SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_C_ACRC607_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 GLY A 216
GLY A 220
PRO A 221
GLY A 224
 None
None
None
CIT  A1000 (-4.2A)
 0.76A 6ag0C-1aj8A:
undetectable		 6ag0C-1aj8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY B 299
TRP B 342
GLY B 431
PRO B 432
GLY B 475
 None
 0.45A 6ag0C-1bplB:
36.3		 6ag0C-1bplB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  67
ASP A  11
GLY A  52
GLY A  49
 None
 0.68A 6ag0C-1bucA:
undetectable		 6ag0C-1bucA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 109
ASP A  89
GLY A 297
PRO A 296
GLY A 298
 None
 1.47A 6ag0C-1bxzA:
undetectable		 6ag0C-1bxzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
ASP A 121
GLY A 140
GLY A 142
 CAA  A 300 (-3.2A)
None
CAA  A 300 (-3.1A)
None
 0.74A 6ag0C-1dubA:
undetectable		 6ag0C-1dubA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLY A 241
ASP A 255
GLY A 205
GLY A 208
 None
 0.77A 6ag0C-1e08A:
undetectable		 6ag0C-1e08A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 299
TRP A 342
GLY A 431
PRO A 432
GLY A 475
 None
 0.27A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 GLY A 230
GLY A 336
PRO A 337
GLY A 333
 None
 0.71A 6ag0C-1eg1A:
undetectable		 6ag0C-1eg1A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 GLY B 184
ASP B 159
GLY B 186
PRO B 222
GLY B 186
 None
 1.47A 6ag0C-1ekbB:
undetectable		 6ag0C-1ekbB:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 GLY A 192
ASP A 142
GLY A 195
PRO A 196
 None
 0.63A 6ag0C-1fd9A:
undetectable		 6ag0C-1fd9A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 236
ASP A 228
GLY A 262
PRO A 263
GLY A 260
 None
None
None
None
ILE  A 500 ( 4.1A)
 1.35A 6ag0C-1h74A:
undetectable		 6ag0C-1h74A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  94
GLY A 261
PRO A 262
GLY A 264
 None
 0.69A 6ag0C-1ivhA:
undetectable		 6ag0C-1ivhA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A  12
ASP A 204
GLY A 376
PRO A 375
GLY A 211
 None
ATP  A 535 ( 3.8A)
None
None
None
 1.24A 6ag0C-1kvkA:
undetectable		 6ag0C-1kvkA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A  90
GLY A  33
PRO A  34
GLY A  36
 None
 0.72A 6ag0C-1oseA:
26.7		 6ag0C-1oseA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 GLY A 334
ASP A 351
GLY A 389
PRO A 390
 None
 0.77A 6ag0C-1pbyA:
2.1		 6ag0C-1pbyA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 GLY A 344
ASP A 349
PRO A 276
GLY A 270
 None
 0.74A 6ag0C-1rrmA:
undetectable		 6ag0C-1rrmA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 299
TRP A 342
GLY A 428
PRO A 429
GLY A 472
 None
 0.67A 6ag0C-1ud3A:
63.6		 6ag0C-1ud3A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 GLY A 339
GLY A 336
PRO A 335
GLY A 324
 None
 0.66A 6ag0C-1upxA:
undetectable		 6ag0C-1upxA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 299
TRP A 342
GLY A 431
PRO A 432
GLY A 475
 None
 0.41A 6ag0C-1vjsA:
55.5		 6ag0C-1vjsA:
6.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 304
TRP A 347
GLY A 433
PRO A 434
GLY A 477
 None
 0.33A 6ag0C-1w9xA:
64.3		 6ag0C-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 GLY A  92
ASP A  28
GLY A  24
GLY A  45
 None
SAM  A3142 ( 4.9A)
None
None
 0.72A 6ag0C-1wg8A:
undetectable		 6ag0C-1wg8A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		4 GLY A 235
GLY A  13
PRO A  14
GLY A  17
 None
 0.69A 6ag0C-1ydoA:
5.6		 6ag0C-1ydoA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 405
TRP A 408
GLY A 375
GLY A 293
 None
 0.77A 6ag0C-2a9cA:
undetectable		 6ag0C-2a9cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 304
TRP A 347
GLY A 433
GLY A 477
 None
 0.35A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 304
TRP A 347
GLY A 433
PRO A 434
GLY A 477
 None
 0.38A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		4 GLY A 341
GLY A 343
PRO A 344
GLY A 346
 None
 0.73A 6ag0C-2f28A:
undetectable		 6ag0C-2f28A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLY A 141
GLY A 170
PRO A 171
GLY A   6
 None
 0.66A 6ag0C-2fa0A:
undetectable		 6ag0C-2fa0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		4 GLY A 328
GLY A 308
PRO A 309
GLY A 292
 None
 0.74A 6ag0C-2gy5A:
undetectable		 6ag0C-2gy5A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A  97
ASP A  62
GLY A  89
GLY A 149
 None
 0.74A 6ag0C-2iikA:
undetectable		 6ag0C-2iikA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 GLY A 266
GLY A 268
PRO A 269
GLY A 271
 FRU  A   1 ( 4.1A)
None
None
None
 0.68A 6ag0C-2invA:
undetectable		 6ag0C-2invA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kno TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF00017
(SH2) 		4 GLY A  54
GLY A  89
PRO A  90
GLY A  92
 None
 0.69A 6ag0C-2knoA:
undetectable		 6ag0C-2knoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf3 U2-SEGESTRITOXIN-SF1
A

(Segestria
florentina) 		PF08115
(Toxin_28) 		4 GLY A   8
GLY A  44
PRO A  45
GLY A  21
 None
 0.71A 6ag0C-2mf3A:
undetectable		 6ag0C-2mf3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A 205
ASP A 228
GLY A 203
PRO A 202
 None
None
4PA  A 369 ( 3.7A)
None
 0.76A 6ag0C-2o7rA:
undetectable		 6ag0C-2o7rA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A  91
ASP A 100
GLY A  28
GLY A 254
 None
 0.76A 6ag0C-2obvA:
undetectable		 6ag0C-2obvA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 GLY A  38
ASP A  83
GLY A  59
GLY A  80
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.2A)
None
None
 0.65A 6ag0C-2p35A:
undetectable		 6ag0C-2p35A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		4 GLY A  52
ASP A 115
GLY A  59
GLY A  73
 None
 0.69A 6ag0C-2porA:
undetectable		 6ag0C-2porA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 GLY A  21
TRP A  38
GLY A 122
GLY A 125
 None
 0.75A 6ag0C-2pw6A:
undetectable		 6ag0C-2pw6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 GLY A 586
ASP A 503
GLY A 578
PRO A 574
 None
 0.61A 6ag0C-2qvwA:
undetectable		 6ag0C-2qvwA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 331
GLY A 334
PRO A 335
GLY A 351
 None
None
None
GOL  A 380 (-3.7A)
 0.72A 6ag0C-2rdxA:
6.9		 6ag0C-2rdxA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu3 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE F
VARIANT

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		4 GLY A  18
TRP A  55
GLY A  91
PRO A  92
 None
 0.66A 6ag0C-2yu3A:
undetectable		 6ag0C-2yu3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 GLY A 326
ASP A 354
GLY A 203
GLY A 201
 None
 0.74A 6ag0C-3errA:
undetectable		 6ag0C-3errA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 GLY A  24
ASP A 287
GLY A  29
GLY A 305
 NAP  A4005 (-3.3A)
NAP  A4005 (-3.8A)
None
None
 0.77A 6ag0C-3f8rA:
undetectable		 6ag0C-3f8rA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 GLY A 273
GLY A 153
PRO A 154
GLY A 157
 None
 0.66A 6ag0C-3iusA:
undetectable		 6ag0C-3iusA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 GLY A 274
ASP A 251
GLY A 241
GLY A 212
 None
 0.72A 6ag0C-3jyfA:
2.5		 6ag0C-3jyfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A  73
ASP A  18
GLY A  55
GLY A  34
 None
 0.69A 6ag0C-3odtA:
undetectable		 6ag0C-3odtA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 GLY A 344
ASP A 349
PRO A 276
GLY A 270
 None
 0.69A 6ag0C-3ox4A:
undetectable		 6ag0C-3ox4A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 ASP A 523
GLY A 587
PRO A 588
GLY A 590
 None
 0.74A 6ag0C-3pfqA:
undetectable		 6ag0C-3pfqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		4 ASP A 319
GLY A 325
PRO A 326
GLY A 329
 None
 0.75A 6ag0C-3pvsA:
undetectable		 6ag0C-3pvsA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A  12
ASP A 140
GLY A 296
PRO A 295
GLY A 147
 None
 1.36A 6ag0C-3pygA:
undetectable		 6ag0C-3pygA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 GLY A  81
GLY A  83
PRO A  84
GLY A  86
 None
 0.75A 6ag0C-3qkaA:
undetectable		 6ag0C-3qkaA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 405
TRP A 408
GLY A 375
GLY A 293
 None
 0.73A 6ag0C-3r18A:
undetectable		 6ag0C-3r18A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		4 GLY A 115
GLY A 113
PRO A 112
GLY A 149
 None
 0.76A 6ag0C-3rstA:
2.5		 6ag0C-3rstA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A  82
ASP A  91
GLY A  16
GLY A 255
 None
 0.73A 6ag0C-3rv2A:
undetectable		 6ag0C-3rv2A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  52
ASP A 145
GLY A  64
GLY A 163
 None
 0.77A 6ag0C-3t9wA:
undetectable		 6ag0C-3t9wA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 273
ASP A 294
GLY A 230
GLY A 232
 None
 0.70A 6ag0C-3u0oA:
undetectable		 6ag0C-3u0oA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 ASP A 250
GLY A 314
PRO A 315
GLY A 317
 None
 0.55A 6ag0C-3ubdA:
undetectable		 6ag0C-3ubdA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A  20
ASP A  33
GLY A  37
GLY A 217
 None
 0.74A 6ag0C-3v4cA:
undetectable		 6ag0C-3v4cA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A  90
GLY A  33
PRO A  34
GLY A  36
 None
 0.67A 6ag0C-3vm5A:
26.6		 6ag0C-3vm5A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 GLY A 300
ASP A 242
GLY A 224
GLY A 237
 None
 0.75A 6ag0C-4avoA:
5.5		 6ag0C-4avoA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0i 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF07977
(FabA) 		4 ASP A  11
GLY A  22
PRO A  23
GLY A  18
 None
 0.70A 6ag0C-4b0iA:
undetectable		 6ag0C-4b0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASP A 207
GLY A 212
PRO A 213
GLY A 215
 None
 0.71A 6ag0C-4b90A:
3.9		 6ag0C-4b90A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASP A 207
GLY A 212
PRO A 213
GLY A 215
 None
 0.73A 6ag0C-4b92A:
4.6		 6ag0C-4b92A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY B 293
GLY A 382
PRO A 383
GLY B 271
 None
 0.75A 6ag0C-4cakB:
undetectable		 6ag0C-4cakB:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 GLY A 113
ASP A  97
GLY A 134
GLY A 110
 None
 0.73A 6ag0C-4hfkA:
undetectable		 6ag0C-4hfkA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi5 MATRIX PROTEIN

(Borna disease
virus) 		PF16520
(BDV_M) 		4 GLY A 129
GLY A 131
PRO A 132
GLY A 134
 None
 0.66A 6ag0C-4hi5A:
undetectable		 6ag0C-4hi5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j30 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF14113
(Tae4) 		4 GLY A 111
ASP A  95
GLY A 132
GLY A 108
 None
 0.67A 6ag0C-4j30A:
undetectable		 6ag0C-4j30A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0v TEK TYROSINE KINASE
VARIANT

(Homo sapiens) 		PF00041
(fn3)
PF10430
(Ig_Tie2_1) 		4 GLY A 328
GLY A 308
PRO A 309
GLY A 292
 None
 0.63A 6ag0C-4k0vA:
undetectable		 6ag0C-4k0vA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  89
GLY A 254
PRO A 255
GLY A 257
 None
 0.67A 6ag0C-4ktoA:
undetectable		 6ag0C-4ktoA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 GLY A 194
ASP A 323
GLY A 183
PRO A 182
GLY A 178
 None
 1.42A 6ag0C-4mdpA:
6.4		 6ag0C-4mdpA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  84
GLY A 249
PRO A 250
GLY A 252
 None
 0.70A 6ag0C-4o5mA:
undetectable		 6ag0C-4o5mA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLY A  81
GLY A  83
PRO A  84
GLY A  86
 None
 0.77A 6ag0C-4qfeA:
undetectable		 6ag0C-4qfeA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLY B  14
GLY B 245
PRO B 246
GLY B 362
 FAD  B 401 (-3.3A)
FAD  B 401 (-3.4A)
None
None
 0.66A 6ag0C-4rphB:
undetectable		 6ag0C-4rphB:
12.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 300
ASP A 341
TRP A 343
GLY A 429
PRO A 430
GLY A 473
 None
 0.28A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY A 119
ASP A 125
GLY A  75
PRO A  76
 None
None
None
CLF  A 605 (-3.8A)
 0.73A 6ag0C-4wn9A:
undetectable		 6ag0C-4wn9A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A  10
GLY A 241
PRO A 242
GLY A 360
 FDA  A 403 (-3.1A)
FDA  A 403 ( 3.7A)
FDA  A 403 (-4.7A)
None
 0.67A 6ag0C-4xgkA:
undetectable		 6ag0C-4xgkA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		4 GLY A 317
ASP A 182
GLY A 319
GLY A 323
 None
 0.77A 6ag0C-4yu5A:
undetectable		 6ag0C-4yu5A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 GLY A 476
ASP A 478
GLY A 388
PRO A 387
GLY A 391
 None
GOL  A 914 (-3.4A)
None
None
None
 1.29A 6ag0C-4zg7A:
undetectable		 6ag0C-4zg7A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyl FIMBRIAL SUBUNIT
CUPB6

(Pseudomonas
aeruginosa) 		PF00419
(Fimbrial) 		4 ASP A 101
GLY A  70
PRO A  71
GLY A  73
 None
 0.75A 6ag0C-5cylA:
undetectable		 6ag0C-5cylA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 GLY A 246
ASP A 407
GLY A 403
GLY A 398
 None
 0.72A 6ag0C-5du9A:
undetectable		 6ag0C-5du9A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA

(Mycobacterium
tuberculosis) 		PF01728
(FtsJ) 		4 GLY A 190
GLY A 193
PRO A 194
GLY A 196
 None
 0.59A 6ag0C-5eovA:
undetectable		 6ag0C-5eovA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A  23
GLY A 254
PRO A 255
GLY A 371
 FAD  A 501 (-3.1A)
FAD  A 501 (-3.6A)
FAD  A 501 ( 4.9A)
None
 0.70A 6ag0C-5eqdA:
undetectable		 6ag0C-5eqdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		4 GLY A 297
ASP A 274
GLY A 264
GLY A 235
 None
 0.77A 6ag0C-5eqvA:
2.2		 6ag0C-5eqvA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 GLY A 626
ASP A 597
GLY A 628
PRO A 629
GLY A 631
 None
 1.25A 6ag0C-5gw7A:
undetectable		 6ag0C-5gw7A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 4 GLY C  78
ASP C  87
GLY C  15
GLY C 247
 None
 0.74A 6ag0C-5h9uC:
undetectable		 6ag0C-5h9uC:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 GLY A 158
GLY A 161
PRO A 162
GLY A 184
 None
 0.62A 6ag0C-5jifA:
undetectable		 6ag0C-5jifA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k95 GTP CYCLOHYDROLASE
FOLE2

(Neisseria
gonorrhoeae) 		PF02649
(GCHY-1) 		4 GLY A  95
ASP A 130
GLY A 126
GLY A 134
 None
 0.75A 6ag0C-5k95A:
undetectable		 6ag0C-5k95A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		4 GLY A 285
ASP A 290
GLY A  64
GLY A  60
 None
 0.68A 6ag0C-5m95A:
undetectable		 6ag0C-5m95A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 ASP A  36
GLY A  44
PRO A  45
GLY A  32
 None
 0.72A 6ag0C-5nyyA:
undetectable		 6ag0C-5nyyA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 GLY A 181
ASP A 195
GLY A 178
GLY A 184
 None
None
None
SNN  A 176 ( 3.3A)
 0.74A 6ag0C-5obtA:
undetectable		 6ag0C-5obtA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A  77
ASP A  86
GLY A  14
GLY A 239
 None
 0.62A 6ag0C-5t8tA:
undetectable		 6ag0C-5t8tA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 ASP A 214
GLY A 219
PRO A 220
GLY A 222
 None
 0.71A 6ag0C-5uqcA:
6.1		 6ag0C-5uqcA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utg EGG-LYSIN

(Haliotis
rufescens) 		no annotation 4 GLY A  30
ASP A  97
GLY A  26
GLY A  93
 None
 0.63A 6ag0C-5utgA:
undetectable		 6ag0C-5utgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		5 GLY A  77
ASP A  79
GLY A 150
PRO A 151
GLY A 153
 None
LMT  A1034 (-2.7A)
None
None
None
 1.49A 6ag0C-5v8kA:
undetectable		 6ag0C-5v8kA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG

(Klebsiella
pneumoniae) 		no annotation 4 GLY A  14
ASP A 127
GLY A 141
PRO A 140
 None
 0.62A 6ag0C-5xktA:
undetectable		 6ag0C-5xktA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 GLY A 713
GLY A 493
PRO A 494
GLY A 497
 None
 0.72A 6ag0C-5z06A:
undetectable		 6ag0C-5z06A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 4 GLY A 182
ASP A 196
GLY A 179
GLY A 185
 None
None
GOL  A 503 (-3.7A)
SNN  A 177 ( 3.2A)
 0.76A 6ag0C-6aztA:
undetectable		 6ag0C-6aztA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 4 GLY F  41
GLY F  36
PRO F  35
GLY F  31
 None
 0.68A 6ag0C-6cfwF:
undetectable		 6ag0C-6cfwF:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 GLY B  45
ASP B  85
GLY B  56
GLY B  82
 None
 0.76A 6ag0C-6ckcB:
undetectable		 6ag0C-6ckcB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 4 GLY D 119
ASP D 187
GLY D 154
GLY D 209
 None
 0.69A 6ag0C-6f45D:
undetectable		 6ag0C-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 GLY D 206
ASP D 187
GLY D 215
PRO D 214
GLY D 209
 None
 1.11A 6ag0C-6f45D:
undetectable		 6ag0C-6f45D:
undetectable