SIMILAR PATTERNS OF AMINO ACIDS FOR 6A94_A_ZOTA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 VAL A 192
GLY A 190
SER A 186
PHE A 247
VAL A 338
 None
 1.15A 6a94A-1dcnA:
4.5		 6a94A-1dcnA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 SER A  52
LEU A 135
VAL A 136
GLY A 138
SER A 139
 None
 1.25A 6a94A-1eblA:
undetectable		 6a94A-1eblA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		5 VAL A 113
GLY A  65
SER A  81
PHE A  77
VAL A  89
 None
 1.30A 6a94A-1f3gA:
undetectable		 6a94A-1f3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		5 VAL A 232
GLY A 234
SER A 238
PHE A 134
VAL A 204
 None
 1.32A 6a94A-1h0nA:
4.1		 6a94A-1h0nA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		5 GLY A  22
SER A  53
PHE A  97
ASN A  99
VAL A 241
 NAD  A1268 ( 4.1A)
None
None
NAD  A1268 (-3.3A)
None
 1.35A 6a94A-1iy8A:
undetectable		 6a94A-1iy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		5 LEU A  32
VAL A  41
GLY A  42
PHE A 102
ASN A 152
 None
 1.39A 6a94A-1lfwA:
undetectable		 6a94A-1lfwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 TRP A 515
SER A 630
GLY A 438
SER A 625
PHE A 485
 None
 1.43A 6a94A-1mpxA:
undetectable		 6a94A-1mpxA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 VAL A 271
SER A 278
TRP A 322
ASN A 272
VAL A 248
 None
 1.34A 6a94A-1ndfA:
undetectable		 6a94A-1ndfA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 LEU B 362
GLY B 723
PHE B 694
PHE B 743
VAL B 705
 None
 1.36A 6a94A-1nexB:
undetectable		 6a94A-1nexB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS

(Laetiporus
sulphureus) 		PF03318
(ETX_MTX2) 		5 VAL A 301
PHE A 216
TRP A 238
PHE A 246
VAL A 234
 None
 1.36A 6a94A-1w3fA:
undetectable		 6a94A-1w3fA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3a SYNAPSE ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF03909
(BSD) 		5 SER A  22
VAL A  51
SER A  60
PHE A  28
VAL A  84
 None
 1.12A 6a94A-1x3aA:
undetectable		 6a94A-1x3aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		5 LEU A 132
VAL A  72
GLY A  73
PHE A 300
VAL A 304
 None
 1.41A 6a94A-1yleA:
undetectable		 6a94A-1yleA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 TRP A  67
GLY A 365
PHE A   8
PHE A 369
VAL A  26
 None
 1.41A 6a94A-1yzyA:
undetectable		 6a94A-1yzyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 LEU A  85
VAL A  91
GLY A  89
PHE A 114
VAL A 169
 None
 1.22A 6a94A-1zaoA:
undetectable		 6a94A-1zaoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 GLY C 119
PHE C 404
PHE C 367
PHE C 363
VAL C 371
 None
 1.41A 6a94A-1zrtC:
undetectable		 6a94A-1zrtC:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Escherichia
coli) 		no annotation 5 LEU A 170
VAL A  96
GLY A  94
SER A  93
VAL A  88
 None
 1.45A 6a94A-2aukA:
undetectable		 6a94A-2aukA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bt7 SIGMA C

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		5 LEU A 237
VAL A 239
GLY A 209
PHE A 305
VAL A 278
 None
 1.19A 6a94A-2bt7A:
undetectable		 6a94A-2bt7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 LEU A 261
VAL A 279
GLY A 280
SER A 284
VAL A   4
 None
 1.43A 6a94A-2ef4A:
undetectable		 6a94A-2ef4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 TRP A 117
VAL A   9
GLY A   8
PHE A  89
VAL A 104
 None
 1.31A 6a94A-2ef4A:
undetectable		 6a94A-2ef4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		5 SER A  98
LEU A  88
VAL A 143
PHE A 323
PHE A 168
 None
 1.43A 6a94A-2greA:
undetectable		 6a94A-2greA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08327
(AHSA1) 		5 VAL A 148
GLY A 150
TRP A  30
PHE A 119
PHE A 155
 None
 1.32A 6a94A-2il5A:
undetectable		 6a94A-2il5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 VAL A 254
SER A 260
PHE A 381
TRP A 374
PHE A 150
 None
 1.38A 6a94A-2m56A:
undetectable		 6a94A-2m56A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6b FULL-LENGTH
TRANSMEMBRANE
DOMAINS OF HUMAN
GLYCINE RECEPTOR
ALPHA1 SUBUNIT

(Homo sapiens) 		PF02932
(Neur_chan_memb) 		5 LEU A 261
VAL A 260
GLY A 256
PHE A 293
VAL A 294
 None
 1.41A 6a94A-2m6bA:
2.8		 6a94A-2m6bA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		5 SER A 263
LEU A 253
VAL A 141
SER A 145
VAL A 281
 None
 1.41A 6a94A-2psfA:
undetectable		 6a94A-2psfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		5 TRP A  45
SER A  87
GLY A  80
SER A  83
VAL A  29
 None
 1.08A 6a94A-2qggA:
undetectable		 6a94A-2qggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 SER A 244
LEU A 441
GLY A 241
SER A 238
VAL A 220
 None
 1.42A 6a94A-2qqmA:
undetectable		 6a94A-2qqmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE

(Campylobacter
jejuni) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 LEU A 359
GLY A 355
PHE A 343
PHE A 341
ASN A 338
 None
 1.45A 6a94A-2rijA:
undetectable		 6a94A-2rijA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		5 LEU A 237
VAL A 239
GLY A 209
PHE A 305
VAL A 278
 None
 1.27A 6a94A-2vrsA:
undetectable		 6a94A-2vrsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj6 ASCORBATE PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 LEU A  23
VAL A 103
GLY A 101
PHE A 247
PHE A 115
 None
 1.41A 6a94A-2xj6A:
undetectable		 6a94A-2xj6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A 297
VAL A 296
PHE A 264
PHE A 198
VAL A 308
 None
 1.30A 6a94A-2ys6A:
undetectable		 6a94A-2ys6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c41 AMINO ACID ABC
TRANSPORTER (ARTP)

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 LEU J 167
VAL J 172
GLY J 173
SER J 177
VAL J  82
 None
 1.43A 6a94A-3c41J:
undetectable		 6a94A-3c41J:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 LEU A  38
GLY A  99
PHE A 203
PHE A  89
VAL A 137
 None
 1.22A 6a94A-3d9wA:
undetectable		 6a94A-3d9wA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		5 VAL A 428
GLY A 405
SER A 345
PHE A 403
VAL A 241
 None
 1.44A 6a94A-3e0jA:
undetectable		 6a94A-3e0jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A  70
VAL A  71
SER A 192
PHE A 252
VAL A 185
 None
 1.44A 6a94A-3euoA:
undetectable		 6a94A-3euoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		5 GLY A  32
SER A  99
PHE A 169
PHE A 168
ASN A 186
 CL  A 401 ( 4.1A)
CL  A 401 (-2.9A)
None
None
None
 1.44A 6a94A-3fobA:
undetectable		 6a94A-3fobA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		5 SER A 237
VAL A 176
GLY A 171
PHE A 222
VAL A 151
 None
 1.26A 6a94A-3ggrA:
undetectable		 6a94A-3ggrA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		5 VAL A 285
SER A 260
PHE A 267
PHE A 298
VAL A 247
 None
 1.42A 6a94A-3grhA:
undetectable		 6a94A-3grhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 LEU C 253
VAL C 245
GLY C 249
SER C 210
VAL C 106
 None
 1.45A 6a94A-3gzdC:
undetectable		 6a94A-3gzdC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 LEU A 118
GLY A 154
PHE A 166
ASN A 159
VAL A 170
 None
 1.30A 6a94A-3hc1A:
undetectable		 6a94A-3hc1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		5 SER A 180
VAL A 170
GLY A 172
SER A 176
ASN A 147
 None
 1.35A 6a94A-3ioyA:
undetectable		 6a94A-3ioyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 SER A 167
LEU A 132
VAL A  27
GLY A  29
VAL A 244
 None
 1.45A 6a94A-3j4sA:
undetectable		 6a94A-3j4sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 LEU A 135
VAL A  85
GLY A  84
SER A  74
VAL A 122
 None
 1.37A 6a94A-3k8kA:
undetectable		 6a94A-3k8kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 LEU A  57
VAL A  29
PHE A 193
PHE A  10
VAL A  14
 None
 1.25A 6a94A-3l4eA:
undetectable		 6a94A-3l4eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A  19
GLY A  23
PHE A 226
PHE A 234
VAL A 315
 None
 1.05A 6a94A-3lmdA:
2.4		 6a94A-3lmdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		5 VAL A  48
GLY A  51
PHE A 202
PHE A  70
VAL A 189
 None
 1.17A 6a94A-3m5uA:
undetectable		 6a94A-3m5uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		5 GLY A  36
SER A 471
PHE A  76
ASN A  80
VAL A 461
 None
 1.31A 6a94A-3nztA:
undetectable		 6a94A-3nztA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 SER A 463
VAL A  70
GLY A  52
SER A 461
PHE A  89
 None
 1.10A 6a94A-3of7A:
undetectable		 6a94A-3of7A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A 189
SER A 196
PHE A 338
TRP A 342
PHE A 345
PHE A 346
 ETQ  A1200 ( 4.2A)
ETQ  A1200 ( 4.6A)
None
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
 0.59A 6a94A-3pblA:
33.3		 6a94A-3pblA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 PHE A 282
TRP A 286
PHE A 289
PHE A 290
ASN A 293
 None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
 0.51A 6a94A-3pdsA:
31.1		 6a94A-3pdsA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
PHE A 282
TRP A 286
PHE A 289
PHE A 290
 None
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
 0.50A 6a94A-3pdsA:
31.1		 6a94A-3pdsA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
SER A 207
PHE A 282
TRP A 286
PHE A 289
 None
ERC  A1201 (-2.7A)
None
None
ERC  A1201 (-4.5A)
 0.74A 6a94A-3pdsA:
31.1		 6a94A-3pdsA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		5 LEU A 171
VAL A 185
GLY A 224
TRP A 228
VAL A 216
 None
 1.24A 6a94A-3q54A:
undetectable		 6a94A-3q54A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 103
SER A 111
PHE A 424
TRP A 428
PHE A 432
 None
5EH  A1200 ( 3.7A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
 0.65A 6a94A-3rzeA:
29.4		 6a94A-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 LEU A 313
VAL A 326
SER A 333
PHE A 385
VAL A 367
 None
 1.45A 6a94A-3s51A:
2.2		 6a94A-3s51A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		5 VAL A  17
GLY A  19
SER A  43
PHE A  88
VAL A  84
 None
 1.45A 6a94A-3ureA:
undetectable		 6a94A-3ureA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 LEU B 525
VAL B 498
GLY B 523
PHE B 223
VAL B 570
 None
 1.44A 6a94A-3x17B:
undetectable		 6a94A-3x17B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		5 SER A 269
PHE A 226
PHE A 254
PHE A 266
VAL A 222
 None
 1.42A 6a94A-4dj2A:
undetectable		 6a94A-4dj2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eln TYPE III EFFECTOR
XOPAI

(Xanthomonas
citri) 		PF01129
(ART) 		5 LEU A  82
VAL A  86
SER A 185
PHE A 226
VAL A 162
 None
 1.35A 6a94A-4elnA:
undetectable		 6a94A-4elnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 SER A 324
VAL A 300
GLY A 297
SER A 293
PHE A 310
 None
 1.38A 6a94A-4g3mA:
undetectable		 6a94A-4g3mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
SER A 207
PHE A 254
TRP A 258
PHE A 261
PHE A 262
ASN A 265
 None
CAU  A 500 (-4.1A)
None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
 0.97A 6a94A-4gbrA:
32.0		 6a94A-4gbrA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 LEU A 779
VAL A 777
GLY A 768
SER A 624
VAL A 614
 None
 1.43A 6a94A-4h6xA:
undetectable		 6a94A-4h6xA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10

(Thermus
thermophilus;
Thermus
thermophilus) 		no annotation
no annotation 		5 LEU J  37
VAL J  56
GLY J  61
PHE H  92
VAL H  91
 None
 1.05A 6a94A-4he8J:
2.3		 6a94A-4he8J:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 PHE A 333
TRP A 337
PHE A 340
PHE A 341
ASN A 344
VAL A 366
 None
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 0.72A 6a94A-4ib4A:
36.7		 6a94A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 SER A 139
GLY A 221
TRP A 337
PHE A 340
PHE A 341
ASN A 344
VAL A 366
 ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 0.78A 6a94A-4ib4A:
36.7		 6a94A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
SER A 139
GLY A 221
PHE A 340
PHE A 341
ASN A 344
VAL A 366
 None
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 0.82A 6a94A-4ib4A:
36.7		 6a94A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 TRP A 131
SER A 139
LEU A 209
PHE A 340
VAL A 366
 None
ERM  A2001 (-3.6A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 1.04A 6a94A-4ib4A:
36.7		 6a94A-4ib4A:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 SER A  74
VAL A  21
GLY A  23
SER A  97
PHE A 112
 None
 1.40A 6a94A-4jypA:
undetectable		 6a94A-4jypA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A  41
VAL A 495
GLY A 492
SER A 490
PHE A 353
 None
 1.42A 6a94A-4lc9A:
undetectable		 6a94A-4lc9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 LEU A1171
VAL A1185
GLY A1224
TRP A1228
VAL A1216
 None
 1.24A 6a94A-4pk1A:
undetectable		 6a94A-4pk1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 SER A  60
VAL A 247
GLY A 235
SER A  92
PHE A  69
 None
 1.12A 6a94A-4qmkA:
2.5		 6a94A-4qmkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 VAL A  65
TRP A  85
PHE A  86
PHE A 263
VAL A  74
 EDO  A 715 (-3.8A)
None
None
None
None
 1.29A 6a94A-4wd1A:
undetectable		 6a94A-4wd1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywn NADH-FMN
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF01613
(Flavin_Reduct) 		5 LEU A  67
GLY A  74
SER A  76
PHE A  55
VAL A  57
 None
 1.21A 6a94A-4ywnA:
undetectable		 6a94A-4ywnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 SER A 180
VAL A 246
GLY A 204
SER A 352
VAL A 412
 None
 1.32A 6a94A-5bp1A:
undetectable		 6a94A-5bp1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che GLUTAMYL-TRNA
REDUCTASE-BINDING
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF10615
(DUF2470) 		5 LEU C 200
GLY C 272
SER C 276
PHE C 222
VAL C 208
 None
 1.36A 6a94A-5cheC:
undetectable		 6a94A-5cheC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5x PUTATIVE
TRANSCRIPTION FACTOR

(Chaetomium
thermophilum) 		PF00447
(HSF_DNA-bind) 		5 PHE B  86
PHE B  91
PHE B  77
ASN B  74
VAL B  95
 None
 1.24A 6a94A-5d5xB:
undetectable		 6a94A-5d5xB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 LEU A 291
VAL A 294
GLY A 243
PHE A 263
VAL A 269
 None
 1.45A 6a94A-5dqrA:
undetectable		 6a94A-5dqrA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 TRP B 117
PHE B 299
TRP B 303
PHE B 306
PHE B 307
ASN B 310
 P32  B 400 (-4.8A)
None
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
 0.75A 6a94A-5f8uB:
31.2		 6a94A-5f8uB:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 TRP B 117
SER B 215
PHE B 299
TRP B 303
PHE B 306
PHE B 307
 P32  B 400 (-4.8A)
P32  B 400 ( 4.2A)
None
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
 0.66A 6a94A-5f8uB:
31.2		 6a94A-5f8uB:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 LEU A 131
VAL A 170
GLY A 172
PHE A 109
PHE A 156
 None
 1.11A 6a94A-5frsA:
2.2		 6a94A-5frsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 LEU A 131
VAL A 170
GLY A 172
PHE A 109
VAL A 105
 None
 0.79A 6a94A-5frsA:
2.2		 6a94A-5frsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 SER A  38
VAL A 181
GLY A 182
PHE A  31
VAL A  32
 None
 1.19A 6a94A-5i32A:
2.2		 6a94A-5i32A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it6 GALECTIN-RELATED
PROTEIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 GLY A 128
SER A  30
PHE A  80
PHE A  88
VAL A  90
 PGE  A 205 (-2.9A)
PGE  A 205 (-2.8A)
None
None
None
 1.26A 6a94A-5it6A:
undetectable		 6a94A-5it6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 581
VAL A 616
SER A 619
PHE A 608
VAL A 606
 None
 1.37A 6a94A-5jznA:
undetectable		 6a94A-5jznA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A  44
GLY A 169
SER A 168
TRP A 161
VAL A 150
 None
 1.45A 6a94A-5kp7A:
undetectable		 6a94A-5kp7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		5 SER A 174
LEU A 207
VAL A 206
GLY A  58
PHE A 132
 None
 1.41A 6a94A-5kxqA:
undetectable		 6a94A-5kxqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1
VP3

(Black queen
cell virus;
Black queen
cell virus) 		PF08762
(CRPV_capsid)
no annotation 		5 SER C  28
VAL A 125
GLY A 166
PHE C  19
VAL A  51
 None
 1.42A 6a94A-5mqcC:
undetectable		 6a94A-5mqcC:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 SER A  21
LEU A 384
VAL A 127
GLY A 129
PHE A 367
 None
 1.14A 6a94A-5o0jA:
undetectable		 6a94A-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 5 LEU A  97
VAL A  96
GLY A 767
PHE A  85
ASN A  81
 None
 1.34A 6a94A-5w1aA:
undetectable		 6a94A-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 163
VAL A  15
GLY A  17
SER A  21
VAL A 178
 None
 1.44A 6a94A-5w4xA:
undetectable		 6a94A-5w4xA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 7 LEU A 187
VAL A 193
SER A 200
PHE A 403
TRP A 407
PHE A 410
PHE A 411
 AQD  A1201 (-4.5A)
AQD  A1201 (-3.9A)
AQD  A1201 (-3.6A)
None
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 0.67A 6a94A-5wivA:
31.5		 6a94A-5wivA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbc NSP1 PROTEIN

(Porcine
epidemic
diarrhea virus) 		no annotation 5 LEU A  70
VAL A  64
GLY A  86
SER A  45
PHE A  96
 None
 1.36A 6a94A-5xbcA:
undetectable		 6a94A-5xbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 SER A 220
GLY A 307
TRP A 356
ASN A 295
VAL A 207
 None
 1.07A 6a94A-5xbpA:
undetectable		 6a94A-5xbpA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		5 LEU A 722
SER A 637
PHE A 632
PHE A  36
PHE A 643
 None
 1.44A 6a94A-5xjyA:
undetectable		 6a94A-5xjyA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICB

(Streptococcus
pneumoniae) 		no annotation 5 VAL A  53
GLY A  50
SER A  46
PHE A   9
PHE A  25
 None
 1.12A 6a94A-5yrzA:
undetectable		 6a94A-5yrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		5 VAL A 224
GLY A 223
PHE A  34
PHE A 193
VAL A  30
 None
 1.16A 6a94A-6an0A:
undetectable		 6a94A-6an0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
SER A 138
LEU A 209
VAL A 215
GLY A 218
PHE A 320
TRP A 324
 None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
 0.87A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 TRP A 130
SER A 138
LEU A 209
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
VAL A 354
 None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.78A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
SER A 138
VAL A 215
GLY A 218
PHE A 320
TRP A 324
ASN A 331
 None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
None
 1.00A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 TRP A 130
SER A 138
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
ASN A 331
VAL A 354
 None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
 0.80A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 6 VAL A 190
SER A 197
PHE A 382
TRP A 386
PHE A 389
PHE A 390
 None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.47A 6a94A-6cm4A:
31.6		 6a94A-6cm4A:
33.18