SIMILAR PATTERNS OF AMINO ACIDS FOR 6AF6_A_GLYA507_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 TYR A 190
HIS A 137
MET A 286
 None
 1.22A 6af6A-1dlmA:
0.0		 6af6A-1dlmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 TYR A  31
HIS A  54
MET A  73
 None
CU  A 107 (-3.1A)
None
 1.10A 6af6A-1id2A:
undetectable		 6af6A-1id2A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		3 TYR A  74
HIS A  61
MET A  68
 None
PO4  A 301 ( 3.8A)
None
 1.17A 6af6A-1k27A:
0.0		 6af6A-1k27A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 TYR L 146
HIS L 415
MET L 422
 None
 1.16A 6af6A-1kfuL:
0.0		 6af6A-1kfuL:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 TYR A 481
HIS A 438
MET A 434
 None
 1.26A 6af6A-1m9iA:
0.0		 6af6A-1m9iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 TYR A  16
HIS A 101
MET A 100
 None
 1.08A 6af6A-1osnA:
0.0		 6af6A-1osnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7d INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 TYR A 318
HIS A 247
MET A 255
 None
 1.14A 6af6A-1p7dA:
0.0		 6af6A-1p7dA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 424
HIS A 524
MET A 527
 None
 1.09A 6af6A-1q8iA:
0.0		 6af6A-1q8iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 TYR A 104
HIS A  77
MET A 181
 None
 1.10A 6af6A-1qf6A:
0.0		 6af6A-1qf6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r88 MPT51/MPB51 ANTIGEN

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 TYR A 149
HIS A 210
MET A 198
 None
 1.20A 6af6A-1r88A:
undetectable		 6af6A-1r88A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		3 TYR A 104
HIS A  77
MET A 181
 SER  A 500 (-4.2A)
SER  A 500 (-4.0A)
None
 1.24A 6af6A-1tkeA:
undetectable		 6af6A-1tkeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		3 TYR A  40
HIS A  63
MET A  19
 None
 1.10A 6af6A-1ya0A:
undetectable		 6af6A-1ya0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5

(Homo sapiens) 		PF00025
(Arf) 		3 TYR A  80
HIS A 112
MET A 109
 None
 1.08A 6af6A-1z6yA:
undetectable		 6af6A-1z6yA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		3 TYR A  92
HIS A 251
MET A 252
 None
GLC  A1606 (-4.2A)
None
 1.16A 6af6A-2bxyA:
undetectable		 6af6A-2bxyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		3 TYR A 258
HIS A 250
MET A 206
 None
 1.21A 6af6A-2ckrA:
undetectable		 6af6A-2ckrA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 TYR A 456
HIS A 645
MET A 648
 None
 1.03A 6af6A-2dfsA:
1.6		 6af6A-2dfsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		3 TYR A 309
HIS A 186
MET A 187
 None
SEP  A1001 (-3.8A)
None
 1.21A 6af6A-2du3A:
undetectable		 6af6A-2du3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		3 TYR A 241
HIS A 198
MET A 199
 None
 0.93A 6af6A-2du7A:
undetectable		 6af6A-2du7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		3 TYR A 162
HIS A 218
MET A 219
 None
 1.25A 6af6A-2dvuA:
undetectable		 6af6A-2dvuA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		3 TYR A 322
HIS A 326
MET A 327
 None
 0.97A 6af6A-2e3jA:
undetectable		 6af6A-2e3jA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 TYR A 126
HIS A  95
MET A  98
 None
 1.07A 6af6A-2g8yA:
undetectable		 6af6A-2g8yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		3 TYR A 326
HIS A 110
MET A 113
 None
 1.08A 6af6A-2gsnA:
undetectable		 6af6A-2gsnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		3 TYR A  12
HIS A 333
MET A 332
 None
 1.16A 6af6A-2gz6A:
undetectable		 6af6A-2gz6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 390
HIS A 393
MET A 384
 None
 1.17A 6af6A-2hdiA:
undetectable		 6af6A-2hdiA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 TYR A 757
HIS A 780
MET A 769
 None
 1.16A 6af6A-2hpiA:
undetectable		 6af6A-2hpiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 TYR A 377
HIS A 333
MET A 278
 None
 1.26A 6af6A-2inpA:
1.4		 6af6A-2inpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 TYR A 304
HIS A  99
MET A 102
 None
 1.22A 6af6A-2j0jA:
2.4		 6af6A-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 TYR A 223
HIS A 251
MET A 252
 None
 1.06A 6af6A-2jh9A:
undetectable		 6af6A-2jh9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		3 TYR A 176
HIS A 342
MET A 336
 None
 1.19A 6af6A-2o14A:
undetectable		 6af6A-2o14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		3 TYR A  69
HIS A  79
MET A 142
 None
 1.13A 6af6A-2pg8A:
2.4		 6af6A-2pg8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		3 TYR A 166
HIS A 138
MET A 140
 None
 1.14A 6af6A-2plwA:
undetectable		 6af6A-2plwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 TYR A 264
HIS A 103
MET A 106
 None
S4M  A 501 (-3.7A)
None
 1.19A 6af6A-2pt6A:
undetectable		 6af6A-2pt6A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		3 TYR A 158
HIS A 228
MET A 226
 None
 1.13A 6af6A-2quqA:
4.1		 6af6A-2quqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 TYR A  60
HIS A 750
MET A 749
 None
 1.18A 6af6A-2r6fA:
undetectable		 6af6A-2r6fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		3 TYR A 345
HIS A 372
MET A 369
 None
 1.04A 6af6A-2r7dA:
undetectable		 6af6A-2r7dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		3 TYR A 428
HIS A 323
MET A 322
 None
 1.15A 6af6A-2tohA:
undetectable		 6af6A-2tohA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		3 TYR A 155
HIS A 336
MET A 333
 None
 1.14A 6af6A-2vugA:
undetectable		 6af6A-2vugA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt4 PROTEIN DGCR8

(Homo sapiens) 		PF00035
(dsrm) 		3 TYR A 530
HIS A 517
MET A 520
 None
 1.15A 6af6A-2yt4A:
undetectable		 6af6A-2yt4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 TYR A 688
HIS A 685
MET A 724
 None
 1.23A 6af6A-2zxqA:
3.6		 6af6A-2zxqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 TYR A  31
HIS A  54
MET A  73
 None
CU  A 107 (-3.1A)
None
 1.10A 6af6A-3c75A:
undetectable		 6af6A-3c75A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 TYR A 561
HIS A 407
MET A 406
 None
 1.03A 6af6A-3ce2A:
2.5		 6af6A-3ce2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID

(Escherichia
coli) 		PF01510
(Amidase_2) 		3 TYR A 212
HIS A 233
MET A 232
 None
 1.00A 6af6A-3d2zA:
undetectable		 6af6A-3d2zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		3 TYR A  54
HIS A  41
MET A 165
 None
959  A 350 (-3.9A)
959  A 350 (-4.4A)
 1.02A 6af6A-3d62A:
undetectable		 6af6A-3d62A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		3 TYR A 159
HIS A 181
MET A 179
 None
FE  A 310 (-3.5A)
None
 0.79A 6af6A-3dcpA:
undetectable		 6af6A-3dcpA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 235
HIS A 175
MET A 172
 None
 1.12A 6af6A-3euwA:
undetectable		 6af6A-3euwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 279
HIS A 174
MET A 171
 None
 1.17A 6af6A-3ezyA:
undetectable		 6af6A-3ezyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01759
(NTR)
PF07677
(A2M_recep) 		3 TYR C1500
HIS C1539
MET C1520
 None
 1.18A 6af6A-3hs0C:
undetectable		 6af6A-3hs0C:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kea K1L

(Vaccinia virus) 		PF12796
(Ank_2) 		3 TYR A  36
HIS A  29
MET A   1
 None
 1.14A 6af6A-3keaA:
undetectable		 6af6A-3keaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		3 TYR A1174
HIS A1275
MET A1276
 None
 1.21A 6af6A-3kuqA:
undetectable		 6af6A-3kuqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		3 TYR A 322
HIS A 202
MET A 203
 None
 1.21A 6af6A-3kxwA:
undetectable		 6af6A-3kxwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		3 TYR A 233
HIS A  19
MET A 179
 None
 1.23A 6af6A-3m3pA:
undetectable		 6af6A-3m3pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		3 TYR B 143
HIS B 160
MET B 190
 None
 1.18A 6af6A-3ojaB:
undetectable		 6af6A-3ojaB:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 TYR A 341
HIS A 319
MET A 320
 None
 0.93A 6af6A-3pieA:
undetectable		 6af6A-3pieA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 TYR B1522
HIS B1561
MET B1542
 None
 1.23A 6af6A-3prxB:
undetectable		 6af6A-3prxB:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sic STREPTOMYCES
SUBTILISIN INHIBITOR
(SSI)

(Streptomyces
albogriseolus) 		PF00720
(SSI) 		3 TYR I  93
HIS I 106
MET I 103
 None
 1.05A 6af6A-3sicI:
undetectable		 6af6A-3sicI:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		3 TYR A  83
HIS A  90
MET A  91
 None
 1.25A 6af6A-3u80A:
undetectable		 6af6A-3u80A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 TYR A 434
HIS A 415
MET A 463
 None
 1.07A 6af6A-3v4oA:
undetectable		 6af6A-3v4oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 TYR A 235
HIS A 258
MET A 226
 None
 1.26A 6af6A-4agsA:
1.9		 6af6A-4agsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 TYR A 257
HIS A 292
MET A 290
 None
 1.24A 6af6A-4aioA:
undetectable		 6af6A-4aioA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		3 TYR A 202
HIS A 260
MET A 261
 None
 0.96A 6af6A-4b2oA:
undetectable		 6af6A-4b2oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 TYR A 710
HIS A 705
MET A 670
 None
 1.06A 6af6A-4b56A:
undetectable		 6af6A-4b56A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		3 TYR A 407
HIS A  91
MET A  94
 FAD  A1492 ( 4.4A)
FAD  A1492 ( 3.7A)
None
 1.13A 6af6A-4b67A:
undetectable		 6af6A-4b67A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9j CS6 FIMBRIAL SUBUNIT
A

(Escherichia
coli) 		no annotation 3 TYR A 128
HIS A  90
MET A  86
 None
 1.06A 6af6A-4b9jA:
undetectable		 6af6A-4b9jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beq ALANINE RACEMASE 2

(Vibrio cholerae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 TYR A 275
HIS A  62
MET A  63
 None
 1.10A 6af6A-4beqA:
undetectable		 6af6A-4beqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		3 TYR A 207
HIS A 228
MET A 227
 None
 0.94A 6af6A-4bxjA:
undetectable		 6af6A-4bxjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		3 TYR A 197
HIS A 221
MET A 220
 None
ZN  A 501 (-3.3A)
None
 1.12A 6af6A-4dykA:
undetectable		 6af6A-4dykA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 235
HIS A 174
MET A 171
 None
 1.16A 6af6A-4hktA:
undetectable		 6af6A-4hktA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		3 TYR A 188
HIS A 151
MET A 156
 None
 1.16A 6af6A-4mhuA:
undetectable		 6af6A-4mhuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 TYR A 349
HIS A  81
MET A  78
 None
 1.22A 6af6A-4mo9A:
undetectable		 6af6A-4mo9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofg CGMP-DEPENDENT
PROTEIN KINASE

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		3 TYR A 417
HIS A 524
MET A 521
 SO4  A 609 ( 4.3A)
SO4  A 609 (-3.5A)
EOH  A 611 ( 4.5A)
 1.10A 6af6A-4ofgA:
undetectable		 6af6A-4ofgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		3 TYR A 109
HIS A 232
MET A 149
 None
 1.11A 6af6A-4pafA:
undetectable		 6af6A-4pafA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		3 TYR A 263
HIS A 175
MET A 174
 None
 0.75A 6af6A-4pprA:
undetectable		 6af6A-4pprA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		3 TYR A 126
HIS A  92
MET A 116
 None
 1.22A 6af6A-4qniA:
undetectable		 6af6A-4qniA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		3 TYR A 262
HIS A 372
MET A 396
 None
 1.22A 6af6A-4rm4A:
2.6		 6af6A-4rm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 3 TYR A 304
HIS A 475
MET A 474
 None
 1.10A 6af6A-4ru5A:
undetectable		 6af6A-4ru5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uds MBDR REGULATOR

(Azoarcus sp.
CIB) 		PF00440
(TetR_N) 		3 TYR A  81
HIS A 142
MET A 139
 None
 1.03A 6af6A-4udsA:
undetectable		 6af6A-4udsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 TYR A 264
HIS A 103
MET A 106
 4ZY  A 501 (-3.4A)
None
None
 1.14A 6af6A-4uoeA:
undetectable		 6af6A-4uoeA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		3 TYR A 103
HIS A  78
MET A  76
 None
 1.10A 6af6A-4uwmA:
undetectable		 6af6A-4uwmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		3 TYR A  54
HIS A  41
MET A 168
 None
PGE  A 402 ( 4.2A)
PGE  A 402 ( 4.8A)
 1.03A 6af6A-4wmdA:
undetectable		 6af6A-4wmdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 3 TYR A 344
HIS A 397
MET A 396
 NAG  A1004 (-3.7A)
NDG  A1005 (-3.7A)
None
 1.17A 6af6A-4xn3A:
undetectable		 6af6A-4xn3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 248
HIS A 168
MET A 167
 None
 0.99A 6af6A-5cekA:
undetectable		 6af6A-5cekA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCOP1

(Pseudomonas
stutzeri) 		PF13442
(Cytochrome_CBB3)
PF14715
(FixP_N) 		3 TYR C 229
HIS C 237
MET C 244
 None
HEC  C 401 (-3.1A)
None
 1.24A 6af6A-5djqC:
undetectable		 6af6A-5djqC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 TYR A 279
HIS A 277
MET A 275
 None
 1.12A 6af6A-5hjrA:
undetectable		 6af6A-5hjrA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q CONTACT-DEPENDENT
INHIBITOR A

(Escherichia
coli) 		no annotation 3 TYR A 191
HIS A 248
MET A 237
 None
 1.01A 6af6A-5i4qA:
undetectable		 6af6A-5i4qA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0n INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 TYR E 318
HIS E 247
MET E 255
 None
 1.09A 6af6A-5j0nE:
undetectable		 6af6A-5j0nE:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		3 TYR A 460
HIS A 555
MET A 507
 None
 1.17A 6af6A-5jseA:
undetectable		 6af6A-5jseA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TYR A 132
HIS A 206
MET A 176
 None
 1.08A 6af6A-5jt8A:
undetectable		 6af6A-5jt8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26) 		no annotation 3 TYR A 131
HIS A  60
MET A  62
 None
 1.24A 6af6A-5ngdA:
1.1		 6af6A-5ngdA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 3 TYR A 334
HIS A 362
MET A 363
 None
 1.11A 6af6A-5o1rA:
undetectable		 6af6A-5o1rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 3 TYR A 353
HIS A 247
MET A 253
 None
 1.18A 6af6A-5umsA:
undetectable		 6af6A-5umsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 TYR A 709
HIS A 707
MET A 704
 None
 1.24A 6af6A-5uowA:
undetectable		 6af6A-5uowA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v13 AAEL008620-PA
ODORANT-BINDING
PROTEIN

(Aedes aegypti) 		no annotation 3 TYR B  33
HIS B 145
MET B 143
 JH3  B 301 (-3.8A)
None
None
 1.12A 6af6A-5v13B:
undetectable		 6af6A-5v13B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wze AMINOPEPTIDASE P

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 366
HIS A 354
MET A 381
 ALA  A 505 (-3.8A)
MN  A 508 (-3.5A)
None
 1.14A 6af6A-5wzeA:
undetectable		 6af6A-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B 479
HIS B1097
MET B1098
 None
G  P   9 ( 4.0A)
None
 1.14A 6af6A-5xogB:
undetectable		 6af6A-5xogB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z59 PROTEIN-TYROSINE
PHOSPHATASE

(Thermococcus
kodakarensis) 		no annotation 3 TYR A  44
HIS A  92
MET A  94
 None
 1.16A 6af6A-5z59A:
undetectable		 6af6A-5z59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 3 TYR C1136
HIS C1184
MET C1178
 None
 1.22A 6af6A-5zyaC:
undetectable		 6af6A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 3 TYR A 360
HIS A 332
MET A 326
 None
 1.23A 6af6A-6c93A:
2.1		 6af6A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10

(Homo sapiens) 		no annotation 3 TYR B 138
HIS B 110
MET B 147
 None
 1.26A 6af6A-6c9mB:
undetectable		 6af6A-6c9mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 3 TYR A 249
HIS A 171
MET A  36
 None
 1.23A 6af6A-6co9A:
undetectable		 6af6A-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 3 TYR A1008
HIS A1036
MET A1031
 None
 1.08A 6af6A-6fj4A:
undetectable		 6af6A-6fj4A:
undetectable