SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_C_ACRC608

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 TRP A   9
ASP A 179
LYS A 182
HIS A 288
ASP A 289
 None
 0.52A 6ag0C-1amyA:
36.1		 6ag0C-1amyA:
13.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TRP A  13
ASP B 231
LYS B 234
HIS B 235
HIS B 327
ASP B 328
GLN B 333
 None
 0.50A 6ag0C-1bplA:
19.2		 6ag0C-1bplA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TRP A  13
ASP B 231
TYR B 290
HIS B 327
ASP B 328
GLN B 333
 None
 0.75A 6ag0C-1bplA:
19.2		 6ag0C-1bplA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 190
ASP A 225
HIS A 229
HIS A 323
ASP A 324
 None
 0.69A 6ag0C-1cygA:
26.9		 6ag0C-1cygA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 190
ASP A 225
LYS A 228
HIS A 229
HIS A 323
 None
 0.95A 6ag0C-1cygA:
26.9		 6ag0C-1cygA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 194
ASP A 229
LYS A 232
HIS A 327
ASP A 328
 QPS  A1001 (-3.2A)
QPS  A1001 (-2.7A)
QPS  A1001 ( 4.1A)
QPS  A1001 (-3.6A)
QPS  A1001 (-1.7A)
 0.87A 6ag0C-1dedA:
26.0		 6ag0C-1dedA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 TYR A 824
MET A 311
LYS A 461
TYR A 450
ASP A 280
 None
 1.44A 6ag0C-1dgjA:
undetectable		 6ag0C-1dgjA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		11 TRP A  11
GLU A 189
TYR A 193
LEU A 196
MET A 197
ASP A 231
LYS A 234
HIS A 235
HIS A 327
ASP A 328
GLN A 333
 None
 0.79A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		5 LEU A 152
HIS A 148
TYR A 394
HIS A 453
GLN A 108
 None
CD  A 596 (-3.5A)
None
CD  A 595 ( 3.5A)
None
 1.32A 6ag0C-1ii0A:
undetectable		 6ag0C-1ii0A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		7 TRP A  56
GLU A 229
ASP A 185
LYS A 188
HIS A 189
HIS A 286
ASP A 287
 None
 1.20A 6ag0C-1jaeA:
29.5		 6ag0C-1jaeA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  56
GLU A 229
TYR A 139
LYS A 188
HIS A 286
ASP A 287
 None
 1.42A 6ag0C-1jaeA:
29.5		 6ag0C-1jaeA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		7 TRP A  56
LEU A 150
ASP A 185
LYS A 188
HIS A 189
HIS A 286
ASP A 287
 None
 0.68A 6ag0C-1jaeA:
29.5		 6ag0C-1jaeA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TRP A  56
LEU A 153
ASP A 185
HIS A 286
ASP A 287
 None
 1.39A 6ag0C-1jaeA:
29.5		 6ag0C-1jaeA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
 1.15A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 GLU A 240
TYR A 151
LYS A 200
HIS A 299
ASP A 300
 None
 1.37A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
 0.62A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  58
GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
 1.21A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TRP A  58
GLU A 240
TYR A 151
LYS A 200
HIS A 299
 None
 1.48A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  58
LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
 0.77A 6ag0C-1jxkA:
26.6		 6ag0C-1jxkA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 194
ASP A 229
HIS A 233
HIS A 327
ASP A 328
 None
GLC  A1695 (-3.2A)
GLC  A1694 ( 4.0A)
GLC  A1695 (-4.1A)
GLC  A1695 ( 3.0A)
 0.50A 6ag0C-1kclA:
28.4		 6ag0C-1kclA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  46
GLU A 207
LYS A 177
HIS A 178
HIS A 263
ASP A 264
 None
None
None
None
None
ACR  A 598 (-3.1A)
 1.42A 6ag0C-1kxhA:
28.8		 6ag0C-1kxhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  46
LEU A 139
LYS A 177
HIS A 178
HIS A 263
ASP A 264
 None
None
None
None
None
ACR  A 598 (-3.1A)
 0.74A 6ag0C-1kxhA:
28.8		 6ag0C-1kxhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TRP A  18
ASP A 198
LYS A 201
HIS A 288
ASP A 289
 None
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-4.0A)
 0.59A 6ag0C-1mwoA:
39.6		 6ag0C-1mwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TRP A  18
ASP A 198
TYR A 249
HIS A 288
ASP A 289
 None
ZN  A 441 ( 4.2A)
None
None
ZN  A 441 (-4.0A)
 0.77A 6ag0C-1mwoA:
39.6		 6ag0C-1mwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 BGC  A 993 ( 3.3A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 1.01A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
ASP A 300
 None
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
 0.53A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  58
GLU A 240
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
BGC  A 993 ( 3.3A)
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
 1.10A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  58
LEU A 162
ASP A 197
LYS A 200
HIS A 201
HIS A 299
 None
None
AC1  A 992 ( 3.3A)
BGC  A 993 ( 2.8A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 3.9A)
 0.73A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ASP A 228
LYS A 231
HIS A 232
HIS A 328
ASP A 329
 ABD  A1200 (-3.1A)
ABD  A1200 (-2.9A)
ABD  A1200 ( 3.8A)
ABD  A1200 (-3.8A)
ABD  A1200 (-2.9A)
 0.42A 6ag0C-1qhoA:
28.6		 6ag0C-1qhoA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		5 TYR A 304
LEU A 302
MET A 301
ASP A 215
GLN A 218
 None
 1.31A 6ag0C-1sb7A:
undetectable		 6ag0C-1sb7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		7 TRP A  58
LEU A 141
ASP A 176
LYS A 179
HIS A 180
HIS A 268
ASP A 269
 None
G6D  A 505 ( 4.7A)
ACI  A 504 (-3.0A)
BGC  A 506 (-2.7A)
G6D  A 505 ( 3.7A)
ACI  A 504 (-3.8A)
ACI  A 504 ( 2.8A)
 0.72A 6ag0C-1ua7A:
28.7		 6ag0C-1ua7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		10 TRP A  13
GLU A 189
TYR A 193
LEU A 196
ASP A 231
LYS A 234
HIS A 235
TYR A 290
HIS A 327
ASP A 328
 None
 0.73A 6ag0C-1ud3A:
63.6		 6ag0C-1ud3A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TRP A  13
ASP A 231
LYS A 234
HIS A 327
ASP A 328
GLN A 333
 None
 0.35A 6ag0C-1vjsA:
55.5		 6ag0C-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TRP A  13
ASP A 231
TYR A 290
HIS A 327
ASP A 328
GLN A 333
 None
 0.78A 6ag0C-1vjsA:
55.5		 6ag0C-1vjsA:
6.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		10 TRP A  15
GLU A 194
TYR A 198
LEU A 201
MET A 202
ASP A 236
LYS A 239
HIS A 240
HIS A 332
ASP A 333
 None
GLC  A1491 (-2.9A)
GLC  A1491 ( 4.7A)
AC1  A1492 ( 4.9A)
GLC  A1493 (-3.5A)
AC1  A1492 (-3.0A)
GLC  A1491 (-2.5A)
AC1  A1492 ( 3.9A)
AC1  A1492 (-3.9A)
AC1  A1492 ( 3.0A)
 0.34A 6ag0C-1w9xA:
64.3		 6ag0C-1w9xA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TRP A  15
LEU A 201
MET A 202
ASP A 236
TYR A 295
HIS A 332
ASP A 333
 None
AC1  A1492 ( 4.9A)
GLC  A1493 (-3.5A)
AC1  A1492 (-3.0A)
BGC  A1490 ( 4.5A)
AC1  A1492 (-3.9A)
AC1  A1492 ( 3.0A)
 0.75A 6ag0C-1w9xA:
64.3		 6ag0C-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 GLU A 376
HIS A 310
TYR A 346
HIS A 399
ASP A 400
 GLC  A1605 (-2.8A)
GLC  A1605 (-4.2A)
None
None
None
 1.08A 6ag0C-2bxyA:
24.9		 6ag0C-2bxyA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 TRP A 175
GLU A 376
ASP A 275
HIS A 399
ASP A 400
 None
GLC  A1605 (-2.8A)
None
None
None
 1.24A 6ag0C-2bxyA:
24.9		 6ag0C-2bxyA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		10 TRP A  15
GLU A 194
TYR A 198
LEU A 201
MET A 202
ASP A 236
LYS A 239
HIS A 240
HIS A 332
ASP A 333
 None
None
None
None
GLC  A 605 ( 3.5A)
None
None
None
None
GLC  A 605 (-3.5A)
 0.39A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TRP A  15
LEU A 201
ASP A 236
HIS A 240
TYR A 295
HIS A 332
ASP A 333
 None
None
None
None
None
None
GLC  A 605 (-3.5A)
 0.82A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		10 TRP A  15
GLU A 194
TYR A 198
LEU A 201
MET A 202
ASP A 236
LYS A 239
HIS A 240
HIS A 332
ASP A 333
 None
 0.49A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TRP A  15
LEU A 201
MET A 202
ASP A 236
TYR A 295
HIS A 332
ASP A 333
 None
 1.01A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 LYS A 209
HIS A 210
TYR A 256
HIS A 296
ASP A 297
 None
 1.32A 6ag0C-2taaA:
22.9		 6ag0C-2taaA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy1 CLEAVAGE STIMULATION
FACTOR 77

(Encephalitozoon
cuniculi) 		PF05843
(Suf) 		5 GLU A 213
TYR A 439
LEU A 436
MET A 432
ASP A 461
 None
 1.49A 6ag0C-2uy1A:
undetectable		 6ag0C-2uy1A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 TYR A 430
LEU A 433
ASP A 477
HIS A 587
ASP A 588
 None
 0.79A 6ag0C-3aibA:
11.6		 6ag0C-3aibA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		8 TRP A 131
LEU A 315
MET A 316
ASP A 350
LYS A 353
HIS A 354
HIS A 446
ASP A 447
 None
None
GLC  A 805 (-3.7A)
ACI  A 806 (-3.1A)
GLC  A 808 (-2.9A)
GLD  A 807 ( 3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.45A 6ag0C-3bc9A:
48.4		 6ag0C-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 LEU A 195
ASP A 230
LYS A 233
HIS A 234
HIS A 328
ASP A 329
 None
ACI  A 694 (-3.2A)
GLC  A 692 ( 2.8A)
G6D  A 693 ( 3.8A)
ACI  A 694 (-3.9A)
ACI  A 694 ( 2.8A)
 0.47A 6ag0C-3bmwA:
28.3		 6ag0C-3bmwA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 ASP A 388
LYS A 391
HIS A 392
HIS A 497
ASP A 498
 ACT  A 961 (-2.8A)
None
None
None
EDO  A 901 (-4.4A)
 0.41A 6ag0C-3k8kA:
25.5		 6ag0C-3k8kA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TRP A  18
ASP A 198
TYR A 249
HIS A 288
ASP A 289
 None
TRS  A 505 (-2.7A)
None
TRS  A 505 (-4.2A)
TRS  A 505 (-3.0A)
 0.80A 6ag0C-3qgvA:
39.7		 6ag0C-3qgvA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TRP A  58
GLU A 240
ASP A 197
HIS A 299
ASP A 300
 None
 1.21A 6ag0C-3vm5A:
26.6		 6ag0C-3vm5A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		6 TRP A  58
LEU A 162
ASP A 197
HIS A 201
HIS A 299
ASP A 300
 None
 0.65A 6ag0C-3vm5A:
26.6		 6ag0C-3vm5A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TRP A  58
LEU A 165
ASP A 197
HIS A 299
ASP A 300
 None
 1.47A 6ag0C-3vm5A:
26.6		 6ag0C-3vm5A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		7 LEU A 185
ASP A 225
LYS A 228
HIS A 229
TYR A 275
HIS A 315
ASP A 316
 None
GLC  A 503 (-3.5A)
GLC  A 503 ( 4.4A)
GLC  A 503 ( 4.0A)
None
None
GLC  A 503 (-3.0A)
 0.90A 6ag0C-3vm7A:
27.4		 6ag0C-3vm7A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		6 LEU A 194
ASP A 229
LYS A 232
HIS A 233
HIS A 327
ASP A 328
 None
 1.01A 6ag0C-4cgtA:
28.1		 6ag0C-4cgtA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 194
ASP A 229
HIS A 233
HIS A 328
ASP A 329
 None
GOL  A 711 (-2.8A)
None
EDO  A 718 ( 3.9A)
None
 0.66A 6ag0C-4jclA:
28.5		 6ag0C-4jclA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 194
ASP A 229
LYS A 232
HIS A 233
HIS A 328
 None
GOL  A 711 (-2.8A)
None
None
EDO  A 718 ( 3.9A)
 0.87A 6ag0C-4jclA:
28.5		 6ag0C-4jclA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A) 		PF00947
(Pico_P2A) 		5 GLU A  88
TYR A  89
LEU A  22
HIS A  21
ASP A 109
 None
 1.31A 6ag0C-4mg3A:
undetectable		 6ag0C-4mg3A:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		12 TRP A  14
GLU A 190
TYR A 194
LEU A 197
MET A 198
ASP A 232
LYS A 235
HIS A 236
TYR A 266
HIS A 328
ASP A 329
GLN A 334
 None
None
None
None
None
NA  A1490 (-2.9A)
None
None
None
None
NA  A1490 ( 4.5A)
None
 0.30A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		6 LEU A 177
ASP A 213
LYS A 216
HIS A 217
HIS A 309
ASP A 310
 None
ACT  A1479 (-2.6A)
None
None
None
ACT  A1479 ( 4.9A)
 0.45A 6ag0C-5a2aA:
29.0		 6ag0C-5a2aA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		5 LEU A 971
ASP A1015
TYR A1079
HIS A1124
ASP A1125
 None
None
ACT  A1706 (-4.6A)
None
GLC  A1711 ( 3.2A)
 0.98A 6ag0C-5jbeA:
12.4		 6ag0C-5jbeA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnf PEROXISOMAL
BIOGENESIS FACTOR 19

(Homo sapiens) 		PF04614
(Pex19) 		5 GLU A 271
LEU A 276
MET A 179
TYR A 199
GLN A 259
 None
None
None
None
FAR  A 301 (-3.2A)
 1.41A 6ag0C-5lnfA:
undetectable		 6ag0C-5lnfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		6 ASP B 213
LYS B 216
HIS B 217
TYR B 276
HIS B 304
ASP B 305
 EDO  B 616 ( 2.8A)
None
NA  B 604 ( 4.9A)
None
None
K  B 605 ( 4.7A)
 0.85A 6ag0C-5m99B:
22.1		 6ag0C-5m99B:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 5 TYR A 626
LEU A 629
ASP A 677
HIS A 789
ASP A 790
 None
 0.82A 6ag0C-5ngyA:
11.0		 6ag0C-5ngyA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		3 TYR A  74
ALA A 166
LEU A 242
 None
 0.70A 6ag0C-1abrA:
undetectable		 6ag0C-1abrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		3 TYR A 142
ALA A 150
LEU A 151
 None
 0.60A 6ag0C-1ahaA:
undetectable		 6ag0C-1ahaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 TYR A  19
ALA A  76
LEU A  77
 None
 0.54A 6ag0C-1amyA:
36.1		 6ag0C-1amyA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		3 TYR A 295
ALA A 301
LEU A 302
 None
 0.56A 6ag0C-1bg4A:
10.1		 6ag0C-1bg4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		3 TYR Y  70
ALA Y 162
LEU Y 239
 None
 0.65A 6ag0C-1bryY:
undetectable		 6ag0C-1bryY:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 TYR A 489
ALA A 495
LEU A 496
 None
 0.51A 6ag0C-1dgfA:
undetectable		 6ag0C-1dgfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		3 TYR A 309
ALA A 315
LEU A 316
 None
 0.56A 6ag0C-1dk5A:
undetectable		 6ag0C-1dk5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		3 TYR A  66
ALA A  90
LEU A  91
 None
 0.50A 6ag0C-1e09A:
undetectable		 6ag0C-1e09A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8y NUCLEOSIDE
2-DEOXYRIBOSYLTRANSF
ERASE

(Lactobacillus
leichmannii) 		PF05014
(Nuc_deoxyrib_tr) 		3 TYR A  21
ALA A  27
LEU A  28
 None
 0.58A 6ag0C-1f8yA:
undetectable		 6ag0C-1f8yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		3 TYR A 305
ALA A 311
LEU A 312
 None
 0.61A 6ag0C-1fokA:
undetectable		 6ag0C-1fokA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 294
ALA A 369
LEU A 370
 None
 0.67A 6ag0C-1fp3A:
undetectable		 6ag0C-1fp3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 TYR A 101
ALA A 107
LEU A 108
 None
 0.61A 6ag0C-1fp9A:
15.1		 6ag0C-1fp9A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 TYR A 214
ALA A 153
LEU A 156
 None
 0.69A 6ag0C-1ghsA:
5.4		 6ag0C-1ghsA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		3 TYR A 195
ALA A 201
LEU A 202
 None
 0.63A 6ag0C-1gl6A:
undetectable		 6ag0C-1gl6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		3 TYR A  37
ALA A  52
LEU A  43
 None
 0.51A 6ag0C-1glvA:
undetectable		 6ag0C-1glvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 TYR A 335
ALA A 341
LEU A 342
 None
 0.52A 6ag0C-1hm6A:
undetectable		 6ag0C-1hm6A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 TYR A  45
ALA A  51
LEU A  52
 None
 0.64A 6ag0C-1jioA:
undetectable		 6ag0C-1jioA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 TYR A 258
ALA A 264
LEU A 265
 None
 0.67A 6ag0C-1jr1A:
6.6		 6ag0C-1jr1A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 129
ALA A  92
LEU A  96
 None
 0.69A 6ag0C-1k9aA:
undetectable		 6ag0C-1k9aA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A1571
ALA A1577
LEU A1578
 None
 0.41A 6ag0C-1larA:
undetectable		 6ag0C-1larA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		3 TYR A  73
ALA A 179
LEU A 246
 CMP  A 901 (-4.1A)
None
None
 0.59A 6ag0C-1lpcA:
undetectable		 6ag0C-1lpcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 193
ALA A 156
LEU A 160
 None
 0.61A 6ag0C-1opkA:
undetectable		 6ag0C-1opkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		3 TYR A 425
ALA A 406
LEU A 422
 None
 0.67A 6ag0C-1p9wA:
undetectable		 6ag0C-1p9wA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		3 TYR A 209
ALA A 215
LEU A 216
 None
 0.68A 6ag0C-1pn4A:
undetectable		 6ag0C-1pn4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 TYR M 247
ALA M 253
LEU M 254
 None
None
PID  M 624 (-4.4A)
 0.63A 6ag0C-1pprM:
undetectable		 6ag0C-1pprM:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		3 TYR A  72
ALA A 178
LEU A 245
 None
 0.69A 6ag0C-1qi7A:
undetectable		 6ag0C-1qi7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 TYR A 151
ALA A  53
LEU A  55
 None
 0.49A 6ag0C-1qlbA:
undetectable		 6ag0C-1qlbA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 TYR A  65
ALA A  71
LEU A  72
 None
 0.57A 6ag0C-1r0lA:
undetectable		 6ag0C-1r0lA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 TYR A 113
ALA A 135
LEU A 136
 None
 0.53A 6ag0C-1r5aA:
undetectable		 6ag0C-1r5aA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		3 TYR A 243
ALA A 156
LEU A 157
 None
 0.61A 6ag0C-1r8yA:
undetectable		 6ag0C-1r8yA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfz HYPOTHETICAL PROTEIN
APC35681

(Geobacillus
stearothermophilus) 		PF04608
(PgpA) 		3 TYR A 118
ALA A 150
LEU A  30
 None
 0.68A 6ag0C-1rfzA:
undetectable		 6ag0C-1rfzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE

(Pyrococcus
furiosus) 		PF03070
(TENA_THI-4) 		3 TYR A  44
ALA A  50
LEU A  51
 None
MP5  A1213 (-3.6A)
None
 0.67A 6ag0C-1rtwA:
undetectable		 6ag0C-1rtwA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 TYR A  34
ALA A 230
LEU A 234
 None
 0.60A 6ag0C-1s2nA:
2.5		 6ag0C-1s2nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sn4 PROTEIN (NEUROTOXIN
BMK M4)

(Mesobuthus
martensii) 		PF00537
(Toxin_3) 		3 TYR A  35
ALA A  31
LEU A  51
 None
 0.70A 6ag0C-1sn4A:
undetectable		 6ag0C-1sn4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 TYR A  92
ALA A  98
LEU A  99
 None
 0.62A 6ag0C-1susA:
undetectable		 6ag0C-1susA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 TYR B 293
ALA B 299
LEU B 300
 None
 0.56A 6ag0C-1ta3B:
5.5		 6ag0C-1ta3B:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 TYR A  70
ALA A 162
LEU A 239
 NDP  A 280 ( 4.7A)
None
None
 0.68A 6ag0C-1tcsA:
undetectable		 6ag0C-1tcsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 TYR A 173
ALA A 179
LEU A 180
 None
 0.65A 6ag0C-1u5uA:
undetectable		 6ag0C-1u5uA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		3 TYR A 273
ALA A 232
LEU A 276
 None
 0.63A 6ag0C-1wf3A:
2.2		 6ag0C-1wf3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwr TRNA ADENOSINE
DEAMINASE TADA

(Aquifex
aeolicus) 		PF14437
(MafB19-deam) 		3 TYR A 130
ALA A  10
LEU A  11
 None
 0.58A 6ag0C-1wwrA:
undetectable		 6ag0C-1wwrA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x27 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		3 TYR A 181
ALA A 137
LEU A 141
 None
 0.69A 6ag0C-1x27A:
undetectable		 6ag0C-1x27A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 TYR A 827
ALA A 833
LEU A 834
 None
 0.60A 6ag0C-1xyzA:
10.7		 6ag0C-1xyzA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		3 TYR B  87
ALA B 137
LEU B  90
 None
 0.68A 6ag0C-1y56B:
undetectable		 6ag0C-1y56B:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		3 TYR A 119
ALA A 151
LEU A  31
 None
 0.68A 6ag0C-1y9iA:
undetectable		 6ag0C-1y9iA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 TYR A 304
ALA A 310
LEU A 311
 None
 0.56A 6ag0C-1ycnA:
undetectable		 6ag0C-1ycnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A 877
ALA A 883
LEU A 884
 None
 0.54A 6ag0C-1yguA:
undetectable		 6ag0C-1yguA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		3 TYR A  95
ALA A 272
LEU A 259
 None
 0.69A 6ag0C-1z7dA:
2.2		 6ag0C-1z7dA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmo HALOHYDRIN
DEHALOGENASE

(Arthrobacter
sp. AD2) 		PF13561
(adh_short_C2) 		3 TYR A 173
ALA A 161
LEU A 165
 None
 0.66A 6ag0C-1zmoA:
undetectable		 6ag0C-1zmoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abl ABL TYROSINE KINASE

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		3 TYR A 193
ALA A 156
LEU A 160
 None
 0.59A 6ag0C-2ablA:
undetectable		 6ag0C-2ablA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		3 TYR C 106
ALA C  82
LEU C  86
 None
 0.62A 6ag0C-2af4C:
undetectable		 6ag0C-2af4C:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		3 TYR A  85
ALA A  19
LEU A  18
 None
 0.66A 6ag0C-2aifA:
undetectable		 6ag0C-2aifA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		3 TYR A 390
ALA A 402
LEU A 403
 None
 0.67A 6ag0C-2am4A:
undetectable		 6ag0C-2am4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 TYR A 115
ALA A 121
LEU A 122
 None
 0.64A 6ag0C-2avdA:
undetectable		 6ag0C-2avdA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		3 TYR A 139
ALA A 145
LEU A 146
 None
 0.50A 6ag0C-2bb6A:
undetectable		 6ag0C-2bb6A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR X 215
ALA X   9
LEU X  46
 None
 0.60A 6ag0C-2bq8X:
undetectable		 6ag0C-2bq8X:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TYR A 151
ALA A 126
LEU A 125
 None
 0.63A 6ag0C-2c11A:
undetectable		 6ag0C-2c11A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 TYR A 126
ALA A 303
LEU A 290
 None
 0.70A 6ag0C-2canA:
2.2		 6ag0C-2canA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		3 TYR A 549
ALA A 559
LEU A 563
 None
 0.61A 6ag0C-2ckhA:
undetectable		 6ag0C-2ckhA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257

(Pyrococcus
horikoshii) 		PF01902
(Diphthami_syn_2) 		3 TYR A  11
ALA A  24
LEU A  25
 None
 0.43A 6ag0C-2d13A:
undetectable		 6ag0C-2d13A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 TYR A  58
ALA A 339
LEU A 340
 GLC  A 605 (-4.8A)
GLC  A 605 ( 4.0A)
None
 0.39A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		3 TYR A 175
ALA A 172
LEU A 142
 None
 0.69A 6ag0C-2d3rA:
undetectable		 6ag0C-2d3rA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9r CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF08922
(DUF1905) 		3 TYR A  98
ALA A  58
LEU A 101
 None
 0.55A 6ag0C-2d9rA:
undetectable		 6ag0C-2d9rA:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 TYR A  58
ALA A 339
LEU A 340
 None
 0.61A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		3 TYR A 365
ALA A 371
LEU A 372
 None
 0.60A 6ag0C-2drqA:
undetectable		 6ag0C-2drqA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec2 136AA LONG
HYPOTHETICAL
TRANSPOSASE

(Sulfurisphaera
tokodaii) 		PF01797
(Y1_Tnp) 		3 TYR A  15
ALA A  44
LEU A  47
 None
 0.69A 6ag0C-2ec2A:
undetectable		 6ag0C-2ec2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 TYR A 163
ALA A 169
LEU A 170
 None
 0.65A 6ag0C-2et6A:
undetectable		 6ag0C-2et6A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eth TRANSCRIPTIONAL
REGULATOR, PUTATIVE,
MAR FAMILY

(Thermotoga
maritima) 		PF01047
(MarR) 		3 TYR A  36
ALA A  42
LEU A  43
 None
 0.54A 6ag0C-2ethA:
undetectable		 6ag0C-2ethA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 602
ALA A 558
LEU A 559
 None
 0.69A 6ag0C-2f3oA:
undetectable		 6ag0C-2f3oA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		3 TYR A  82
ALA A  66
LEU A  86
 None
 0.58A 6ag0C-2fe7A:
undetectable		 6ag0C-2fe7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 TYR A  79
ALA A  85
LEU A  86
 None
 0.58A 6ag0C-2ffhA:
undetectable		 6ag0C-2ffhA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		3 TYR A 344
ALA A 310
LEU A 311
 None
 0.68A 6ag0C-2fnaA:
undetectable		 6ag0C-2fnaA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TYR A 179
ALA A 186
LEU A 188
 None
 0.67A 6ag0C-2fzwA:
undetectable		 6ag0C-2fzwA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge9 TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF00017
(SH2) 		3 TYR A  65
ALA A  22
LEU A  26
 None
 0.69A 6ag0C-2ge9A:
undetectable		 6ag0C-2ge9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		3 TYR A 114
ALA A 120
LEU A 121
 None
 0.68A 6ag0C-2gm8A:
undetectable		 6ag0C-2gm8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		3 TYR A 112
ALA A 118
LEU A 119
 None
 0.55A 6ag0C-2hngA:
undetectable		 6ag0C-2hngA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		3 TYR A 199
ALA A 228
LEU A 202
 None
 0.54A 6ag0C-2hpwA:
undetectable		 6ag0C-2hpwA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE

(Homo sapiens) 		PF03266
(NTPase_1) 		3 TYR A  36
ALA A  91
LEU A  90
 None
 0.61A 6ag0C-2i3bA:
undetectable		 6ag0C-2i3bA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 TYR A  47
ALA A 187
LEU A 190
 None
 0.63A 6ag0C-2if6A:
undetectable		 6ag0C-2if6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 TYR A 212
ALA A 147
LEU A 149
 None
 0.64A 6ag0C-2ifyA:
undetectable		 6ag0C-2ifyA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00120
(Gln-synt_C) 		3 TYR A 330
ALA A 106
LEU A 107
 None
 0.60A 6ag0C-2j9iA:
undetectable		 6ag0C-2j9iA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		3 TYR A  58
ALA A  64
LEU A  65
 None
 0.32A 6ag0C-2ja2A:
undetectable		 6ag0C-2ja2A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lig ASPARTATE RECEPTOR

(Salmonella
enterica) 		PF02203
(TarH) 		3 TYR A 130
ALA A 164
LEU A 165
 None
 0.60A 6ag0C-2ligA:
undetectable		 6ag0C-2ligA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A1109
ALA A1115
LEU A1116
 None
 0.51A 6ag0C-2nlkA:
undetectable		 6ag0C-2nlkA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 TYR A 127
ALA A 133
LEU A 134
 None
 0.54A 6ag0C-2ntjA:
undetectable		 6ag0C-2ntjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 TYR A1473
ALA A1479
LEU A1480
 None
 0.53A 6ag0C-2nv5A:
undetectable		 6ag0C-2nv5A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR C  86
ALA C 102
LEU C 103
 None
 0.63A 6ag0C-2nymC:
undetectable		 6ag0C-2nymC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2a HYPOTHETICAL PROTEIN
GBS1413

(Streptococcus
agalactiae) 		PF06619
(DUF1149) 		3 TYR A 108
ALA A 114
LEU A 115
 None
 0.68A 6ag0C-2o2aA:
undetectable		 6ag0C-2o2aA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 TYR A 588
ALA A 527
LEU A 528
 None
 0.58A 6ag0C-2olsA:
9.5		 6ag0C-2olsA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		3 TYR A 176
ALA A 173
LEU A 142
 None
 0.69A 6ag0C-2ow4A:
undetectable		 6ag0C-2ow4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 TYR A  49
ALA A  55
LEU A  56
 None
 0.66A 6ag0C-2pljA:
4.2		 6ag0C-2pljA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TYR A 150
ALA A 125
LEU A 124
 None
 0.64A 6ag0C-2pncA:
undetectable		 6ag0C-2pncA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq4 PROTEIN NAPD
PERIPLASMIC NITRATE
REDUCTASE PRECURSOR

(Escherichia
coli;
Escherichia
coli) 		PF03927
(NapD)
PF10518
(TAT_signal) 		3 TYR A  79
ALA B  21
LEU B  23
 None
 0.52A 6ag0C-2pq4A:
undetectable		 6ag0C-2pq4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 TYR A 282
ALA A 304
LEU A 308
 None
 0.68A 6ag0C-2puzA:
6.3		 6ag0C-2puzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 TYR A 108
ALA A 165
LEU A 166
 None
 0.46A 6ag0C-2q7xA:
undetectable		 6ag0C-2q7xA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE

(Helicobacter
pylori) 		PF13500
(AAA_26) 		3 TYR A  23
ALA A 216
LEU A 217
 None
 0.56A 6ag0C-2qmoA:
undetectable		 6ag0C-2qmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 TYR A  20
ALA A  77
LEU A  78
 None
 0.64A 6ag0C-2qpsA:
36.3		 6ag0C-2qpsA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		3 TYR A 233
ALA A 239
LEU A 240
 None
 0.70A 6ag0C-2qptA:
2.6		 6ag0C-2qptA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		3 TYR A 274
ALA A 280
LEU A 278
 None
 0.70A 6ag0C-2qvlA:
undetectable		 6ag0C-2qvlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		3 TYR A 712
ALA A 718
LEU A 719
 None
 0.44A 6ag0C-2r8qA:
undetectable		 6ag0C-2r8qA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9g AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C) 		3 TYR A 334
ALA A 340
LEU A 341
 None
 0.63A 6ag0C-2r9gA:
undetectable		 6ag0C-2r9gA:
24.31