SIMILAR PATTERNS OF AMINO ACIDS FOR 6A93_A_8NUA3001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b97 RESTRICTION
ENDONUCLEASE ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		5 THR A  96
ILE A 103
LEU A  33
PHE A 105
PHE A  44
 None
 1.30A 6a93A-1b97A:
undetectable		 6a93A-1b97A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		5 SER A 162
THR A 159
PHE A 208
LEU A 226
TYR A 217
 None
 1.27A 6a93A-1bf6A:
undetectable		 6a93A-1bf6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 LEU A1437
TRP A1506
PHE A1231
PHE A1503
LEU A1445
 None
 1.42A 6a93A-1ihmA:
undetectable		 6a93A-1ihmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A1033
ILE A 942
PHE A 901
PHE A 897
LEU A 895
 None
 1.40A 6a93A-1kcwA:
undetectable		 6a93A-1kcwA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		5 SER A 205
THR A 195
ILE A 204
LEU A 157
PHE A 113
 None
 1.36A 6a93A-1l9xA:
undetectable		 6a93A-1l9xA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdm C-ETS-1 PROTEIN

(Mus musculus) 		PF00178
(Ets) 		5 LEU B 326
PHE B 414
PHE B 363
LEU B 418
TYR B 396
 None
 1.13A 6a93A-1mdmB:
undetectable		 6a93A-1mdmB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 580
TRP A 615
THR A 676
LEU A 592
PHE A 776
 None
 1.34A 6a93A-1nd7A:
undetectable		 6a93A-1nd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 THR A 336
ILE A 339
LEU A 240
PHE A  12
LEU A  13
 None
None
None
None
NAD  A1200 (-3.7A)
 1.11A 6a93A-1orrA:
undetectable		 6a93A-1orrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus) 		PF09212
(CBM27) 		5 ILE X 122
LEU X   9
PHE X 103
PHE X 160
LEU X 158
 None
 1.25A 6a93A-1pmjX:
undetectable		 6a93A-1pmjX:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu5 PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		5 SER A 657
ILE A 696
PHE A 577
LEU A 717
TYR A 649
 None
 1.39A 6a93A-1qu5A:
undetectable		 6a93A-1qu5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		5 SER A  90
SER A  46
PHE A   5
PHE A  40
LEU A  79
 None
 1.36A 6a93A-1t1jA:
undetectable		 6a93A-1t1jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		5 THR A 287
ILE A 286
LEU A 254
PHE A 232
LEU A 209
 None
 1.43A 6a93A-1uc4A:
undetectable		 6a93A-1uc4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmo HALOHYDRIN
DEHALOGENASE

(Arthrobacter
sp. AD2) 		PF13561
(adh_short_C2) 		5 SER A 134
ILE A 132
PHE A  12
PHE A 186
LEU A 197
 None
 1.27A 6a93A-1zmoA:
undetectable		 6a93A-1zmoA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 THR A 190
ILE A 194
LEU A 100
PHE A 169
LEU A 145
 None
 1.42A 6a93A-1zzmA:
undetectable		 6a93A-1zzmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 SER A  98
ILE A  26
PHE A  20
PHE A  71
LEU A 165
 None
 1.29A 6a93A-2c0nA:
undetectable		 6a93A-2c0nA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 THR A 257
ILE A 256
LEU A  83
PHE A  70
LEU A 165
 None
 1.37A 6a93A-2c7zA:
undetectable		 6a93A-2c7zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		5 SER A 102
THR A 100
PHE A  45
PHE A  42
LEU A   6
 None
 1.33A 6a93A-2fq1A:
undetectable		 6a93A-2fq1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge5 TYPE II RESTRICTION
ENZYME ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		5 THR A  96
ILE A 103
LEU A  33
PHE A 105
PHE A  44
 None
 1.30A 6a93A-2ge5A:
undetectable		 6a93A-2ge5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 SER A 963
SER A 917
LEU A 796
PHE A 943
TYR A 919
 None
 1.40A 6a93A-2j7nA:
2.7		 6a93A-2j7nA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 THR A 356
ILE A 352
LEU A 401
PHE A 347
LEU A 343
 None
 1.05A 6a93A-2osaA:
undetectable		 6a93A-2osaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 ILE A 101
LEU A 192
PHE A 106
PHE A 154
LEU A 177
 None
 1.12A 6a93A-2xotA:
undetectable		 6a93A-2xotA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A 241
ILE A 156
LEU A 142
PHE A 169
LEU A 172
 NAD  A 818 (-4.5A)
NAD  A 818 (-4.8A)
None
None
None
 1.07A 6a93A-3cgdA:
undetectable		 6a93A-3cgdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 THR A 356
ILE A 352
LEU A 401
PHE A 347
LEU A 343
 None
 1.12A 6a93A-3cxlA:
undetectable		 6a93A-3cxlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 THR A 240
ILE A 239
LEU A  57
PHE A 232
TYR A  87
 None
 1.07A 6a93A-3f9tA:
undetectable		 6a93A-3f9tA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 THR A 156
LEU A  13
PHE A 121
PHE A   6
PHE A   3
 None
 1.02A 6a93A-3gdeA:
undetectable		 6a93A-3gdeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 SER A 564
THR A 488
ILE A 489
LEU A 584
PHE A 549
 None
 1.29A 6a93A-3hjeA:
undetectable		 6a93A-3hjeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 SER A 416
THR A  57
ILE A  56
LEU A  92
PHE A  19
 None
 1.36A 6a93A-3i4xA:
undetectable		 6a93A-3i4xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 THR A 184
ILE A 182
LEU A 122
PHE A 239
LEU A 168
 None
 1.34A 6a93A-3iieA:
undetectable		 6a93A-3iieA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 TRP A 260
ILE A 172
LEU A 278
PHE A  59
LEU A  58
 None
 1.15A 6a93A-3islA:
undetectable		 6a93A-3islA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 THR A 149
ILE A 150
LEU A 346
PHE A 205
LEU A 363
 None
 1.34A 6a93A-3l01A:
undetectable		 6a93A-3l01A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A  79
SER A  17
LEU A  42
PHE A  91
PHE A  63
 None
 1.37A 6a93A-3l84A:
undetectable		 6a93A-3l84A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 SER A 429
THR A  90
LEU A  70
PHE A 307
LEU A 295
 None
 1.37A 6a93A-3lewA:
2.3		 6a93A-3lewA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 THR A 115
ILE A 118
PHE A 338
TRP A 342
PHE A 345
PHE A 346
TYR A 373
 None
None
None
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.54A 6a93A-3pblA:
31.4		 6a93A-3pblA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
THR A 118
ILE A 121
PHE A 282
TRP A 286
PHE A 289
PHE A 290
TYR A 316
 None
None
None
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
None
 0.69A 6a93A-3pdsA:
28.9		 6a93A-3pdsA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 SER A 286
THR A 285
ILE A 288
PHE A 273
TYR A 343
 None
 1.15A 6a93A-3q3hA:
undetectable		 6a93A-3q3hA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 SER A 131
ILE A 109
LEU A 171
PHE A 205
LEU A 153
 None
 1.19A 6a93A-3qvmA:
undetectable		 6a93A-3qvmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 103
SER A 111
THR A 112
ILE A 115
PHE A 424
TRP A 428
PHE A 432
TYR A 458
 None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.53A 6a93A-3rzeA:
27.4		 6a93A-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		5 SER A 112
SER A 283
THR A 282
PHE A 279
LEU A 229
 PEG  A 293 (-2.9A)
None
GOL  A 290 (-3.4A)
None
None
 1.24A 6a93A-3sbuA:
undetectable		 6a93A-3sbuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te6 REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		no annotation 5 SER A 599
THR A 598
ILE A 597
PHE A 608
TYR A 564
 None
 1.21A 6a93A-3te6A:
undetectable		 6a93A-3te6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 5 THR A 304
ILE A 305
LEU A 331
PHE A 386
PHE A 328
 None
 1.25A 6a93A-3tknA:
undetectable		 6a93A-3tknA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3z MICROCEPHALIN

(Homo sapiens) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		5 SER A 819
THR A 821
ILE A 820
PHE A 756
LEU A 833
 None
 1.19A 6a93A-3u3zA:
undetectable		 6a93A-3u3zA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 466
ILE A 384
LEU A 507
PHE A 542
LEU A 460
 None
 1.29A 6a93A-3uk1A:
undetectable		 6a93A-3uk1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul4 CELLULOSOME-ANCHORIN
G PROTEIN

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 THR A 127
ILE A  37
PHE A  69
PHE A 101
LEU A  56
 None
 1.44A 6a93A-3ul4A:
undetectable		 6a93A-3ul4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 5 SER A 125
SER A 129
ILE A 230
LEU A 254
PHE A  64
 None
 1.40A 6a93A-4ateA:
undetectable		 6a93A-4ateA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqa PROTEIN C-ETS-2

(Homo sapiens) 		PF00178
(Ets) 		5 LEU A 354
PHE A 442
PHE A 391
LEU A 446
TYR A 424
 None
 1.13A 6a93A-4bqaA:
undetectable		 6a93A-4bqaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eln TYPE III EFFECTOR
XOPAI

(Xanthomonas
citri) 		PF01129
(ART) 		5 ILE A 254
LEU A 177
TRP A 154
PHE A 226
LEU A 166
 None
 1.41A 6a93A-4elnA:
undetectable		 6a93A-4elnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
THR A 118
ILE A 121
PHE A 254
TRP A 258
PHE A 261
PHE A 262
TYR A 288
 None
CAU  A 500 ( 4.7A)
None
None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 0.67A 6a93A-4gbrA:
30.0		 6a93A-4gbrA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 182
LEU A 218
PHE A 197
PHE A 237
LEU A 255
 None
 1.42A 6a93A-4i3gA:
undetectable		 6a93A-4i3gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 ILE A  46
LEU A1114
PHE A1096
LEU A1079
TYR A 140
 None
 1.37A 6a93A-4i99A:
undetectable		 6a93A-4i99A:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 LEU A 132
PHE A 333
TRP A 337
PHE A 341
TYR A 370
 None
None
None
None
ERM  A2001 ( 4.8A)
 1.41A 6a93A-4ib4A:
36.7		 6a93A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
SER A 139
THR A 140
ILE A 143
PHE A 340
PHE A 341
TYR A 370
 None
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 0.73A 6a93A-4ib4A:
36.7		 6a93A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		8 TRP A 131
SER A 139
THR A 140
TRP A 337
PHE A 340
PHE A 341
LEU A 362
TYR A 370
 None
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.8A)
 0.76A 6a93A-4ib4A:
36.7		 6a93A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
THR A 140
ILE A 143
PHE A 333
PHE A 340
PHE A 341
TYR A 370
 None
ERM  A2001 (-3.9A)
None
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 0.90A 6a93A-4ib4A:
36.7		 6a93A-4ib4A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		8 TRP A 131
THR A 140
PHE A 333
TRP A 337
PHE A 340
PHE A 341
LEU A 362
TYR A 370
 None
ERM  A2001 (-3.9A)
None
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.8A)
 0.86A 6a93A-4ib4A:
36.7		 6a93A-4ib4A:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 5 ILE A 130
LEU A 554
PHE A 588
PHE A 573
LEU A 589
 None
 1.39A 6a93A-4iegA:
undetectable		 6a93A-4iegA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 SER A 290
THR A  10
ILE A   9
PHE A 197
LEU A 173
 None
 1.37A 6a93A-4jn6A:
undetectable		 6a93A-4jn6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 SER C 137
ILE C 136
LEU C 167
PHE C  55
TYR C 120
 1XL  C 401 (-2.9A)
None
None
None
1XL  C 401 (-3.9A)
 1.08A 6a93A-4lccC:
undetectable		 6a93A-4lccC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A1109
THR A1118
ILE A1121
PHE A1289
PHE A1290
TYR A1316
 None
None
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
None
 0.87A 6a93A-4ldeA:
26.1		 6a93A-4ldeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A1109
THR A1118
TRP A1286
PHE A1289
PHE A1290
TYR A1316
 None
None
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
None
 0.68A 6a93A-4ldeA:
26.1		 6a93A-4ldeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oso REDUCTASE HOMOLOG

(Streptomyces
cyanogenus) 		PF13561
(adh_short_C2) 		5 SER A 134
THR A  86
LEU A  94
PHE A  59
LEU A  74
 None
 1.40A 6a93A-4osoA:
undetectable		 6a93A-4osoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9a POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 SER A 291
THR A 498
ILE A 292
LEU A 283
LEU A 563
 None
 1.31A 6a93A-4p9aA:
undetectable		 6a93A-4p9aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9a POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 SER A 291
THR A 498
ILE A 292
PHE A 525
LEU A 563
 None
 1.42A 6a93A-4p9aA:
undetectable		 6a93A-4p9aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvj VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 489
TRP A 555
PHE A 227
PHE A 552
LEU A 497
 None
 1.44A 6a93A-4qvjA:
undetectable		 6a93A-4qvjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqw PROTEIN CLPV1

(Pseudomonas
aeruginosa) 		PF02861
(Clp_N) 		5 SER A  60
SER A  51
LEU A 122
PHE A  42
LEU A 131
 None
 1.18A 6a93A-4uqwA:
undetectable		 6a93A-4uqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A 124
ILE A 125
LEU A  20
PHE A  41
LEU A 202
 None
 1.38A 6a93A-4xeaA:
undetectable		 6a93A-4xeaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 SER A 155
ILE A 152
PHE A 450
PHE A 461
LEU A 503
 None
 1.39A 6a93A-4zuzA:
4.0		 6a93A-4zuzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 THR A1453
ILE A1458
PHE A1400
PHE A1488
TYR A1370
 None
 1.29A 6a93A-5a22A:
2.1		 6a93A-5a22A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF09440
(eIF3_N) 		5 SER E  46
TRP E 170
THR E 190
LEU E 178
PHE E 220
 None
 1.41A 6a93A-5a5tE:
undetectable		 6a93A-5a5tE:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		5 SER A  77
ILE A 173
PHE A 146
LEU A 149
TYR A 141
 None
 1.39A 6a93A-5djqA:
3.8		 6a93A-5djqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 ILE B 347
LEU B 229
PHE B 323
PHE B 278
LEU B 206
 None
 1.43A 6a93A-5dlqB:
undetectable		 6a93A-5dlqB:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
THR B 126
ILE B 129
PHE B 299
TRP B 303
PHE B 306
PHE B 307
TYR B 333
 P32  B 400 (-4.8A)
None
None
None
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-4.6A)
 0.69A 6a93A-5f8uB:
29.1		 6a93A-5f8uB:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 SER C 496
THR C 156
ILE C 192
LEU C 219
PHE C 140
 None
None
None
KCX  C 220 ( 4.0A)
None
 1.24A 6a93A-5fseC:
undetectable		 6a93A-5fseC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 TRP A  86
SER A  93
THR A  91
ILE A  94
LEU A  75
 GOL  A 506 (-4.3A)
None
PLP  A1222 (-3.5A)
None
None
 1.34A 6a93A-5ft6A:
undetectable		 6a93A-5ft6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 TRP A  86
SER A  93
THR A  91
ILE A  94
LEU A 286
 GOL  A 506 (-4.3A)
None
PLP  A1222 (-3.5A)
None
None
 1.37A 6a93A-5ft6A:
undetectable		 6a93A-5ft6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER B 187
THR B 123
LEU B 169
PHE B 158
LEU B 182
 None
 1.31A 6a93A-5gqrB:
undetectable		 6a93A-5gqrB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG

(Homo sapiens) 		PF10341
(TPP1) 		5 SER A 165
THR A 164
TRP A 167
PHE A 173
LEU A 117
 None
 1.38A 6a93A-5i2xA:
undetectable		 6a93A-5i2xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		5 SER A 569
THR A 568
ILE A 567
LEU A 680
LEU A 622
 None
 1.34A 6a93A-5j8jA:
undetectable		 6a93A-5j8jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD

(Escherichia
coli) 		PF07072
(ZapD) 		5 ILE A 158
TRP A 157
PHE A  44
PHE A  43
LEU A 139
 None
 1.41A 6a93A-5koaA:
3.2		 6a93A-5koaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 SER A 360
SER A 159
THR A 160
ILE A 161
LEU A 402
 None
 1.35A 6a93A-5tr1A:
3.6		 6a93A-5tr1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 SER A 301
SER A 330
LEU A 325
PHE A 247
PHE A 234
 None
 1.38A 6a93A-5uaoA:
undetectable		 6a93A-5uaoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 8 SER A 106
TRP A 125
THR A 134
ILE A 137
PHE A 323
TRP A 327
PHE A 330
PHE A 331
 None
None
89F  A1201 (-4.2A)
None
None
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
 0.87A 6a93A-5v54A:
32.7		 6a93A-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 8 SER A 106
TRP A 125
THR A 134
ILE A 137
TRP A 327
PHE A 330
PHE A 331
TYR A 359
 None
None
89F  A1201 (-4.2A)
None
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.63A 6a93A-5v54A:
32.7		 6a93A-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 THR A1449
ILE A1450
PHE A1868
PHE A1354
LEU A1506
 None
 1.27A 6a93A-5v6tA:
undetectable		 6a93A-5v6tA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 7 THR A 120
ILE A 123
PHE A 403
TRP A 407
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-4.4A)
None
None
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.78A 6a93A-5wivA:
34.4		 6a93A-5wivA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 THR A1240
ILE A1239
LEU A 525
PHE A1270
TYR A1124
 None
 1.44A 6a93A-5wlhA:
2.6		 6a93A-5wlhA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		5 SER A 255
LEU A  95
PHE A 131
PHE A 130
LEU A 123
 None
 1.38A 6a93A-5wtfA:
undetectable		 6a93A-5wtfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 ILE A  46
LEU A1114
PHE A1096
LEU A1079
TYR A 140
 None
 1.41A 6a93A-5xnsA:
6.1		 6a93A-5xnsA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 11 SER A 110
TRP A 130
SER A 138
THR A 139
ILE A 142
PHE A 320
TRP A 324
PHE A 327
PHE A 328
LEU A 350
TYR A 358
 E2J  A1201 ( 4.5A)
None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 (-3.5A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
None
 0.49A 6a93A-6bqhA:
36.7		 6a93A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 5 SER C 236
THR C 238
ILE C 237
LEU C  92
PHE C 306
 None
 1.44A 6a93A-6c4mC:
undetectable		 6a93A-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Saccharomyces
cerevisiae;
Influenza A
virus) 		no annotation 5 SER A 291
THR A 498
ILE A 292
LEU A 283
LEU A 563
 None
 1.34A 6a93A-6cfpA:
undetectable		 6a93A-6cfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Saccharomyces
cerevisiae;
Influenza A
virus) 		no annotation 5 SER A 291
THR A 498
ILE A 292
PHE A 525
LEU A 563
 None
 1.42A 6a93A-6cfpA:
undetectable		 6a93A-6cfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 SER A 460
SER A 152
THR A 153
ILE A 584
LEU A 172
 None
 1.27A 6a93A-6cgmA:
undetectable		 6a93A-6cgmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 6 THR A 119
PHE A 382
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.53A 6a93A-6cm4A:
29.9		 6a93A-6cm4A:
33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp0 -

(-) 		no annotation 5 SER A 152
ILE A 149
PHE A 445
PHE A 456
LEU A 498
 None
 1.44A 6a93A-6cp0A:
2.4		 6a93A-6cp0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 5 THR A 356
ILE A 359
PHE A 219
PHE A 340
LEU A 506
 None
 1.28A 6a93A-6dd6A:
undetectable		 6a93A-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 5 SER A 326
THR A 315
PHE A 494
PHE A 497
LEU A 490
 None
78M  A 614 ( 4.5A)
None
None
None
 1.21A 6a93A-6ei3A:
undetectable		 6a93A-6ei3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eua ANGIOPOIETIN-RELATED
PROTEIN 3

(Homo sapiens) 		no annotation 5 LEU A 362
PHE A 306
TRP A 314
PHE A 381
LEU A 351
 None
 1.32A 6a93A-6euaA:
undetectable		 6a93A-6euaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Mus musculus) 		no annotation 5 SER H 188
ILE H 187
LEU H 154
PHE H 242
LEU H 174
 None
 1.39A 6a93A-6g72H:
undetectable		 6a93A-6g72H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 7 SER S 106
TRP S 125
THR S 134
TRP S 327
PHE S 330
PHE S 331
TYR S 359
 None
None
EP5  S 401 (-3.8A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.81A 6a93A-6g79S:
24.9		 6a93A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 THR S 134
PHE S 323
TRP S 327
PHE S 330
PHE S 331
 EP5  S 401 (-3.8A)
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 1.34A 6a93A-6g79S:
24.9		 6a93A-6g79S:
undetectable