHYDROGENASE (Elizabethkingiaanophelis) |
PF00815(Histidinol_dh) | 6 | GLU A 98LYS A 100ARG A 113GLU A 114ALA A 115LYS A 385 | HIS A 520 (-3.5A)NoneHIS A 520 (-4.9A)HIS A 520 (-4.4A)HIS A 520 (-3.5A)HIS A 520 (-3.7A) | 0.00A | 6an0A-6an0A:60.4 | 6an0A-6an0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b6l | GLYCOSYL HYDROLASEFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 4 | GLU A 344LYS A 342ARG A 337GLU A 339 | None | 1.21A | 6an0A-6b6lA:undetectable | 6an0A-6b6lA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9u | DNA GYRASE, SUBUNITB:SHORT-CHAINDEHYDROGENASE/REDUCTASESDR:GLUCOSE/RIBITOLDEHYDROGENASE (Brucellaabortus) |
no annotation | 4 | LYS A 40ARG A 45GLU A 44ALA A 47 | None | 1.00A | 6an0A-6b9uA:4.5 | 6an0A-6b9uA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btm | ALTERNATIVE COMPLEXIII SUBUNIT BALTERNATIVE COMPLEXIII SUBUNIT E (Flavobacteriumjohnsoniae;Flavobacteriumjohnsoniae) |
no annotationno annotation | 4 | GLU E 41LYS B 76GLU E 45ALA E 46 | None | 1.24A | 6an0A-6btmE:undetectable | 6an0A-6btmE:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 4 | LYS B 235ARG B 233GLU B 232ALA B 231 | None | 1.14A | 6an0A-6evjB:undetectable | 6an0A-6evjB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5o | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Bvirus) |
no annotation | 4 | LYS B 235ARG B 233GLU B 232ALA B 231 | None | 1.19A | 6an0A-6f5oB:undetectable | 6an0A-6f5oB:undetectable |