SIMILAR PATTERNS OF AMINO ACIDS FOR 6AG0_A_ACRA605_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TYR A 158
GLY A 179
ASP B 202
ASP B 204
HIS B 205
PRO B 206
 None
 0.86A 6ag0A-1bplA:
19.3		 6ag0A-1bplA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 GLY A 174
ASP A 166
ASP A 168
HIS A 191
 None
None
ZN  A 501 ( 2.3A)
None
 0.79A 6ag0A-1c3rA:
undetectable		 6ag0A-1c3rA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 156
GLY A 177
LYS A 180
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
None
None
CA  A 502 (-2.9A)
CA  A 502 (-3.2A)
None
None
 0.71A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvi CHLORELLA VIRUS DNA
LIGASE-ADENYLATE

(Chlorella virus) 		PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2) 		4 GLY A 291
ILE A 292
ASP A 252
ASP A 254
 None
 0.90A 6ag0A-1fviA:
undetectable		 6ag0A-1fviA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A  43
ASP A  45
HIS A  46
PRO A  47
 None
 0.81A 6ag0A-1h0hA:
undetectable		 6ag0A-1h0hA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		4 ASP N 135
ASP N 137
HIS N 138
PRO N 139
 G  A 135 ( 3.3A)
A  A 145 ( 3.4A)
C  A 136 ( 4.1A)
C  A 251 ( 4.0A)
 0.84A 6ag0A-1kc8N:
undetectable		 6ag0A-1kc8N:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A  81
ASP A  83
HIS A  84
PRO A  85
 None
 0.80A 6ag0A-1kqfA:
undetectable		 6ag0A-1kqfA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5z C4-DICARBOXYLATE
TRANSPORT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DCTD

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 GLY A  50
ILE A  51
ASP A  74
ASP A  76
 None
 0.87A 6ag0A-1l5zA:
undetectable		 6ag0A-1l5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY O  13
ILE O  12
ASP O  50
HIS O  53
 None
 0.94A 6ag0A-1obfO:
undetectable		 6ag0A-1obfO:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 211
ILE Q 212
ASP Q 189
ASP Q 191
 None
 0.90A 6ag0A-1oh2Q:
undetectable		 6ag0A-1oh2Q:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 TYR A 650
GLY A 687
ASP A 648
PRO A 643
 None
 0.83A 6ag0A-1pemA:
4.0		 6ag0A-1pemA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6F
COMPLEX SUBUNIT PETN

(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii) 		PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		4 TYR D  38
GLY N  94
ASP D  35
PRO D  30
 None
 0.76A 6ag0A-1q90D:
undetectable		 6ag0A-1q90D:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 GLY B 100
ILE B  99
ASP B 252
PRO B 254
 None
 0.89A 6ag0A-1r4nB:
undetectable		 6ag0A-1r4nB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 TYR A 182
GLY A 227
ILE A 180
LYS A 229
 None
 0.93A 6ag0A-1t06A:
undetectable		 6ag0A-1t06A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		4 TYR A 421
GLY A 464
ASP A 268
ASP A 298
 None
 0.73A 6ag0A-1uxtA:
undetectable		 6ag0A-1uxtA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 179
LYS A 180
ASP A 202
HIS A 205
PRO A 206
 None
 1.37A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		6 TYR A 158
GLY A 179
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
 0.82A 6ag0A-1vjsA:
55.5		 6ag0A-1vjsA:
6.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 None
None
None
CA  A1487 (-2.9A)
CA  A1487 (-3.6A)
None
None
 0.59A 6ag0A-1w9xA:
64.2		 6ag0A-1w9xA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmy LECTIN CEL-I,
N-ACETYL-D-GALACTOSA
MINE-SPECIFIC C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		4 TYR A  76
GLY A 112
ILE A  73
HIS A  28
 None
 0.93A 6ag0A-1wmyA:
undetectable		 6ag0A-1wmyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE

(Saccharomyces
cerevisiae) 		PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 TYR G  74
ILE G  56
ASP G  50
ASP G  52
 None
 0.90A 6ag0A-2b8kG:
undetectable		 6ag0A-2b8kG:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		4 TYR A  80
GLY A 104
ASP A  75
PRO A  77
 None
 0.76A 6ag0A-2bkxA:
undetectable		 6ag0A-2bkxA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 GLC  A 621 (-4.0A)
None
None
CA  A 501 (-2.9A)
CA  A 501 (-3.4A)
None
None
 0.64A 6ag0A-2d3lA:
59.6		 6ag0A-2d3lA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d81 PHB DEPOLYMERASE

(Talaromyces
funiculosus) 		PF10503
(Esterase_phd) 		4 GLY A 309
ILE A 292
ASP A 286
PRO A 301
 None
None
None
RB3  A 451 (-4.3A)
 0.86A 6ag0A-2d81A:
undetectable		 6ag0A-2d81A:
12.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 160
GLY A 182
LYS A 185
ASP A 207
ASP A 209
HIS A 210
PRO A 211
 None
None
None
CA  A 778 (-2.9A)
None
None
None
 0.69A 6ag0A-2dieA:
64.2		 6ag0A-2dieA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 GLY A 267
ASP A 332
ASP A 261
HIS A 260
 None
 0.84A 6ag0A-2eceA:
undetectable		 6ag0A-2eceA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  14
ILE A  13
ASP A  48
HIS A  51
 None
NAD  A 401 (-4.2A)
None
None
 0.92A 6ag0A-2ep7A:
undetectable		 6ag0A-2ep7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ILE A 138
ASP A 313
HIS A 314
PRO A 315
 None
 0.77A 6ag0A-2fvlA:
8.1		 6ag0A-2fvlA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 TYR A 177
GLY A 144
ILE A 145
ASP A 139
 None
 0.87A 6ag0A-2gfiA:
undetectable		 6ag0A-2gfiA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 TYR A  22
GLY A  30
ILE A  24
ASP A  42
 None
 0.80A 6ag0A-2h4cA:
undetectable		 6ag0A-2h4cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		4 TYR A 551
GLY A 561
ILE A 560
ASP A 521
 None
 0.81A 6ag0A-2hl9A:
undetectable		 6ag0A-2hl9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 GLY B2100
ILE B2099
ASP B2252
PRO B2254
 None
 0.92A 6ag0A-2nvuB:
undetectable		 6ag0A-2nvuB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 341
ILE A 403
HIS A 365
PRO A 366
 None
 0.90A 6ag0A-2oejA:
10.0		 6ag0A-2oejA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 294
ILE A 295
ASP A 288
PRO A 314
 None
 0.93A 6ag0A-2og9A:
8.3		 6ag0A-2og9A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 GLY A  89
ILE A  90
ASP A 177
PRO A 224
 None
 0.88A 6ag0A-2ojhA:
undetectable		 6ag0A-2ojhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 307
ILE A 308
ASP A 301
PRO A 327
 None
 0.95A 6ag0A-2pp3A:
7.1		 6ag0A-2pp3A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  83
ILE A  86
ASP A 289
PRO A 288
 None
 0.84A 6ag0A-2qq6A:
9.0		 6ag0A-2qq6A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 TYR A 209
GLY A 342
ILE A 341
PRO A 147
 None
ATP  A1002 (-3.3A)
None
None
 0.91A 6ag0A-2qxlA:
undetectable		 6ag0A-2qxlA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A 438
GLY A 445
ILE A 252
ASP A 412
 None
 0.94A 6ag0A-2w40A:
undetectable		 6ag0A-2w40A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 TYR A 180
GLY A 182
ILE A 335
ASP A 171
 None
None
None
ZZU  A1359 ( 4.9A)
 0.92A 6ag0A-2wbpA:
undetectable		 6ag0A-2wbpA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 216
GLY A 246
ILE A 247
PRO A 188
 None
 0.78A 6ag0A-2x50A:
undetectable		 6ag0A-2x50A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  12
ILE A  11
ASP A  47
HIS A  50
 None
3CD  A 600 (-4.2A)
None
None
 0.87A 6ag0A-2xf8A:
undetectable		 6ag0A-2xf8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		4 TYR A  16
ASP A  59
ASP A  38
HIS A  15
 None
 0.90A 6ag0A-2xuaA:
undetectable		 6ag0A-2xuaA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 8

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		4 TYR B  38
GLY H  25
ASP B  35
PRO B  30
 None
None
HEM  A 303 ( 4.6A)
None
 0.78A 6ag0A-2zt9B:
undetectable		 6ag0A-2zt9B:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 474
ASP A 103
HIS A 105
PRO A 106
 None
 0.62A 6ag0A-3aw5A:
2.2		 6ag0A-3aw5A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLY A 713
ASP A 705
ASP A 707
HIS A 730
 None
K  A 201 (-3.2A)
ZN  A 101 (-2.1A)
None
 0.86A 6ag0A-3c10A:
undetectable		 6ag0A-3c10A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 TYR A 154
GLY A 174
ILE A 173
ASP A 153
 None
 0.80A 6ag0A-3cvoA:
undetectable		 6ag0A-3cvoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  14
ILE A  13
ASP A  50
HIS A  53
 None
NAD  A 901 (-3.4A)
None
None
 0.89A 6ag0A-3docA:
undetectable		 6ag0A-3docA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 GLY O  15
ILE O  14
ASP O  50
HIS O  53
 None
 0.93A 6ag0A-3e6aO:
undetectable		 6ag0A-3e6aO:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 121
ILE A 124
ASP A 293
PRO A 292
 None
 0.78A 6ag0A-3ekgA:
7.5		 6ag0A-3ekgA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et6 SOLUBLE GUANYLYL
CYCLASE BETA

(Chlamydomonas
reinhardtii) 		PF00211
(Guanylate_cyc) 		4 GLY A 485
ILE A 489
ASP A 482
ASP A 527
 PO4  A   2 (-3.4A)
None
None
None
 0.92A 6ag0A-3et6A:
undetectable		 6ag0A-3et6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 126
ILE A 129
ASP A 297
PRO A 296
 None
 0.76A 6ag0A-3fxgA:
7.6		 6ag0A-3fxgA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  13
ILE A  12
ASP A  50
HIS A  53
 None
 0.92A 6ag0A-3gnqA:
undetectable		 6ag0A-3gnqA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 GLY A 175
ASP A 145
ASP A 147
PRO A 149
 None
None
None
BEZ  A 302 (-4.2A)
 0.83A 6ag0A-3gv1A:
undetectable		 6ag0A-3gv1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE

(Homo sapiens) 		PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 TYR G  74
ILE G  56
ASP G  50
ASP G  52
 None
 0.84A 6ag0A-3j0kG:
undetectable		 6ag0A-3j0kG:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		5 TYR A  45
GLY A 115
ILE A 118
ASP A  72
HIS A  76
 None
 1.35A 6ag0A-3llcA:
undetectable		 6ag0A-3llcA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz6 LEUCYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00133
(tRNA-synt_1) 		4 GLY A 522
ILE A 523
ASP A 440
PRO A 477
 None
 0.93A 6ag0A-3pz6A:
undetectable		 6ag0A-3pz6A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 GLY A 201
ASP A 193
ASP A 195
HIS A 218
 None
K  A 342 (-3.2A)
ZN  A 343 (-2.3A)
None
 0.94A 6ag0A-3q9cA:
undetectable		 6ag0A-3q9cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 TYR A 152
GLY A  22
ASP A 208
PRO A 206
 BGC  A 316 (-4.2A)
BGC  A 316 ( 4.7A)
None
None
 0.92A 6ag0A-3qt2A:
undetectable		 6ag0A-3qt2A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 GLY A  81
ASP A  31
ASP A  29
PRO A 240
 None
ZN  A 299 (-2.1A)
ZN  A 299 ( 4.4A)
CL  A 298 (-3.7A)
 0.91A 6ag0A-3rxzA:
6.7		 6ag0A-3rxzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		4 GLY A 375
ILE A 365
ASP A 348
HIS A 352
 None
None
ZN  A   1 (-2.1A)
None
 0.93A 6ag0A-3rzvA:
undetectable		 6ag0A-3rzvA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLY A  71
ILE A 108
ASP A  95
ASP A 397
 None
 0.94A 6ag0A-3s8mA:
undetectable		 6ag0A-3s8mA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  97
ILE A 100
ASP A 274
PRO A 273
 None
 0.78A 6ag0A-3sjnA:
8.8		 6ag0A-3sjnA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 407
ILE A 406
LYS A 399
ASP A 403
 None
 0.91A 6ag0A-3sutA:
9.7		 6ag0A-3sutA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 GLY A 154
ASP A 185
ASP A   8
HIS A 181
 None
MG  A 301 ( 4.7A)
MG  A 301 (-2.4A)
None
 0.94A 6ag0A-3vayA:
undetectable		 6ag0A-3vayA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 GLY A 154
ILE A 155
ASP A 110
PRO A 107
 None
 0.84A 6ag0A-3wlaA:
undetectable		 6ag0A-3wlaA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A 126
ASP A 119
ASP A 121
PRO A 140
 None
 0.94A 6ag0A-4a5oA:
undetectable		 6ag0A-4a5oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 GLY A 192
ASP A 184
ASP A 186
HIS A 209
 None
K  A 600 (-3.3A)
ZN  A 500 (-2.3A)
None
 0.92A 6ag0A-4bz7A:
undetectable		 6ag0A-4bz7A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 GLY A  57
ILE A  33
HIS A 229
PRO A 230
 None
 0.70A 6ag0A-4c1lA:
7.7		 6ag0A-4c1lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  13
ILE A  12
ASP A  47
HIS A  50
 None
 0.93A 6ag0A-4dibA:
undetectable		 6ag0A-4dibA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 GLY A 128
ILE A 104
HIS A 300
PRO A 301
 None
 0.77A 6ag0A-4grsA:
4.6		 6ag0A-4grsA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 TYR A 180
GLY A  65
ILE A  66
PRO A  85
 None
 0.82A 6ag0A-4gu7A:
undetectable		 6ag0A-4gu7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 131
GLY A 184
ILE A 182
ASP A 125
 None
None
None
SO4  A 905 (-3.7A)
 0.94A 6ag0A-4i3gA:
5.6		 6ag0A-4i3gA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 TYR A 459
GLY A 463
ILE A  41
HIS A  93
 FAD  A 501 (-4.4A)
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.5A)
None
 0.92A 6ag0A-4i59A:
undetectable		 6ag0A-4i59A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 481
GLY A 182
ILE A 183
PRO A 453
 None
 0.87A 6ag0A-4igoA:
undetectable		 6ag0A-4igoA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 TYR A 379
GLY A 474
ASP A 308
PRO A 219
 None
None
GOL  A 734 (-2.6A)
None
 0.83A 6ag0A-4kcaA:
undetectable		 6ag0A-4kcaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  20
ILE A  19
ASP A  54
HIS A  57
 None
NAD  A 401 (-4.0A)
None
None
 0.94A 6ag0A-4lsmA:
undetectable		 6ag0A-4lsmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 TYR B 323
ASP B 276
ASP B 278
PRO B 320
 None
 0.75A 6ag0A-4o6dB:
undetectable		 6ag0A-4o6dB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oie NON-STRUCTURAL
PROTEIN NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 TYR A 323
ASP A 276
ASP A 278
PRO A 320
 None
 0.81A 6ag0A-4oieA:
undetectable		 6ag0A-4oieA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		4 GLY X 207
ILE X 206
ASP X 200
HIS X 201
 None
 0.95A 6ag0A-4oj2X:
undetectable		 6ag0A-4oj2X:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  14
ILE A  13
ASP A  48
HIS A  51
 None
NAD  A 400 (-4.3A)
None
None
 0.92A 6ag0A-4p8rA:
undetectable		 6ag0A-4p8rA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 TYR B  42
GLY B  36
ILE A  19
ASP B  43
 None
 0.92A 6ag0A-4pelB:
undetectable		 6ag0A-4pelB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		4 GLY A 134
ILE A 136
LYS A 131
ASP A 129
 None
 0.94A 6ag0A-4pfeA:
undetectable		 6ag0A-4pfeA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 GLY A  14
ILE A  15
ASP A 419
PRO A 417
 None
 0.88A 6ag0A-4s3pA:
3.0		 6ag0A-4s3pA:
8.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A 159
GLY A 180
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
None
CA  A1483 (-3.0A)
None
None
None
 1.00A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		4 GLY A 210
ILE A 209
ASP A 290
HIS A  63
 None
None
None
ZN  A 401 (-3.3A)
 0.83A 6ag0A-4x8iA:
undetectable		 6ag0A-4x8iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY O  12
ILE O  11
ASP O  47
HIS O  50
 None
NAD  O 401 (-4.1A)
None
None
 0.94A 6ag0A-4z0hO:
undetectable		 6ag0A-4z0hO:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 381
ILE A 371
ASP A 354
HIS A 358
 None
None
ZN  A 501 ( 2.0A)
None
 0.93A 6ag0A-4zd5A:
undetectable		 6ag0A-4zd5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 ILE A 136
ASP A 201
ASP A 203
HIS A 205
 None
 0.93A 6ag0A-5a3cA:
undetectable		 6ag0A-5a3cA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLY A 308
ILE A 307
ASP A 315
HIS A  50
 None
 0.86A 6ag0A-5cweA:
undetectable		 6ag0A-5cweA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 256
ILE A   7
ASP A 252
HIS A 253
 None
 0.89A 6ag0A-5e6kA:
undetectable		 6ag0A-5e6kA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 TYR A 229
GLY A 198
ILE A 195
ASP A 185
 None
None
None
SAM  A 400 (-2.8A)
 0.91A 6ag0A-5e72A:
undetectable		 6ag0A-5e72A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 GLY B 655
ASP B 647
ASP B 649
HIS B 672
 None
K  B2504 (-3.3A)
ZN  B2502 (-2.2A)
K  B2504 ( 4.8A)
 0.85A 6ag0A-5eduB:
undetectable		 6ag0A-5eduB:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 270
ILE A  11
ASP A 266
HIS A 267
 None
 0.85A 6ag0A-5erbA:
undetectable		 6ag0A-5erbA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 TYR A 601
GLY A  42
ILE A  43
PRO A 573
 None
 0.91A 6ag0A-5fwjA:
undetectable		 6ag0A-5fwjA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLY A  85
ILE A  84
ASP A 125
HIS A 129
 None
None
None
HEM  A 501 (-3.8A)
 0.92A 6ag0A-5hdiA:
undetectable		 6ag0A-5hdiA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLY A  67
ILE A  65
ASP A1171
ASP A1173
 None
 0.79A 6ag0A-5hy7A:
undetectable		 6ag0A-5hy7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.28A 6ag0A-5i6gA:
undetectable		 6ag0A-5i6gA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.28A 6ag0A-5i6hA:
undetectable		 6ag0A-5i6hA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 GLY A2070
ILE A2072
ASP A2139
ASP A2136
HIS A2138
 None
 1.23A 6ag0A-5i6iA:
undetectable		 6ag0A-5i6iA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES8

(Chaetomium
thermophilum) 		no annotation 4 GLY t  30
ILE t   3
ASP t   6
HIS t   9
 U  2 332 ( 4.0A)
None
None
None
 0.88A 6ag0A-5jpqt:
undetectable		 6ag0A-5jpqt:
17.87