SIMILAR PATTERNS OF AMINO ACIDS FOR 6A93_B_8NUB3001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 VAL A 160
THR A 164
LEU A 152
PHE A 184
VAL A 140
 None
 1.22A 6a93B-1hxjA:
undetectable		 6a93B-1hxjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly7 FRATAXIN

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		5 THR A 191
PHE A 110
PHE A 109
LEU A 132
VAL A 134
 None
 1.06A 6a93B-1ly7A:
undetectable		 6a93B-1ly7A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 580
TRP A 615
THR A 676
LEU A 592
PHE A 776
 None
 1.32A 6a93B-1nd7A:
undetectable		 6a93B-1nd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 SER A  69
VAL A  91
THR A 100
PHE A  47
PHE A   2
 None
 1.14A 6a93B-1o1uA:
undetectable		 6a93B-1o1uA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 TYR A 328
VAL A 392
SER A 432
THR A 431
LEU A 349
LEU A 408
 None
None
None
None
EST  A   1 ( 4.8A)
None
 1.49A 6a93B-1pcgA:
undetectable		 6a93B-1pcgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		5 TYR A  33
THR A  84
LEU A  66
LEU A  36
VAL A  97
 None
 1.37A 6a93B-1sh8A:
undetectable		 6a93B-1sh8A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		5 VAL A 353
THR A 316
LEU A 430
PHE A 277
LEU A 450
 None
 1.05A 6a93B-1slqA:
undetectable		 6a93B-1slqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 TYR A  92
THR A  82
LEU A  71
PHE A  49
LEU A  44
 TYR  A  92 ( 1.3A)
THR  A  82 ( 0.8A)
LEU  A  71 ( 0.6A)
PHE  A  49 ( 1.3A)
LEU  A  44 ( 0.6A)
 1.31A 6a93B-1szbA:
undetectable		 6a93B-1szbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		5 SER A  90
SER A  46
PHE A   5
PHE A  40
LEU A  79
 None
 1.36A 6a93B-1t1jA:
undetectable		 6a93B-1t1jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 SER A  43
VAL A  30
SER A 362
LEU A  15
LEU A 439
 None
 1.34A 6a93B-1w5dA:
undetectable		 6a93B-1w5dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjj HYPOTHETICAL PROTEIN
F20O9.120

(Arabidopsis
thaliana) 		no annotation 5 VAL A  93
THR A 120
LEU A  67
PHE A 125
VAL A  19
 None
 1.25A 6a93B-1wjjA:
undetectable		 6a93B-1wjjA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 THR A 306
LEU A  96
TRP A 310
LEU A 366
VAL A 394
 None
 1.30A 6a93B-1wl4A:
undetectable		 6a93B-1wl4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 TYR A 122
VAL A  28
LEU A 152
PHE A  17
LEU A 125
 None
 1.30A 6a93B-1z82A:
undetectable		 6a93B-1z82A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		5 TYR A  54
VAL A 284
LEU A 290
PHE A  69
VAL A 297
 None
 1.26A 6a93B-2a1rA:
undetectable		 6a93B-2a1rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A 840
THR A 849
LEU A 831
PHE A 824
PHE A 821
 None
 1.36A 6a93B-2b49A:
undetectable		 6a93B-2b49A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 VAL A 823
THR A 825
PHE A 987
PHE A 960
VAL A1065
 None
 1.35A 6a93B-2c3oA:
3.0		 6a93B-2c3oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 VAL A 823
THR A 825
TRP A 958
PHE A 987
PHE A 960
 None
 1.29A 6a93B-2c3oA:
3.0		 6a93B-2c3oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		5 VAL A 509
LEU A 567
PHE A 493
LEU A 524
VAL A 526
 None
 1.30A 6a93B-2ckhA:
undetectable		 6a93B-2ckhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8;
Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		5 TYR A  94
SER A 120
PHE B  52
PHE B  55
LEU B 130
 None
CSO  A 121 (-3.7A)
None
None
None
 1.10A 6a93B-2dppA:
undetectable		 6a93B-2dppA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		5 SER A  11
THR A 111
LEU A 127
LEU A  21
VAL A  23
 None
 1.22A 6a93B-2dt8A:
undetectable		 6a93B-2dt8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 VAL A 111
THR A 129
LEU A  83
PHE A 124
LEU A  91
 None
 1.33A 6a93B-2fi1A:
undetectable		 6a93B-2fi1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		5 SER A 102
THR A 100
PHE A  45
PHE A  42
LEU A   6
 None
 1.29A 6a93B-2fq1A:
undetectable		 6a93B-2fq1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbb TALIN-1

(Mus musculus) 		no annotation 5 TYR A1777
VAL A1807
THR A1811
PHE A1738
LEU A1668
 None
 1.33A 6a93B-2kbbA:
7.6		 6a93B-2kbbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly8 BUDDING YEAST
CHAPERONE SCM3

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF15511
(CENP-T_C) 		5 THR A 115
LEU A  35
PHE A  80
LEU A  81
VAL A  84
 None
 1.36A 6a93B-2ly8A:
undetectable		 6a93B-2ly8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0h DNA PACKAGING
PROTEIN GP17

(Escherichia
virus T4) 		PF03237
(Terminase_6) 		5 SER A 336
SER A 161
THR A 287
LEU A 345
LEU A  21
 None
 1.37A 6a93B-2o0hA:
undetectable		 6a93B-2o0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oix XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		5 LEU A 498
PHE A 400
PHE A 366
LEU A 412
VAL A 414
 None
 1.35A 6a93B-2oixA:
undetectable		 6a93B-2oixA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 VAL A 650
THR A 645
LEU A 675
LEU A 678
VAL A 681
 None
ADP  A1001 (-3.7A)
None
None
None
 1.36A 6a93B-2r6fA:
undetectable		 6a93B-2r6fA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		5 TYR A 179
VAL A 228
THR A 225
LEU A 194
VAL A 283
 None
 1.03A 6a93B-2wv9A:
undetectable		 6a93B-2wv9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 SER 3  92
VAL 3 202
LEU 3 105
PHE 3  77
LEU 3  79
 None
 1.28A 6a93B-2wzr3:
undetectable		 6a93B-2wzr3:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 581
PHE A 750
PHE A 749
LEU A 622
VAL A 626
 None
 1.31A 6a93B-3cemA:
undetectable		 6a93B-3cemA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		5 SER A 173
TYR A 196
VAL A 244
SER A 143
THR A 142
 None
 1.36A 6a93B-3ctyA:
undetectable		 6a93B-3ctyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d12 EPHRIN-B3

(Mus musculus) 		PF00812
(Ephrin) 		5 TYR B  51
LEU B  30
TRP B  35
LEU B 165
VAL B 163
 None
 1.19A 6a93B-3d12B:
undetectable		 6a93B-3d12B:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 VAL A 476
SER A 477
PHE A 533
LEU A 176
VAL A 532
 None
FMN  A1002 (-3.0A)
None
J5Z  A1001 ( 4.3A)
J5Z  A1001 (-4.2A)
 1.33A 6a93B-3i6rA:
undetectable		 6a93B-3i6rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		5 VAL A   7
THR A   9
LEU A 100
LEU A  92
VAL A 129
 None
 1.24A 6a93B-3iefA:
undetectable		 6a93B-3iefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ila RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF08709
(Ins145_P3_rec) 		5 SER A 183
THR A 184
LEU A 171
LEU A 118
VAL A 135
 None
 1.31A 6a93B-3ilaA:
undetectable		 6a93B-3ilaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		5 TYR A  96
SER A 136
THR A 135
LEU A 242
VAL A 127
 None
 1.17A 6a93B-3jclA:
undetectable		 6a93B-3jclA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		5 VAL A 184
LEU A  73
PHE A  17
LEU A  24
VAL A  22
 None
None
None
ACT  A 229 (-4.8A)
None
 1.13A 6a93B-3kmhA:
undetectable		 6a93B-3kmhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		5 VAL A 172
THR A 173
LEU A 155
PHE A   6
VAL A   8
 None
 1.30A 6a93B-3mvgA:
undetectable		 6a93B-3mvgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwj HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD) 		5 VAL A 125
THR A  79
LEU A  99
PHE A  55
VAL A 147
 None
 1.17A 6a93B-3mwjA:
undetectable		 6a93B-3mwjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		5 SER W 693
VAL W 616
SER W 821
PHE W 789
LEU W 727
 None
 1.34A 6a93B-3mwyW:
undetectable		 6a93B-3mwyW:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 VAL A 371
THR A 367
LEU A 250
LEU A 384
VAL A 383
 None
 1.10A 6a93B-3o57A:
undetectable		 6a93B-3o57A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 VAL B 227
LEU B 253
PHE B 239
PHE B 238
LEU B 266
 None
 1.27A 6a93B-3ogkB:
undetectable		 6a93B-3ogkB:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
THR A 115
TRP A 342
PHE A 345
PHE A 346
 ETQ  A1200 (-3.4A)
None
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
 0.44A 6a93B-3pblA:
33.4		 6a93B-3pblA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A 109
VAL A 114
THR A 118
TRP A 286
PHE A 289
PHE A 290
 None
ERC  A1201 (-3.8A)
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
 0.51A 6a93B-3pdsA:
30.8		 6a93B-3pdsA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL B 200
THR B 211
PHE B 214
LEU B 188
VAL B 143
 None
 1.24A 6a93B-3prxB:
undetectable		 6a93B-3prxB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 VAL X 403
SER X 402
THR X 499
PHE X 396
VAL X 459
 None
 1.33A 6a93B-3rwkX:
undetectable		 6a93B-3rwkX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 103
SER A 111
THR A 112
TRP A 428
PHE A 432
 None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
 0.58A 6a93B-3rzeA:
29.1		 6a93B-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 530
THR A 558
PHE A 592
LEU A 577
VAL A 572
 None
 1.34A 6a93B-3sqwA:
undetectable		 6a93B-3sqwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		5 VAL A 528
THR A 524
LEU A 375
LEU A 449
VAL A 448
 None
 1.29A 6a93B-3zrhA:
undetectable		 6a93B-3zrhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 VAL A 274
PHE A 293
PHE A 286
LEU A 296
VAL A 292
 None
 1.34A 6a93B-4a0hA:
undetectable		 6a93B-4a0hA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		5 VAL A 363
SER A 353
PHE A 321
LEU A 613
VAL A 611
 None
 1.14A 6a93B-4ascA:
undetectable		 6a93B-4ascA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkf EPHRIN-B3

(Homo sapiens) 		PF00812
(Ephrin) 		5 TYR C  51
LEU C  30
TRP C  35
LEU C 165
VAL C 163
 None
 1.18A 6a93B-4bkfC:
undetectable		 6a93B-4bkfC:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 TRP A  39
LEU A 293
PHE A 527
PHE A  32
VAL A 525
 None
 1.36A 6a93B-4btpA:
undetectable		 6a93B-4btpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 VAL A 176
SER A 175
THR A 174
LEU A  78
VAL A  74
 None
 1.20A 6a93B-4btpA:
undetectable		 6a93B-4btpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq6 ALLENE OXIDE CYCLASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06351
(Allene_ox_cyc) 		5 TYR A  92
SER A 111
LEU A  55
LEU A  99
VAL A 101
 None
 1.35A 6a93B-4cq6A:
undetectable		 6a93B-4cq6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		no annotation 5 TYR B1777
VAL B1807
THR B1811
PHE B1738
LEU B1668
 None
 1.36A 6a93B-4f7gB:
2.3		 6a93B-4f7gB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 VAL A 461
THR A 454
LEU A 483
LEU A 443
VAL A 366
 None
 1.27A 6a93B-4fwwA:
undetectable		 6a93B-4fwwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
VAL A 114
THR A 118
TRP A 258
PHE A 261
PHE A 262
 None
CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
 0.51A 6a93B-4gbrA:
31.1		 6a93B-4gbrA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 214
SER A 213
PHE A 206
PHE A 281
LEU A 199
 None
 1.34A 6a93B-4hkaA:
undetectable		 6a93B-4hkaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		5 VAL A  79
THR A  58
PHE A 120
LEU A 121
VAL A 124
 None
 1.37A 6a93B-4i6kA:
undetectable		 6a93B-4i6kA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
VAL A 136
SER A 139
THR A 140
PHE A 340
PHE A 341
VAL A 366
 None
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.2A)
 0.73A 6a93B-4ib4A:
36.2		 6a93B-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		8 TRP A 131
VAL A 136
SER A 139
TRP A 337
PHE A 340
PHE A 341
LEU A 362
VAL A 366
 None
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.2A)
 0.82A 6a93B-4ib4A:
36.2		 6a93B-4ib4A:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		5 VAL A 237
THR A 379
PHE A 362
LEU A 366
VAL A 365
 None
 1.33A 6a93B-4kavA:
undetectable		 6a93B-4kavA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 125
THR A  79
LEU A  99
PHE A  55
VAL A 147
 None
 1.10A 6a93B-4kbfA:
undetectable		 6a93B-4kbfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l18 RUNT-RELATED
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF00853
(Runt) 		5 VAL A 152
THR A 101
LEU A 148
PHE A 131
LEU A 134
 None
 1.33A 6a93B-4l18A:
undetectable		 6a93B-4l18A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A1109
VAL A1114
THR A1118
TRP A1286
PHE A1289
PHE A1290
 None
P0G  A1401 (-3.7A)
None
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
 0.70A 6a93B-4ldeA:
27.4		 6a93B-4ldeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 LEU A 305
PHE A 378
PHE A 375
LEU A 380
VAL A 379
 None
 1.33A 6a93B-4p69A:
undetectable		 6a93B-4p69A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 TYR 2 238
VAL 2  69
SER 2  68
LEU 2 236
LEU 2 199
 None
 1.28A 6a93B-4q4y2:
undetectable		 6a93B-4q4y2:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 VAL B 461
THR B 454
LEU B 483
LEU B 443
VAL B 366
 None
 1.31A 6a93B-4qt8B:
undetectable		 6a93B-4qt8B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 VAL A 119
THR A 129
PHE A  42
PHE A  41
VAL A  34
 None
None
None
CL  A 402 ( 3.8A)
None
 1.36A 6a93B-4rweA:
undetectable		 6a93B-4rweA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 SER A 289
VAL A 363
THR A 361
PHE A 310
VAL A 303
 None
 1.10A 6a93B-4u3wA:
undetectable		 6a93B-4u3wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqw PROTEIN CLPV1

(Pseudomonas
aeruginosa) 		PF02861
(Clp_N) 		5 SER A  60
SER A  51
LEU A 122
PHE A  42
LEU A 131
 None
 1.19A 6a93B-4uqwA:
undetectable		 6a93B-4uqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		5 SER A 261
VAL A 202
THR A 209
LEU A 161
LEU A 254
 None
 1.34A 6a93B-4xjxA:
undetectable		 6a93B-4xjxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 VAL A 302
SER A 303
TRP A  40
LEU A 125
VAL A 102
 None
 1.34A 6a93B-4y9sA:
undetectable		 6a93B-4y9sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		6 VAL A 448
SER A 451
THR A 452
PHE A 335
PHE A 397
VAL A 331
 None
 1.46A 6a93B-5diyA:
undetectable		 6a93B-5diyA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 TRP B 117
VAL B 122
THR B 126
TRP B 303
PHE B 306
PHE B 307
 P32  B 400 (-4.8A)
P32  B 400 (-3.5A)
None
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
 0.63A 6a93B-5f8uB:
31.1		 6a93B-5f8uB:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 VAL A 608
SER A 503
THR A 502
LEU A 723
PHE A 389
 None
 1.34A 6a93B-5favA:
undetectable		 6a93B-5favA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL C 306
SER C 307
THR C 308
PHE C 387
LEU C 191
 None
 1.26A 6a93B-5flzC:
undetectable		 6a93B-5flzC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER B 187
THR B 123
LEU B 169
PHE B 158
LEU B 182
 None
 1.37A 6a93B-5gqrB:
undetectable		 6a93B-5gqrB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG

(Homo sapiens) 		PF10341
(TPP1) 		5 SER A 165
THR A 164
TRP A 167
PHE A 173
LEU A 117
 None
 1.37A 6a93B-5i2xA:
undetectable		 6a93B-5i2xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		5 LEU A 498
PHE A 400
PHE A 366
LEU A 412
VAL A 414
 None
 1.30A 6a93B-5jp3A:
undetectable		 6a93B-5jp3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		5 VAL A 256
LEU A 154
PHE A 165
LEU A 190
VAL A 192
 None
None
None
None
PG4  A 523 (-3.7A)
 1.26A 6a93B-5kc9A:
undetectable		 6a93B-5kc9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 VAL A 416
SER A 412
THR A 417
LEU A 437
VAL A 385
 None
None
None
FAD  A 601 ( 4.0A)
None
 1.37A 6a93B-5m10A:
undetectable		 6a93B-5m10A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 SER A 225
SER A 316
THR A 329
PHE A 267
VAL A 253
 None
 0.99A 6a93B-5neuA:
undetectable		 6a93B-5neuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16)
PF00583
(Acetyltransf_1) 		5 TYR B 132
VAL A 321
SER A 323
THR A 324
VAL B  87
 None
 1.37A 6a93B-5nnpB:
undetectable		 6a93B-5nnpB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 TYR A 221
VAL A 130
THR A 131
LEU A 262
VAL A 186
 None
 1.09A 6a93B-5nwsA:
undetectable		 6a93B-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 5 SER A 371
SER A 239
THR A 238
LEU A 364
VAL A 265
 None
 0.97A 6a93B-5olkA:
undetectable		 6a93B-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 6 SER A 106
TRP A 125
THR A 134
TRP A 327
PHE A 330
PHE A 331
 None
None
89F  A1201 (-4.2A)
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
 0.53A 6a93B-5v54A:
33.5		 6a93B-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		5 SER A1233
VAL A1004
LEU A1239
PHE A 997
LEU A 993
 None
 1.35A 6a93B-5w0mA:
undetectable		 6a93B-5w0mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		5 SER A1233
VAL A1004
LEU A1239
PHE A1318
LEU A 993
 None
 1.29A 6a93B-5w0mA:
undetectable		 6a93B-5w0mA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 116
THR A 120
TRP A 407
PHE A 410
PHE A 411
 AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 0.72A 6a93B-5wivA:
34.8		 6a93B-5wivA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 5 TYR A 318
VAL A 275
PHE A 261
LEU A 285
VAL A 290
 None
 1.33A 6a93B-5wmmA:
undetectable		 6a93B-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		5 SER A 255
LEU A  95
PHE A 131
PHE A 130
LEU A 123
 None
 1.32A 6a93B-5wtfA:
undetectable		 6a93B-5wtfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 10 SER A 110
TRP A 130
VAL A 135
SER A 138
THR A 139
TRP A 324
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 ( 4.5A)
None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.58A 6a93B-6bqhA:
37.6		 6a93B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 10 SER A 110
TYR A 118
TRP A 130
VAL A 135
THR A 139
TRP A 324
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 ( 4.5A)
None
None
E2J  A1201 (-3.8A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.68A 6a93B-6bqhA:
37.6		 6a93B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 TYR A 286
VAL A 291
SER A 406
LEU A 311
VAL A 281
 EDO  A 506 (-4.2A)
None
None
EQG  A 504 ( 4.2A)
None
 1.34A 6a93B-6c4gA:
undetectable		 6a93B-6c4gA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 VAL A 115
THR A 119
TRP A 386
PHE A 389
PHE A 390
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.45A 6a93B-6cm4A:
32.1		 6a93B-6cm4A:
33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A  53
SER A  85
THR A  86
LEU A 262
VAL A 311
 None
 1.11A 6a93B-6fv4A:
undetectable		 6a93B-6fv4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 SER S 106
TRP S 125
THR S 134
PHE S 330
PHE S 331
 None
None
EP5  S 401 (-3.8A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 0.79A 6a93B-6g79S:
26.4		 6a93B-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 SER S 106
TRP S 125
TRP S 327
PHE S 330
PHE S 331
 None
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 0.72A 6a93B-6g79S:
26.4		 6a93B-6g79S:
undetectable