SIMILAR PATTERNS OF AMINO ACIDS FOR 6AK3_A_P2EA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		5 GLN A 136
THR A 108
VAL A  72
TYR A 197
LEU A 129
 None
 1.18A 6ak3A-1ei6A:
0.0		 6ak3A-1ei6A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 THR A 647
THR A 644
LEU A 478
SER A 174
GLN A 173
 None
 1.40A 6ak3A-1g8xA:
1.8		 6ak3A-1g8xA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 THR A 658
THR A 655
LEU A 489
SER A 185
GLN A 184
 None
 1.42A 6ak3A-1jx2A:
1.6		 6ak3A-1jx2A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)

(Methanothermobacter
thermautotrophicus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 THR A 176
VAL A 198
TYR A 235
LEU A 172
ARG A 124
 None
 1.39A 6ak3A-1ltlA:
0.0		 6ak3A-1ltlA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		5 GLN 1  88
THR 1  79
THR 1  72
LEU 1  98
SER 1 169
 None
 1.46A 6ak3A-1y791:
1.7		 6ak3A-1y791:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 GLN A 270
THR A 167
VAL A 234
LEU A  13
ARG A 160
 None
 1.35A 6ak3A-1yp4A:
0.0		 6ak3A-1yp4A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bri URIDYLATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 THR A 140
VAL A 138
THR A 199
LEU A 167
SER A 182
 ANP  A1226 (-4.0A)
None
None
None
ANP  A1226 ( 4.0A)
 1.31A 6ak3A-2briA:
0.0		 6ak3A-2briA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 MET A 690
THR A 650
VAL A 906
TYR A 623
GLN A 740
 None
 1.38A 6ak3A-2inyA:
0.0		 6ak3A-2inyA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 GLN A 290
VAL A 282
TYR A 268
THR A 279
LEU A  10
 None
 1.29A 6ak3A-2xqwA:
1.2		 6ak3A-2xqwA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 GLN B1261
VAL B1253
TYR B1239
THR B1250
LEU B 981
 None
 1.31A 6ak3A-2xwbB:
undetectable		 6ak3A-2xwbB:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		5 GLN A 133
THR A 154
THR A 131
VAL A 156
THR A 158
 None
 1.31A 6ak3A-3bzwA:
undetectable		 6ak3A-3bzwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 GLN A 253
THR A 251
VAL A 274
ARG A 258
SER A 257
 None
 1.47A 6ak3A-3cboA:
undetectable		 6ak3A-3cboA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		5 THR A  52
THR A  53
VAL A 107
THR A 111
GLN A  60
 None
 1.45A 6ak3A-3l7oA:
undetectable		 6ak3A-3l7oA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 GLN A 796
THR A 771
THR A 770
VAL A 725
THR A 648
 None
 1.42A 6ak3A-3lh5A:
undetectable		 6ak3A-3lh5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLN A1813
THR A1812
VAL A1807
TYR A1803
LEU A1882
 None
 1.46A 6ak3A-3vkgA:
undetectable		 6ak3A-3vkgA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcx SPHINGOMYELINASE C

(Streptomyces
griseocarneus) 		PF03372
(Exo_endo_phos) 		5 GLN A 115
THR A 116
THR A 144
VAL A 143
THR A 190
 None
 1.46A 6ak3A-3wcxA:
undetectable		 6ak3A-3wcxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 THR A 304
VAL A 309
THR A 538
LEU A 346
SER A 275
 None
 1.40A 6ak3A-4byfA:
undetectable		 6ak3A-4byfA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 THR A 289
VAL A 120
LEU A 126
ARG A 158
SER A 106
 None
None
None
None
NAD  A 403 (-3.6A)
 1.27A 6ak3A-4id9A:
undetectable		 6ak3A-4id9A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 470
THR A 469
VAL A 468
THR A 550
LEU A 483
 None
 1.48A 6ak3A-4ipeA:
undetectable		 6ak3A-4ipeA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 THR A 530
VAL A 537
LEU A 518
SER A 468
GLN A 417
 None
 1.45A 6ak3A-4q6kA:
undetectable		 6ak3A-4q6kA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF04998
(RNA_pol_Rpb1_5) 		5 THR C 245
VAL C 118
THR C 264
LEU C 254
SER C 227
 None
 1.19A 6ak3A-4qiwC:
undetectable		 6ak3A-4qiwC:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 THR A 228
THR A 227
VAL A 189
THR A 191
GLN A 234
 None
 1.23A 6ak3A-4trrA:
undetectable		 6ak3A-4trrA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9l HEAT SHOCK PROTEIN

(Oryza sativa) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 THR A 140
THR A 139
VAL A 138
LEU A  36
GLN A  61
 None
PG4  A 302 ( 4.2A)
None
None
None
 1.40A 6ak3A-4x9lA:
undetectable		 6ak3A-4x9lA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn2 NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 MET A 338
THR A 367
THR A 404
VAL A 365
TYR A 375
 None
 1.47A 6ak3A-5dn2A:
undetectable		 6ak3A-5dn2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 471
TYR A 588
LEU A 501
SER A 497
GLN A 496
 None
EDO  A1865 (-4.2A)
None
None
EDO  A1864 (-3.0A)
 1.35A 6ak3A-5fjiA:
undetectable		 6ak3A-5fjiA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Streptococcus
pyogenes;
Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 470
THR A 469
VAL A 468
THR A 550
LEU A 483
 None
 1.45A 6ak3A-5tthA:
undetectable		 6ak3A-5tthA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wee VENOM ALLERGEN LIKE
PROTEIN 4

(Heligmosomoides
polygyrus) 		no annotation 5 GLN A 123
THR A  97
VAL A  94
TYR A 139
THR A  15
 None
 1.40A 6ak3A-5weeA:
undetectable		 6ak3A-5weeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		5 THR A  39
THR A  40
VAL A  34
TYR A  80
THR A  78
 None
 1.47A 6ak3A-5xkoA:
undetectable		 6ak3A-5xkoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 THR A 623
VAL A 609
TYR A 587
THR A 612
LEU A 649
 None
 1.24A 6ak3A-5xt3A:
undetectable		 6ak3A-5xt3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 PRO A  13
MET A 185
GLY A 183
VAL A 201
 None
 1.39A 6ak3A-1ao0A:
0.0		 6ak3A-1ao0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 PRO A 430
MET A 224
GLY A   4
VAL A   7
 PC1  A 777 (-4.7A)
None
None
PC1  A 777 (-4.6A)
 1.39A 6ak3A-1bp1A:
0.0		 6ak3A-1bp1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 PRO A 430
MET A 224
GLY A 226
VAL A   7
 PC1  A 777 (-4.7A)
None
None
PC1  A 777 (-4.6A)
 1.48A 6ak3A-1bp1A:
0.0		 6ak3A-1bp1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		4 PRO A 288
MET A 260
GLY A 267
VAL A 398
 None
 1.38A 6ak3A-1d5tA:
0.0		 6ak3A-1d5tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PRO A 201
MET A 231
GLY A 240
VAL A 209
 None
 1.26A 6ak3A-1fdrA:
0.0		 6ak3A-1fdrA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 PRO A  70
MET A 120
GLY A  51
VAL A  10
 None
 1.34A 6ak3A-1jctA:
0.0		 6ak3A-1jctA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 PRO A 266
MET A 230
GLY A 226
VAL A 243
 None
 1.24A 6ak3A-1jftA:
0.0		 6ak3A-1jftA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 PRO A 266
MET A 230
GLY A 226
VAL A 243
 None
 1.32A 6ak3A-1jhzA:
0.0		 6ak3A-1jhzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PRO A 841
MET A 812
GLY A 798
VAL A 821
 None
 1.31A 6ak3A-1pd1A:
0.0		 6ak3A-1pd1A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 PRO A 156
MET A 127
GLY A 181
VAL A 172
 None
 1.10A 6ak3A-1pgjA:
0.2		 6ak3A-1pgjA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 PRO A 274
MET A 287
GLY A 285
VAL A 348
 None
 1.44A 6ak3A-1q5dA:
2.5		 6ak3A-1q5dA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 PRO A 142
MET A 180
GLY A 182
VAL A 176
 None
 1.50A 6ak3A-1vecA:
undetectable		 6ak3A-1vecA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 PRO A 370
MET A 273
GLY A 275
VAL A 365
 None
 1.49A 6ak3A-1wacA:
undetectable		 6ak3A-1wacA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		4 PRO A 251
MET A  20
GLY A  23
VAL A 173
 None
 1.43A 6ak3A-1xcrA:
undetectable		 6ak3A-1xcrA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PRO A 272
MET A 244
GLY A 257
VAL A 214
 None
 1.41A 6ak3A-1zr6A:
undetectable		 6ak3A-1zr6A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PRO A  38
MET A  74
GLY A  49
VAL A  52
 None
 1.17A 6ak3A-2dldA:
undetectable		 6ak3A-2dldA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 PRO A 223
MET A 213
GLY A 217
VAL A 164
 None
 1.41A 6ak3A-2fywA:
undetectable		 6ak3A-2fywA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 PRO A 371
MET A 332
GLY A 330
VAL A 352
 None
 1.43A 6ak3A-2i7tA:
undetectable		 6ak3A-2i7tA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus) 		PF00497
(SBP_bac_3) 		4 PRO A 210
MET A  54
GLY A  58
VAL A  23
 None
 1.48A 6ak3A-2pvuA:
undetectable		 6ak3A-2pvuA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 PRO A 443
MET A 391
GLY A 464
VAL A 458
 None
 0.96A 6ak3A-2qa1A:
undetectable		 6ak3A-2qa1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg3 DESERT HEDGEHOG
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01085
(HH_signal) 		4 PRO A  83
MET A  99
GLY A 128
VAL A 107
 None
 1.33A 6ak3A-2wg3A:
undetectable		 6ak3A-2wg3A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		4 PRO A  44
MET A 144
GLY A 111
VAL A  49
 None
 1.38A 6ak3A-2wuqA:
undetectable		 6ak3A-2wuqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 PRO A 297
MET A 276
GLY A 280
VAL A 308
 None
 1.17A 6ak3A-3b4wA:
undetectable		 6ak3A-3b4wA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		4 PRO A  25
MET A  31
GLY A  78
VAL A  64
 None
 1.46A 6ak3A-3db7A:
undetectable		 6ak3A-3db7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PRO A 201
MET A 231
GLY A 240
VAL A 209
 None
 1.32A 6ak3A-3fpkA:
undetectable		 6ak3A-3fpkA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PRO A 424
MET A 317
GLY A 319
VAL A 196
 None
 1.38A 6ak3A-3gzyA:
undetectable		 6ak3A-3gzyA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 164
MET A 154
GLY A 152
VAL A 320
 None
 1.36A 6ak3A-3m6iA:
undetectable		 6ak3A-3m6iA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 PRO A 106
MET A  70
GLY A  89
VAL A  75
 None
 1.46A 6ak3A-3myxA:
undetectable		 6ak3A-3myxA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1q DESERT HEDGEHOG
PROTEIN

(Homo sapiens) 		no annotation 4 PRO B  83
MET B  99
GLY B 128
VAL B 107
 None
 1.37A 6ak3A-3n1qB:
undetectable		 6ak3A-3n1qB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 PRO A 582
MET A 176
GLY A 157
VAL A 130
 None
None
None
DIO  A2947 ( 4.7A)
 1.27A 6ak3A-3npeA:
undetectable		 6ak3A-3npeA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 PRO A 194
MET A  92
GLY A  94
VAL A 190
 None
 1.47A 6ak3A-3qucA:
undetectable		 6ak3A-3qucA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 PRO A 186
MET A 206
GLY A 163
VAL A 181
 None
 1.42A 6ak3A-3t5tA:
undetectable		 6ak3A-3t5tA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 PRO A  98
MET A 227
GLY A 253
VAL A 238
 None
 1.16A 6ak3A-3vbeA:
undetectable		 6ak3A-3vbeA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		4 PRO A 100
MET A 231
GLY A 226
VAL A 164
 None
 1.47A 6ak3A-3wbdA:
undetectable		 6ak3A-3wbdA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PRO A 539
MET A 461
GLY A 411
VAL A 297
 None
 1.04A 6ak3A-4b9yA:
undetectable		 6ak3A-4b9yA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh4 OSMC-LIKE PROTEIN

(Burkholderia
cenocepacia) 		PF02566
(OsmC) 		4 PRO A 112
MET A  71
GLY A  69
VAL A  88
 None
 1.45A 6ak3A-4mh4A:
undetectable		 6ak3A-4mh4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 PRO A 130
MET A 239
GLY A 236
VAL A 189
 None
 1.17A 6ak3A-4p4gA:
undetectable		 6ak3A-4p4gA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 PRO A   8
MET A 143
GLY A 147
VAL A  14
 None
 1.32A 6ak3A-4q65A:
2.5		 6ak3A-4q65A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 4 PRO A 135
MET A 245
GLY A 243
VAL A  90
 None
IPD  A 304 ( 3.7A)
None
None
 1.01A 6ak3A-4rw3A:
undetectable		 6ak3A-4rw3A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		4 PRO A 341
MET A  74
GLY A  78
VAL A  47
 None
 1.46A 6ak3A-4tufA:
undetectable		 6ak3A-4tufA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzk BASAL-BODY ROD
MODIFICATION PROTEIN
FLGD

(Helicobacter
pylori) 		PF13860
(FlgD_ig) 		4 PRO A 259
MET A 131
GLY A 133
VAL A 242
 None
 1.12A 6ak3A-4zzkA:
undetectable		 6ak3A-4zzkA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PRO C 122
MET C 142
GLY C 146
VAL C 151
 CL  C 409 ( 4.9A)
None
None
None
 1.25A 6ak3A-5dwzC:
undetectable		 6ak3A-5dwzC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		4 PRO A 301
MET A 324
GLY A 328
VAL A 306
 None
 0.93A 6ak3A-5e05A:
undetectable		 6ak3A-5e05A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 PRO A 783
MET A 679
GLY A 741
VAL A 725
 None
 1.38A 6ak3A-5kbpA:
2.1		 6ak3A-5kbpA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A 447
MET A 394
GLY A 396
VAL A 440
 None
 1.47A 6ak3A-5lm8A:
undetectable		 6ak3A-5lm8A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 4 PRO A  79
MET A  31
GLY A  92
VAL A  85
 None
NA  A 403 (-2.8A)
None
None
 1.36A 6ak3A-5ogxA:
undetectable		 6ak3A-5ogxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PRO A 223
MET A 173
GLY A 186
VAL A 208
 None
 1.48A 6ak3A-5t88A:
undetectable		 6ak3A-5t88A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 PRO A 286
MET A  49
GLY A 256
VAL A 168
 None
 1.17A 6ak3A-6b5fA:
undetectable		 6ak3A-6b5fA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1
MRNA
3'-END-PROCESSING
PROTEIN YTH1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 PRO B   1
MET A1228
GLY A1248
VAL A 516
 None
 1.48A 6ak3A-6eojB:
undetectable		 6ak3A-6eojB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 PRO A1292
MET A1243
GLY A1262
VAL A1296
 None
 1.38A 6ak3A-6fb3A:
undetectable		 6ak3A-6fb3A:
23.96