SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_C_ACRC609

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 4 GLY A  41
ASP A  90
TRP A  50
MET A  86
 None
 1.26A 6ag0C-1aqzA:
undetectable		 6ag0C-1aqzA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LYS A  70
GLY A 108
TRP A 138
TRP A 165
TYR B 198
 None
 0.40A 6ag0C-1bplA:
19.2		 6ag0C-1bplA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 LYS A  68
GLY A 106
TRP A 136
ASP A 162
TRP A 163
MET A 197
TYR A 198
 None
 0.49A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		4 LYS A  54
GLY A 164
ASP A 137
MET A 140
 PLP  A 342 (-2.7A)
None
None
None
 1.34A 6ag0C-1f2dA:
undetectable		 6ag0C-1f2dA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg7 VSV MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		4 GLY A 218
TRP A 220
ASP A 191
TRP A 190
 None
 1.50A 6ag0C-1lg7A:
undetectable		 6ag0C-1lg7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 LYS A  63
GLY A  53
ASP A 278
TYR A  54
 None
 1.15A 6ag0C-1lwhA:
23.6		 6ag0C-1lwhA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 GLY A 476
ASP A 427
MET A 426
TYR A 477
 None
 1.18A 6ag0C-1pemA:
4.1		 6ag0C-1pemA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LYS A  70
GLY A 108
TRP A 138
ASP A 164
TRP A 165
 None
 0.43A 6ag0C-1ud3A:
63.6		 6ag0C-1ud3A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LYS A  70
GLY A 108
TRP A 138
TRP A 165
TYR A 198
 None
 0.46A 6ag0C-1vjsA:
55.5		 6ag0C-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		4 LYS A1089
GLY A1068
MET A1153
TYR A1168
 None
 1.41A 6ag0C-1vprA:
undetectable		 6ag0C-1vprA:
13.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 LYS A  72
GLY A 110
TRP A 140
ASP A 166
TRP A 167
MET A 202
TYR A 203
 AC1  A1496 (-2.9A)
AC1  A1496 (-3.4A)
AC1  A1496 (-3.7A)
GLC  A1495 (-2.7A)
AC1  A1496 (-4.7A)
GLC  A1493 (-3.5A)
GLC  A1495 (-4.0A)
 0.28A 6ag0C-1w9xA:
64.3		 6ag0C-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 LYS A 191
GLY A 290
ASP A  56
MET A  55
 None
5GP  A1340 (-3.1A)
None
5GP  A1340 (-3.9A)
 1.47A 6ag0C-2bwgA:
7.1		 6ag0C-2bwgA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 LYS A  72
GLY A 110
TRP A 140
ASP A 166
TRP A 167
MET A 202
TYR A 203
 GLC  A 601 (-3.0A)
GLC  A 602 ( 3.2A)
GLC  A 602 ( 3.7A)
GLC  A 603 (-2.8A)
GLC  A 602 ( 4.8A)
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 0.36A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 LYS A  72
GLY A 110
TRP A 140
ASP A 166
TRP A 167
MET A 202
TYR A 203
 None
 0.33A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		4 LYS A  47
GLY A  11
ASP A  99
TYR A  97
 None
 1.36A 6ag0C-2zg6A:
undetectable		 6ag0C-2zg6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 LYS A 198
GLY A 236
TRP A 260
ASP A 286
TRP A 287
MET A 316
 G6D  A 801 (-3.5A)
GLC  A 802 ( 3.3A)
G6D  A 801 ( 3.6A)
ACI  A 803 (-2.6A)
GLC  A 802 ( 4.3A)
GLC  A 805 (-3.7A)
 0.38A 6ag0C-3bc9A:
48.4		 6ag0C-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A  86
ASP A 219
MET A 216
TYR A 217
 None
 0.84A 6ag0C-3bvmA:
undetectable		 6ag0C-3bvmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9s PUTATIVE POLYKETIDE
CYCLASE

(Acidithiobacillus
ferrooxidans) 		PF07366
(SnoaL) 		4 GLY A 124
TRP A 126
MET A  85
TYR A 115
 None
 1.13A 6ag0C-3f9sA:
undetectable		 6ag0C-3f9sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 GLY A1282
TRP A1212
ASP A1247
TYR A1322
 None
 1.26A 6ag0C-3km5A:
undetectable		 6ag0C-3km5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TRP A 271
ASP A 328
MET A 331
TYR A 274
 None
 1.45A 6ag0C-3kmuA:
undetectable		 6ag0C-3kmuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LYS A  76
GLY A 114
TRP A 128
TYR A 162
 None
 0.80A 6ag0C-3qgvA:
39.7		 6ag0C-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 GLY A 182
ASP A 237
TRP A 241
TYR A 181
 None
 1.33A 6ag0C-3r67A:
undetectable		 6ag0C-3r67A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 GLY A 159
ASP A 165
TRP A 164
TYR A 440
 None
 0.96A 6ag0C-3sdoA:
8.9		 6ag0C-3sdoA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		4 LYS A 170
GLY A 166
ASP A 379
MET A 378
 KWS  A 168 ( 3.3A)
KWS  A 168 ( 2.5A)
None
None
 1.36A 6ag0C-3unvA:
undetectable		 6ag0C-3unvA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epu ANGIOPOIETIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 GLY A 469
TRP A 380
MET A 460
TYR A 462
 None
 1.43A 6ag0C-4epuA:
undetectable		 6ag0C-4epuA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 LYS A 388
GLY A 398
ASP A 366
TYR A 342
 None
 1.43A 6ag0C-4i5sA:
undetectable		 6ag0C-4i5sA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		4 GLY A 205
TRP A 160
MET A 179
TYR A 182
 None
 1.50A 6ag0C-4i8iA:
2.5		 6ag0C-4i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		4 GLY A 189
TRP A  17
ASP A  13
MET A 193
 None
None
NDG  A 501 (-3.6A)
None
 1.39A 6ag0C-4kruA:
6.7		 6ag0C-4kruA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		4 GLY A 397
ASP A 176
TRP A 150
TYR A 390
 None
 1.47A 6ag0C-4umzA:
undetectable		 6ag0C-4umzA:
11.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 LYS A  71
GLY A 109
TRP A 139
ASP A 165
TRP A 166
MET A 198
TYR A 199
 None
GLY  A1489 (-3.6A)
GLY  A1489 ( 4.8A)
None
None
None
GLY  A1489 (-4.8A)
 0.46A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLY A 390
TRP A 386
ASP A 448
TYR A 452
 None
 1.35A 6ag0C-4wz9A:
undetectable		 6ag0C-4wz9A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn0 THIOREDOXIN
REDUCTASE

(Methanosarcina
mazei) 		PF07992
(Pyr_redox_2) 		4 LYS A  92
GLY A 271
ASP A 262
MET A 265
 None
 1.43A 6ag0C-4zn0A:
undetectable		 6ag0C-4zn0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 GLY D 243
TRP D 232
ASP D 236
TYR D 242
 None
 1.48A 6ag0C-5disD:
undetectable		 6ag0C-5disD:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		4 GLY A  19
TRP A  20
MET A   1
TYR A  44
 IPA  A 302 (-3.6A)
None
None
None
 1.25A 6ag0C-5h3bA:
undetectable		 6ag0C-5h3bA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 GLY A1438
ASP A1387
TRP A1422
TYR A1456
 None
 1.35A 6ag0C-5jbeA:
12.3		 6ag0C-5jbeA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY B 571
ASP B 621
TRP A 407
MET B 568
 EPE  A 704 ( 4.9A)
None
None
None
 1.35A 6ag0C-5l9wB:
undetectable		 6ag0C-5l9wB:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY B 617
ASP B 621
TRP A 407
MET B 568
 None
 1.06A 6ag0C-5l9wB:
undetectable		 6ag0C-5l9wB:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 GLY A 407
TRP A 403
ASP A 468
TYR A 472
 None
None
None
SO4  A1032 ( 4.1A)
 1.38A 6ag0C-6bv2A:
undetectable		 6ag0C-6bv2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 4 GLY G 232
TRP G 238
MET G 190
TYR G 164
 None
 1.45A 6ag0C-6d6qG:
undetectable		 6ag0C-6d6qG:
20.69