SIMILAR PATTERNS OF AMINO ACIDS FOR 6A7P_B_9SCB601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 VAL A 251
VAL A 103
LEU A 287
PHE A 118
LEU A 119
 None
 1.39A 6a7pB-1akcA:
undetectable		 6a7pB-1akcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		5 LEU A 335
VAL A 214
VAL A 202
LEU A 262
PHE A 299
 None
 1.37A 6a7pB-1guqA:
undetectable		 6a7pB-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 ILE A 773
VAL A 870
VAL A 903
ALA A 761
LEU A 847
 None
 1.45A 6a7pB-1hq0A:
undetectable		 6a7pB-1hq0A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ILE A 236
VAL A 230
LEU A 127
ARG A 130
LEU A 260
 None
 1.07A 6a7pB-1idmA:
undetectable		 6a7pB-1idmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A 140
VAL A  96
VAL A 125
LEU A  75
LEU A  40
 None
 1.33A 6a7pB-1k20A:
undetectable		 6a7pB-1k20A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A 140
VAL A 125
LEU A  75
PHE A   7
LEU A  40
 None
 0.81A 6a7pB-1k20A:
undetectable		 6a7pB-1k20A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 ILE A  56
VAL A  84
LEU A 249
PHE A 122
LEU A 144
 None
 1.42A 6a7pB-1p4aA:
undetectable		 6a7pB-1p4aA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli) 		PF02685
(Glucokinase) 		5 ILE A 218
VAL A 258
LEU A 248
ALA A 233
PHE A 277
 None
 1.44A 6a7pB-1q18A:
0.2		 6a7pB-1q18A:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ILE A 388
VAL A 433
ALA A 449
LEU A 460
ARG A 485
 None
 0.63A 6a7pB-1tf0A:
47.9		 6a7pB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 423
VAL A 426
VAL A 433
ALA A 449
LEU A 460
PHE A 488
LEU A 491
 None
 0.45A 6a7pB-1tf0A:
47.9		 6a7pB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LYS A 414
LEU A 423
VAL A 426
LEU A 460
LEU A 491
 None
 0.78A 6a7pB-1tf0A:
47.9		 6a7pB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LYS A 414
VAL A 415
LEU A 423
LEU A 460
LEU A 491
 None
 0.90A 6a7pB-1tf0A:
47.9		 6a7pB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 VAL A 426
VAL A 433
ALA A 449
LEU A 460
ARG A 485
PHE A 488
 None
 0.49A 6a7pB-1tf0A:
47.9		 6a7pB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 ILE A 356
VAL A 427
LEU A 298
PHE A 239
LEU A 334
 None
 1.48A 6a7pB-1vl4A:
undetectable		 6a7pB-1vl4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 310
LEU A 320
VAL A 398
PHE A 447
LEU A 441
 None
NAD  A1001 ( 4.5A)
None
None
None
 1.31A 6a7pB-2d3tA:
0.7		 6a7pB-2d3tA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 320
VAL A 398
ALA A 311
PHE A 447
LEU A 441
 NAD  A1001 ( 4.5A)
None
None
None
None
 1.34A 6a7pB-2d3tA:
0.7		 6a7pB-2d3tA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 ILE A 349
VAL A 206
VAL A 324
ARG A 221
LEU A 182
 None
None
None
NGA  A 702 (-3.6A)
None
 1.17A 6a7pB-2d7iA:
undetectable		 6a7pB-2d7iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ott T-CELL SURFACE
GLYCOPROTEIN CD5

(Homo sapiens) 		PF00530
(SRCR) 		5 VAL X   9
VAL X  24
VAL X  64
ALA X  67
ARG X  91
 None
 1.44A 6a7pB-2ottX:
undetectable		 6a7pB-2ottX:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 ILE A  84
VAL A  16
LEU A 186
ALA A 123
LEU A  12
 None
 1.14A 6a7pB-2vrcA:
undetectable		 6a7pB-2vrcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 ILE A  84
VAL A  16
LEU A 186
ALA A 123
LEU A 138
 None
 1.13A 6a7pB-2vrcA:
undetectable		 6a7pB-2vrcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 VAL A 303
VAL A 391
ALA A 339
PHE A  22
LEU A 378
 None
 1.39A 6a7pB-3caiA:
undetectable		 6a7pB-3caiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 167
VAL B 181
ALA B 158
LEU B 147
LEU B 304
 None
 1.19A 6a7pB-3dm9B:
4.2		 6a7pB-3dm9B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 ILE B  30
LEU B 306
LEU B 336
PHE B 415
LEU B 413
 None
 1.50A 6a7pB-3dw8B:
undetectable		 6a7pB-3dw8B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 VAL A 135
LEU A  23
ARG A  12
PHE A  11
LEU A  84
 None
 1.42A 6a7pB-3fy4A:
undetectable		 6a7pB-3fy4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 ILE A  50
VAL A 213
VAL A  93
ALA A 268
LEU A 215
 None
 1.49A 6a7pB-3hwpA:
undetectable		 6a7pB-3hwpA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		5 ILE 1 609
VAL 1 474
LEU 1 436
PHE 1 401
LEU 1 425
 None
 1.35A 6a7pB-3izq1:
0.4		 6a7pB-3izq1:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE A 278
VAL A 446
VAL A 359
ALA A 431
LEU A 443
 None
 1.50A 6a7pB-3j04A:
undetectable		 6a7pB-3j04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 5 VAL A 119
LEU A 470
LEU A 222
PHE A 212
LEU A 209
 None
 1.34A 6a7pB-3j26A:
undetectable		 6a7pB-3j26A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		5 VAL A 121
ALA A 210
ARG A   8
PHE A  35
LEU A  37
 None
None
ACT  A 251 ( 3.9A)
None
None
 1.39A 6a7pB-3ks5A:
undetectable		 6a7pB-3ks5A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l43 DYNAMIN-3

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 VAL A  36
VAL A 234
LEU A 277
PHE A  51
LEU A 134
 None
 1.39A 6a7pB-3l43A:
undetectable		 6a7pB-3l43A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwz 3-DEHYDROQUINATE
DEHYDRATASE

(Yersinia pestis) 		PF01220
(DHquinase_II) 		5 ILE A  61
VAL A  47
VAL A  95
ALA A  91
LEU A  49
 None
 0.87A 6a7pB-3lwzA:
undetectable		 6a7pB-3lwzA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
PF00287
(Na_K-ATPase) 		5 ILE B  61
LEU A 990
VAL A 864
ALA A 867
LEU A 856
 None
 1.43A 6a7pB-3n23B:
undetectable		 6a7pB-3n23B:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXX

(Starkeya
novella) 		PF00034
(Cytochrom_C) 		5 VAL B 195
LEU B 199
ALA B 174
PHE B 181
LEU B 187
 HEC  B 401 ( 4.6A)
None
None
HEC  B 401 (-3.8A)
None
 1.22A 6a7pB-3ocdB:
undetectable		 6a7pB-3ocdB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXX

(Starkeya
novella) 		PF00034
(Cytochrom_C) 		5 VAL B 195
LEU B 199
ARG B 180
PHE B 181
LEU B 187
 HEC  B 401 ( 4.6A)
None
None
HEC  B 401 (-3.8A)
None
 1.18A 6a7pB-3ocdB:
undetectable		 6a7pB-3ocdB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 276
VAL A 301
LEU A 304
ALA A 205
PHE A 247
 None
 1.41A 6a7pB-3plrA:
undetectable		 6a7pB-3plrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A  13
VAL A  56
ALA A  70
PHE A  88
LEU A 250
 None
 1.36A 6a7pB-4a14A:
undetectable		 6a7pB-4a14A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 VAL A 234
ALA A 158
LEU A 179
PHE A 202
LEU A 262
 None
 1.43A 6a7pB-4e2zA:
undetectable		 6a7pB-4e2zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwr PROTEIN
DISULFIDE-ISOMERASE
A6

(Homo sapiens) 		PF00085
(Thioredoxin) 		5 VAL A 220
VAL A 162
ALA A 204
PHE A 243
LEU A 175
 None
 1.38A 6a7pB-4gwrA:
undetectable		 6a7pB-4gwrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 VAL A 183
LEU A 220
ARG A 246
PHE A 222
LEU A 387
 VAL  A 183 ( 0.6A)
LEU  A 220 ( 0.6A)
ARG  A 246 ( 0.6A)
PHE  A 222 ( 1.3A)
LEU  A 387 ( 0.6A)
 1.45A 6a7pB-4iknA:
undetectable		 6a7pB-4iknA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		5 ILE A 419
VAL A 366
ALA A 334
LEU A 371
ARG A 415
 EDO  A 505 (-4.7A)
None
None
None
EDO  A 504 (-4.2A)
 1.48A 6a7pB-4j7hA:
undetectable		 6a7pB-4j7hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 ILE A 227
VAL A 328
VAL A 255
ALA A 252
LEU A 317
 None
 1.47A 6a7pB-4kh3A:
undetectable		 6a7pB-4kh3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 ILE A 766
VAL A 553
VAL A 608
ALA A 715
LEU A 510
 None
 1.15A 6a7pB-4l1mA:
undetectable		 6a7pB-4l1mA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp7 MATRIX PROTEIN M

(Human
metapneumovirus) 		PF03393
(Pneumo_matrix) 		5 ILE A 203
VAL A   6
ALA A 195
PHE A  36
LEU A  84
 None
 1.50A 6a7pB-4lp7A:
undetectable		 6a7pB-4lp7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 172
VAL A 175
VAL A 183
LEU A 160
LEU A 460
 None
 1.36A 6a7pB-4ny4A:
undetectable		 6a7pB-4ny4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 ILE A  35
VAL A1281
ALA A  32
PHE A1320
LEU A1179
 None
 1.33A 6a7pB-4pj3A:
undetectable		 6a7pB-4pj3A:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 423
VAL A 433
LEU A 460
ARG A 485
PHE A 488
LEU A 491
 None
 0.63A 6a7pB-4po0A:
45.4		 6a7pB-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LYS A 414
LEU A 423
LEU A 460
PHE A 488
LEU A 491
 NPS  A 601 (-2.7A)
None
None
None
None
 0.90A 6a7pB-4po0A:
45.4		 6a7pB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 VAL A 554
ALA A 144
LEU A 273
PHE A 134
LEU A 130
 None
 1.28A 6a7pB-4uirA:
undetectable		 6a7pB-4uirA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 VAL A 422
ALA A 453
LEU A 443
PHE A 345
LEU A 303
 None
 1.41A 6a7pB-4uqgA:
1.5		 6a7pB-4uqgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ILE A 129
LEU A 388
LEU A  59
ARG A 143
LEU A 396
 None
 1.47A 6a7pB-4y9lA:
undetectable		 6a7pB-4y9lA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LYS A 324
VAL A 325
VAL A 440
VAL A 526
LEU A 445
 None
 1.17A 6a7pB-4ye5A:
undetectable		 6a7pB-4ye5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zij THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Escherichia
coli) 		PF01323
(DSBA) 		5 VAL A  16
VAL A  46
ALA A 179
PHE A 154
LEU A  12
 None
 1.48A 6a7pB-4zijA:
undetectable		 6a7pB-4zijA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 VAL A  36
ALA A 253
LEU A 277
PHE A  51
LEU A  48
 None
 1.26A 6a7pB-5d3qA:
undetectable		 6a7pB-5d3qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 VAL A  36
ALA A 254
LEU A 277
PHE A  51
LEU A  48
 None
 1.18A 6a7pB-5d3qA:
undetectable		 6a7pB-5d3qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 VAL A 184
VAL A 177
ALA A 444
LEU A 244
LEU A 508
 None
 1.27A 6a7pB-5djsA:
undetectable		 6a7pB-5djsA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 422
LEU A 459
ARG A 484
PHE A 487
LEU A 490
 None
 0.62A 6a7pB-5dqfA:
45.2		 6a7pB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 422
VAL A 432
LEU A 459
PHE A 487
LEU A 490
 None
 0.58A 6a7pB-5dqfA:
45.2		 6a7pB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LYS A 413
LEU A 422
VAL A 432
LEU A 459
LEU A 490
 None
 0.92A 6a7pB-5dqfA:
45.2		 6a7pB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ILE A 199
VAL A 394
ALA A 204
PHE A 230
LEU A 253
 None
 1.37A 6a7pB-5e84A:
undetectable		 6a7pB-5e84A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 109
VAL A 510
LEU A  45
VAL A  31
LEU A 506
 None
 1.17A 6a7pB-5eb5A:
undetectable		 6a7pB-5eb5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		5 ILE B 387
VAL B 198
VAL B 185
VAL B  96
ALA B 234
 None
 1.42A 6a7pB-5fn3B:
undetectable		 6a7pB-5fn3B:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LEU A 423
VAL A 426
ALA A 449
LEU A 460
ARG A 485
PHE A 488
 None
 0.84A 6a7pB-5ghkA:
44.7		 6a7pB-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LEU A 423
VAL A 426
LEU A 460
ARG A 485
PHE A 488
LEU A 491
 None
 0.87A 6a7pB-5ghkA:
44.7		 6a7pB-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LEU A 423
VAL A 426
VAL A 433
ALA A 449
LEU A 460
PHE A 488
 None
 0.86A 6a7pB-5ghkA:
44.7		 6a7pB-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LEU A 423
VAL A 426
VAL A 433
LEU A 460
PHE A 488
LEU A 491
 None
 0.69A 6a7pB-5ghkA:
44.7		 6a7pB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		5 VAL A 242
LEU A 224
VAL A 350
ALA A 346
LEU A 274
 None
 1.13A 6a7pB-5lxgA:
undetectable		 6a7pB-5lxgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ILE B 752
VAL B 810
ALA B 756
LEU B 800
LEU B 563
 None
 1.05A 6a7pB-5my0B:
undetectable		 6a7pB-5my0B:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 422
VAL A 432
LEU A 459
ARG A 484
PHE A 487
LEU A 490
 None
 0.56A 6a7pB-5oriA:
44.3		 6a7pB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		5 ILE A 379
VAL A 392
ALA A 297
LEU A 398
LEU A 146
 None
 1.09A 6a7pB-5u7wA:
undetectable		 6a7pB-5u7wA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxx RNA POLYMERASE SIGMA
FACTOR

(Bartonella
quintana) 		no annotation 5 LEU A  41
VAL A  37
LEU A  19
ARG A  66
PHE A  62
 None
 1.41A 6a7pB-5uxxA:
2.5		 6a7pB-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 198
LEU A  85
VAL A  81
VAL A 220
PHE A  73
 None
 1.48A 6a7pB-5vk4A:
undetectable		 6a7pB-5vk4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 LEU A 423
VAL A 426
VAL A 433
ALA A 449
LEU A 460
PHE A 488
LEU A 491
 None
 0.51A 6a7pB-5yxeA:
45.0		 6a7pB-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LYS A 414
VAL A 415
LEU A 423
VAL A 426
LEU A 460
LEU A 491
 None
 0.79A 6a7pB-5yxeA:
45.0		 6a7pB-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 VAL A 415
LEU A 423
VAL A 426
LEU A 460
PHE A 488
LEU A 491
 None
 0.65A 6a7pB-5yxeA:
45.0		 6a7pB-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 5 ILE A  16
VAL A 107
VAL A  49
VAL A  29
ALA A  19
 None
 1.47A 6a7pB-6f8yA:
undetectable		 6a7pB-6f8yA:
undetectable