SIMILAR PATTERNS OF AMINO ACIDS FOR 6AJI_A_AY6A1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 240
TYR A 450
LEU A 434
VAL A 437
ALA A 438
 None
 0.87A 6ajiA-1dgjA:
0.0		 6ajiA-1dgjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp9 TATA-BINDING PROTEIN

(Sulfolobus
acidocaldarius) 		PF00352
(TBP) 		5 VAL A 150
ILE A 178
ILE A 162
LEU A 141
LEU A 128
 None
 1.22A 6ajiA-1mp9A:
0.0		 6ajiA-1mp9A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmn HYPOTHETICAL PROTEIN
YQGF

(Escherichia
coli) 		PF03652
(RuvX) 		5 ILE A  83
ILE A  15
VAL A  17
LEU A   6
LEU A  49
 None
 0.91A 6ajiA-1nmnA:
0.0		 6ajiA-1nmnA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		5 LEU A  98
ILE A  71
VAL A  38
VAL A 121
LEU A  59
 None
 1.03A 6ajiA-1ofmA:
0.0		 6ajiA-1ofmA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE B 168
LEU B 209
LEU B 186
ALA B 190
LEU B 236
 None
 0.94A 6ajiA-1pjmB:
0.0		 6ajiA-1pjmB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 ILE A  37
VAL A  43
LEU A  40
LEU A  59
ALA A  61
 None
 1.13A 6ajiA-1pznA:
undetectable		 6ajiA-1pznA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 266
ILE A 273
ILE A 197
VAL A 288
LEU A 280
 None
 1.09A 6ajiA-1txgA:
undetectable		 6ajiA-1txgA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 ILE C 799
ILE C 739
LEU C 776
ALA C 805
LEU C 806
 None
 0.80A 6ajiA-1u6gC:
1.3		 6ajiA-1u6gC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 VAL A 317
VAL A 388
LEU A 409
ALA A 685
LEU A 686
 None
 1.16A 6ajiA-1urjA:
undetectable		 6ajiA-1urjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE B 179
LEU B 197
VAL B 200
ALA B 201
LEU B 242
 None
 0.93A 6ajiA-1wa5B:
1.1		 6ajiA-1wa5B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3

(Mus musculus) 		PF00104
(Hormone_recep) 		5 LEU E 151
PHE E 228
VAL E 240
ALA E 242
LEU E 167
 None
 1.15A 6ajiA-1xlsE:
undetectable		 6ajiA-1xlsE:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		5 VAL A  74
ILE A 164
ILE A 129
VAL A 167
ALA A 139
 None
 1.17A 6ajiA-1xttA:
undetectable		 6ajiA-1xttA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzg ADP-RIBOSYLATION
FACTOR-LIKE 8

(Homo sapiens) 		PF00025
(Arf) 		5 VAL A  91
ILE A  88
ILE A 122
PHE A  12
ALA A 159
 None
None
None
None
GDP  A 181 (-3.3A)
 1.00A 6ajiA-1yzgA:
undetectable		 6ajiA-1yzgA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		5 ILE A 449
VAL A 360
LEU A 357
VAL A 501
LEU A 508
 None
 0.80A 6ajiA-2adcA:
3.4		 6ajiA-2adcA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		5 VAL A 150
LEU A  76
VAL A 184
ALA A 187
LEU A 191
 None
 1.03A 6ajiA-2bdvA:
undetectable		 6ajiA-2bdvA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A  55
ILE A  65
VAL A  67
PHE A  24
LEU A  88
 None
None
FAD  A 600 (-3.8A)
None
FAD  A 600 (-4.6A)
 1.21A 6ajiA-2bvgA:
3.8		 6ajiA-2bvgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 VAL A 224
LEU A 221
VAL A  92
ALA A  93
LEU A 215
 None
 1.18A 6ajiA-2cu2A:
undetectable		 6ajiA-2cu2A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 5 VAL A 152
ILE A 149
LEU A  73
TYR A 105
VAL A  77
 None
 1.22A 6ajiA-2ddxA:
undetectable		 6ajiA-2ddxA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A  95
ILE A  71
TYR A  31
ALA A 296
LEU A  18
 None
 1.19A 6ajiA-2eklA:
undetectable		 6ajiA-2eklA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 VAL A 441
ILE A 439
VAL A 468
VAL A 280
LEU A 287
 None
 1.20A 6ajiA-2f2aA:
0.3		 6ajiA-2f2aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 VAL A 441
LEU A 453
ILE A 439
VAL A 468
LEU A 287
 None
 1.16A 6ajiA-2f2aA:
0.3		 6ajiA-2f2aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 VAL A 207
ILE A 164
ILE A 188
LEU A 195
ALA A 255
 None
 1.08A 6ajiA-2hi1A:
undetectable		 6ajiA-2hi1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		5 VAL A 286
ILE A 311
VAL A 271
LEU A 267
TYR A 263
 None
 1.05A 6ajiA-2jakA:
undetectable		 6ajiA-2jakA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 ILE A2901
ILE A3001
VAL A3003
LEU A2914
LEU A2965
 None
 1.12A 6ajiA-2jd4A:
undetectable		 6ajiA-2jd4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		5 ILE A 109
VAL A  69
LEU A  66
LEU A 105
ALA A  95
 None
 1.13A 6ajiA-2jftA:
undetectable		 6ajiA-2jftA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6h FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03623
(Focal_AT) 		5 VAL A  64
LEU A  65
ILE A  73
VAL A  14
LEU A 125
 None
 0.97A 6ajiA-2l6hA:
undetectable		 6ajiA-2l6hA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		5 VAL A   8
ILE A  65
LEU A  95
LEU A 287
ALA A 283
 None
 0.97A 6ajiA-2lbpA:
undetectable		 6ajiA-2lbpA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		5 VAL A  52
VAL A 242
LEU A  25
PHE A 250
VAL A  60
 None
 1.11A 6ajiA-2nygA:
undetectable		 6ajiA-2nygA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		5 ILE X 113
LEU X 103
LEU X 269
ALA X 272
LEU X 273
 None
 1.18A 6ajiA-2odtX:
undetectable		 6ajiA-2odtX:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ILE A  75
VAL A  62
LEU A 102
ALA A 105
LEU A  82
 None
 1.13A 6ajiA-2qfqA:
undetectable		 6ajiA-2qfqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C

(Francisella
tularensis) 		PF11550
(IglC) 		5 LEU A 146
ILE A 120
ILE A  38
VAL A  73
LEU A 183
 None
 1.04A 6ajiA-2qwuA:
undetectable		 6ajiA-2qwuA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voa EXODEOXYRIBONUCLEASE
III

(Archaeoglobus
fulgidus) 		PF03372
(Exo_endo_phos) 		5 VAL A 231
VAL A 257
VAL A 185
ALA A 222
LEU A 226
 None
 1.17A 6ajiA-2voaA:
undetectable		 6ajiA-2voaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		5 VAL A  42
VAL A  83
LEU A  76
LEU A  36
LEU A  54
 None
 1.10A 6ajiA-2vriA:
undetectable		 6ajiA-2vriA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		5 ILE A  72
ILE A  40
VAL A  59
LEU A  63
LEU A 101
 None
 1.06A 6ajiA-2xa7A:
undetectable		 6ajiA-2xa7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 VAL A   6
LEU A   7
ILE A 302
LEU A 265
ALA A 269
 None
 1.16A 6ajiA-2z2bA:
undetectable		 6ajiA-2z2bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ILE A  98
LEU A 129
PHE A 145
ALA A 362
LEU A 365
 None
None
A5A  A 801 (-3.5A)
None
None
 1.09A 6ajiA-2ztgA:
undetectable		 6ajiA-2ztgA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 VAL A 208
LEU A  79
ILE A  77
ILE A 268
LEU A 104
 None
 1.15A 6ajiA-3a4tA:
undetectable		 6ajiA-3a4tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 VAL A 208
LEU A  79
ILE A  77
LEU A 104
LEU A 101
 None
 1.07A 6ajiA-3a4tA:
undetectable		 6ajiA-3a4tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 VAL A 426
ILE A 456
ILE A 416
LEU A 458
ALA A 520
 None
 1.17A 6ajiA-3af5A:
undetectable		 6ajiA-3af5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		5 ILE K 208
VAL K 270
LEU K 267
LEU K 219
LEU K 222
 None
 1.11A 6ajiA-3ci0K:
undetectable		 6ajiA-3ci0K:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
ILE A2128
ILE A2141
VAL A2143
LEU A2149
 None
 1.12A 6ajiA-3cmvA:
undetectable		 6ajiA-3cmvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		5 LEU A 272
VAL A 204
LEU A 205
VAL A 233
ALA A 234
 None
 0.76A 6ajiA-3d62A:
undetectable		 6ajiA-3d62A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 LEU A  41
VAL A 124
LEU A 122
ALA A  92
LEU A  93
 None
 1.07A 6ajiA-3d9wA:
undetectable		 6ajiA-3d9wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 VAL A  80
LEU A  83
LEU A  20
VAL A  23
ALA A  24
 None
 0.70A 6ajiA-3e8pA:
undetectable		 6ajiA-3e8pA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 LEU A 185
ILE A 183
TYR A 175
ALA A 138
LEU A 135
 None
 1.21A 6ajiA-3gvcA:
undetectable		 6ajiA-3gvcA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix7 UNCHARACTERIZED
PROTEIN TTHA0540

(Thermus
thermophilus) 		no annotation 5 VAL A 149
VAL A 170
LEU A 175
LEU A 197
LEU A 200
 None
 1.11A 6ajiA-3ix7A:
undetectable		 6ajiA-3ix7A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		5 ILE A 193
ILE A  55
VAL A  53
ALA A 215
LEU A 211
 None
 1.16A 6ajiA-3ke3A:
undetectable		 6ajiA-3ke3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		5 ILE A 261
PHE A 168
VAL A  72
ALA A  73
LEU A 307
 None
B4P  A 349 (-3.4A)
None
None
None
 1.00A 6ajiA-3looA:
undetectable		 6ajiA-3looA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc9 ALR2269 PROTEIN

(Nostoc sp. PCC
7120) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 VAL A 315
LEU A 316
VAL A 375
LEU A 373
LEU A 345
 None
 0.91A 6ajiA-3mc9A:
undetectable		 6ajiA-3mc9A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 VAL A  28
ILE A 246
ILE A 162
LEU A  35
ALA A  33
 None
 1.20A 6ajiA-3ncyA:
undetectable		 6ajiA-3ncyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1

(Homo sapiens) 		PF00168
(C2) 		5 VAL A  98
ILE A  40
ILE A 133
LEU A  68
LEU A 137
 None
 0.95A 6ajiA-3pycA:
undetectable		 6ajiA-3pycA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 364
ILE A 249
ILE A 366
LEU A 348
ALA A  72
 None
 1.02A 6ajiA-3qqvA:
undetectable		 6ajiA-3qqvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		5 VAL A 105
TYR A 440
LEU A 187
VAL A 196
LEU A 200
 None
 1.20A 6ajiA-3sdoA:
undetectable		 6ajiA-3sdoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		5 VAL A 441
VAL A 544
LEU A 542
VAL A 489
LEU A 533
 None
 1.03A 6ajiA-3u7vA:
undetectable		 6ajiA-3u7vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 5 ILE B 583
VAL B 536
LEU B 537
VAL B 505
LEU B 522
 None
 1.17A 6ajiA-3w0lB:
undetectable		 6ajiA-3w0lB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 VAL A 171
LEU A 174
VAL A 437
ALA A 409
LEU A 410
 None
 1.06A 6ajiA-3wajA:
undetectable		 6ajiA-3wajA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3q ALANINE RACEMASE 1

(Staphylococcus
aureus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A  54
ILE A  78
LEU A  15
VAL A  18
ALA A  19
 None
 0.97A 6ajiA-4a3qA:
undetectable		 6ajiA-4a3qA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 LEU A 125
ILE A 235
ILE A  96
VAL A  99
LEU A 136
 None
 1.09A 6ajiA-4aqsA:
undetectable		 6ajiA-4aqsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		5 LEU A 452
PHE A 585
VAL A 456
ALA A 455
LEU A 517
 None
 1.22A 6ajiA-4b2gA:
undetectable		 6ajiA-4b2gA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 LEU A 251
ILE A 279
VAL A 222
TYR A 246
ALA A 287
 None
 1.13A 6ajiA-4dn7A:
undetectable		 6ajiA-4dn7A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 207
ILE A 141
VAL A 115
LEU A 116
PHE A 299
 None
 0.84A 6ajiA-4eutA:
0.5		 6ajiA-4eutA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 444
LEU A 485
LEU A 462
ALA A 466
LEU A 507
 None
 0.81A 6ajiA-4fddA:
undetectable		 6ajiA-4fddA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe1 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Thermosynechococcus
elongatus) 		PF02605
(PsaL) 		5 LEU L  85
ILE L  83
ILE L  59
VAL L  88
ALA L  89
 None
None
None
None
BCR  L1005 ( 3.5A)
 0.96A 6ajiA-4fe1L:
undetectable		 6ajiA-4fe1L:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ILE A 108
ILE A 122
VAL A 126
LEU A 129
ALA A 263
 None
 1.18A 6ajiA-4ga6A:
undetectable		 6ajiA-4ga6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Rhodopseudomonas
palustris;
Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  45
VAL A 105
LEU A 128
ALA A  72
LEU A  69
 None
 1.00A 6ajiA-4gxrA:
undetectable		 6ajiA-4gxrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 225
LEU A 386
PHE A 379
ALA A 297
LEU A 298
 None
 0.81A 6ajiA-4hgvA:
undetectable		 6ajiA-4hgvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hht RIBONUCLEASE HII

(Thermotoga
maritima) 		PF01351
(RNase_HII) 		5 VAL A  14
VAL A 115
LEU A 113
ALA A  33
LEU A  94
 None
 1.20A 6ajiA-4hhtA:
undetectable		 6ajiA-4hhtA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN

(Ketogulonicigenium
vulgare) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A 259
LEU A 257
VAL A 203
VAL A 276
LEU A 229
 None
 1.07A 6ajiA-4lswA:
undetectable		 6ajiA-4lswA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		5 VAL A 263
ILE A 205
LEU A 249
PHE A 272
LEU A 194
 None
 1.19A 6ajiA-4lw8A:
undetectable		 6ajiA-4lw8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 LEU A 218
ILE A 247
VAL A 178
VAL A 244
ALA A 216
 None
 1.20A 6ajiA-4m0pA:
undetectable		 6ajiA-4m0pA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 ILE A 863
ILE A 812
VAL A 728
LEU A 847
TYR A 843
 None
 1.08A 6ajiA-4mhcA:
undetectable		 6ajiA-4mhcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 VAL A 180
ILE A  32
VAL A 521
LEU A  67
LEU A  63
 None
 1.05A 6ajiA-4mk0A:
undetectable		 6ajiA-4mk0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 LEU A 244
ILE A 242
LEU A 199
VAL A 301
LEU A 197
 None
 0.93A 6ajiA-4muoA:
undetectable		 6ajiA-4muoA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		5 ILE A 233
VAL A 184
TYR A 220
VAL A  20
LEU A 178
 None
 1.03A 6ajiA-4o8uA:
undetectable		 6ajiA-4o8uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 ILE A 145
ILE A  82
VAL A  86
LEU A 147
VAL A 175
 None
 1.16A 6ajiA-4oyaA:
5.6		 6ajiA-4oyaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 LEU A 493
VAL A 502
LEU A 500
VAL A 456
ALA A 455
 None
 0.82A 6ajiA-4q2cA:
undetectable		 6ajiA-4q2cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		5 VAL A   8
ILE A  65
LEU A  95
LEU A 279
ALA A 275
 None
 0.93A 6ajiA-4qwvA:
undetectable		 6ajiA-4qwvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		5 VAL A 124
LEU A 127
ILE A 143
ILE A 159
VAL A  99
 None
 0.88A 6ajiA-4r10A:
undetectable		 6ajiA-4r10A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		5 ILE A  87
ILE A 118
VAL A  45
VAL A  61
LEU A  38
 None
 1.04A 6ajiA-4xvhA:
undetectable		 6ajiA-4xvhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 VAL A 500
LEU A 504
PHE A 511
ALA A 535
LEU A 536
 None
 0.89A 6ajiA-4y21A:
2.1		 6ajiA-4y21A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y82 PROTEASOME SUBUNIT
BETA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 VAL M 170
ILE M 177
ILE M 199
LEU M 155
VAL M 158
 None
 0.97A 6ajiA-4y82M:
undetectable		 6ajiA-4y82M:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		5 ILE A 548
VAL A 509
LEU A 527
LEU A 427
ALA A 430
 None
 1.06A 6ajiA-5axhA:
2.0		 6ajiA-5axhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		5 LEU A  94
ILE A 102
ILE A  77
PHE A 106
VAL A  30
 None
 0.91A 6ajiA-5ewtA:
undetectable		 6ajiA-5ewtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		5 LEU A  94
ILE A 102
ILE A  77
PHE A 145
VAL A  30
 None
 1.17A 6ajiA-5ewtA:
undetectable		 6ajiA-5ewtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 VAL A 297
LEU A 267
LEU A 332
VAL A 339
ALA A 340
 None
 1.19A 6ajiA-5fsrA:
undetectable		 6ajiA-5fsrA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		5 LEU A2209
ILE A2222
LEU A2201
PHE A2358
VAL A2403
 None
 1.12A 6ajiA-5h64A:
undetectable		 6ajiA-5h64A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		5 LEU A 286
VAL A 182
LEU A 168
ALA A 171
LEU A 172
 None
 1.13A 6ajiA-5ix8A:
undetectable		 6ajiA-5ix8A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		5 VAL A 153
ILE A  90
ILE A 103
LEU A 121
VAL A  97
 None
 0.98A 6ajiA-5kymA:
undetectable		 6ajiA-5kymA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus;
Bos taurus) 		PF00507
(Oxidored_q4)
PF00499
(Oxidored_q3) 		5 LEU A  71
ILE A  69
ILE J  59
LEU A  98
LEU J 161
 None
 0.94A 6ajiA-5lc5A:
undetectable		 6ajiA-5lc5A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 VAL A 180
ILE A  32
VAL A 521
LEU A  67
LEU A  63
 None
 0.97A 6ajiA-5uuuA:
undetectable		 6ajiA-5uuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 LEU A 386
ILE A 388
VAL A 395
LEU A 403
LEU A 400
 None
 1.20A 6ajiA-5wveA:
undetectable		 6ajiA-5wveA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 VAL A 415
LEU A 406
ILE A 404
LEU A 378
PHE A 317
 None
 1.18A 6ajiA-5z5dA:
undetectable		 6ajiA-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 5 ILE A  86
ILE A 159
VAL A  68
ALA A  71
LEU A  75
 None
 1.06A 6ajiA-5zbiA:
undetectable		 6ajiA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 VAL A 995
ILE A 990
VAL A1047
ALA A1050
LEU A1054
 None
 1.16A 6ajiA-6a91A:
undetectable		 6ajiA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 5 ILE A  44
ILE A 244
VAL A 246
VAL A  21
ALA A  20
 None
 1.18A 6ajiA-6ap4A:
undetectable		 6ajiA-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 5 ILE B 690
VAL B 776
LEU B 780
LEU B 694
ALA B 696
 None
 1.09A 6ajiA-6bcqB:
undetectable		 6ajiA-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 5 VAL A 298
LEU A 301
ILE A 269
ALA A 275
LEU A 276
 None
 1.03A 6ajiA-6bldA:
undetectable		 6ajiA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 5 VAL A  68
ILE A  39
VAL A  15
LEU A 131
ALA A 135
 None
 0.60A 6ajiA-6cyzA:
undetectable		 6ajiA-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 5 ILE A 133
VAL A 244
LEU A 242
ALA A 116
LEU A 293
 None
 1.05A 6ajiA-6enxA:
undetectable		 6ajiA-6enxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A1202
ILE A1193
VAL A1169
VAL A1207
ALA A1208
 None
 1.01A 6ajiA-6f42A:
undetectable		 6ajiA-6f42A:
undetectable