SIMILAR PATTERNS OF AMINO ACIDS FOR 6A7P_A_9SCA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE


(Homo sapiens;
Homo sapiens)
PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2)
4 ASN B 202
VAL A 105
LEU A 103
SER B 215
None
1.32A 6a7pA-1apyB:
undetectable
6a7pA-1apyB:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT


(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 ASN A 282
VAL A 435
LEU A 241
SER A 423
None
1.12A 6a7pA-1ddgA:
undetectable
6a7pA-1ddgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
4 ASN A 291
VAL A 283
LEU A 274
SER A 314
None
1.22A 6a7pA-1e43A:
undetectable
6a7pA-1e43A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus)
PF00160
(Pro_isomerase)
PF13176
(TPR_7)
4 TYR A 110
VAL A 148
LEU A 117
SER A  11
None
1.10A 6a7pA-1iipA:
4.3
6a7pA-1iipA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1


(Homo sapiens)
PF01704
(UDPGP)
4 ASN A 495
VAL A 481
LEU A 477
SER A 467
None
1.31A 6a7pA-1jv1A:
undetectable
6a7pA-1jv1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18E


(Haloarcula
marismortui)
PF00828
(Ribosomal_L27A)
4 ASN P 104
VAL P  29
LEU P  33
SER P  97
None
1.32A 6a7pA-1kc8P:
undetectable
6a7pA-1kc8P:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli)
PF01709
(Transcrip_reg)
4 ASN A 107
TYR A  87
VAL A 229
LEU A 223
None
1.09A 6a7pA-1konA:
2.8
6a7pA-1konA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575


(Aquifex
aeolicus)
PF01709
(Transcrip_reg)
4 ASN A 107
TYR A  87
VAL A 231
LEU A 225
None
1.07A 6a7pA-1lfpA:
2.3
6a7pA-1lfpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 201
VAL A 200
LEU A  67
SER A 110
None
None
None
GSH  A 500 (-2.5A)
1.23A 6a7pA-1m0uA:
3.1
6a7pA-1m0uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN


(Gallus gallus;
Gallus gallus;
Gallus gallus)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
4 ASN C  30
TYR A  63
VAL B  98
LEU B 102
None
1.24A 6a7pA-1m1jC:
undetectable
6a7pA-1m1jC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE


(Equine
arteritis virus)
PF05579
(Peptidase_S32)
4 ASN A  30
VAL A  34
LEU A  58
SER A  74
None
1.28A 6a7pA-1mbmA:
undetectable
6a7pA-1mbmA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)


(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
4 ASN A 514
VAL A 432
LEU A 425
SER A 552
None
1.30A 6a7pA-1qhvA:
undetectable
6a7pA-1qhvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
PF00608
(Adeno_shaft)
4 ASN A 514
VAL A 432
LEU A 425
SER A 552
None
1.26A 6a7pA-1qiuA:
undetectable
6a7pA-1qiuA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe)
PF00307
(CH)
4 ASN A 195
VAL A 390
LEU A 603
SER A 610
None
1.25A 6a7pA-1rt8A:
undetectable
6a7pA-1rt8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA
FAB 17-IA


(Mus musculus;
Mus musculus)
PF07686
(V-set)
PF07686
(V-set)
4 ASN H  97
VAL L  58
LEU L  54
SER L  50
None
1.14A 6a7pA-1rvfH:
undetectable
6a7pA-1rvfH:
12.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 ASN A 391
TYR A 411
VAL A 426
LEU A 460
SER A 489
None
1.04A 6a7pA-1tf0A:
47.4
6a7pA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd2 PROTEIN KINASE C,
IOTA TYPE


(Homo sapiens)
PF00564
(PB1)
4 ASN A  43
VAL A  19
LEU A  92
SER A  37
None
1.31A 6a7pA-1vd2A:
undetectable
6a7pA-1vd2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF00291
(PALP)
4 ASN A  72
TYR A 172
VAL A 199
SER A 288
PLP  A 413 (-3.6A)
PLP  A 413 (-4.4A)
None
None
1.23A 6a7pA-1ve1A:
undetectable
6a7pA-1ve1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis)
PF01391
(Collagen)
4 ASN A 108
VAL A 191
LEU A 151
SER A 205
None
1.32A 6a7pA-1wckA:
undetectable
6a7pA-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis)
PF01391
(Collagen)
4 ASN A 108
VAL A 193
LEU A 198
SER A 205
None
1.13A 6a7pA-1wckA:
undetectable
6a7pA-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgd HOMOCYSTEINE-RESPONS
IVE ENDOPLASMIC
RETICULUM-RESIDENT
UBIQUITIN-LIKE
DOMAIN MEMBER 1
PROTEIN


(Homo sapiens)
PF00240
(ubiquitin)
4 TYR A  43
VAL A  42
LEU A  24
SER A  14
None
1.20A 6a7pA-1wgdA:
undetectable
6a7pA-1wgdA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus)
PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro)
4 ASN A 184
TYR A 384
VAL A 329
SER A 379
None
1.22A 6a7pA-1x9yA:
undetectable
6a7pA-1x9yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT


(Thermotoga
maritima)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
4 ASN A 496
TYR A 512
VAL A 529
LEU A 527
None
1.31A 6a7pA-1xjeA:
undetectable
6a7pA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)


(Escherichia
virus phiX174)
PF02306
(Phage_G)
4 TYR 2 107
VAL 2  92
LEU 2  57
SER 2  27
None
1.14A 6a7pA-2bpa2:
undetectable
6a7pA-2bpa2:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
4 ASN A  44
VAL A  56
LEU A  60
SER A  75
None
1.30A 6a7pA-2ch1A:
undetectable
6a7pA-2ch1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Synechococcus
sp.)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ASN A  36
VAL A   5
LEU A  94
SER A  98
NAP  A1341 (-4.2A)
None
None
None
1.31A 6a7pA-2d2iA:
undetectable
6a7pA-2d2iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
4 ASN A 569
VAL A 288
LEU A 815
SER A 346
None
FAD  A1001 (-4.9A)
None
None
1.03A 6a7pA-2dw4A:
4.3
6a7pA-2dw4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE


(Aquifex
aeolicus)
PF02153
(PDH)
4 TYR A  61
VAL A  87
LEU A  34
SER A  99
NAD  A3686 (-4.2A)
None
None
NAD  A3686 (-4.6A)
1.24A 6a7pA-2g5cA:
undetectable
6a7pA-2g5cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 ASN A3094
TYR A3000
LEU A2937
SER A3127
None
1.27A 6a7pA-2h84A:
undetectable
6a7pA-2h84A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Mimivirus)
PF00160
(Pro_isomerase)
4 ASN A  24
VAL A 179
LEU A  31
SER A 199
None
1.19A 6a7pA-2oseA:
undetectable
6a7pA-2oseA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ASN A 371
VAL A 470
LEU A 526
SER A 377
None
1.17A 6a7pA-2q27A:
undetectable
6a7pA-2q27A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
4 ASN B 203
VAL B 354
LEU B 317
SER B 109
None
1.11A 6a7pA-2q2eB:
undetectable
6a7pA-2q2eB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE


(Plasmodium
vivax)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 ASN B 183
TYR B 276
LEU B 372
SER B 165
None
1.27A 6a7pA-2qgaB:
2.9
6a7pA-2qgaB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE


(Paraburkholderia
xenovorans)
PF12697
(Abhydrolase_6)
4 ASN A  75
VAL A  56
LEU A   4
SER A  10
None
1.23A 6a7pA-2ri6A:
undetectable
6a7pA-2ri6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Staphylococcus
aureus)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
4 ASN A 281
TYR A 297
VAL A 331
LEU A 323
None
1.27A 6a7pA-2wqdA:
undetectable
6a7pA-2wqdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0x SENSOR PROTEIN

(Thermotoga
maritima)
PF02518
(HATPase_c)
4 ASN A 610
VAL A 654
LEU A 658
SER A 676
None
1.17A 6a7pA-3a0xA:
undetectable
6a7pA-3a0xA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN

(Bacillus
anthracis)
no annotation 4 ASN A 108
VAL A 193
LEU A 198
SER A 205
None
0.87A 6a7pA-3ab0A:
undetectable
6a7pA-3ab0A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
4 TYR A  38
VAL A 475
LEU A 455
SER A 510
None
None
None
EDO  A8301 (-2.3A)
1.18A 6a7pA-3al9A:
undetectable
6a7pA-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
4 ASN A 369
VAL A 348
LEU A 346
SER A 331
None
1.03A 6a7pA-3aupA:
undetectable
6a7pA-3aupA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans)
no annotation 4 ASN A 733
TYR A 681
VAL A 684
LEU A 700
None
1.25A 6a7pA-3c2gA:
3.2
6a7pA-3c2gA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
PF12704
(MacB_PCD)
4 ASN A 490
VAL A 483
LEU A 348
SER A 497
None
1.20A 6a7pA-3ftjA:
undetectable
6a7pA-3ftjA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 ASN A 328
TYR A 289
VAL A 383
LEU A 348
None
1.31A 6a7pA-3hhdA:
undetectable
6a7pA-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans)
no annotation 4 ASN A 330
TYR A 364
VAL A  96
LEU A  45
None
1.29A 6a7pA-3hkaA:
undetectable
6a7pA-3hkaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
4 ASN A 595
VAL A 444
LEU A 451
SER A 419
None
1.26A 6a7pA-3hs0A:
undetectable
6a7pA-3hs0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)


(Legionella
pneumophila)
PF00378
(ECH_1)
4 TYR A 149
VAL A 145
LEU A  88
SER A  94
None
1.19A 6a7pA-3i47A:
3.7
6a7pA-3i47A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe)
PF08389
(Xpo1)
4 ASN T 229
VAL T 214
LEU T 151
SER T 190
None
1.29A 6a7pA-3icqT:
2.2
6a7pA-3icqT:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B


(Legionella
pneumophila)
PF00501
(AMP-binding)
4 ASN A 447
VAL A 358
LEU A 348
SER A 373
None
1.23A 6a7pA-3kxwA:
undetectable
6a7pA-3kxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2


(Sulfolobus
solfataricus)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 TYR A 225
VAL A 194
LEU A 262
SER A 256
None
1.21A 6a7pA-3l7zA:
undetectable
6a7pA-3l7zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9k RE64145P

(Drosophila
melanogaster)
PF03259
(Robl_LC7)
4 ASN A  94
VAL A  81
LEU A  70
SER A  74
None
1.29A 6a7pA-3l9kA:
undetectable
6a7pA-3l9kA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
4 ASN A 688
TYR A 410
VAL A 416
LEU A 415
None
1.30A 6a7pA-3la4A:
undetectable
6a7pA-3la4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE


(Francisella
tularensis)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 ASN A 303
TYR A 194
VAL A  67
LEU A  83
None
SO4  A 400 (-4.9A)
None
None
1.15A 6a7pA-3qtyA:
undetectable
6a7pA-3qtyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis)
PF05053
(Menin)
4 ASN A  26
VAL A  37
LEU A  10
SER A   5
None
1.17A 6a7pA-3re2A:
undetectable
6a7pA-3re2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 TYR A 610
VAL A 728
LEU A 829
SER A 596
None
1.13A 6a7pA-3s9vA:
2.3
6a7pA-3s9vA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus)
PF00085
(Thioredoxin)
PF04777
(Evr1_Alr)
4 ASN A 246
VAL A 216
LEU A 266
SER A 250
None
1.19A 6a7pA-3t58A:
undetectable
6a7pA-3t58A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-BETA-1

(Mus musculus)
PF00536
(SAM_1)
PF07647
(SAM_2)
4 ASN C 768
VAL C 683
LEU C 709
SER C 730
None
1.19A 6a7pA-3tadC:
undetectable
6a7pA-3tadC:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis)
no annotation 4 ASN A 108
VAL A 193
LEU A 198
SER A 205
None
1.19A 6a7pA-3tyjA:
undetectable
6a7pA-3tyjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ASN A 572
VAL A 609
LEU A 613
SER A 246
None
1.26A 6a7pA-3vf1A:
3.8
6a7pA-3vf1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans)
PF13199
(Glyco_hydro_66)
4 ASN A 248
TYR A 115
VAL A 208
LEU A 179
None
1.22A 6a7pA-3vmnA:
undetectable
6a7pA-3vmnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus)
PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD)
4 ASN A 359
VAL A 618
LEU A 614
SER A 724
U  C1670 ( 3.9A)
None
None
A  C1668 ( 4.7A)
1.24A 6a7pA-3wqyA:
2.7
6a7pA-3wqyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
4 ASN A 100
VAL A 225
LEU A 155
SER A 131
None
None
None
FMN  A 500 (-4.1A)
1.30A 6a7pA-3x0yA:
2.2
6a7pA-3x0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN


(Homo sapiens)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
4 ASN A 650
TYR A 344
VAL A 468
LEU A 660
None
1.29A 6a7pA-4bejA:
2.4
6a7pA-4bejA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE


(Drosophila
melanogaster)
PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2)
4 ASN A 228
TYR A 342
VAL A 338
LEU A 413
None
1.23A 6a7pA-4c0jA:
undetectable
6a7pA-4c0jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3q TRANSCRIPTIONAL
REGULATORY PROTEIN
CBU_1566


(Coxiella
burnetii)
PF01709
(Transcrip_reg)
4 ASN A 107
TYR A  87
VAL A 230
LEU A 224
None
1.08A 6a7pA-4f3qA:
2.4
6a7pA-4f3qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3


(Legionella
pneumophila)
no annotation 4 ASN A 242
TYR A 357
VAL A 360
LEU A 655
None
1.30A 6a7pA-4fyeA:
2.6
6a7pA-4fyeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE


(Methylococcus
capsulatus)
PF00815
(Histidinol_dh)
4 ASN A 174
VAL A 186
LEU A 162
SER A 146
None
1.24A 6a7pA-4gicA:
undetectable
6a7pA-4gicA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3o LECTIN

(Allium sativum)
PF01453
(B_lectin)
4 ASN A  44
VAL A  95
LEU A  89
SER A  39
None
1.30A 6a7pA-4h3oA:
undetectable
6a7pA-4h3oA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE


(Leishmania
infantum)
PF00155
(Aminotran_1_2)
4 ASN A  59
TYR A 398
VAL A 409
LEU A 421
None
1.16A 6a7pA-4ix8A:
undetectable
6a7pA-4ix8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1


(Escherichia
coli)
PF07690
(MFS_1)
4 ASN A 324
VAL A 354
LEU A 335
SER A 269
None
None
None
GYP  A 502 ( 4.8A)
1.29A 6a7pA-4jreA:
3.2
6a7pA-4jreA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus)
PF00085
(Thioredoxin)
PF04777
(Evr1_Alr)
4 ASN A 246
VAL A 216
LEU A 266
SER A 250
None
1.02A 6a7pA-4p2lA:
2.0
6a7pA-4p2lA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Homo sapiens)
PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N)
4 ASN A 391
VAL A 431
LEU A 352
SER A 613
None
1.30A 6a7pA-4p7hA:
undetectable
6a7pA-4p7hA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
4 ASN A 391
TYR A 411
LEU A 460
SER A 489
NPS  A 601 (-4.3A)
NPS  A 601 (-4.3A)
None
NPS  A 601 (-3.1A)
0.97A 6a7pA-4po0A:
45.4
6a7pA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlz CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
4 ASN A 394
VAL A 351
LEU A 369
SER A 357
GOL  A 601 (-3.3A)
None
None
GOL  A 601 (-4.7A)
1.22A 6a7pA-4rlzA:
undetectable
6a7pA-4rlzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN


(Homo sapiens;
Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN L  32
TYR L  37
LEU H  45
SER H  99
None
1.18A 6a7pA-4uomL:
undetectable
6a7pA-4uomL:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4


(Drosophila
melanogaster;
Drosophila
melanogaster)
PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C)
4 ASN A 828
TYR D  29
LEU D 218
SER D  60
None
1.31A 6a7pA-4xgcA:
undetectable
6a7pA-4xgcA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 ASN A 257
VAL A 297
LEU A 291
SER A 283
None
1.23A 6a7pA-5a4jA:
undetectable
6a7pA-5a4jA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Thermus
thermophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 ASN A 295
TYR A 190
VAL A  63
LEU A  79
None
1.21A 6a7pA-5avmA:
undetectable
6a7pA-5avmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8i SULFHYDRYL OXIDASE 1

(Mus musculus)
PF00085
(Thioredoxin)
4 ASN A 246
VAL A 216
LEU A 266
SER A 250
None
1.10A 6a7pA-5d8iA:
undetectable
6a7pA-5d8iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B


(Chlamydomonas
reinhardtii)
PF00025
(Arf)
4 ASN B 128
VAL B  67
LEU B  58
SER B  38
GNP  B 301 (-3.2A)
None
None
None
1.30A 6a7pA-5di3B:
undetectable
6a7pA-5di3B:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
4 ASN A 390
TYR A 410
LEU A 459
SER A 488
None
1.10A 6a7pA-5dqfA:
45.4
6a7pA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
4 ASN A 341
TYR A 118
VAL A 407
LEU A 402
None
1.23A 6a7pA-5g2vA:
undetectable
6a7pA-5g2vA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
4 ASN A 391
TYR A 411
VAL A 426
SER A 489
None
1.20A 6a7pA-5ghkA:
44.2
6a7pA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
4 ASN A 391
VAL A 426
LEU A 460
SER A 489
None
0.75A 6a7pA-5ghkA:
44.2
6a7pA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE


(Bacillus
anthracis)
PF04127
(DFP)
4 ASN A 341
TYR A 264
VAL A 267
LEU A 191
None
1.25A 6a7pA-5intA:
undetectable
6a7pA-5intA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE


(Aspergillus
terreus)
PF11991
(Trp_DMAT)
4 ASN A 411
VAL A 416
LEU A  90
SER A 177
GST  A 502 (-3.7A)
None
None
XBU  A 501 (-2.7A)
1.24A 6a7pA-5kd0A:
undetectable
6a7pA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
4 TYR A  38
VAL A 475
LEU A 455
SER A 510
None
1.15A 6a7pA-5l5gA:
undetectable
6a7pA-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
no annotation 4 ASN A 477
VAL A 470
LEU A 335
SER A 484
None
1.16A 6a7pA-5lj6A:
3.3
6a7pA-5lj6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN


(Chaetomium
thermophilum)
PF06427
(UDP-g_GGTase)
4 ASN A  32
TYR A 232
VAL A1004
LEU A1036
None
1.04A 6a7pA-5mzoA:
undetectable
6a7pA-5mzoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878


(Staphylococcus
aureus)
no annotation 4 ASN A 157
VAL A 227
LEU A 174
SER A 259
None
1.04A 6a7pA-5na4A:
undetectable
6a7pA-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 4 ASN A 379
VAL A 133
LEU A 136
SER A 100
None
1.15A 6a7pA-5nbsA:
undetectable
6a7pA-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Legionella
pneumophila)
no annotation 4 TYR A 184
VAL A 186
LEU A 237
SER A 218
None
1.24A 6a7pA-5o96A:
undetectable
6a7pA-5o96A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 4 TYR W1192
VAL W1257
LEU W1261
SER W1132
None
1.28A 6a7pA-5o9gW:
undetectable
6a7pA-5o9gW:
16.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 4 ASN A 390
TYR A 410
LEU A 459
SER A 488
None
1.03A 6a7pA-5oriA:
44.1
6a7pA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1


(Alicyclobacillus
acidoterrestris)
no annotation 4 TYR A 716
VAL A 719
LEU A 655
SER A 660
None
1.25A 6a7pA-5u30A:
3.5
6a7pA-5u30A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2


(Homo sapiens)
PF00004
(AAA)
4 ASN f 473
VAL f 504
LEU f 501
SER f 481
None
1.17A 6a7pA-5vhif:
undetectable
6a7pA-5vhif:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
4 ASN A 220
VAL A  21
LEU A 234
SER A 227
None
NAG  A1409 (-3.3A)
None
None
1.31A 6a7pA-5x59A:
4.8
6a7pA-5x59A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 5 ASN A 391
TYR A 411
VAL A 426
LEU A 460
SER A 489
None
0.98A 6a7pA-5yxeA:
44.9
6a7pA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE


(Mycobacterium
tuberculosis)
no annotation 4 ASN A 357
VAL A 455
LEU A 387
SER A 426
None
1.31A 6a7pA-6ax8A:
undetectable
6a7pA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE


(Pectobacterium
atrosepticum)
no annotation 4 ASN A 348
VAL A 284
LEU A 454
SER A 458
PO4  A1003 (-2.8A)
None
None
None
1.30A 6a7pA-6brsA:
undetectable
6a7pA-6brsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g47 FIBER-1

(Human
mastadenovirus
G)
no annotation 4 ASN A 307
VAL A 228
LEU A 221
SER A 337
None
1.23A 6a7pA-6g47A:
undetectable
6a7pA-6g47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A


(Mus musculus)
no annotation 4 ASN A 576
TYR A 534
VAL A 561
LEU A 540
None
1.27A 6a7pA-6g9oA:
4.3
6a7pA-6g9oA:
undetectable