SIMILAR PATTERNS OF AMINO ACIDS FOR 6AN0_A_HISA520

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey1 ANTITERMINATION
FACTOR NUSB


(Escherichia
coli)
PF01029
(NusB)
4 GLU A  50
ARG A  49
GLU A  31
ALA A  28
None
1.17A 6an0A-1ey1A:
undetectable
6an0A-1ey1A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE


(Fusarium
oxysporum)
PF00067
(p450)
4 GLU A 361
LYS A 359
GLU A 355
ALA A 354
None
None
None
HEM  A 501 (-3.2A)
1.07A 6an0A-1f26A:
undetectable
6an0A-1f26A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7h FERREDOXIN

(Escherichia
coli)
PF00111
(Fer2)
4 GLU A  39
ARG A 109
GLU A 110
ALA A 108
None
0.99A 6an0A-1i7hA:
undetectable
6an0A-1i7hA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens)
PF00102
(Y_phosphatase)
4 GLU A1616
LYS A1618
GLU A1614
ALA A1612
None
1.05A 6an0A-1larA:
0.4
6an0A-1larA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum)
PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N)
4 GLU A 232
LYS A 182
GLU A 167
ALA A 226
None
1.11A 6an0A-1lf9A:
0.8
6an0A-1lf9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE


(Pyrococcus
furiosus)
PF03070
(TENA_THI-4)
4 GLU A 198
LYS A 130
GLU A 134
ALA A 135
MP5  A1213 (-2.6A)
None
None
None
1.24A 6an0A-1rtwA:
0.5
6an0A-1rtwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufn PUTATIVE NUCLEAR
PROTEIN HOMOLOG
5830484A20RIK


(Mus musculus)
PF01342
(SAND)
4 GLU A  58
LYS A  25
GLU A  45
ALA A  46
None
1.10A 6an0A-1ufnA:
undetectable
6an0A-1ufnA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus)
PF00962
(A_deaminase)
4 GLU A 139
GLU A  85
ALA A  83
LYS A  80
None
1.20A 6an0A-1uioA:
0.3
6an0A-1uioA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT


(Blastochloris
viridis)
PF02276
(CytoC_RC)
4 LYS C  29
ARG C  34
GLU C  33
ALA C  36
None
1.16A 6an0A-1vrnC:
undetectable
6an0A-1vrnC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2


(Thermotoga
maritima)
PF00871
(Acetate_kinase)
4 GLU A 164
GLU A 334
ALA A 337
LYS A 336
None
1.02A 6an0A-1x9jA:
0.7
6an0A-1x9jA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD


(Thermus
thermophilus)
PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
4 LYS F 230
ARG F 104
GLU F 107
ALA F 103
None
0.80A 6an0A-2a6eF:
undetectable
6an0A-2a6eF:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
4 GLU A  67
ARG A 122
GLU A 123
ALA A 124
None
1.24A 6an0A-2c11A:
undetectable
6an0A-2c11A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2da6 HEPATOCYTE NUCLEAR
FACTOR 1-BETA


(Homo sapiens)
PF00046
(Homeobox)
4 GLU A  35
LYS A  33
GLU A  37
ALA A  38
None
1.12A 6an0A-2da6A:
undetectable
6an0A-2da6A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 LYS A 444
ARG A 410
GLU A 441
ALA A 439
None
1.23A 6an0A-2e5vA:
1.8
6an0A-2e5vA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME


(Agrobacterium
tumefaciens)
PF00206
(Lyase_1)
4 GLU A  46
ARG A 218
GLU A  44
ALA A  45
None
1.16A 6an0A-2felA:
undetectable
6an0A-2felA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqc RHOMBOID
INTRAMEMBRANE
PROTEASE


(Pseudomonas
aeruginosa)
PF16733
(NRho)
4 GLU A  68
ARG A  57
GLU A  60
ALA A  70
None
1.23A 6an0A-2gqcA:
undetectable
6an0A-2gqcA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msy HOMEOBOX PROTEIN
HOX-C9


(Homo sapiens)
PF00046
(Homeobox)
4 GLU A  50
ARG A  39
GLU A  41
ALA A  43
None
1.25A 6an0A-2msyA:
undetectable
6an0A-2msyA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov1 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER


(Synechocystis
sp. PCC 6803)
PF01297
(ZnuA)
4 GLU A 197
GLU A  99
ALA A 100
LYS A 124
None
1.20A 6an0A-2ov1A:
undetectable
6an0A-2ov1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7v RNA POLYMERASE SIGMA
FACTOR RPOD


(Escherichia
coli)
PF04545
(Sigma70_r4)
4 GLU B 555
GLU B 591
ALA B 594
LYS B 593
None
0.95A 6an0A-2p7vB:
undetectable
6an0A-2p7vB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qni UNCHARACTERIZED
PROTEIN ATU0299


(Agrobacterium
fabrum)
PF00300
(His_Phos_1)
4 LYS A 171
GLU A 175
ALA A 205
LYS A 203
None
1.24A 6an0A-2qniA:
undetectable
6an0A-2qniA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, LIGHT
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 GLU L 185
LYS L 183
ARG L 188
GLU L 187
None
1.17A 6an0A-2r4sL:
undetectable
6an0A-2r4sL:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli)
PF00154
(RecA)
4 GLU A 320
LYS A 322
GLU A 318
ALA A 316
None
1.20A 6an0A-2rebA:
3.0
6an0A-2rebA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE


(Acetobacter
pasteurianus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 GLU A 365
LYS A 508
GLU A 358
ALA A 359
None
0.83A 6an0A-2vbiA:
undetectable
6an0A-2vbiA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN


(Thermotoga
maritima)
PF01887
(SAM_adeno_trans)
4 GLU A 173
ARG A  44
GLU A 255
ALA A 175
None
1.05A 6an0A-2zbvA:
undetectable
6an0A-2zbvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
4 GLU A  59
LYS A  26
GLU A  30
LYS A  32
None
1.09A 6an0A-3a4tA:
3.9
6an0A-3a4tA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bey CONSERVED PROTEIN
O27018


(Methanothermobacter
thermautotrophicus)
PF02627
(CMD)
4 LYS A  37
ARG A  35
GLU A  34
ALA A  61
None
1.05A 6an0A-3beyA:
undetectable
6an0A-3beyA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwl SENSOR PROTEIN

(Haloarcula
marismortui)
PF08448
(PAS_4)
4 ARG A 388
GLU A 387
ALA A 386
LYS A 389
None
1.10A 6an0A-3bwlA:
undetectable
6an0A-3bwlA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES


(Corynebacterium
glutamicum)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
4 LYS A 286
ARG A 276
GLU A 285
ALA A 279
None
0.95A 6an0A-3c4qA:
3.9
6an0A-3c4qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
4 GLU A 395
ARG A 288
ALA A 284
LYS A 285
None
1.17A 6an0A-3cmmA:
undetectable
6an0A-3cmmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A 320
LYS A 322
GLU A 318
ALA A 316
None
0.97A 6an0A-3cmtA:
2.5
6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A1320
LYS A1322
GLU A1318
ALA A1316
None
0.97A 6an0A-3cmtA:
2.5
6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A2320
LYS A2322
GLU A2318
ALA A2316
None
0.98A 6an0A-3cmtA:
2.5
6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A3320
LYS A3322
GLU A3318
ALA A3316
None
0.97A 6an0A-3cmtA:
2.5
6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A4320
LYS A4322
GLU A4318
ALA A4316
None
0.97A 6an0A-3cmtA:
2.5
6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A 320
LYS A 322
GLU A 318
ALA A 316
None
1.18A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A1320
LYS A1322
GLU A1318
ALA A1316
None
1.21A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A2320
LYS A2322
GLU A2318
ALA A2316
None
1.19A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A3320
LYS A3322
GLU A3318
ALA A3316
None
1.19A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A4320
LYS A4322
GLU A4318
ALA A4316
None
1.19A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A5320
LYS A5322
GLU A5318
ALA A5316
None
1.19A 6an0A-3cmuA:
undetectable
6an0A-3cmuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A 320
LYS A 322
GLU A 318
ALA A 316
None
1.14A 6an0A-3cmvA:
3.0
6an0A-3cmvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A2320
LYS A2322
GLU A2318
ALA A2316
None
1.05A 6an0A-3cmvA:
3.0
6an0A-3cmvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 GLU A3320
LYS A3322
GLU A3318
ALA A3316
None
1.22A 6an0A-3cmvA:
3.0
6an0A-3cmvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN


(Bacteroides
thetaiotaomicron)
PF02661
(Fic)
4 LYS A  68
GLU A  72
ALA A  75
LYS A  74
None
1.19A 6an0A-3cucA:
undetectable
6an0A-3cucA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382


(Thermotoga
maritima)
PF00293
(NUDIX)
4 GLU A  49
ARG A  45
GLU A  47
ALA A  48
None
1.22A 6an0A-3e57A:
undetectable
6an0A-3e57A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B


(Escherichia
coli)
PF02518
(HATPase_c)
4 GLU A  82
ARG A  93
GLU A  88
ALA A  86
None
1.21A 6an0A-3fv5A:
undetectable
6an0A-3fv5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLU A 205
ARG A 198
GLU A 200
ALA A 237
None
1.14A 6an0A-3gvpA:
3.3
6an0A-3gvpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik5 PROTEIN NEF

(Simian
immunodeficiency
virus)
PF00469
(F-protein)
4 GLU A 150
LYS A 148
ARG A 109
GLU A 147
GLU  A 150 ( 0.6A)
LYS  A 148 ( 0.0A)
ARG  A 109 ( 0.6A)
GLU  A 147 ( 0.6A)
1.06A 6an0A-3ik5A:
undetectable
6an0A-3ik5A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2v PREC/CORE PROTEIN

(Hepatitis B
virus)
no annotation 4 GLU C  46
ARG C  56
GLU C  43
ALA C  41
None
1.21A 6an0A-3j2vC:
undetectable
6an0A-3j2vC:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254


(Thermotoga
maritima)
PF13419
(HAD_2)
5 GLU A 164
LYS A 167
GLU A 171
ALA A 172
LYS A 140
GLU  A 164 ( 0.6A)
LYS  A 167 (-0.0A)
GLU  A 171 ( 0.6A)
ALA  A 172 ( 0.0A)
LYS  A 140 (-0.0A)
1.48A 6an0A-3kbbA:
4.2
6an0A-3kbbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A


(Homo sapiens)
PF13419
(HAD_2)
4 GLU A 175
GLU A 182
ALA A 183
LYS A 149
K  A 229 (-3.3A)
None
None
K  A 229 ( 4.2A)
1.02A 6an0A-3l5kA:
3.8
6an0A-3l5kA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Trypanosoma
brucei)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 LYS A 240
ARG A 235
GLU A 236
ALA A 234
None
0.88A 6an0A-3nvlA:
4.2
6an0A-3nvlA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1
ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1


(Anopheles
gambiae;
Anopheles
gambiae)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 GLU B 705
LYS B 700
ARG A 500
GLU A 501
None
1.20A 6an0A-3ojaB:
undetectable
6an0A-3ojaB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdt MYOSIN HEAVY CHAIN
KINASE A


(Dictyostelium
discoideum)
PF02816
(Alpha_kinase)
4 ARG A 592
GLU A 593
ALA A 594
LYS A 645
ADP  A 811 (-4.1A)
None
ADP  A 811 ( 3.8A)
ADP  A 811 (-2.7A)
0.48A 6an0A-3pdtA:
undetectable
6an0A-3pdtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE


(Bacteroides
thetaiotaomicron)
PF13419
(HAD_2)
4 GLU A 171
GLU A 178
ALA A 179
LYS A 147
None
1.03A 6an0A-3qucA:
3.6
6an0A-3qucA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro3 G-PROTEIN-SIGNALING
MODULATOR 2


(Mus musculus)
PF13424
(TPR_12)
4 LYS A 231
ARG A 235
GLU A 234
ALA A 237
None
1.03A 6an0A-3ro3A:
undetectable
6an0A-3ro3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ub0 NON-STRUCTURAL
PROTEIN 6, NSP6,


(Alphacoronavirus
1)
PF08717
(nsp8)
4 LYS A  46
ARG A  51
GLU A  50
ALA A  53
None
1.22A 6an0A-3ub0A:
undetectable
6an0A-3ub0A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)


(Homo sapiens;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
4 GLU A1064
GLU A1062
ALA A1063
LYS A1060
None
1.22A 6an0A-3v2yA:
undetectable
6an0A-3v2yA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vep UNCHARACTERIZED
PROTEIN
RV3413C/MT3522


(Mycobacterium
tuberculosis)
no annotation 4 GLU X  32
ARG X  51
GLU X  29
ALA X  26
None
1.06A 6an0A-3vepX:
undetectable
6an0A-3vepX:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bja PROTEIN GLB-12

(Caenorhabditis
elegans)
PF00042
(Globin)
4 GLU A 208
ARG A 211
GLU A 210
ALA A 212
None
0.93A 6an0A-4bjaA:
undetectable
6an0A-4bjaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgk SECRETED 45 KDA
PROTEIN


(Streptococcus
pneumoniae)
PF05257
(CHAP)
4 GLU A 227
GLU A 195
ALA A 198
LYS A 197
None
0.97A 6an0A-4cgkA:
undetectable
6an0A-4cgkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
4 GLU A 808
GLU A 807
ALA A 806
LYS A 944
None
0.82A 6an0A-4ddwA:
undetectable
6an0A-4ddwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6d RNA POLYMERASE SIGMA
FACTOR RPOD


(Staphylococcus
aureus)
PF04545
(Sigma70_r4)
4 GLU A 553
GLU A 589
ALA A 592
LYS A 591
None
0.98A 6an0A-4g6dA:
undetectable
6an0A-4g6dA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8x RNA POLYMERASE SIGMA
FACTOR RPOD


(Staphylococcus
aureus)
PF04545
(Sigma70_r4)
4 GLU A 311
GLU A 347
ALA A 350
LYS A 349
None
0.86A 6an0A-4g8xA:
undetectable
6an0A-4g8xA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT


(Streptococcus
pneumoniae)
PF13458
(Peripla_BP_6)
4 GLU A  48
LYS A  90
GLU A  95
ALA A  96
None
0.83A 6an0A-4gnrA:
4.4
6an0A-4gnrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE


(Fusobacterium
nucleatum)
PF00905
(Transpeptidase)
4 LYS A  19
ARG A  24
GLU A  23
LYS A  25
None
1.23A 6an0A-4iedA:
undetectable
6an0A-4iedA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga)
no annotation 4 GLU B 638
ARG B 513
ALA B 531
LYS B 516
None
1.10A 6an0A-4iglB:
undetectable
6an0A-4iglB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3


(Saccharomyces
cerevisiae)
PF01237
(Oxysterol_BP)
4 LYS A 985
ARG A 983
GLU A 982
LYS A 978
None
1.24A 6an0A-4inqA:
undetectable
6an0A-4inqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1


(Homo sapiens)
PF03985
(Paf1)
PF04004
(Leo1)
4 LYS A 143
ARG A 151
GLU A 147
ALA A  18
None
1.14A 6an0A-4m6tA:
undetectable
6an0A-4m6tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Sulfurospirillum
deleyianum)
PF03480
(DctP)
4 GLU A 265
LYS A 267
GLU A 263
ALA A 261
None
1.06A 6an0A-4ovsA:
undetectable
6an0A-4ovsA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 GLU A 179
GLU A  65
ALA A  57
LYS A  64
None
1.07A 6an0A-4qq1A:
undetectable
6an0A-4qq1A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmo CPTN TOXIN

([Eubacterium]
rectale)
no annotation 4 GLU A 123
LYS A 125
GLU A 121
ALA A 119
None
1.21A 6an0A-4rmoA:
undetectable
6an0A-4rmoA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
4 GLU A 216
LYS A 218
GLU A 214
ALA A 212
None
1.02A 6an0A-4wsqA:
undetectable
6an0A-4wsqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes)
PF05721
(PhyH)
4 GLU A  83
ARG A  41
GLU A  40
ALA A  39
None
1.16A 6an0A-4xaaA:
undetectable
6an0A-4xaaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjw DUF3829 FAMILY
PROTEIN


(Bacteroides
vulgatus)
no annotation 4 GLU A 155
LYS A 129
GLU A 126
ALA A 123
None
1.06A 6an0A-4yjwA:
undetectable
6an0A-4yjwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 LYS A 470
ARG A 468
GLU A 413
ALA A 412
None
0.98A 6an0A-5dfaA:
undetectable
6an0A-5dfaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyj MYOSIN HEAVY CHAIN
KINASE A


(Dictyostelium
discoideum)
PF02816
(Alpha_kinase)
4 ARG A 592
GLU A 593
ALA A 594
LYS A 645
AMP  A 904 (-3.9A)
None
AMP  A 904 ( 4.0A)
AMP  A 904 (-2.9A)
0.46A 6an0A-5dyjA:
undetectable
6an0A-5dyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e53 CONTACTIN-1

(Gallus gallus)
PF00041
(fn3)
4 LYS A 761
ARG A 712
GLU A 713
ALA A 795
None
1.16A 6an0A-5e53A:
undetectable
6an0A-5e53A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Clostridium sp.)
PF13561
(adh_short_C2)
4 GLU A  60
LYS A  62
GLU A  58
ALA A  56
None
0.98A 6an0A-5g4lA:
4.3
6an0A-5g4lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae)
PF00154
(RecA)
4 GLU A 327
LYS A 329
GLU A 325
ALA A 323
None
1.08A 6an0A-5jrjA:
2.9
6an0A-5jrjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae)
PF00154
(RecA)
4 LYS A 329
ARG A 324
GLU A 325
ALA A 323
None
1.20A 6an0A-5jrjA:
2.9
6an0A-5jrjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE


(Bradyrhizobium
sp.)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 GLU A 316
LYS A 329
GLU A 327
ALA A 326
None
1.20A 6an0A-5k8oA:
undetectable
6an0A-5k8oA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga)
no annotation 4 GLU B 637
ARG B 512
ALA B 530
LYS B 515
None
1.12A 6an0A-5kisB:
undetectable
6an0A-5kisB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lso SPLICING FACTOR 45

(Homo sapiens)
PF00076
(RRM_1)
4 GLU A 351
ARG A 354
GLU A 343
ALA A 347
None
1.11A 6an0A-5lsoA:
undetectable
6an0A-5lsoA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp4 PROTOPLAST SECRETED
PROTEIN 2


(Saccharomyces
cerevisiae)
PF03358
(FMN_red)
4 GLU A 185
LYS A  23
GLU A  27
ALA A  28
None
0.92A 6an0A-5mp4A:
2.6
6an0A-5mp4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx2 PHOTOSYSTEM II 12
KDA EXTRINSIC
PROTEIN


(Thermosynechococcus
elongatus)
PF06514
(PsbU)
4 GLU U  77
LYS U  72
ARG U  70
GLU U  69
None
1.16A 6an0A-5mx2U:
undetectable
6an0A-5mx2U:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr4 CLIP-ASSOCIATING
PROTEIN 2


(Homo sapiens)
no annotation 4 LYS A 107
ARG A 100
GLU A 111
ALA A 112
None
1.23A 6an0A-5nr4A:
undetectable
6an0A-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7


(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
4 GLU A 114
ARG A 172
GLU A 175
ALA A 174
CA  A 505 ( 2.9A)
CA  A 505 ( 4.8A)
None
None
1.16A 6an0A-5szpA:
undetectable
6an0A-5szpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli)
PF00117
(GATase)
PF06418
(CTP_synth_N)
4 GLU A 517
LYS A 306
GLU A 310
ALA A 311
None
1.11A 6an0A-5u3cA:
undetectable
6an0A-5u3cA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1


(Mus musculus)
PF00595
(PDZ)
4 GLU A 179
ARG A 131
GLU A 213
LYS A 128
None
1.08A 6an0A-5v6bA:
undetectable
6an0A-5v6bA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana)
no annotation 4 LYS A 600
ARG A 560
GLU A 561
ALA A 564
None
1.05A 6an0A-5wzkA:
undetectable
6an0A-5wzkA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE


(Trichomonas
vaginalis)
PF00177
(Ribosomal_S7)
4 LYS F 182
ARG F 187
GLU F 186
ALA F 189
None
1.04A 6an0A-5xyiF:
undetectable
6an0A-5xyiF:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY


(uncultured
archaeon
MedDCM-OCT-S05-C57)
no annotation 4 GLU A 246
ARG A 200
GLU A 244
ALA A 242
None
1.01A 6an0A-5y1gA:
2.6
6an0A-5y1gA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-)
no annotation 4 LYS A 258
GLU A 262
ALA A 265
LYS A 264
None
1.22A 6an0A-5zxdA:
undetectable
6an0A-5zxdA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6an0 HISTIDINOL
DEHYDROGENASE


(Elizabethkingia
anophelis)
PF00815
(Histidinol_dh)
6 GLU A  98
LYS A 100
ARG A 113
GLU A 114
ALA A 115
LYS A 385
HIS  A 520 (-3.5A)
None
HIS  A 520 (-4.9A)
HIS  A 520 (-4.4A)
HIS  A 520 (-3.5A)
HIS  A 520 (-3.7A)
0.00A 6an0A-6an0A:
60.4
6an0A-6an0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 4 GLU A 344
LYS A 342
ARG A 337
GLU A 339
None
1.21A 6an0A-6b6lA:
undetectable
6an0A-6b6lA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE


(Brucella
abortus)
no annotation 4 LYS A  40
ARG A  45
GLU A  44
ALA A  47
None
1.00A 6an0A-6b9uA:
4.5
6an0A-6b9uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT E


(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae)
no annotation
no annotation
4 GLU E  41
LYS B  76
GLU E  45
ALA E  46
None
1.24A 6an0A-6btmE:
undetectable
6an0A-6btmE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza A
virus)
no annotation 4 LYS B 235
ARG B 233
GLU B 232
ALA B 231
None
1.14A 6an0A-6evjB:
undetectable
6an0A-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza B
virus)
no annotation 4 LYS B 235
ARG B 233
GLU B 232
ALA B 231
None
1.19A 6an0A-6f5oB:
undetectable
6an0A-6f5oB:
undetectable