SIMILAR PATTERNS OF AMINO ACIDS FOR 6AK3_B_P2EB1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 THR A 647
THR A 644
LEU A 478
SER A 174
GLN A 173
 None
 1.39A 6ak3B-1g8xA:
2.7		 6ak3B-1g8xA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 THR A 658
THR A 655
LEU A 489
SER A 185
GLN A 184
 None
 1.41A 6ak3B-1jx2A:
1.6		 6ak3B-1jx2A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		5 GLN 1  88
THR 1  79
THR 1  72
LEU 1  98
SER 1 169
 None
 1.45A 6ak3B-1y791:
0.0		 6ak3B-1y791:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 THR B  97
THR B  98
TYR B 468
LEU B 502
SER B 457
 None
 1.44A 6ak3B-6btmB:
0.0		 6ak3B-6btmB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 PRO A 292
VAL A 326
GLY A 308
VAL A 313
 None
 1.02A 6ak3B-1dm3A:
0.0		 6ak3B-1dm3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		4 PRO A 216
VAL A  90
GLY A  34
VAL A 141
 None
 1.09A 6ak3B-1dmuA:
0.3		 6ak3B-1dmuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 PRO A 129
VAL A  97
GLY A 152
VAL A 115
 None
 1.07A 6ak3B-1e2zA:
0.0		 6ak3B-1e2zA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		4 PRO A  83
VAL A  97
GLY A 145
VAL A 117
 None
 1.09A 6ak3B-1esoA:
undetectable		 6ak3B-1esoA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 193
VAL A 173
GLY A 163
VAL A 143
 None
 0.88A 6ak3B-1fw8A:
0.0		 6ak3B-1fw8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 193
VAL A 173
GLY A 164
VAL A 143
 None
 1.09A 6ak3B-1fw8A:
0.0		 6ak3B-1fw8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum
bicolor;
Sorghum bicolor) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 PRO A  14
VAL B 303
GLY A  78
VAL A  82
 None
 0.86A 6ak3B-1gxsA:
0.3		 6ak3B-1gxsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 297
VAL A  82
GLY A  65
VAL A 117
 None
 1.11A 6ak3B-1i41A:
0.0		 6ak3B-1i41A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 PRO A 237
VAL A 105
GLY A  23
VAL A  28
 None
 0.98A 6ak3B-1m33A:
0.0		 6ak3B-1m33A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PRO A 332
VAL A  17
GLY A 317
VAL A 255
 None
 1.11A 6ak3B-1mzjA:
undetectable		 6ak3B-1mzjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PRO A 332
VAL A  17
GLY A 326
VAL A 255
 None
 1.00A 6ak3B-1mzjA:
undetectable		 6ak3B-1mzjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 PRO A 486
VAL A 323
GLY A 420
VAL A 417
 None
 0.87A 6ak3B-1oseA:
undetectable		 6ak3B-1oseA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		4 PRO B 405
VAL B 451
GLY B 464
VAL B 496
 None
 1.06A 6ak3B-1ox4B:
undetectable		 6ak3B-1ox4B:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 PRO A 129
VAL A  97
GLY A 152
VAL A 115
 None
 1.06A 6ak3B-1q90A:
undetectable		 6ak3B-1q90A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PRO A1272
VAL A1187
GLY A1197
VAL A1044
 None
 1.11A 6ak3B-1s16A:
undetectable		 6ak3B-1s16A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PRO B  78
VAL B  59
GLY B  72
VAL B  34
 None
 1.08A 6ak3B-1skyB:
undetectable		 6ak3B-1skyB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A  36
VAL A  62
GLY A  76
VAL A  73
 None
 1.11A 6ak3B-1uypA:
undetectable		 6ak3B-1uypA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 PRO A   6
VAL A  37
GLY A 108
VAL A 135
 None
 1.11A 6ak3B-1ycdA:
undetectable		 6ak3B-1ycdA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 PRO A 296
VAL A 312
GLY A 306
VAL A 341
 None
 1.12A 6ak3B-1yx2A:
undetectable		 6ak3B-1yx2A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		4 PRO A 189
VAL A 201
GLY A 196
VAL A 153
 None
 0.99A 6ak3B-1zyoA:
undetectable		 6ak3B-1zyoA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 PRO A 738
VAL A 392
GLY A 492
VAL A 498
 None
 1.02A 6ak3B-2a3lA:
undetectable		 6ak3B-2a3lA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 PRO A 356
VAL A 460
GLY A 422
VAL A 360
 None
 1.05A 6ak3B-2a9cA:
undetectable		 6ak3B-2a9cA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A 314
VAL A 288
GLY A  84
TRP A  52
 None
 1.02A 6ak3B-2aeyA:
undetectable		 6ak3B-2aeyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 PRO A 426
VAL A 510
GLY A 458
VAL A 422
 None
 0.94A 6ak3B-2b3oA:
undetectable		 6ak3B-2b3oA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		4 PRO X 114
VAL X  96
GLY X  11
VAL X  85
 None
 1.11A 6ak3B-2bq8X:
undetectable		 6ak3B-2bq8X:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 PRO A 210
VAL A  60
GLY A 217
VAL A 195
 None
 1.12A 6ak3B-2cdqA:
undetectable		 6ak3B-2cdqA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkl L,D-TRANSPEPTIDASE

(Enterococcus
faecium) 		PF03734
(YkuD)
PF12229
(PG_binding_4) 		4 PRO A 378
VAL A 418
GLY A 430
VAL A 347
 None
 0.89A 6ak3B-2hklA:
undetectable		 6ak3B-2hklA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iab HYPOTHETICAL PROTEIN

(Streptomyces
avermitilis) 		PF01243
(Putative_PNPOx) 		4 PRO A 127
VAL A  85
GLY A  63
VAL A  54
 None
 1.07A 6ak3B-2iabA:
undetectable		 6ak3B-2iabA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp6 GIFSY-2 PROPHAGE
ATP-BINDING SUGAR
TRANSPORTER-LIKE
PROTEIN

(Salmonella
enterica) 		PF13856
(Gifsy-2) 		4 PRO A  86
VAL A  54
GLY A  49
VAL A  76
 None
 1.00A 6ak3B-2pp6A:
undetectable		 6ak3B-2pp6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdr UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF14499
(DUF4437) 		4 PRO A 236
VAL A 294
GLY A 241
VAL A 284
 None
 1.08A 6ak3B-2qdrA:
undetectable		 6ak3B-2qdrA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yro GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PRO A  92
VAL A 114
GLY A 139
VAL A  39
 None
 1.09A 6ak3B-2yroA:
undetectable		 6ak3B-2yroA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		4 PRO A 211
VAL A 199
GLY A 147
VAL A 137
 None
 1.06A 6ak3B-2ywrA:
undetectable		 6ak3B-2ywrA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zd2 ATP12 ATPASE

(Paracoccus
denitrificans) 		PF07542
(ATP12) 		4 PRO A1163
VAL A1082
GLY A1182
VAL A1158
 None
 1.02A 6ak3B-2zd2A:
undetectable		 6ak3B-2zd2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhp BLEOMYCIN RESISTANCE
PROTEIN

(Streptoalloteichus
hindustanus) 		no annotation 4 PRO A  59
VAL A  53
GLY A  40
VAL A  10
 None
 1.12A 6ak3B-2zhpA:
undetectable		 6ak3B-2zhpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 612
VAL A 556
GLY A 561
TRP A 588
 None
 0.92A 6ak3B-3ddrA:
undetectable		 6ak3B-3ddrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		4 PRO A 261
VAL A 238
GLY A 304
VAL A 309
 None
 1.01A 6ak3B-3dtgA:
undetectable		 6ak3B-3dtgA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE

(Lactobacillus
delbrueckii) 		PF00155
(Aminotran_1_2) 		4 VAL A 132
GLY A 352
TRP A 324
VAL A 117
 None
 1.08A 6ak3B-3dzzA:
undetectable		 6ak3B-3dzzA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eet PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 PRO A 154
VAL A 229
GLY A 173
VAL A 163
 None
 0.96A 6ak3B-3eetA:
undetectable		 6ak3B-3eetA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 PRO A  34
VAL A 288
GLY A 376
VAL A 140
 None
 1.05A 6ak3B-3gkqA:
undetectable		 6ak3B-3gkqA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		4 PRO A  81
VAL A 106
GLY A 111
VAL A 129
 None
 1.08A 6ak3B-3iefA:
undetectable		 6ak3B-3iefA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klu UNCHARACTERIZED
PROTEIN YQBN

(Bacillus
subtilis) 		PF08890
(Phage_TAC_5) 		4 PRO A 109
VAL A  87
GLY A 120
VAL A 116
 None
 1.00A 6ak3B-3kluA:
undetectable		 6ak3B-3kluA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 PRO A 281
VAL A 225
GLY A 358
VAL A 234
 None
 1.08A 6ak3B-3oepA:
undetectable		 6ak3B-3oepA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouo NUCLEOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF05733
(Tenui_N) 		4 PRO A 230
VAL A 234
GLY A 113
VAL A 153
 None
 0.99A 6ak3B-3ouoA:
undetectable		 6ak3B-3ouoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PRO A 121
VAL A 149
GLY A  89
VAL A 108
 None
 0.99A 6ak3B-3popA:
undetectable		 6ak3B-3popA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 PRO A 239
VAL A 298
GLY A 346
VAL A 243
 None
 0.96A 6ak3B-3rcnA:
undetectable		 6ak3B-3rcnA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 PRO A 513
VAL A 409
GLY A 481
VAL A 477
 None
 1.00A 6ak3B-3thcA:
undetectable		 6ak3B-3thcA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 135
VAL A 472
GLY A 128
VAL A  81
 None
 1.09A 6ak3B-3uk1A:
undetectable		 6ak3B-3uk1A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcx SPHINGOMYELINASE C

(Streptomyces
griseocarneus) 		PF03372
(Exo_endo_phos) 		4 PRO A  49
VAL A 180
GLY A 189
VAL A  53
 None
 1.12A 6ak3B-3wcxA:
undetectable		 6ak3B-3wcxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 PRO A 169
VAL A 197
GLY A 121
VAL A 175
 None
 1.09A 6ak3B-3wwxA:
undetectable		 6ak3B-3wwxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg4 ERFK/YBIS/YCFS/YNHG

(Enterococcus
faecium) 		PF03734
(YkuD) 		4 PRO A 378
VAL A 418
GLY A 430
VAL A 347
 None
 1.01A 6ak3B-3zg4A:
undetectable		 6ak3B-3zg4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		4 PRO A 100
VAL A 105
GLY A 348
VAL A  85
 None
 1.09A 6ak3B-4a39A:
undetectable		 6ak3B-4a39A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 PRO A  11
VAL B 318
GLY A  65
VAL A  75
 None
 0.86A 6ak3B-4az3A:
undetectable		 6ak3B-4az3A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 PRO A  11
VAL B 318
GLY A  71
VAL A  75
 None
 1.07A 6ak3B-4az3A:
undetectable		 6ak3B-4az3A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		4 PRO A  74
VAL A 122
GLY A 129
VAL A 148
 None
 1.09A 6ak3B-4b43A:
undetectable		 6ak3B-4b43A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PRO A 510
VAL A 555
GLY A 537
VAL A 550
 None
 1.08A 6ak3B-4cgtA:
undetectable		 6ak3B-4cgtA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO A   5
VAL A 384
GLY A  11
VAL A 305
 None
 1.06A 6ak3B-4cw4A:
undetectable		 6ak3B-4cw4A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 PRO A 137
VAL A 110
GLY A  11
VAL A  52
 None
None
GOL  A1229 (-3.5A)
None
 1.09A 6ak3B-4d7uA:
undetectable		 6ak3B-4d7uA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 PRO A1420
VAL A1334
GLY A1354
VAL A1382
 None
 1.06A 6ak3B-4d8oA:
undetectable		 6ak3B-4d8oA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PRO A 618
VAL A 488
GLY A 567
VAL A 615
 None
 0.95A 6ak3B-4fn5A:
undetectable		 6ak3B-4fn5A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PRO A 123
VAL A  59
GLY A  43
VAL A  74
 None
 0.99A 6ak3B-4fquA:
undetectable		 6ak3B-4fquA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 PRO A 429
VAL A 407
GLY A 387
VAL A 393
 None
 1.07A 6ak3B-4idmA:
undetectable		 6ak3B-4idmA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4w NUCLEOCAPSID

(Punta Toro
phlebovirus) 		PF05733
(Tenui_N) 		4 PRO A 229
VAL A 233
GLY A 112
VAL A 152
 None
 0.83A 6ak3B-4j4wA:
undetectable		 6ak3B-4j4wA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 PRO A 324
VAL A 282
GLY A 193
VAL A 228
 None
 1.10A 6ak3B-4krfA:
undetectable		 6ak3B-4krfA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 PRO A  95
VAL A 109
GLY A 151
VAL A 127
 None
 0.93A 6ak3B-4l05A:
undetectable		 6ak3B-4l05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 PRO A  11
VAL A 318
GLY A  65
VAL A  75
 PRO  A  11 ( 1.1A)
VAL  A 318 ( 0.6A)
GLY  A  65 ( 0.0A)
VAL  A  75 ( 0.6A)
 0.94A 6ak3B-4mwtA:
undetectable		 6ak3B-4mwtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 PRO A  11
VAL A 318
GLY A  71
VAL A  75
 PRO  A  11 ( 1.1A)
VAL  A 318 ( 0.6A)
GLY  A  71 ( 0.0A)
VAL  A  75 ( 0.6A)
 1.01A 6ak3B-4mwtA:
undetectable		 6ak3B-4mwtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		4 PRO A 237
VAL A 105
GLY A  23
VAL A  28
 None
 0.96A 6ak3B-4nmwA:
undetectable		 6ak3B-4nmwA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohx PROTEIN CLPF-1

(Caenorhabditis
elegans) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 PRO A 183
VAL A 157
GLY A 225
VAL A 168
 None
 1.00A 6ak3B-4ohxA:
undetectable		 6ak3B-4ohxA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR

(Streptomyces
aurantiacus) 		PF03446
(NAD_binding_2) 		4 PRO A  52
VAL A  75
GLY A  85
VAL A  62
 None
 1.10A 6ak3B-4oqzA:
undetectable		 6ak3B-4oqzA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR

(Streptomyces
aurantiacus) 		PF03446
(NAD_binding_2) 		4 PRO A  52
VAL A  75
GLY A 111
VAL A  62
 None
 1.11A 6ak3B-4oqzA:
undetectable		 6ak3B-4oqzA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A  71
VAL A 132
GLY A 583
VAL A  56
 None
 1.02A 6ak3B-4rvwA:
undetectable		 6ak3B-4rvwA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uon CAPSID PROTEASE

(Aura virus) 		PF00944
(Peptidase_S3) 		4 PRO A 221
VAL A 133
GLY A 254
VAL A 248
 None
 1.04A 6ak3B-4uonA:
undetectable		 6ak3B-4uonA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 201
VAL A 225
GLY A 249
VAL A 205
 None
 1.11A 6ak3B-4y1bA:
undetectable		 6ak3B-4y1bA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 PRO A 222
VAL A 267
GLY A 272
VAL A 181
 None
 1.00A 6ak3B-4yyfA:
undetectable		 6ak3B-4yyfA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 PRO A 118
VAL A 254
GLY A 161
VAL A 164
 None
 1.12A 6ak3B-4zadA:
undetectable		 6ak3B-4zadA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24

(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		PF00238
(Ribosomal_L14)
PF01246
(Ribosomal_L24e) 		4 PRO E 116
VAL G  22
GLY E  16
VAL E  54
 None
 1.09A 6ak3B-5an9E:
undetectable		 6ak3B-5an9E:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PRO A 114
VAL A 107
GLY A 159
VAL A 167
 None
 1.10A 6ak3B-5bp1A:
undetectable		 6ak3B-5bp1A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 PRO A 301
VAL A 164
GLY A 210
VAL A 194
 None
 1.01A 6ak3B-5bq2A:
undetectable		 6ak3B-5bq2A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		4 PRO A 395
VAL A 325
GLY A 370
VAL A 373
 None
 0.86A 6ak3B-5c6uA:
undetectable		 6ak3B-5c6uA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ces PA0618

(Pseudomonas
aeruginosa) 		no annotation 4 PRO A 269
VAL A 210
GLY A 291
VAL A 264
 None
 1.11A 6ak3B-5cesA:
undetectable		 6ak3B-5cesA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 VAL A 214
GLY A 163
TRP A 148
VAL A 349
 None
 1.06A 6ak3B-5f15A:
2.5		 6ak3B-5f15A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 860
VAL A 766
GLY A 847
VAL A 788
 None
 1.03A 6ak3B-5fjiA:
undetectable		 6ak3B-5fjiA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 146
VAL A 196
GLY A 206
VAL A 122
 None
 0.92A 6ak3B-5h7jA:
undetectable		 6ak3B-5h7jA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 146
VAL A 196
GLY A 206
VAL A 122
 None
 0.89A 6ak3B-5h7kA:
undetectable		 6ak3B-5h7kA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		4 PRO A 123
VAL A 215
GLY A 101
VAL A 127
 None
 1.00A 6ak3B-5hhaA:
undetectable		 6ak3B-5hhaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 PRO A 126
VAL A   4
GLY A 206
VAL A 157
 CL  A 305 (-3.9A)
None
UPG  A 301 ( 4.3A)
None
 0.97A 6ak3B-5i1fA:
undetectable		 6ak3B-5i1fA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PRO A  78
VAL A  59
GLY A  72
VAL A  34
 None
 1.01A 6ak3B-5ik2A:
undetectable		 6ak3B-5ik2A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 PRO A 126
VAL A   4
GLY A 206
VAL A 157
 None
 0.95A 6ak3B-5j49A:
undetectable		 6ak3B-5j49A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		4 PRO C1573
VAL B1403
GLY B 937
VAL C1549
 None
 1.06A 6ak3B-5jpnC:
undetectable		 6ak3B-5jpnC:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 742
VAL A 786
GLY A 774
VAL A 766
 None
 0.98A 6ak3B-5lohA:
undetectable		 6ak3B-5lohA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 4 PRO A   8
VAL A  72
GLY A  64
VAL A  20
 None
 1.11A 6ak3B-5mszA:
undetectable		 6ak3B-5mszA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 PRO A 114
VAL A 170
GLY A 104
VAL A 136
 None
 0.91A 6ak3B-5tlcA:
undetectable		 6ak3B-5tlcA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 PRO A1079
VAL A1125
GLY A1274
VAL A1150
 None
None
PRO  A1602 (-3.7A)
None
 0.99A 6ak3B-5vadA:
undetectable		 6ak3B-5vadA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		4 PRO A 371
VAL A 314
GLY A 376
VAL A 393
 None
 1.02A 6ak3B-5vbfA:
undetectable		 6ak3B-5vbfA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vst BILIARY GLYCOPROTEIN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 PRO A 109
VAL A 186
GLY A  84
VAL A  78
 None
 1.02A 6ak3B-5vstA:
undetectable		 6ak3B-5vstA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 PRO A 326
VAL A 284
GLY A 195
VAL A 230
 None
 1.08A 6ak3B-5weaA:
undetectable		 6ak3B-5weaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 PRO A 124
VAL A  33
GLY A 175
VAL A 249
 None
None
CA  A 302 (-4.0A)
None
 1.11A 6ak3B-5wslA:
undetectable		 6ak3B-5wslA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvx TRYPSIN/CHYMOTRYPSIN
INHIBITOR

(Alocasia
macrorrhizos) 		no annotation 4 PRO A 145
VAL A 135
GLY A  53
VAL A  43
 None
 1.03A 6ak3B-5wvxA:
undetectable		 6ak3B-5wvxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5v GLYCOPROTEIN 42

(Human
gammaherpesvirus
4) 		no annotation 4 PRO C 144
VAL C 164
GLY C 172
VAL C 184
 None
 1.04A 6ak3B-6c5vC:
undetectable		 6ak3B-6c5vC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 PRO A 301
VAL A 164
GLY A 210
VAL A 194
 None
 1.10A 6ak3B-6cn1A:
undetectable		 6ak3B-6cn1A:
26.44