SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_C_ACRC605_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A 158
ASP B 202
ASP B 204
HIS B 205
PRO B 206
 None
 0.63A 6ag0C-1bplA:
19.2		 6ag0C-1bplA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A 158
GLY A 179
HIS B 205
PRO B 206
 None
 0.53A 6ag0C-1bplA:
19.2		 6ag0C-1bplA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 156
GLY A 177
LYS A 180
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
None
None
CA  A 502 (-2.9A)
CA  A 502 (-3.2A)
None
None
 0.74A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvi CHLORELLA VIRUS DNA
LIGASE-ADENYLATE

(Chlorella virus) 		PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2) 		4 GLY A 291
ILE A 292
ASP A 252
ASP A 254
 None
 0.85A 6ag0C-1fviA:
undetectable		 6ag0C-1fviA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE

(Rattus rattus) 		PF00168
(C2) 		4 GLY A  90
ILE A  89
ASP A  93
HIS A  85
 None
 0.98A 6ag0C-1gmiA:
undetectable		 6ag0C-1gmiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A  43
ASP A  45
HIS A  46
PRO A  47
 None
 0.85A 6ag0C-1h0hA:
undetectable		 6ag0C-1h0hA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		4 ASP N 135
ASP N 137
HIS N 138
PRO N 139
 G  A 135 ( 3.3A)
A  A 145 ( 3.4A)
C  A 136 ( 4.1A)
C  A 251 ( 4.0A)
 0.88A 6ag0C-1kc8N:
undetectable		 6ag0C-1kc8N:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A  81
ASP A  83
HIS A  84
PRO A  85
 None
 0.84A 6ag0C-1kqfA:
undetectable		 6ag0C-1kqfA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5z C4-DICARBOXYLATE
TRANSPORT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DCTD

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 GLY A  50
ILE A  51
ASP A  74
ASP A  76
 None
 0.91A 6ag0C-1l5zA:
undetectable		 6ag0C-1l5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 TYR A 457
GLY A  87
ILE A  84
ASP A 428
 None
 1.03A 6ag0C-1m7jA:
7.0		 6ag0C-1m7jA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 211
ILE Q 212
ASP Q 189
ASP Q 191
 None
 0.85A 6ag0C-1oh2Q:
undetectable		 6ag0C-1oh2Q:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 TYR A 650
GLY A 687
ASP A 648
PRO A 643
 None
 0.80A 6ag0C-1pemA:
3.6		 6ag0C-1pemA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6F
COMPLEX SUBUNIT PETN

(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii) 		PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		4 TYR D  38
GLY N  94
ASP D  35
PRO D  30
 None
 0.81A 6ag0C-1q90D:
undetectable		 6ag0C-1q90D:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 GLY B 100
ILE B  99
ASP B 252
PRO B 254
 None
 0.88A 6ag0C-1r4nB:
undetectable		 6ag0C-1r4nB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 TYR A 182
GLY A 227
ILE A 180
LYS A 229
 None
 0.89A 6ag0C-1t06A:
undetectable		 6ag0C-1t06A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		4 TYR A 421
GLY A 464
ASP A 268
ASP A 298
 None
 0.66A 6ag0C-1uxtA:
undetectable		 6ag0C-1uxtA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TYR A 158
GLY A 179
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
 0.80A 6ag0C-1vjsA:
55.5		 6ag0C-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 GLY A  78
ASP A 224
HIS A  81
PRO A 226
 None
 1.03A 6ag0C-1vrqA:
undetectable		 6ag0C-1vrqA:
5.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 None
None
None
CA  A1487 (-2.9A)
CA  A1487 (-3.6A)
None
None
 0.61A 6ag0C-1w9xA:
64.3		 6ag0C-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 GLC  A 621 (-4.0A)
None
None
CA  A 501 (-2.9A)
CA  A 501 (-3.4A)
None
None
 0.65A 6ag0C-2d3lA:
59.6		 6ag0C-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 None
None
CA  A 778 (-2.9A)
None
None
None
 0.73A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
 None
None
None
CA  A 778 (-2.9A)
None
None
 0.55A 6ag0C-2dieA:
64.2		 6ag0C-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		4 GLY A  51
ILE A  52
ASP A 298
ASP A 294
 None
 1.02A 6ag0C-2dvuA:
4.2		 6ag0C-2dvuA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ILE A 138
ASP A 313
HIS A 314
PRO A 315
 None
 0.83A 6ag0C-2fvlA:
8.3		 6ag0C-2fvlA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 TYR A 177
GLY A 144
ILE A 145
ASP A 139
 None
 0.90A 6ag0C-2gfiA:
undetectable		 6ag0C-2gfiA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 TYR A  22
GLY A  30
ILE A  24
ASP A  42
 None
 0.81A 6ag0C-2h4cA:
undetectable		 6ag0C-2h4cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ici EXOTOXIN I

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A  89
GLY A  91
ILE A  92
ASP A 207
 None
 1.06A 6ag0C-2iciA:
undetectable		 6ag0C-2iciA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 GLY B2100
ILE B2099
ASP B2252
PRO B2254
 None
 0.92A 6ag0C-2nvuB:
undetectable		 6ag0C-2nvuB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ILE A 800
LYS A 802
ASP A 796
HIS A 797
 None
 0.96A 6ag0C-2o2qA:
undetectable		 6ag0C-2o2qA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 GLY A  89
ILE A  90
ASP A 177
PRO A 224
 None
 0.93A 6ag0C-2ojhA:
undetectable		 6ag0C-2ojhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 GLY A   3
ILE A   4
ASP A  31
HIS A 217
 None
 1.06A 6ag0C-2qjpA:
undetectable		 6ag0C-2qjpA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A 438
GLY A 445
ILE A 252
ASP A 412
 None
 0.89A 6ag0C-2w40A:
undetectable		 6ag0C-2w40A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		4 GLY A 475
ILE A 476
ASP A 395
PRO A 430
 None
 0.99A 6ag0C-2wfdA:
undetectable		 6ag0C-2wfdA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 216
GLY A 246
ILE A 247
PRO A 188
 None
 0.71A 6ag0C-2x50A:
undetectable		 6ag0C-2x50A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  12
ILE A  11
ASP A  47
HIS A  50
 None
3CD  A 600 (-4.2A)
None
None
 0.85A 6ag0C-2xf8A:
undetectable		 6ag0C-2xf8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 320
ILE A 317
LYS A 321
ASP A 374
 None
 1.00A 6ag0C-2xtsA:
undetectable		 6ag0C-2xtsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 GLY D 668
ILE D 669
ASP D 665
PRO D 360
 None
 1.06A 6ag0C-2yibD:
undetectable		 6ag0C-2yibD:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 GLY B  78
ILE B  79
ASP B  48
PRO B 225
 None
 1.01A 6ag0C-2zbkB:
undetectable		 6ag0C-2zbkB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 8

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		4 TYR B  38
GLY H  25
ASP B  35
PRO B  30
 None
None
HEM  A 303 ( 4.6A)
None
 0.82A 6ag0C-2zt9B:
undetectable		 6ag0C-2zt9B:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 474
ASP A 103
HIS A 105
PRO A 106
 None
 0.63A 6ag0C-3aw5A:
2.3		 6ag0C-3aw5A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 TYR A 154
GLY A 174
ILE A 173
ASP A 153
 None
 0.78A 6ag0C-3cvoA:
undetectable		 6ag0C-3cvoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  14
ILE A  13
ASP A  50
HIS A  53
 None
NAD  A 901 (-3.4A)
None
None
 0.88A 6ag0C-3docA:
undetectable		 6ag0C-3docA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 GLY A 133
ILE A  83
ASP A 204
HIS A 144
 None
 1.06A 6ag0C-3dxnA:
undetectable		 6ag0C-3dxnA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 GLY D 154
ILE D 150
LYS D 155
ASP D 364
 None
 0.99A 6ag0C-3edlD:
undetectable		 6ag0C-3edlD:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et6 SOLUBLE GUANYLYL
CYCLASE BETA

(Chlamydomonas
reinhardtii) 		PF00211
(Guanylate_cyc) 		4 GLY A 485
ILE A 489
ASP A 482
ASP A 527
 PO4  A   2 (-3.4A)
None
None
None
 0.94A 6ag0C-3et6A:
undetectable		 6ag0C-3et6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 TYR A 272
GLY A 188
ILE A 189
ASP A 275
 None
 1.04A 6ag0C-3gf7A:
undetectable		 6ag0C-3gf7A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  13
ILE A  12
ASP A  50
HIS A  53
 None
 0.88A 6ag0C-3gnqA:
undetectable		 6ag0C-3gnqA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 GLY A 175
ASP A 145
ASP A 147
PRO A 149
 None
None
None
BEZ  A 302 (-4.2A)
 0.79A 6ag0C-3gv1A:
undetectable		 6ag0C-3gv1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLY A  92
ASP A  85
HIS A  77
PRO A 103
 HEM  A 400 (-3.6A)
None
HEM  A 400 (-3.2A)
HEM  A 400 (-4.3A)
 1.04A 6ag0C-3hq9A:
undetectable		 6ag0C-3hq9A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 GLY A 343
ILE A 339
ASP A 360
PRO A 371
 None
None
EDO  A   8 (-2.9A)
None
 0.97A 6ag0C-3kyaA:
undetectable		 6ag0C-3kyaA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		4 TYR A  45
GLY A 115
ILE A 118
HIS A  76
 None
 0.72A 6ag0C-3llcA:
undetectable		 6ag0C-3llcA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 GLY A 144
ILE A  94
ASP A 215
HIS A 155
 None
 1.04A 6ag0C-3ma6A:
undetectable		 6ag0C-3ma6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 TYR A  70
GLY A  95
ASP A  66
ASP A 281
 None
None
None
ZN  A 401 (-2.1A)
 0.99A 6ag0C-3mfqA:
undetectable		 6ag0C-3mfqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		4 TYR A 163
GLY A 170
ASP A 141
PRO A 144
 None
 0.94A 6ag0C-3mgfA:
undetectable		 6ag0C-3mgfA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 514
ASP A 490
HIS A 491
PRO A 492
 None
 0.94A 6ag0C-3n6rA:
undetectable		 6ag0C-3n6rA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  13
ILE A  12
ASP A  48
HIS A  51
 None
NAD  A 333 (-4.0A)
None
None
 1.00A 6ag0C-3pymA:
undetectable		 6ag0C-3pymA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 TYR A 247
GLY A 230
ASP A 193
ASP A 195
 None
None
K  A 342 (-3.2A)
ZN  A 343 (-2.3A)
 1.02A 6ag0C-3q9cA:
undetectable		 6ag0C-3q9cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzu STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		4 GLY A 375
ILE A 365
ASP A 348
HIS A 352
 None
None
ZN  A   1 (-2.2A)
None
 1.05A 6ag0C-3rzuA:
undetectable		 6ag0C-3rzuA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666) 		PF04909
(Amidohydro_2) 		4 GLY A  51
ILE A  52
ASP A 298
ASP A 294
 None
None
None
ACT  A 353 (-3.3A)
 1.04A 6ag0C-3s4tA:
4.1		 6ag0C-3s4tA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  97
ILE A 100
ASP A 274
PRO A 273
 None
 0.76A 6ag0C-3sjnA:
5.6		 6ag0C-3sjnA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 GLY A 400
ASP A 391
HIS A 408
PRO A 410
 None
 1.01A 6ag0C-3tp9A:
undetectable		 6ag0C-3tp9A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A 126
ASP A 119
ASP A 121
PRO A 140
 None
 1.02A 6ag0C-4a5oA:
undetectable		 6ag0C-4a5oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 GLY A  57
ILE A  33
HIS A 229
PRO A 230
 None
 0.77A 6ag0C-4c1lA:
5.9		 6ag0C-4c1lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  13
ILE A  12
ASP A  47
HIS A  50
 None
 0.87A 6ag0C-4dibA:
undetectable		 6ag0C-4dibA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 GLY A 142
ILE A  17
LYS A 143
ASP A  42
 None
 1.00A 6ag0C-4fqzA:
undetectable		 6ag0C-4fqzA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 TYR A 180
GLY A  65
ILE A  66
PRO A  85
 None
 0.89A 6ag0C-4gu7A:
undetectable		 6ag0C-4gu7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 TYR A 459
GLY A 463
ILE A  41
HIS A  93
 FAD  A 501 (-4.4A)
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.5A)
None
 0.95A 6ag0C-4i59A:
undetectable		 6ag0C-4i59A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  20
ILE A  19
ASP A  54
HIS A  57
 None
NAD  A 401 (-4.0A)
None
None
 0.96A 6ag0C-4lsmA:
undetectable		 6ag0C-4lsmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 GLY A  67
ILE A  65
ASP A  84
ASP A  83
 None
 1.05A 6ag0C-4mx8A:
undetectable		 6ag0C-4mx8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		4 GLY A 207
ILE A 206
ASP A 200
HIS A 201
 None
 0.96A 6ag0C-4nefA:
undetectable		 6ag0C-4nefA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 TYR B 323
ASP B 276
ASP B 278
PRO B 320
 None
 0.71A 6ag0C-4o6dB:
undetectable		 6ag0C-4o6dB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oie NON-STRUCTURAL
PROTEIN NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 TYR A 323
ASP A 276
ASP A 278
PRO A 320
 None
 0.77A 6ag0C-4oieA:
undetectable		 6ag0C-4oieA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		4 GLY X 207
ILE X 206
ASP X 200
HIS X 201
 None
 0.94A 6ag0C-4oj2X:
undetectable		 6ag0C-4oj2X:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 GLY A 311
ILE A 310
ASP A 318
HIS A  53
 None
 1.02A 6ag0C-4oqsA:
undetectable		 6ag0C-4oqsA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 GLY A 206
ILE A 342
ASP A 209
PRO A 113
 None
 1.01A 6ag0C-4pprA:
undetectable		 6ag0C-4pprA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 ASP A  44
ASP A  45
HIS A  46
PRO A  47
 None
 1.00A 6ag0C-4qr8A:
undetectable		 6ag0C-4qr8A:
10.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 180
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
CA  A1483 (-3.0A)
None
None
None
 0.96A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TYR A 159
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
CA  A1483 (-3.0A)
None
None
None
 0.89A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		4 GLY A 210
ILE A 209
ASP A 290
HIS A  63
 None
None
None
ZN  A 401 (-3.3A)
 0.90A 6ag0C-4x8iA:
undetectable		 6ag0C-4x8iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7v NUCLEOTIDYL
TRANSFERASE

(Pseudomonas
putida) 		PF00483
(NTP_transferase) 		4 GLY A  67
ILE A  74
ASP A  62
HIS A  63
 None
 1.06A 6ag0C-4y7vA:
undetectable		 6ag0C-4y7vA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 GLY A  93
ILE A  94
ASP A  36
HIS A  41
 NAI  A 500 (-3.0A)
NAI  A 500 ( 4.7A)
NAI  A 500 (-2.2A)
NAI  A 500 (-3.9A)
 1.05A 6ag0C-4yaiA:
undetectable		 6ag0C-4yaiA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 115
ILE A  63
ASP A 186
HIS A 126
 None
 1.02A 6ag0C-4yc6A:
undetectable		 6ag0C-4yc6A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 381
ILE A 371
ASP A 354
HIS A 358
 None
None
ZN  A 501 ( 2.0A)
None
 0.98A 6ag0C-4zd5A:
undetectable		 6ag0C-4zd5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY O 119
ILE O 118
ASP O 153
HIS O 156
 None
 0.95A 6ag0C-5c7iO:
undetectable		 6ag0C-5c7iO:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY O  87
ILE O  86
ASP O 121
HIS O 124
 None
NAD  O 501 (-4.1A)
None
None
 1.00A 6ag0C-5c7oO:
undetectable		 6ag0C-5c7oO:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLY A 308
ILE A 307
ASP A 315
HIS A  50
 None
 0.90A 6ag0C-5cweA:
undetectable		 6ag0C-5cweA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 TYR A 556
GLY A 345
ILE A 346
ASP A 217
 None
None
None
UNX  A 604 ( 3.5A)
 0.97A 6ag0C-5e26A:
undetectable		 6ag0C-5e26A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 GLY H 151
ILE H 152
ASP H 218
ASP H 224
 None
 1.02A 6ag0C-5fcsH:
undetectable		 6ag0C-5fcsH:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLY A  67
ILE A  65
ASP A1171
ASP A1173
 None
 0.81A 6ag0C-5hy7A:
undetectable		 6ag0C-5hy7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.25A 6ag0C-5i6gA:
undetectable		 6ag0C-5i6gA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.26A 6ag0C-5i6hA:
undetectable		 6ag0C-5i6hA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.20A 6ag0C-5i6iA:
undetectable		 6ag0C-5i6iA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI)
PF01833
(TIG) 		4 GLY A 679
ILE A 659
ASP A 656
PRO A 574
 None
 0.96A 6ag0C-5lspA:
undetectable		 6ag0C-5lspA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		4 ILE A   7
ASP A 105
ASP A  28
PRO A  30
 None
 0.98A 6ag0C-5lxvA:
undetectable		 6ag0C-5lxvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 4 GLY A 122
ILE A 123
LYS A 125
ASP A 152
 None
 0.94A 6ag0C-5n2pA:
6.4		 6ag0C-5n2pA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		4 ASP A 175
ASP A 177
HIS A 178
PRO A 179
 BU3  A 302 (-2.8A)
BU3  A 302 (-4.2A)
GOL  A 304 ( 3.6A)
BU3  A 302 ( 4.1A)
 1.06A 6ag0C-5n5dA:
undetectable		 6ag0C-5n5dA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 4 GLY A 149
ILE A 102
ASP A 105
HIS A 106
 None
 1.00A 6ag0C-5ofnA:
undetectable		 6ag0C-5ofnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		4 GLY A 115
ILE A 116
ASP A 217
PRO A  83
 None
None
NA  A 402 ( 2.3A)
None
 1.03A 6ag0C-5ubuA:
undetectable		 6ag0C-5ubuA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 TYR A 443
GLY A 428
ILE A 431
ASP A 439
 None
SF4  A 603 ( 4.4A)
SF4  A 603 (-3.5A)
None
 1.00A 6ag0C-6dd6A:
undetectable		 6ag0C-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 4 ILE A 107
ASP A 116
HIS A 121
PRO A 122
 None
 0.85A 6ag0C-6de8A:
undetectable		 6ag0C-6de8A:
19.23