SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_A_ACRA606_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 GLY A 109
GLY A  43
PRO A  44
GLY A  45
GLY A  46
 None
 0.87A 6ag0A-1azwA:
undetectable		 6ag0A-1azwA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY B 299
GLY B 300
GLY B 431
PRO B 432
GLY B 433
GLY B 474
 None
 1.30A 6ag0A-1bplB:
36.1		 6ag0A-1bplB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY B 299
GLY B 300
TRP B 342
GLY B 431
PRO B 432
GLY B 474
GLY B 475
 None
 0.50A 6ag0A-1bplB:
36.1		 6ag0A-1bplB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY B 301
GLY B 300
GLY B 431
PRO B 432
GLY B 474
GLY B 475
 None
 1.38A 6ag0A-1bplB:
36.1		 6ag0A-1bplB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  42
GLY A  15
PRO A  16
GLY A  17
GLY A  18
 None
FAD  A 480 (-3.9A)
FAD  A 480 (-3.8A)
FAD  A 480 (-3.2A)
None
 0.97A 6ag0A-1dxlA:
undetectable		 6ag0A-1dxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 GLY A 193
GLY A 194
GLY A  52
GLY A  11
GLY A  10
 None
None
None
ADP  A 315 (-3.5A)
ADP  A 315 (-3.6A)
 1.02A 6ag0A-1e19A:
undetectable		 6ag0A-1e19A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY A 299
GLY A 300
TRP A 342
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 None
CA  A 504 (-4.1A)
None
None
None
None
None
 0.31A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 301
GLY A 300
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 CA  A 504 ( 4.3A)
CA  A 504 (-4.1A)
None
None
None
None
 1.42A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		5 GLY A 185
GLY A 189
PRO A 190
GLY A  30
GLY A  29
 None
 1.06A 6ag0A-1fonA:
undetectable		 6ag0A-1fonA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 GLY P 331
GLY P 330
GLY P 348
GLY P 366
GLY P 367
 CA  P 503 (-4.4A)
CA  P 503 ( 4.8A)
CA  P 503 (-4.3A)
CA  P 501 (-4.4A)
CA  P 502 (-4.2A)
 1.01A 6ag0A-1h71P:
undetectable		 6ag0A-1h71P:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk6 NEUROPHYSIN 2

(Bos taurus) 		PF00184
(Hormone_5) 		5 GLY A  33
GLY A  29
GLY A  19
GLY A  17
GLY A  14
 None
 1.07A 6ag0A-1jk6A:
undetectable		 6ag0A-1jk6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 GLY A 918
GLY A 917
GLY A 964
GLY A 989
GLY A 990
 None
 0.90A 6ag0A-1k32A:
undetectable		 6ag0A-1k32A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		5 GLY A 122
GLY A  91
PRO A  92
GLY A  93
GLY A  94
 None
 0.83A 6ag0A-1konA:
undetectable		 6ag0A-1konA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 GLY A 119
GLY A  13
GLY A  15
GLY A  38
GLY A  39
 None
 1.04A 6ag0A-1lnzA:
undetectable		 6ag0A-1lnzA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 GLY A 119
GLY A 120
GLY A 122
GLY A  38
GLY A  16
 None
 1.04A 6ag0A-1lnzA:
undetectable		 6ag0A-1lnzA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		6 GLY D 842
GLY D 893
GLY D 897
PRO D 898
GLY D 744
GLY D 743
 None
 1.09A 6ag0A-1pytD:
undetectable		 6ag0A-1pytD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 739
GLY A 743
PRO A 744
GLY A 590
GLY A 589
 None
 1.06A 6ag0A-1qrzA:
undetectable		 6ag0A-1qrzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY A 299
GLY A 300
TRP A 342
GLY A 428
PRO A 429
GLY A 471
GLY A 472
 None
NA  A1002 (-4.2A)
None
None
None
None
None
 0.71A 6ag0A-1ud3A:
63.5		 6ag0A-1ud3A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		5 GLY A  81
GLY A  80
GLY A  39
GLY A 122
GLY A 121
 None
 0.87A 6ag0A-1udxA:
undetectable		 6ag0A-1udxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		5 GLY A 142
GLY A  16
GLY A  68
GLY A  42
GLY A  13
 None
 1.08A 6ag0A-1udxA:
undetectable		 6ag0A-1udxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		5 GLY A 213
GLY A 214
GLY A 210
GLY A 102
GLY A 103
 None
 0.86A 6ag0A-1v6mA:
undetectable		 6ag0A-1v6mA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 299
GLY A 300
GLY A 431
PRO A 432
GLY A 433
GLY A 474
 None
 1.27A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY A 299
GLY A 300
TRP A 342
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 None
 0.43A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 301
GLY A 300
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 None
 1.35A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 304
GLY A 305
GLY A 433
PRO A 434
GLY A 476
 None
CA  A1488 (-4.2A)
None
None
None
 0.91A 6ag0A-1w9xA:
64.2		 6ag0A-1w9xA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY A 304
GLY A 305
TRP A 347
GLY A 433
PRO A 434
GLY A 476
GLY A 477
 None
CA  A1488 (-4.2A)
None
None
None
None
None
 0.37A 6ag0A-1w9xA:
64.2		 6ag0A-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 GLY A 112
GLY A  46
PRO A  47
GLY A  48
GLY A  49
 STX  A 401 (-4.8A)
STX  A 401 (-3.6A)
None
None
None
 0.86A 6ag0A-1x2bA:
undetectable		 6ag0A-1x2bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 304
GLY A 305
TRP A 347
GLY A 433
GLY A 476
GLY A 477
 None
CA  A 503 (-4.1A)
None
None
None
None
 0.39A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 GLY A 304
GLY A 305
GLY A 433
PRO A 434
GLY A 435
GLY A 476
 None
CA  A 780 (-4.2A)
None
None
None
None
 1.40A 6ag0A-2dieA:
64.2		 6ag0A-2dieA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 GLY A 304
GLY A 305
TRP A 347
GLY A 433
PRO A 434
GLY A 476
GLY A 477
 None
CA  A 780 (-4.2A)
None
None
None
None
None
 0.40A 6ag0A-2dieA:
64.2		 6ag0A-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 GLY A 193
GLY A 194
GLY A  54
GLY A  13
GLY A  12
 None
 1.05A 6ag0A-2e9yA:
undetectable		 6ag0A-2e9yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 242
GLY A 243
GLY A 196
GLY A 173
GLY A 352
 None
 1.09A 6ag0A-2gp6A:
undetectable		 6ag0A-2gp6A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnw OXYTOCIN-NEUROPHYSIN
1

(Bos taurus) 		PF00184
(Hormone_5) 		5 GLY A  33
GLY A  29
GLY A  19
GLY A  17
GLY A  14
 None
 1.03A 6ag0A-2hnwA:
undetectable		 6ag0A-2hnwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 GLY A 120
GLY A 119
GLY A 143
PRO A 144
GLY A 147
 None
 0.96A 6ag0A-2iexA:
undetectable		 6ag0A-2iexA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima;
Thermotoga
maritima) 		PF01680
(SOR_SNZ)
PF01174
(SNO) 		5 GLY A  21
GLY A  20
GLY D  10
GLY D  45
GLY D  46
 None
 1.04A 6ag0A-2issA:
6.9		 6ag0A-2issA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 101
GLY A 100
GLY A 124
GLY A 178
GLY A 180
 None
 1.07A 6ag0A-2iyoA:
undetectable		 6ag0A-2iyoA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		5 GLY A 211
GLY A 210
GLY A 143
GLY A 145
GLY A 144
 G4P  A1307 (-3.8A)
G4P  A1307 ( 3.7A)
G4P  A1307 ( 3.7A)
None
G4P  A1307 ( 4.7A)
 1.08A 6ag0A-2j4rA:
undetectable		 6ag0A-2j4rA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 GLY A 240
GLY A 241
GLY A 219
GLY A 145
GLY A 146
 None
 0.85A 6ag0A-2jbwA:
undetectable		 6ag0A-2jbwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		6 GLY B 142
GLY C 193
GLY C 197
PRO C 198
GLY B  44
GLY B  43
 None
 1.20A 6ag0A-2jetB:
undetectable		 6ag0A-2jetB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbh NEUROPHYSIN 1

(Bos taurus) 		PF00184
(Hormone_5) 		5 GLY A  33
GLY A  29
GLY A  19
GLY A  17
GLY A  14
 None
 0.92A 6ag0A-2lbhA:
undetectable		 6ag0A-2lbhA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		6 GLY A 260
GLY A 313
GLY A 317
PRO A 318
GLY A 142
GLY A 141
 None
 1.20A 6ag0A-2olgA:
undetectable		 6ag0A-2olgA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 279
GLY A 280
GLY A 472
GLY A 420
GLY A 419
 None
 0.99A 6ag0A-2p2mA:
undetectable		 6ag0A-2p2mA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 101
GLY A 100
GLY A 124
GLY A 176
GLY A 178
 None
 1.04A 6ag0A-2p4qA:
undetectable		 6ag0A-2p4qA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 GLY B 162
GLY B 161
GLY B 505
GLY B 508
GLY B 507
 None
 1.02A 6ag0A-2pffB:
undetectable		 6ag0A-2pffB:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  30
GLY A  31
GLY A  33
GLY A  64
GLY A  63
 None
 1.05A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  49
GLY A  48
GLY A  46
GLY A  15
GLY A  37
 None
 0.95A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  52
GLY A  51
GLY A  49
GLY A  18
GLY A  34
 None
 0.96A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  64
GLY A  63
GLY A  61
GLY A  30
GLY A  31
 None
 1.09A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  64
GLY A  63
GLY A  61
GLY A  30
GLY A  52
 None
 1.01A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  67
GLY A  66
GLY A  64
GLY A  33
GLY A  49
 None
 0.94A 6ag0A-2pneA:
undetectable		 6ag0A-2pneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 GLY A 493
GLY A 491
GLY A 508
GLY A 527
GLY A 528
 CA  A 614 (-4.3A)
CA  A 614 (-4.3A)
CA  A 614 (-4.3A)
CA  A 616 (-4.4A)
CA  A 616 (-4.3A)
 1.06A 6ag0A-2quaA:
undetectable		 6ag0A-2quaA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 GLY A 142
GLY A 141
GLY A 137
GLY A 134
GLY A 135
 None
 0.75A 6ag0A-2r9hA:
undetectable		 6ag0A-2r9hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A 115
GLY A 114
GLY A  41
GLY A  43
GLY A  42
 None
None
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
 1.04A 6ag0A-2ri6A:
undetectable		 6ag0A-2ri6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		6 GLY A 221
GLY A 222
GLY A 227
PRO A 228
GLY A 232
GLY A 231
 None
 1.19A 6ag0A-2rinA:
undetectable		 6ag0A-2rinA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzf NAPHTHOATE SYNTHASE

(Staphylococcus
aureus) 		PF00378
(ECH_1) 		5 GLY A 121
GLY A 120
GLY A 144
PRO A 145
GLY A 148
 CAA  A1274 (-3.8A)
CAA  A1274 ( 4.3A)
None
None
None
 0.93A 6ag0A-2uzfA:
undetectable		 6ag0A-2uzfA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT GAMMA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF04358
(DsrC) 		5 GLY A  78
GLY A  77
GLY C  87
GLY C  91
GLY C  89
 None
 0.95A 6ag0A-2v4jA:
undetectable		 6ag0A-2v4jA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 101
GLY A 100
GLY A 124
GLY A 176
GLY A 178
 None
 1.04A 6ag0A-2w8zA:
undetectable		 6ag0A-2w8zA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A 207
GLY A 206
GLY A 226
GLY A  70
GLY A  71
 None
 0.79A 6ag0A-2wa2A:
undetectable		 6ag0A-2wa2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY

(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF04358
(DsrC) 		5 GLY A  78
GLY A  77
GLY C  87
GLY C  91
GLY C  89
 None
 1.01A 6ag0A-2xsjA:
undetectable		 6ag0A-2xsjA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		6 GLY A 266
GLY A 316
GLY A 320
PRO A 321
GLY A 150
GLY A 149
 None
 1.32A 6ag0A-2xxlA:
undetectable		 6ag0A-2xxlA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 104
GLY A 103
PRO A 101
GLY A  99
GLY A  96
 None
 1.08A 6ag0A-2yfqA:
undetectable		 6ag0A-2yfqA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 GLY A 103
GLY A  34
PRO A  35
GLY A  36
GLY A  37
 None
GOL  A 500 (-3.9A)
None
None
None
 0.98A 6ag0A-2yysA:
undetectable		 6ag0A-2yysA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		5 GLY A 270
GLY A 268
GLY A 264
GLY A 260
GLY A  17
 None
 0.95A 6ag0A-2yzwA:
undetectable		 6ag0A-2yzwA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 105
GLY A 104
GLY A 102
GLY A 273
GLY A 274
 None
 0.84A 6ag0A-2z1qA:
undetectable		 6ag0A-2z1qA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 101
GLY A 100
GLY A 124
GLY A 177
GLY A 179
 None
 1.05A 6ag0A-2zygA:
undetectable		 6ag0A-2zygA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CP43
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		5 GLY C  96
GLY C 100
PRO C 101
GLY C 102
GLY C 103
 None
 0.96A 6ag0A-3a0hC:
undetectable		 6ag0A-3a0hC:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 GLY A 189
GLY A 144
GLY A 163
GLY A 104
GLY A 161
 None
 0.89A 6ag0A-3a21A:
11.9		 6ag0A-3a21A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agf GLUTAMINASE 1

(Bacillus
subtilis) 		PF04960
(Glutaminase) 		5 GLY A  50
GLY A 299
PRO A 300
GLY A 273
GLY A 274
 None
 0.92A 6ag0A-3agfA:
undetectable		 6ag0A-3agfA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  18
GLY A  48
GLY A  63
GLY A  61
GLY A  51
 None
 1.00A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  30
GLY A  31
GLY A  33
GLY A  64
GLY A  63
 None
 1.04A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  49
GLY A  48
GLY A  46
GLY A  15
GLY A  37
 None
None
None
SYS  A  11 ( 4.3A)
SYS  A  11 ( 4.2A)
 0.95A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  52
GLY A  51
GLY A  49
GLY A  18
GLY A  34
 None
 0.93A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  64
GLY A  63
GLY A  61
GLY A  30
GLY A  52
 None
 1.02A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 GLY A  67
GLY A  66
GLY A  64
GLY A  33
GLY A  49
 None
 0.94A 6ag0A-3bogA:
undetectable		 6ag0A-3bogA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 GLY A 180
GLY A 179
GLY A 149
GLY A 147
GLY A 146
 None
None
None
None
HIU  A 502 (-2.7A)
 0.84A 6ag0A-3bptA:
undetectable		 6ag0A-3bptA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A  82
GLY A  83
GLY A 221
PRO A 220
GLY A 218
 None
 1.01A 6ag0A-3gbrA:
undetectable		 6ag0A-3gbrA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 GLY P 346
GLY P 345
GLY P 363
GLY P 381
GLY P 382
 CA  P 482 (-4.4A)
CA  P 482 ( 4.7A)
CA  P 482 (-4.4A)
CA  P 485 (-4.5A)
CA  P 484 (-4.0A)
 0.99A 6ag0A-3hbuP:
undetectable		 6ag0A-3hbuP:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 GLY A 213
GLY A 212
GLY A 147
GLY A 149
GLY A 170
 None
 1.04A 6ag0A-3hi0A:
undetectable		 6ag0A-3hi0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 GLY A  53
GLY A  52
PRO A  50
GLY A 125
GLY A 130
 None
 1.08A 6ag0A-3hxkA:
undetectable		 6ag0A-3hxkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i86 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00877
(NLPC_P60) 		5 GLY A 233
GLY A 198
PRO A 199
GLY A 200
GLY A 201
 None
 0.98A 6ag0A-3i86A:
undetectable		 6ag0A-3i86A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		5 GLY 1  66
GLY 1  67
GLY 1 324
GLY 1 327
GLY 1 326
 FMN  1 440 (-3.6A)
None
None
None
None
 0.92A 6ag0A-3i9v1:
undetectable		 6ag0A-3i9v1:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		5 GLY A 147
GLY A 146
GLY A 182
GLY A 185
GLY A 184
 None
 0.85A 6ag0A-3ioqA:
undetectable		 6ag0A-3ioqA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A 168
GLY A 167
GLY A 137
GLY A 135
GLY A 134
 None
 0.88A 6ag0A-3ju1A:
undetectable		 6ag0A-3ju1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzv UNCHARACTERIZED
PROTEIN RRU_A2000

(Rhodospirillum
rubrum) 		PF07883
(Cupin_2) 		5 GLY A 118
GLY A  59
PRO A  60
GLY A  61
GLY A  62
 None
 0.85A 6ag0A-3jzvA:
undetectable		 6ag0A-3jzvA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A  57
GLY A  62
GLY A 295
GLY A 293
GLY A 292
 None
 0.91A 6ag0A-3mcxA:
undetectable		 6ag0A-3mcxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmz PUTATIVE HAD FAMILY
HYDROLASE

(Streptomyces
avermitilis) 		PF08282
(Hydrolase_3) 		5 GLY A  45
GLY A  43
GLY A 149
GLY A 146
GLY A 147
 CL  A 503 ( 3.8A)
None
None
None
None
 0.85A 6ag0A-3mmzA:
undetectable		 6ag0A-3mmzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 GLY A 269
GLY A 270
GLY A 240
GLY A 203
GLY A 202
 None
 1.09A 6ag0A-3n6zA:
undetectable		 6ag0A-3n6zA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		5 GLY A 228
GLY A 232
PRO A 233
GLY A 237
GLY A 236
 None
 0.84A 6ag0A-3o8jA:
undetectable		 6ag0A-3o8jA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 GLY A  38
GLY A  37
PRO A 113
GLY A 117
GLY A 118
 HEA  A   1 (-3.6A)
None
None
None
None
 0.99A 6ag0A-3omnA:
undetectable		 6ag0A-3omnA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT GAMA

(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		PF01077
(NIR_SIR)
PF04358
(DsrC) 		5 GLY A  78
GLY A  77
GLY C  87
GLY C  91
GLY C  89
 None
 0.97A 6ag0A-3or2A:
undetectable		 6ag0A-3or2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 GLY A 230
GLY A 195
PRO A 196
GLY A 197
GLY A 198
 None
 0.98A 6ag0A-3pbiA:
undetectable		 6ag0A-3pbiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr7 USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 135
GLY A 136
GLY A 152
GLY A 167
GLY A 166
 None
 0.84A 6ag0A-3pr7A:
undetectable		 6ag0A-3pr7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr7 USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 151
GLY A 150
GLY A 134
GLY A 119
GLY A 120
 None
 1.08A 6ag0A-3pr7A:
undetectable		 6ag0A-3pr7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 GLY A 384
GLY A 383
GLY A 246
GLY A 248
GLY A 274
 None
None
PO4  A   2 (-3.7A)
None
None
 0.80A 6ag0A-3qmlA:
undetectable		 6ag0A-3qmlA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		5 GLY A 251
GLY A 252
GLY A 136
GLY A 246
GLY A 158
 None
None
None
None
211  A 280 (-3.5A)
 0.98A 6ag0A-3rq0A:
undetectable		 6ag0A-3rq0A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tek THERMODBP-SINGLE
STRANDED DNA BINDING
PROTEIN

(Thermoproteus
tenax) 		no annotation 5 GLY A  38
GLY A  45
PRO A  46
GLY A  47
GLY A  48
 None
 1.05A 6ag0A-3tekA:
undetectable		 6ag0A-3tekA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A  20
GLY A  18
GLY A  37
GLY A 218
GLY A 217
 None
 0.84A 6ag0A-3v4cA:
undetectable		 6ag0A-3v4cA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 GLY A 334
GLY A 333
GLY A 351
GLY A 369
GLY A 370
 CA  A 503 (-4.4A)
CA  A 503 ( 4.8A)
CA  A 503 (-4.3A)
CA  A 505 (-4.4A)
CA  A 504 (-4.1A)
 1.03A 6ag0A-3vi1A:
undetectable		 6ag0A-3vi1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLY A 107
GLY A 106
GLY A 102
GLY A  99
GLY A 100
 None
None
None
SO4  A 704 (-3.2A)
SO4  A 704 (-4.1A)
 0.79A 6ag0A-3vueA:
undetectable		 6ag0A-3vueA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		5 GLY A 390
GLY A 388
GLY A 305
GLY A  86
GLY A 309
 None
 0.87A 6ag0A-3wbnA:
undetectable		 6ag0A-3wbnA:
10.28