SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_C_ACRC608_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		3 TYR A  74
ALA A 166
LEU A 242
 None
 0.70A 6ag0C-1abrA:
undetectable		 6ag0C-1abrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		3 TYR A 142
ALA A 150
LEU A 151
 None
 0.60A 6ag0C-1ahaA:
undetectable		 6ag0C-1ahaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 TYR A  19
ALA A  76
LEU A  77
 None
 0.54A 6ag0C-1amyA:
36.1		 6ag0C-1amyA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		3 TYR A 295
ALA A 301
LEU A 302
 None
 0.56A 6ag0C-1bg4A:
10.1		 6ag0C-1bg4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		3 TYR Y  70
ALA Y 162
LEU Y 239
 None
 0.65A 6ag0C-1bryY:
undetectable		 6ag0C-1bryY:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 TYR A 489
ALA A 495
LEU A 496
 None
 0.51A 6ag0C-1dgfA:
undetectable		 6ag0C-1dgfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		3 TYR A 309
ALA A 315
LEU A 316
 None
 0.56A 6ag0C-1dk5A:
undetectable		 6ag0C-1dk5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		3 TYR A  66
ALA A  90
LEU A  91
 None
 0.50A 6ag0C-1e09A:
undetectable		 6ag0C-1e09A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8y NUCLEOSIDE
2-DEOXYRIBOSYLTRANSF
ERASE

(Lactobacillus
leichmannii) 		PF05014
(Nuc_deoxyrib_tr) 		3 TYR A  21
ALA A  27
LEU A  28
 None
 0.58A 6ag0C-1f8yA:
undetectable		 6ag0C-1f8yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		3 TYR A 305
ALA A 311
LEU A 312
 None
 0.61A 6ag0C-1fokA:
undetectable		 6ag0C-1fokA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 294
ALA A 369
LEU A 370
 None
 0.67A 6ag0C-1fp3A:
undetectable		 6ag0C-1fp3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 TYR A 101
ALA A 107
LEU A 108
 None
 0.61A 6ag0C-1fp9A:
15.1		 6ag0C-1fp9A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 TYR A 214
ALA A 153
LEU A 156
 None
 0.69A 6ag0C-1ghsA:
5.4		 6ag0C-1ghsA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		3 TYR A 195
ALA A 201
LEU A 202
 None
 0.63A 6ag0C-1gl6A:
undetectable		 6ag0C-1gl6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		3 TYR A  37
ALA A  52
LEU A  43
 None
 0.51A 6ag0C-1glvA:
undetectable		 6ag0C-1glvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 TYR A 335
ALA A 341
LEU A 342
 None
 0.52A 6ag0C-1hm6A:
undetectable		 6ag0C-1hm6A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 TYR A  45
ALA A  51
LEU A  52
 None
 0.64A 6ag0C-1jioA:
undetectable		 6ag0C-1jioA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 TYR A 258
ALA A 264
LEU A 265
 None
 0.67A 6ag0C-1jr1A:
6.6		 6ag0C-1jr1A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 129
ALA A  92
LEU A  96
 None
 0.69A 6ag0C-1k9aA:
undetectable		 6ag0C-1k9aA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A1571
ALA A1577
LEU A1578
 None
 0.41A 6ag0C-1larA:
undetectable		 6ag0C-1larA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		3 TYR A  73
ALA A 179
LEU A 246
 CMP  A 901 (-4.1A)
None
None
 0.59A 6ag0C-1lpcA:
undetectable		 6ag0C-1lpcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 193
ALA A 156
LEU A 160
 None
 0.61A 6ag0C-1opkA:
undetectable		 6ag0C-1opkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		3 TYR A 425
ALA A 406
LEU A 422
 None
 0.67A 6ag0C-1p9wA:
undetectable		 6ag0C-1p9wA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		3 TYR A 209
ALA A 215
LEU A 216
 None
 0.68A 6ag0C-1pn4A:
undetectable		 6ag0C-1pn4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 TYR M 247
ALA M 253
LEU M 254
 None
None
PID  M 624 (-4.4A)
 0.63A 6ag0C-1pprM:
undetectable		 6ag0C-1pprM:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		3 TYR A  72
ALA A 178
LEU A 245
 None
 0.69A 6ag0C-1qi7A:
undetectable		 6ag0C-1qi7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 TYR A 151
ALA A  53
LEU A  55
 None
 0.49A 6ag0C-1qlbA:
undetectable		 6ag0C-1qlbA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 TYR A  65
ALA A  71
LEU A  72
 None
 0.57A 6ag0C-1r0lA:
undetectable		 6ag0C-1r0lA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 TYR A 113
ALA A 135
LEU A 136
 None
 0.53A 6ag0C-1r5aA:
undetectable		 6ag0C-1r5aA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		3 TYR A 243
ALA A 156
LEU A 157
 None
 0.61A 6ag0C-1r8yA:
undetectable		 6ag0C-1r8yA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfz HYPOTHETICAL PROTEIN
APC35681

(Geobacillus
stearothermophilus) 		PF04608
(PgpA) 		3 TYR A 118
ALA A 150
LEU A  30
 None
 0.68A 6ag0C-1rfzA:
undetectable		 6ag0C-1rfzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE

(Pyrococcus
furiosus) 		PF03070
(TENA_THI-4) 		3 TYR A  44
ALA A  50
LEU A  51
 None
MP5  A1213 (-3.6A)
None
 0.67A 6ag0C-1rtwA:
undetectable		 6ag0C-1rtwA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 TYR A  34
ALA A 230
LEU A 234
 None
 0.60A 6ag0C-1s2nA:
2.5		 6ag0C-1s2nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sn4 PROTEIN (NEUROTOXIN
BMK M4)

(Mesobuthus
martensii) 		PF00537
(Toxin_3) 		3 TYR A  35
ALA A  31
LEU A  51
 None
 0.70A 6ag0C-1sn4A:
undetectable		 6ag0C-1sn4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 TYR A  92
ALA A  98
LEU A  99
 None
 0.62A 6ag0C-1susA:
undetectable		 6ag0C-1susA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 TYR B 293
ALA B 299
LEU B 300
 None
 0.56A 6ag0C-1ta3B:
5.5		 6ag0C-1ta3B:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 TYR A  70
ALA A 162
LEU A 239
 NDP  A 280 ( 4.7A)
None
None
 0.68A 6ag0C-1tcsA:
undetectable		 6ag0C-1tcsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 TYR A 173
ALA A 179
LEU A 180
 None
 0.65A 6ag0C-1u5uA:
undetectable		 6ag0C-1u5uA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		3 TYR A 273
ALA A 232
LEU A 276
 None
 0.63A 6ag0C-1wf3A:
2.2		 6ag0C-1wf3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwr TRNA ADENOSINE
DEAMINASE TADA

(Aquifex
aeolicus) 		PF14437
(MafB19-deam) 		3 TYR A 130
ALA A  10
LEU A  11
 None
 0.58A 6ag0C-1wwrA:
undetectable		 6ag0C-1wwrA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x27 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		3 TYR A 181
ALA A 137
LEU A 141
 None
 0.69A 6ag0C-1x27A:
undetectable		 6ag0C-1x27A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 TYR A 827
ALA A 833
LEU A 834
 None
 0.60A 6ag0C-1xyzA:
10.7		 6ag0C-1xyzA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		3 TYR B  87
ALA B 137
LEU B  90
 None
 0.68A 6ag0C-1y56B:
undetectable		 6ag0C-1y56B:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		3 TYR A 119
ALA A 151
LEU A  31
 None
 0.68A 6ag0C-1y9iA:
undetectable		 6ag0C-1y9iA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 TYR A 304
ALA A 310
LEU A 311
 None
 0.56A 6ag0C-1ycnA:
undetectable		 6ag0C-1ycnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A 877
ALA A 883
LEU A 884
 None
 0.54A 6ag0C-1yguA:
undetectable		 6ag0C-1yguA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		3 TYR A  95
ALA A 272
LEU A 259
 None
 0.69A 6ag0C-1z7dA:
2.2		 6ag0C-1z7dA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmo HALOHYDRIN
DEHALOGENASE

(Arthrobacter
sp. AD2) 		PF13561
(adh_short_C2) 		3 TYR A 173
ALA A 161
LEU A 165
 None
 0.66A 6ag0C-1zmoA:
undetectable		 6ag0C-1zmoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abl ABL TYROSINE KINASE

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		3 TYR A 193
ALA A 156
LEU A 160
 None
 0.59A 6ag0C-2ablA:
undetectable		 6ag0C-2ablA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		3 TYR C 106
ALA C  82
LEU C  86
 None
 0.62A 6ag0C-2af4C:
undetectable		 6ag0C-2af4C:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		3 TYR A  85
ALA A  19
LEU A  18
 None
 0.66A 6ag0C-2aifA:
undetectable		 6ag0C-2aifA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		3 TYR A 390
ALA A 402
LEU A 403
 None
 0.67A 6ag0C-2am4A:
undetectable		 6ag0C-2am4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 TYR A 115
ALA A 121
LEU A 122
 None
 0.64A 6ag0C-2avdA:
undetectable		 6ag0C-2avdA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		3 TYR A 139
ALA A 145
LEU A 146
 None
 0.50A 6ag0C-2bb6A:
undetectable		 6ag0C-2bb6A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR X 215
ALA X   9
LEU X  46
 None
 0.60A 6ag0C-2bq8X:
undetectable		 6ag0C-2bq8X:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TYR A 151
ALA A 126
LEU A 125
 None
 0.63A 6ag0C-2c11A:
undetectable		 6ag0C-2c11A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 TYR A 126
ALA A 303
LEU A 290
 None
 0.70A 6ag0C-2canA:
2.2		 6ag0C-2canA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		3 TYR A 549
ALA A 559
LEU A 563
 None
 0.61A 6ag0C-2ckhA:
undetectable		 6ag0C-2ckhA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257

(Pyrococcus
horikoshii) 		PF01902
(Diphthami_syn_2) 		3 TYR A  11
ALA A  24
LEU A  25
 None
 0.43A 6ag0C-2d13A:
undetectable		 6ag0C-2d13A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 TYR A  58
ALA A 339
LEU A 340
 GLC  A 605 (-4.8A)
GLC  A 605 ( 4.0A)
None
 0.39A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		3 TYR A 175
ALA A 172
LEU A 142
 None
 0.69A 6ag0C-2d3rA:
undetectable		 6ag0C-2d3rA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9r CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF08922
(DUF1905) 		3 TYR A  98
ALA A  58
LEU A 101
 None
 0.55A 6ag0C-2d9rA:
undetectable		 6ag0C-2d9rA:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 TYR A  58
ALA A 339
LEU A 340
 None
 0.61A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		3 TYR A 365
ALA A 371
LEU A 372
 None
 0.60A 6ag0C-2drqA:
undetectable		 6ag0C-2drqA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec2 136AA LONG
HYPOTHETICAL
TRANSPOSASE

(Sulfurisphaera
tokodaii) 		PF01797
(Y1_Tnp) 		3 TYR A  15
ALA A  44
LEU A  47
 None
 0.69A 6ag0C-2ec2A:
undetectable		 6ag0C-2ec2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 TYR A 163
ALA A 169
LEU A 170
 None
 0.65A 6ag0C-2et6A:
undetectable		 6ag0C-2et6A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eth TRANSCRIPTIONAL
REGULATOR, PUTATIVE,
MAR FAMILY

(Thermotoga
maritima) 		PF01047
(MarR) 		3 TYR A  36
ALA A  42
LEU A  43
 None
 0.54A 6ag0C-2ethA:
undetectable		 6ag0C-2ethA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 602
ALA A 558
LEU A 559
 None
 0.69A 6ag0C-2f3oA:
undetectable		 6ag0C-2f3oA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		3 TYR A  82
ALA A  66
LEU A  86
 None
 0.58A 6ag0C-2fe7A:
undetectable		 6ag0C-2fe7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 TYR A  79
ALA A  85
LEU A  86
 None
 0.58A 6ag0C-2ffhA:
undetectable		 6ag0C-2ffhA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		3 TYR A 344
ALA A 310
LEU A 311
 None
 0.68A 6ag0C-2fnaA:
undetectable		 6ag0C-2fnaA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TYR A 179
ALA A 186
LEU A 188
 None
 0.67A 6ag0C-2fzwA:
undetectable		 6ag0C-2fzwA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge9 TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF00017
(SH2) 		3 TYR A  65
ALA A  22
LEU A  26
 None
 0.69A 6ag0C-2ge9A:
undetectable		 6ag0C-2ge9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		3 TYR A 114
ALA A 120
LEU A 121
 None
 0.68A 6ag0C-2gm8A:
undetectable		 6ag0C-2gm8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		3 TYR A 112
ALA A 118
LEU A 119
 None
 0.55A 6ag0C-2hngA:
undetectable		 6ag0C-2hngA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		3 TYR A 199
ALA A 228
LEU A 202
 None
 0.54A 6ag0C-2hpwA:
undetectable		 6ag0C-2hpwA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE

(Homo sapiens) 		PF03266
(NTPase_1) 		3 TYR A  36
ALA A  91
LEU A  90
 None
 0.61A 6ag0C-2i3bA:
undetectable		 6ag0C-2i3bA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 TYR A  47
ALA A 187
LEU A 190
 None
 0.63A 6ag0C-2if6A:
undetectable		 6ag0C-2if6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 TYR A 212
ALA A 147
LEU A 149
 None
 0.64A 6ag0C-2ifyA:
undetectable		 6ag0C-2ifyA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00120
(Gln-synt_C) 		3 TYR A 330
ALA A 106
LEU A 107
 None
 0.60A 6ag0C-2j9iA:
undetectable		 6ag0C-2j9iA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		3 TYR A  58
ALA A  64
LEU A  65
 None
 0.32A 6ag0C-2ja2A:
undetectable		 6ag0C-2ja2A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lig ASPARTATE RECEPTOR

(Salmonella
enterica) 		PF02203
(TarH) 		3 TYR A 130
ALA A 164
LEU A 165
 None
 0.60A 6ag0C-2ligA:
undetectable		 6ag0C-2ligA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A1109
ALA A1115
LEU A1116
 None
 0.51A 6ag0C-2nlkA:
undetectable		 6ag0C-2nlkA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 TYR A 127
ALA A 133
LEU A 134
 None
 0.54A 6ag0C-2ntjA:
undetectable		 6ag0C-2ntjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 TYR A1473
ALA A1479
LEU A1480
 None
 0.53A 6ag0C-2nv5A:
undetectable		 6ag0C-2nv5A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR C  86
ALA C 102
LEU C 103
 None
 0.63A 6ag0C-2nymC:
undetectable		 6ag0C-2nymC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2a HYPOTHETICAL PROTEIN
GBS1413

(Streptococcus
agalactiae) 		PF06619
(DUF1149) 		3 TYR A 108
ALA A 114
LEU A 115
 None
 0.68A 6ag0C-2o2aA:
undetectable		 6ag0C-2o2aA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 TYR A 588
ALA A 527
LEU A 528
 None
 0.58A 6ag0C-2olsA:
9.5		 6ag0C-2olsA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		3 TYR A 176
ALA A 173
LEU A 142
 None
 0.69A 6ag0C-2ow4A:
undetectable		 6ag0C-2ow4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 TYR A  49
ALA A  55
LEU A  56
 None
 0.66A 6ag0C-2pljA:
4.2		 6ag0C-2pljA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TYR A 150
ALA A 125
LEU A 124
 None
 0.64A 6ag0C-2pncA:
undetectable		 6ag0C-2pncA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq4 PROTEIN NAPD
PERIPLASMIC NITRATE
REDUCTASE PRECURSOR

(Escherichia
coli;
Escherichia
coli) 		PF03927
(NapD)
PF10518
(TAT_signal) 		3 TYR A  79
ALA B  21
LEU B  23
 None
 0.52A 6ag0C-2pq4A:
undetectable		 6ag0C-2pq4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 TYR A 282
ALA A 304
LEU A 308
 None
 0.68A 6ag0C-2puzA:
6.3		 6ag0C-2puzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 TYR A 108
ALA A 165
LEU A 166
 None
 0.46A 6ag0C-2q7xA:
undetectable		 6ag0C-2q7xA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE

(Helicobacter
pylori) 		PF13500
(AAA_26) 		3 TYR A  23
ALA A 216
LEU A 217
 None
 0.56A 6ag0C-2qmoA:
undetectable		 6ag0C-2qmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 TYR A  20
ALA A  77
LEU A  78
 None
 0.64A 6ag0C-2qpsA:
36.3		 6ag0C-2qpsA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		3 TYR A 233
ALA A 239
LEU A 240
 None
 0.70A 6ag0C-2qptA:
2.6		 6ag0C-2qptA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		3 TYR A 274
ALA A 280
LEU A 278
 None
 0.70A 6ag0C-2qvlA:
undetectable		 6ag0C-2qvlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		3 TYR A 712
ALA A 718
LEU A 719
 None
 0.44A 6ag0C-2r8qA:
undetectable		 6ag0C-2r8qA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9g AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C) 		3 TYR A 334
ALA A 340
LEU A 341
 None
 0.63A 6ag0C-2r9gA:
undetectable		 6ag0C-2r9gA:
24.31