SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_A_ACRA608

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A   5
THR A  38
TYR A  98
TYR B 358
 None
 0.25A 6ag0A-1bplA:
19.3		 6ag0A-1bplA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A   3
THR A  36
GLN A  94
TYR A  96
TYR A 358
 None
 0.35A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		4 PHE A  11
GLY A 101
THR A  16
TYR A 186
 None
 1.20A 6ag0A-1escA:
undetectable		 6ag0A-1escA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 GLY A  88
GLN A  93
TYR A  95
TYR A 174
 None
 0.98A 6ag0A-1f0pA:
0.5		 6ag0A-1f0pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		4 GLY A 166
GLN A 158
TYR A 126
TYR A 169
 None
 1.22A 6ag0A-1f1uA:
undetectable		 6ag0A-1f1uA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLY A 166
GLN A 158
TYR A 126
TYR A 169
 None
 1.19A 6ag0A-1f1xA:
undetectable		 6ag0A-1f1xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 GLY A 128
GLN A  57
TYR A  29
TYR A 147
 None
ICP  A2001 (-3.3A)
ICP  A2001 (-4.2A)
None
 1.08A 6ag0A-1g67A:
8.5		 6ag0A-1g67A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		4 GLY A 132
THR A  96
TYR A 153
TYR A 146
 None
 1.30A 6ag0A-1hvyA:
undetectable		 6ag0A-1hvyA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 GLY A 292
THR A 183
GLN A 203
TYR A 220
 None
 1.15A 6ag0A-1inpA:
undetectable		 6ag0A-1inpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLY A 145
THR A 148
GLN A  39
TYR A 136
 None
BR  A2007 ( 4.6A)
None
None
 1.15A 6ag0A-1jhdA:
undetectable		 6ag0A-1jhdA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcv PC282 IMMUNOGLOBULIN
PC282 IMMUNOGLOBULIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  57
GLN H   1
TYR H 105
TYR L  55
 None
 1.16A 6ag0A-1kcvL:
undetectable		 6ag0A-1kcvL:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 GLY A 122
THR A  38
GLN A  99
TYR A 133
 None
 1.13A 6ag0A-1mppA:
undetectable		 6ag0A-1mppA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 PHE A 121
GLY A 122
GLN A  99
TYR A 133
 None
 1.25A 6ag0A-1mppA:
undetectable		 6ag0A-1mppA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		4 GLY A  20
GLN A 246
TYR A 250
TYR A  37
 None
 1.02A 6ag0A-1npyA:
undetectable		 6ag0A-1npyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		4 PHE A  66
GLY A  14
THR A  41
GLN A  43
 None
 1.30A 6ag0A-1npyA:
undetectable		 6ag0A-1npyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 PHE A 134
GLY A  97
THR A 100
GLN A 131
 None
SAM  A1401 (-3.3A)
None
None
 1.13A 6ag0A-1p91A:
undetectable		 6ag0A-1p91A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 GLY A  88
GLN A  93
TYR A  95
TYR A 174
 None
 1.00A 6ag0A-1sfrA:
undetectable		 6ag0A-1sfrA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A   5
THR A  38
TYR A  98
TYR A 358
 None
 0.16A 6ag0A-1ud3A:
63.5		 6ag0A-1ud3A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A   4
THR A  16
GLN A  99
TYR A   5
 None
 1.21A 6ag0A-1v7vA:
undetectable		 6ag0A-1v7vA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A   5
THR A  38
TYR A  98
TYR A 358
 None
 0.26A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A   7
THR A  40
GLN A  98
TYR A 100
TYR A 363
 None
 0.32A 6ag0A-1w9xA:
64.2		 6ag0A-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF02581
(TMP-TENI) 		4 GLY A 104
GLN A  36
TYR A  10
TYR A 123
 None
 1.14A 6ag0A-1xi3A:
9.1		 6ag0A-1xi3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 802
THR A 791
GLN A 757
TYR A 760
 None
 1.30A 6ag0A-1xkhA:
undetectable		 6ag0A-1xkhA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmo HALOHYDRIN
DEHALOGENASE

(Arthrobacter
sp. AD2) 		PF13561
(adh_short_C2) 		4 PHE A 235
GLY A 176
THR A 133
TYR A 147
 None
 1.14A 6ag0A-1zmoA:
undetectable		 6ag0A-1zmoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A  73
THR A 432
TYR A 443
TYR A  75
 None
 1.12A 6ag0A-1zr6A:
undetectable		 6ag0A-1zr6A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 GLY A 124
THR A  88
TYR A 145
TYR A 138
 None
 1.30A 6ag0A-2aazA:
undetectable		 6ag0A-2aazA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 GLY A 107
THR A 105
GLN A 114
TYR A 295
 PLP  A 413 (-3.5A)
None
None
None
 1.30A 6ag0A-2ay9A:
undetectable		 6ag0A-2ay9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 GLY A 634
THR A 630
GLN A 627
TYR A 638
 None
 1.15A 6ag0A-2bf6A:
undetectable		 6ag0A-2bf6A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A   7
THR A  40
GLN A  98
TYR A 100
TYR A 363
 GLC  A 632 (-3.6A)
GLC  A 631 (-3.8A)
GLC  A 631 (-3.4A)
None
GLC  A 632 (-3.8A)
 0.32A 6ag0A-2d3lA:
55.4		 6ag0A-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A   7
THR A  40
GLN A  98
TYR A 100
TYR A 363
 None
 0.36A 6ag0A-2dieA:
43.8		 6ag0A-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32

(Delftia
acidovorans) 		PF13609
(Porin_4) 		4 PHE X 228
GLY X 124
THR X 194
GLN X 192
 None
 0.71A 6ag0A-2fgqX:
undetectable		 6ag0A-2fgqX:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE X 512
GLY X 353
GLN X 339
TYR X 354
 None
 1.27A 6ag0A-2iv2X:
undetectable		 6ag0A-2iv2X:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  55
GLN A  48
TYR A  19
TYR A  15
 None
 1.14A 6ag0A-2nadA:
undetectable		 6ag0A-2nadA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		4 GLY A 261
THR A 256
GLN A 255
TYR A 253
 None
 1.19A 6ag0A-2vqxA:
undetectable		 6ag0A-2vqxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		4 GLY A1318
THR A1317
GLN A1315
TYR A1309
 None
 1.27A 6ag0A-2wqsA:
undetectable		 6ag0A-2wqsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		4 GLY A 132
THR A 131
GLN A 104
TYR A  71
 None
 1.28A 6ag0A-3afoA:
undetectable		 6ag0A-3afoA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 PHE A  92
GLY A  91
THR A 115
GLN A 114
 None
 0.87A 6ag0A-3dcpA:
4.9		 6ag0A-3dcpA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 GLY X 376
THR X 362
GLN X 361
TYR X 359
 None
None
C8E  X 461 ( 4.4A)
C8E  X 456 ( 4.9A)
 1.28A 6ag0A-3dwoX:
undetectable		 6ag0A-3dwoX:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ead NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 PHE A 491
GLY A 493
THR A 480
GLN A 481
 None
 1.29A 6ag0A-3eadA:
undetectable		 6ag0A-3eadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLY A 166
GLN A 158
TYR A 126
TYR A 169
 None
 1.22A 6ag0A-3eckA:
undetectable		 6ag0A-3eckA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezz DUAL SPECIFICITY
PROTEIN PHOSPHATASE
4

(Homo sapiens) 		PF00782
(DSPc) 		4 GLY A 274
THR A 223
GLN A 241
TYR A 265
 None
 1.03A 6ag0A-3ezzA:
undetectable		 6ag0A-3ezzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PHE A 164
GLY A 165
GLN A 325
TYR A 171
 None
 1.08A 6ag0A-3fn9A:
10.9		 6ag0A-3fn9A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 461
GLY A 494
GLN A 506
TYR A 496
 None
 1.15A 6ag0A-3holA:
undetectable		 6ag0A-3holA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 PHE A  11
GLY A  94
THR A  62
TYR A 101
 None
 1.22A 6ag0A-3htzA:
undetectable		 6ag0A-3htzA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A 100
THR A 235
GLN A 236
TYR A 238
 None
None
35C  A   1 ( 4.0A)
None
 1.16A 6ag0A-3i4yA:
undetectable		 6ag0A-3i4yA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 PHE A 152
GLY A 148
THR A 114
GLN A 111
 None
 1.17A 6ag0A-3icvA:
undetectable		 6ag0A-3icvA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLY A 330
THR A 294
TYR A 351
TYR A 344
 None
 1.30A 6ag0A-3kjrA:
undetectable		 6ag0A-3kjrA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 468
GLN A 438
TYR A 450
TYR A 472
 None
 1.24A 6ag0A-3o5aA:
undetectable		 6ag0A-3o5aA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF02581
(TMP-TENI) 		4 GLY A 118
GLN A  40
TYR A  12
TYR A 137
 None
 1.23A 6ag0A-3o63A:
8.8		 6ag0A-3o63A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q08 CHLORITE DISMUTASE

(Dechloromonas
aromatica) 		PF06778
(Chlor_dismutase) 		4 GLY A  12
THR A  16
GLN A  17
TYR A  82
 None
 1.24A 6ag0A-3q08A:
undetectable		 6ag0A-3q08A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 PHE A  15
GLY A  88
THR A  91
GLN A  95
 None
 1.10A 6ag0A-3tqiA:
undetectable		 6ag0A-3tqiA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		no annotation 4 PHE A 536
THR A 500
GLN A 502
TYR A 545
 None
 1.02A 6ag0A-3vu0A:
undetectable		 6ag0A-3vu0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 GLY A 233
THR A 237
GLN A 239
TYR A 500
 ADP  A 600 (-2.4A)
ADP  A 600 ( 4.8A)
None
None
 1.28A 6ag0A-3w3aA:
undetectable		 6ag0A-3w3aA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A 208
THR A 212
GLN A 213
TYR A 189
 ATP  A 400 (-3.5A)
None
None
None
 1.30A 6ag0A-3wt0A:
undetectable		 6ag0A-3wt0A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA

(Homo sapiens) 		PF01504
(PIP5K) 		4 PHE A  95
GLY A  49
THR A  53
TYR A 117
 None
 0.92A 6ag0A-3x05A:
undetectable		 6ag0A-3x05A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		4 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.20A 6ag0A-4aejA:
undetectable		 6ag0A-4aejA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		4 GLY A  49
THR A  47
GLN A 128
TYR A  70
 None
 1.15A 6ag0A-4amgA:
undetectable		 6ag0A-4amgA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 PHE A 674
GLY A 692
THR A 676
TYR A 694
 None
 1.29A 6ag0A-4ci8A:
undetectable		 6ag0A-4ci8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A

(Branchiostoma
floridae) 		PF01353
(GFP) 		4 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  60 ( 4.7A)
None
CR2  A  60 ( 4.7A)
None
 1.15A 6ag0A-4dkmA:
undetectable		 6ag0A-4dkmA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 PHE A 201
GLY A 168
GLN A 126
TYR A 137
 None
GOL  A 306 (-4.7A)
GOL  A 306 (-4.0A)
GOL  A 306 (-4.8A)
 1.27A 6ag0A-4e4yA:
undetectable		 6ag0A-4e4yA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 178
GLY A 315
GLN A 157
TYR A 123
 None
 0.85A 6ag0A-4eyeA:
undetectable		 6ag0A-4eyeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 178
GLY A 315
THR A 153
GLN A 157
 None
 0.83A 6ag0A-4eyeA:
undetectable		 6ag0A-4eyeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A1052
GLY A1048
THR A 738
TYR A1041
 None
 1.20A 6ag0A-4f4cA:
undetectable		 6ag0A-4f4cA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H 175
GLY H 160
GLN L 202
TYR L 149
 None
 0.98A 6ag0A-4hjjH:
undetectable		 6ag0A-4hjjH:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 PHE A 116
GLY A 114
GLN A  63
TYR A 107
 CR2  A  58 ( 4.4A)
None
CR2  A  58 ( 4.9A)
None
 1.25A 6ag0A-4hvfA:
undetectable		 6ag0A-4hvfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 GLY A 592
THR A 606
TYR A 460
TYR A 454
 None
HEC  A 807 (-3.4A)
HEC  A 807 (-3.9A)
None
 1.29A 6ag0A-4lmhA:
undetectable		 6ag0A-4lmhA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 GLY A  68
THR A  72
GLN A  73
TYR A 316
 None
 1.06A 6ag0A-4n03A:
undetectable		 6ag0A-4n03A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 468
GLY A 501
GLN A 513
TYR A 503
 None
None
GOL  A 603 (-4.3A)
None
 1.22A 6ag0A-4o4xA:
undetectable		 6ag0A-4o4xA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 THR A 272
GLN A 308
TYR A 275
TYR A 257
 None
 1.27A 6ag0A-4pq0A:
undetectable		 6ag0A-4pq0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 GLY A2629
THR A2659
GLN A2661
TYR A2630
 None
 1.28A 6ag0A-4rlvA:
undetectable		 6ag0A-4rlvA:
7.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A   6
THR A  39
GLN A  97
TYR A  99
TYR A 359
 None
 0.21A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL

(Candida
tropicalis) 		no annotation 4 PHE A 104
GLY A 102
THR A 131
TYR A 370
 None
 1.26A 6ag0A-4w99A:
undetectable		 6ag0A-4w99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywc TRANSCRIPTION FACTOR
MYC3

(Arabidopsis
thaliana) 		PF14215
(bHLH-MYC_N) 		4 PHE A  72
GLY A 211
THR A 208
GLN A 209
 None
 1.17A 6ag0A-4ywcA:
undetectable		 6ag0A-4ywcA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		4 GLY A 246
THR A 230
TYR A 135
TYR A 247
 None
 1.27A 6ag0A-4zpiA:
undetectable		 6ag0A-4zpiA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 PHE A 118
GLY A 114
THR A  80
GLN A  77
 None
 1.16A 6ag0A-4zv7A:
undetectable		 6ag0A-4zv7A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmo HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Neisseria
meningitidis) 		PF01648
(ACPS) 		4 PHE A  89
GLY A  77
THR A  32
TYR A  48
 None
 1.16A 6ag0A-5cmoA:
undetectable		 6ag0A-5cmoA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 436
GLY A 432
GLN A 180
TYR A 178
 None
 0.82A 6ag0A-5djwA:
10.4		 6ag0A-5djwA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		4 PHE A 220
GLY A 218
THR A  47
TYR A 156
 None
 1.29A 6ag0A-5dm4A:
undetectable		 6ag0A-5dm4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		4 GLY A 313
GLN A 290
TYR A 213
TYR A 234
 None
 1.13A 6ag0A-5h0iA:
undetectable		 6ag0A-5h0iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		4 GLY A 156
THR A 120
TYR A 177
TYR A 170
 None
 1.27A 6ag0A-5h3aA:
undetectable		 6ag0A-5h3aA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		4 GLY B  76
THR B  67
GLN B  65
TYR B 108
 None
 0.79A 6ag0A-5ivaB:
undetectable		 6ag0A-5ivaB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh6 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETDB1

(Homo sapiens) 		no annotation 4 GLY A 227
THR A 223
GLN A 195
TYR A 230
 None
 1.19A 6ag0A-5kh6A:
undetectable		 6ag0A-5kh6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 383
THR A 390
TYR A 399
TYR A 382
 None
 1.19A 6ag0A-5l6fA:
undetectable		 6ag0A-5l6fA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 122
THR A 127
GLN A 119
TYR A 137
 None
 1.29A 6ag0A-5lm8A:
2.0		 6ag0A-5lm8A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  59 ( 4.5A)
None
None
None
 1.25A 6ag0A-5ltqA:
undetectable		 6ag0A-5ltqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 GLY A 187
THR A 191
GLN A 192
TYR A  53
 NAP  A 602 (-3.3A)
None
NAP  A 602 (-3.4A)
None
 0.86A 6ag0A-5m10A:
undetectable		 6ag0A-5m10A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 PHE A 441
THR A 104
GLN A 155
TYR A 197
 None
 1.00A 6ag0A-5m3xA:
undetectable		 6ag0A-5m3xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi 50S RIBOSOMAL
PROTEIN L31
PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea;
Spinacia
oleracea) 		PF01197
(Ribosomal_L31)
PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 GLY F 115
THR 0  64
GLN 0  65
TYR 0  68
 None
 1.21A 6ag0A-5mmiF:
undetectable		 6ag0A-5mmiF:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 GLY A 509
THR A 506
TYR A 603
TYR A 525
 None
 1.21A 6ag0A-5mqsA:
undetectable		 6ag0A-5mqsA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mun LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF08126
(Propeptide_C25) 		4 PHE A  64
GLY A  61
THR A  59
GLN A 124
 None
 1.14A 6ag0A-5munA:
undetectable		 6ag0A-5munA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 PHE A 253
GLY A 194
THR A 151
TYR A 165
 None
 1.13A 6ag0A-5o30A:
undetectable		 6ag0A-5o30A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY 1 142
THR 1 385
GLN 1 386
TYR 1 145
 CLA  1 829 (-4.6A)
None
None
None
 1.08A 6ag0A-5oy01:
undetectable		 6ag0A-5oy01:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 GLY B 120
GLN B 127
TYR B 319
TYR B 308
 None
 1.08A 6ag0A-5t5iB:
undetectable		 6ag0A-5t5iB:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN
SECURIN

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50)
PF04856
(Securin) 		4 GLY A1506
GLN B 266
TYR A1511
TYR A1502
 None
 1.28A 6ag0A-5u1sA:
undetectable		 6ag0A-5u1sA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 GLY A 208
THR A 180
GLN A 181
TYR A 273
 None
None
ACY  A 302 ( 3.9A)
ACY  A 302 ( 4.0A)
 1.13A 6ag0A-5umeA:
6.7		 6ag0A-5umeA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 PHE A 280
GLY A 308
TYR A 390
TYR A 306
 None
 1.29A 6ag0A-5yfbA:
undetectable		 6ag0A-5yfbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs9 STAGE III
SPORULATION PROTEIN
AB

(Bacillus
subtilis) 		no annotation 4 PHE A 114
GLY A 115
THR A 117
GLN A 126
 None
 1.20A 6ag0A-6bs9A:
undetectable		 6ag0A-6bs9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 4 PHE B 411
GLY B 413
THR B 384
TYR B 422
 None
PLP  B 501 (-2.9A)
PLP  B 501 ( 4.6A)
None
 1.03A 6ag0A-6eqnB:
undetectable		 6ag0A-6eqnB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 217
THR A 188
GLN A 189
TYR A 286
 None
None
FAD  A 701 (-4.9A)
None
 1.14A 6ag0A-6fnuA:
9.8		 6ag0A-6fnuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 4 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.23A 6ag0A-6fzwA:
undetectable		 6ag0A-6fzwA:
21.69