SIMILAR PATTERNS OF AMINO ACIDS FOR 6A7P_A_9SCA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 LEU A 562
ILE A 565
LEU A 527
GLY A 580
LEU A 514
 None
 1.00A 6a7pA-1bf5A:
3.0		 6a7pA-1bf5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 295
ILE A 296
CYH A 300
PHE A 100
VAL A  27
 None
 1.23A 6a7pA-1h4rA:
0.0		 6a7pA-1h4rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens;
Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		5 LEU B  53
ILE B  81
VAL A 432
GLY B 168
CYH B 167
 None
 1.26A 6a7pA-1i7qB:
0.5		 6a7pA-1i7qB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 LEU A  45
ILE A 140
PHE A  51
GLY A 125
LEU A  35
 None
 1.14A 6a7pA-1qcxA:
undetectable		 6a7pA-1qcxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE

(Thermosynechococcus
elongatus) 		PF01716
(MSP) 		5 LEU O  43
PHE O 146
LEU O  51
GLY O 144
LEU O 199
 None
 1.18A 6a7pA-1s5lO:
undetectable		 6a7pA-1s5lO:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		5 ILE A  25
LEU A  94
GLY A  22
LEU A  34
PHE A  74
 None
 0.99A 6a7pA-1sbdA:
undetectable		 6a7pA-1sbdA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		8 LEU A 387
ILE A 388
PHE A 403
LEU A 423
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 None
 1.00A 6a7pA-1tf0A:
47.4		 6a7pA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 387
ILE A 388
VAL A 418
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 None
 1.12A 6a7pA-1tf0A:
47.4		 6a7pA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PHE A 403
LYS A 414
VAL A 415
LEU A 423
PHE A 488
 None
 0.86A 6a7pA-1tf0A:
47.4		 6a7pA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		5 LEU A 166
ILE A 163
PHE B 276
LEU B 386
GLY A 158
 None
 1.21A 6a7pA-1w2wA:
2.7		 6a7pA-1w2wA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		5 LEU A  55
ILE A  82
LEU A 318
GLY A  79
LEU A  70
 None
 1.23A 6a7pA-1wp5A:
undetectable		 6a7pA-1wp5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LEU A 174
ILE A 177
GLY A 181
LEU A 189
PHE A 146
 None
 1.24A 6a7pA-1xeuA:
undetectable		 6a7pA-1xeuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y97 THREE PRIME REPAIR
EXONUCLEASE 2

(Homo sapiens) 		no annotation 5 LEU A  57
VAL A 143
GLY A 192
LEU A 198
PHE A  10
 None
 1.22A 6a7pA-1y97A:
0.0		 6a7pA-1y97A:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 CYH A 392
PHE A 403
LYS A 414
LEU A 423
GLY A 434
 4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.9A)
4EB  A1000 (-4.1A)
4EB  A1000 ( 4.7A)
 0.96A 6a7pA-1ysxA:
0.0		 6a7pA-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PHE A 403
LYS A 414
LEU A 423
GLY A 434
CYH A 437
 4EB  A1000 ( 4.1A)
4EB  A1000 (-3.9A)
4EB  A1000 (-4.1A)
4EB  A1000 ( 4.7A)
4EB  A1000 ( 3.7A)
 1.06A 6a7pA-1ysxA:
0.0		 6a7pA-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PHE A 403
LYS A 414
VAL A 415
LEU A 423
GLY A 434
 4EB  A1000 ( 4.1A)
4EB  A1000 (-3.9A)
4EB  A1000 (-3.8A)
4EB  A1000 (-4.1A)
4EB  A1000 ( 4.7A)
 0.73A 6a7pA-1ysxA:
0.0		 6a7pA-1ysxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 LEU A 562
ILE A 565
LEU A 527
GLY A 580
LEU A 514
 None
 0.90A 6a7pA-1yvlA:
undetectable		 6a7pA-1yvlA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx3 HYPOTHETICAL PROTEIN
DSRC

(Allochromatium
vinosum) 		PF04358
(DsrC) 		5 LEU A  23
VAL A  73
LEU A  87
GLY A  18
ARG A  54
 None
 1.09A 6a7pA-1yx3A:
undetectable		 6a7pA-1yx3A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 LEU A 276
ILE A 275
VAL A 174
GLY A  23
ARG A  17
 None
 1.25A 6a7pA-2cevA:
undetectable		 6a7pA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 162
VAL A 316
LEU A 244
GLY A 104
ARG A 234
 None
 1.18A 6a7pA-2fqdA:
undetectable		 6a7pA-2fqdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h63 BILIVERDIN REDUCTASE
A

(Homo sapiens) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 LEU A  95
LEU A  48
GLY A  10
LEU A  27
ARG A  23
 None
 1.26A 6a7pA-2h63A:
undetectable		 6a7pA-2h63A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 LEU A 120
ILE A 121
PHE A 141
VAL A  39
LEU A  20
 None
 1.17A 6a7pA-2nyuA:
undetectable		 6a7pA-2nyuA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A  98
ILE A  94
PHE A  64
GLY A 117
LEU A  39
 None
 1.24A 6a7pA-2wtbA:
undetectable		 6a7pA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 491
ILE A 476
LEU A 461
GLY A 438
LEU A 321
 None
 1.18A 6a7pA-2x3kA:
undetectable		 6a7pA-2x3kA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A 485
ILE A 484
LYS A 459
GLY A 444
LEU A 439
 None
 1.15A 6a7pA-2xpzA:
undetectable		 6a7pA-2xpzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		5 LEU C 163
ILE C 152
VAL C  24
GLY C 147
LEU C 141
 None
 1.13A 6a7pA-3ad9C:
undetectable		 6a7pA-3ad9C:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392

(Methanocaldococcus
jannaschii) 		PF02163
(Peptidase_M50) 		5 LEU A 157
ILE A 156
PHE A 145
LEU A 179
GLY A 149
 None
 1.16A 6a7pA-3b4rA:
3.5		 6a7pA-3b4rA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus) 		PF09367
(CpeS) 		5 LEU A 128
ILE A   7
GLY A  68
CYH A  67
LEU A 104
 None
 1.07A 6a7pA-3bdrA:
undetectable		 6a7pA-3bdrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 296
ILE A 297
VAL A 150
LEU A 124
GLY A 262
 None
 1.24A 6a7pA-3h5qA:
undetectable		 6a7pA-3h5qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 LEU D 199
ILE D 203
PHE D 282
CYH D 206
LEU D  93
 None
 1.23A 6a7pA-3jazD:
undetectable		 6a7pA-3jazD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		5 LYS A 133
VAL A 134
LEU A 123
LEU A 101
PHE A 107
 None
 1.16A 6a7pA-3kd6A:
undetectable		 6a7pA-3kd6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 173
LEU A  85
CYH A 204
LEU A 224
ARG A 226
 None
None
None
None
LLP  A  47 ( 3.9A)
 1.16A 6a7pA-3kw3A:
undetectable		 6a7pA-3kw3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		5 ILE A 105
VAL A 203
LEU A 155
GLY A 117
LEU A  34
 None
 0.99A 6a7pA-3l39A:
2.1		 6a7pA-3l39A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 LEU A 217
ILE A 221
LEU A 262
GLY A 228
LEU A 300
 None
 1.23A 6a7pA-3m4xA:
undetectable		 6a7pA-3m4xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7k BOTULINUM NEUROTOXIN
TYPE C1

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ILE A 929
VAL A 899
LEU A 901
GLY A 888
LEU A 874
 None
 1.25A 6a7pA-3n7kA:
undetectable		 6a7pA-3n7kA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A  12
ILE A 472
LEU A 249
GLY A 268
LEU A 192
 None
None
None
None
AMP  A 577 ( 4.3A)
 0.96A 6a7pA-3nyoA:
2.3		 6a7pA-3nyoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 LEU A 147
ILE A 151
PHE A  61
VAL A 239
LEU A 262
 None
None
CLJ  A 394 ( 4.0A)
None
None
 1.04A 6a7pA-3othA:
undetectable		 6a7pA-3othA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A 208
ILE A 238
VAL A 126
LEU A 356
LEU A 233
 None
 1.15A 6a7pA-3qlvA:
undetectable		 6a7pA-3qlvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 ILE L 353
PHE L 437
LEU L 389
LEU L 308
PHE L 341
 None
 1.18A 6a7pA-3rkoL:
2.5		 6a7pA-3rkoL:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 LEU L 403
ILE L 402
LEU L 506
GLY L 395
PHE L 423
 None
 1.23A 6a7pA-3rkoL:
2.5		 6a7pA-3rkoL:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J

(Escherichia
coli;
Escherichia
coli) 		PF00507
(Oxidored_q4)
no annotation 		5 LEU J  32
ILE J  33
LEU J 147
GLY J  61
CYH A  27
 None
 1.12A 6a7pA-3rkoJ:
4.5		 6a7pA-3rkoJ:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwr DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		5 LEU A  28
PHE A 111
VAL A 122
GLY A 109
LEU A  74
 None
 1.25A 6a7pA-3rwrA:
undetectable		 6a7pA-3rwrA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU X 357
PHE X 245
LEU X 171
GLY X 290
LEU X 276
 None
 1.26A 6a7pA-3ss7X:
undetectable		 6a7pA-3ss7X:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		5 LEU A 414
VAL A 332
GLY A 548
LEU A 397
PHE A 386
 None
 1.18A 6a7pA-3tj0A:
undetectable		 6a7pA-3tj0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 225
ILE A 226
CYH A 230
PHE A  81
PHE A 114
 URE  A 903 (-4.5A)
None
None
None
URE  A 905 (-4.0A)
 1.11A 6a7pA-3umvA:
undetectable		 6a7pA-3umvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A2050
ILE A2046
PHE A2074
VAL A1926
GLY A2023
 None
 1.16A 6a7pA-3vkgA:
undetectable		 6a7pA-3vkgA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 LEU A1581
ILE A1584
LYS A1628
GLY A1588
PHE A1633
 None
 1.22A 6a7pA-4a5wA:
2.5		 6a7pA-4a5wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 ILE A 101
VAL A 202
LEU A   5
GLY A  85
LEU A  44
 None
 0.96A 6a7pA-4ad9A:
undetectable		 6a7pA-4ad9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 LEU A 394
ILE A 392
VAL A 638
LEU A 646
GLY A 289
 None
 1.19A 6a7pA-4aioA:
undetectable		 6a7pA-4aioA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		6 ILE A 256
PHE A 210
LYS A 200
VAL A 201
LEU A 432
LEU A 267
 None
 1.48A 6a7pA-4djiA:
undetectable		 6a7pA-4djiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 ILE A 687
VAL A 712
LEU A 756
GLY A 702
LEU A 869
 None
 1.24A 6a7pA-4dqkA:
undetectable		 6a7pA-4dqkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		5 LEU A 515
ILE A 519
GLY A 463
CYH A 522
LEU A 564
 None
 1.23A 6a7pA-4f1nA:
undetectable		 6a7pA-4f1nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN

(Streptomyces
himastatinicus) 		PF00067
(p450) 		5 LEU A  47
ILE A  46
GLY A  39
LEU A 311
PHE A 339
 None
None
None
None
HEM  A 401 (-4.7A)
 1.26A 6a7pA-4ggvA:
undetectable		 6a7pA-4ggvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 ILE A 485
VAL A 382
LEU A 370
GLY A 456
LEU A 459
 None
 1.20A 6a7pA-4k17A:
undetectable		 6a7pA-4k17A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 ILE A 789
LYS A 827
VAL A 828
LEU A 858
CYH A 776
 None
 1.08A 6a7pA-4k6jA:
undetectable		 6a7pA-4k6jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 112
VAL A  76
LEU A 399
GLY A 444
ARG A 440
 HEM  A 600 (-3.2A)
None
None
HEM  A 600 ( 3.7A)
HEM  A 600 (-4.1A)
 1.18A 6a7pA-4nkyA:
undetectable		 6a7pA-4nkyA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 387
LEU A 423
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 NPS  A 601 ( 4.7A)
None
None
NPS  A 601 (-4.7A)
None
None
 0.80A 6a7pA-4po0A:
45.4		 6a7pA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 387
PHE A 403
LEU A 423
LEU A 453
ARG A 485
PHE A 488
 NPS  A 601 ( 4.7A)
None
None
NPS  A 601 (-4.7A)
None
None
 1.03A 6a7pA-4po0A:
45.4		 6a7pA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 387
PHE A 403
VAL A 418
LEU A 453
ARG A 485
PHE A 488
 NPS  A 601 ( 4.7A)
None
None
NPS  A 601 (-4.7A)
None
None
 1.26A 6a7pA-4po0A:
45.4		 6a7pA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 387
VAL A 418
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 NPS  A 601 ( 4.7A)
None
None
NPS  A 601 (-4.7A)
None
None
 1.28A 6a7pA-4po0A:
45.4		 6a7pA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 741
PHE A 462
VAL A 440
LEU A 469
LEU B 878
 None
 1.24A 6a7pA-4qiwB:
undetectable		 6a7pA-4qiwB:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 ILE A 125
VAL A  89
LEU A 410
GLY A 455
ARG A 451
 HEM  A 600 ( 4.5A)
None
None
HEM  A 600 (-3.6A)
HEM  A 600 (-3.9A)
 1.13A 6a7pA-4r1zA:
undetectable		 6a7pA-4r1zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		5 ILE M   9
VAL M 132
LEU M  89
GLY M 110
LEU M  42
 None
 1.26A 6a7pA-4rrpM:
undetectable		 6a7pA-4rrpM:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 LEU A 377
ILE A 376
CYH A 313
LEU A 160
GLY A 262
 None
 1.16A 6a7pA-4tqtA:
undetectable		 6a7pA-4tqtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		5 LEU A 209
ILE A 194
LEU A  98
GLY A 275
PHE A 110
 None
None
None
None
GOL  A 517 ( 3.6A)
 1.14A 6a7pA-4ur2A:
undetectable		 6a7pA-4ur2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 967
ILE A 938
VAL A 997
LEU A1046
GLY A1029
 None
 1.22A 6a7pA-4uvjA:
2.4		 6a7pA-4uvjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		5 LEU B  41
ILE B  50
PHE B 164
VAL B 124
GLY B  68
 PTY  B 200 ( 3.9A)
None
PTY  B 200 (-4.0A)
None
PTY  B 200 ( 4.8A)
 1.24A 6a7pA-4v3dB:
undetectable		 6a7pA-4v3dB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ILE A 397
VAL A 179
LEU A 104
GLY A  34
PHE A 124
 None
None
LLP  A 247 ( 4.5A)
None
None
 1.17A 6a7pA-4wlhA:
undetectable		 6a7pA-4wlhA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ILE A 397
VAL A 179
LEU A 104
GLY A  34
PHE A 124
 None
 1.24A 6a7pA-4wp0A:
undetectable		 6a7pA-4wp0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		5 LYS B 414
VAL B 413
LEU B 393
GLY B 313
LEU B 308
 None
 1.24A 6a7pA-5aa4B:
undetectable		 6a7pA-5aa4B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		5 LEU A  23
ILE A  31
VAL A 159
GLY A  90
LEU A  36
 None
 1.17A 6a7pA-5d6oA:
undetectable		 6a7pA-5d6oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 5 LEU A 572
VAL A 489
LEU A 471
GLY A 541
LEU A 548
 None
 1.09A 6a7pA-5dn7A:
2.8		 6a7pA-5dn7A:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
LEU A 422
GLY A 433
ARG A 484
PHE A 487
 None
 0.97A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
LEU A 422
GLY A 433
LEU A 452
ARG A 484
 None
 0.94A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
PHE A 402
LEU A 422
ARG A 484
PHE A 487
 None
 1.17A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
PHE A 402
LEU A 422
LEU A 452
ARG A 484
 None
 1.18A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
PHE A 402
VAL A 417
LEU A 452
ARG A 484
 None
 1.22A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 386
VAL A 417
GLY A 433
LEU A 452
ARG A 484
 None
 1.19A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A 204
ILE A 199
LEU A  88
LEU A 235
PHE A 248
 None
 1.18A 6a7pA-5ey8A:
undetectable		 6a7pA-5ey8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		5 LEU A1408
ILE A1467
PHE A1430
LEU A1557
LEU A1450
 None
 1.10A 6a7pA-5f3yA:
2.1		 6a7pA-5f3yA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 LEU A 387
PHE A 403
GLY A 434
LEU A 453
ARG A 485
 None
 1.13A 6a7pA-5ghkA:
44.2		 6a7pA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 PHE A 403
LEU A 423
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 None
 1.02A 6a7pA-5ghkA:
44.2		 6a7pA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 194
ILE B 185
CYH B 213
GLY B 211
LEU B 206
 None
 1.23A 6a7pA-5hz1B:
undetectable		 6a7pA-5hz1B:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 LEU A 330
VAL A 430
LEU A 383
GLY A 338
LEU A 341
 None
 1.14A 6a7pA-5i5hA:
undetectable		 6a7pA-5i5hA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 ILE A 349
PHE A 257
LEU A 249
GLY A 326
LEU A 115
 None
 1.26A 6a7pA-5j44A:
undetectable		 6a7pA-5j44A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 LEU S 301
ILE S 296
GLY S 293
LEU S 371
PHE S 328
 None
 1.23A 6a7pA-5k0yS:
undetectable		 6a7pA-5k0yS:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 LEU A 158
VAL A 236
LEU A 209
LEU A 144
PHE A 248
 None
 1.14A 6a7pA-5kdxA:
undetectable		 6a7pA-5kdxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 LEU B 841
VAL B 324
GLY B 783
LEU B 341
PHE B 334
 None
 1.26A 6a7pA-5khnB:
undetectable		 6a7pA-5khnB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 ILE X 205
LEU X  73
GLY X 158
LEU X   7
PHE X   4
 MLY  X 203 ( 4.7A)
None
None
None
None
 1.22A 6a7pA-5liyX:
undetectable		 6a7pA-5liyX:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES
DESIGN OF ANTIBODIES

(Escherichia
coli;
Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE H  95
PHE L 102
LYS L  59
VAL L  58
GLY H  44
 None
 1.22A 6a7pA-5nbiH:
undetectable		 6a7pA-5nbiH:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 ILE A 387
PHE A 402
LEU A 422
GLY A 433
LEU A 452
ARG A 484
PHE A 487
 None
 1.09A 6a7pA-5oriA:
44.1		 6a7pA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 386
ILE A 387
PHE A 402
GLY A 433
LEU A 452
PHE A 487
 None
 1.22A 6a7pA-5oriA:
44.1		 6a7pA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 386
ILE A 387
PHE A 402
VAL A 417
GLY A 433
LEU A 452
 None
 1.27A 6a7pA-5oriA:
44.1		 6a7pA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 330
PHE A 379
VAL A 246
GLY A 282
LEU A 323
 None
 1.04A 6a7pA-5wx4A:
undetectable		 6a7pA-5wx4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 5 LEU A  27
ILE A 152
VAL A 135
GLY A 150
LEU A 371
 None
 1.26A 6a7pA-5wxiA:
undetectable		 6a7pA-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 LEU A 387
PHE A 403
LEU A 423
GLY A 434
LEU A 453
ARG A 485
PHE A 488
 None
 1.34A 6a7pA-5yxeA:
44.9		 6a7pA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 387
PHE A 403
VAL A 418
GLY A 434
LEU A 453
 None
 1.15A 6a7pA-5yxeA:
44.9		 6a7pA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 PHE A 403
VAL A 415
LEU A 423
GLY A 434
LEU A 453
PHE A 488
 None
 0.83A 6a7pA-5yxeA:
44.9		 6a7pA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 ILE A 350
LEU A 317
GLY A 329
LEU A 406
PHE A  35
 None
 1.15A 6a7pA-6c9eA:
undetectable		 6a7pA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 160
VAL K  72
GLY K  30
CYH K  39
LEU K  48
 None
None
None
ZN  K2002 (-2.3A)
None
 1.04A 6a7pA-6d6qK:
undetectable		 6a7pA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE

(Homo sapiens;
Homo sapiens) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		4 ASN B 202
VAL A 105
LEU A 103
SER B 215
 None
 1.32A 6a7pA-1apyB:
undetectable		 6a7pA-1apyB:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 ASN A 282
VAL A 435
LEU A 241
SER A 423
 None
 1.12A 6a7pA-1ddgA:
undetectable		 6a7pA-1ddgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ASN A 291
VAL A 283
LEU A 274
SER A 314
 None
 1.22A 6a7pA-1e43A:
undetectable		 6a7pA-1e43A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 TYR A 110
VAL A 148
LEU A 117
SER A  11
 None
 1.10A 6a7pA-1iipA:
4.3		 6a7pA-1iipA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		4 ASN A 495
VAL A 481
LEU A 477
SER A 467
 None
 1.31A 6a7pA-1jv1A:
undetectable		 6a7pA-1jv1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18E

(Haloarcula
marismortui) 		PF00828
(Ribosomal_L27A) 		4 ASN P 104
VAL P  29
LEU P  33
SER P  97
 None
 1.32A 6a7pA-1kc8P:
undetectable		 6a7pA-1kc8P:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		4 ASN A 107
TYR A  87
VAL A 229
LEU A 223
 None
 1.09A 6a7pA-1konA:
2.8		 6a7pA-1konA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 ASN A 107
TYR A  87
VAL A 231
LEU A 225
 None
 1.07A 6a7pA-1lfpA:
2.3		 6a7pA-1lfpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A 201
VAL A 200
LEU A  67
SER A 110
 None
None
None
GSH  A 500 (-2.5A)
 1.23A 6a7pA-1m0uA:
3.1		 6a7pA-1m0uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ASN C  30
TYR A  63
VAL B  98
LEU B 102
 None
 1.24A 6a7pA-1m1jC:
undetectable		 6a7pA-1m1jC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		4 ASN A  30
VAL A  34
LEU A  58
SER A  74
 None
 1.28A 6a7pA-1mbmA:
undetectable		 6a7pA-1mbmA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 ASN A 514
VAL A 432
LEU A 425
SER A 552
 None
 1.30A 6a7pA-1qhvA:
undetectable		 6a7pA-1qhvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		4 ASN A 514
VAL A 432
LEU A 425
SER A 552
 None
 1.26A 6a7pA-1qiuA:
undetectable		 6a7pA-1qiuA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ASN A 195
VAL A 390
LEU A 603
SER A 610
 None
 1.25A 6a7pA-1rt8A:
undetectable		 6a7pA-1rt8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA
FAB 17-IA

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 ASN H  97
VAL L  58
LEU L  54
SER L  50
 None
 1.14A 6a7pA-1rvfH:
undetectable		 6a7pA-1rvfH:
12.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ASN A 391
TYR A 411
VAL A 426
LEU A 460
SER A 489
 None
 1.04A 6a7pA-1tf0A:
47.4		 6a7pA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd2 PROTEIN KINASE C,
IOTA TYPE

(Homo sapiens) 		PF00564
(PB1) 		4 ASN A  43
VAL A  19
LEU A  92
SER A  37
 None
 1.31A 6a7pA-1vd2A:
undetectable		 6a7pA-1vd2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 ASN A  72
TYR A 172
VAL A 199
SER A 288
 PLP  A 413 (-3.6A)
PLP  A 413 (-4.4A)
None
None
 1.23A 6a7pA-1ve1A:
undetectable		 6a7pA-1ve1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis) 		PF01391
(Collagen) 		4 ASN A 108
VAL A 191
LEU A 151
SER A 205
 None
 1.32A 6a7pA-1wckA:
undetectable		 6a7pA-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis) 		PF01391
(Collagen) 		4 ASN A 108
VAL A 193
LEU A 198
SER A 205
 None
 1.13A 6a7pA-1wckA:
undetectable		 6a7pA-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgd HOMOCYSTEINE-RESPONS
IVE ENDOPLASMIC
RETICULUM-RESIDENT
UBIQUITIN-LIKE
DOMAIN MEMBER 1
PROTEIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 TYR A  43
VAL A  42
LEU A  24
SER A  14
 None
 1.20A 6a7pA-1wgdA:
undetectable		 6a7pA-1wgdA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 ASN A 184
TYR A 384
VAL A 329
SER A 379
 None
 1.22A 6a7pA-1x9yA:
undetectable		 6a7pA-1x9yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ASN A 496
TYR A 512
VAL A 529
LEU A 527
 None
 1.31A 6a7pA-1xjeA:
undetectable		 6a7pA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		4 TYR 2 107
VAL 2  92
LEU 2  57
SER 2  27
 None
 1.14A 6a7pA-2bpa2:
undetectable		 6a7pA-2bpa2:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 ASN A  44
VAL A  56
LEU A  60
SER A  75
 None
 1.30A 6a7pA-2ch1A:
undetectable		 6a7pA-2ch1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASN A  36
VAL A   5
LEU A  94
SER A  98
 NAP  A1341 (-4.2A)
None
None
None
 1.31A 6a7pA-2d2iA:
undetectable		 6a7pA-2d2iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 ASN A 569
VAL A 288
LEU A 815
SER A 346
 None
FAD  A1001 (-4.9A)
None
None
 1.03A 6a7pA-2dw4A:
4.3		 6a7pA-2dw4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		4 TYR A  61
VAL A  87
LEU A  34
SER A  99
 NAD  A3686 (-4.2A)
None
None
NAD  A3686 (-4.6A)
 1.24A 6a7pA-2g5cA:
undetectable		 6a7pA-2g5cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASN A3094
TYR A3000
LEU A2937
SER A3127
 None
 1.27A 6a7pA-2h84A:
undetectable		 6a7pA-2h84A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		4 ASN A  24
VAL A 179
LEU A  31
SER A 199
 None
 1.19A 6a7pA-2oseA:
undetectable		 6a7pA-2oseA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASN A 371
VAL A 470
LEU A 526
SER A 377
 None
 1.17A 6a7pA-2q27A:
undetectable		 6a7pA-2q27A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 ASN B 203
VAL B 354
LEU B 317
SER B 109
 None
 1.11A 6a7pA-2q2eB:
undetectable		 6a7pA-2q2eB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 ASN B 183
TYR B 276
LEU B 372
SER B 165
 None
 1.27A 6a7pA-2qgaB:
2.9		 6a7pA-2qgaB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		4 ASN A  75
VAL A  56
LEU A   4
SER A  10
 None
 1.23A 6a7pA-2ri6A:
undetectable		 6a7pA-2ri6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ASN A 281
TYR A 297
VAL A 331
LEU A 323
 None
 1.27A 6a7pA-2wqdA:
undetectable		 6a7pA-2wqdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0x SENSOR PROTEIN

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		4 ASN A 610
VAL A 654
LEU A 658
SER A 676
 None
 1.17A 6a7pA-3a0xA:
undetectable		 6a7pA-3a0xA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN

(Bacillus
anthracis) 		no annotation 4 ASN A 108
VAL A 193
LEU A 198
SER A 205
 None
 0.87A 6a7pA-3ab0A:
undetectable		 6a7pA-3ab0A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 TYR A  38
VAL A 475
LEU A 455
SER A 510
 None
None
None
EDO  A8301 (-2.3A)
 1.18A 6a7pA-3al9A:
undetectable		 6a7pA-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASN A 369
VAL A 348
LEU A 346
SER A 331
 None
 1.03A 6a7pA-3aupA:
undetectable		 6a7pA-3aupA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 ASN A 733
TYR A 681
VAL A 684
LEU A 700
 None
 1.25A 6a7pA-3c2gA:
3.2		 6a7pA-3c2gA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		4 ASN A 490
VAL A 483
LEU A 348
SER A 497
 None
 1.20A 6a7pA-3ftjA:
undetectable		 6a7pA-3ftjA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASN A 328
TYR A 289
VAL A 383
LEU A 348
 None
 1.31A 6a7pA-3hhdA:
undetectable		 6a7pA-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 ASN A 330
TYR A 364
VAL A  96
LEU A  45
 None
 1.29A 6a7pA-3hkaA:
undetectable		 6a7pA-3hkaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 ASN A 595
VAL A 444
LEU A 451
SER A 419
 None
 1.26A 6a7pA-3hs0A:
undetectable		 6a7pA-3hs0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)

(Legionella
pneumophila) 		PF00378
(ECH_1) 		4 TYR A 149
VAL A 145
LEU A  88
SER A  94
 None
 1.19A 6a7pA-3i47A:
3.7		 6a7pA-3i47A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 ASN T 229
VAL T 214
LEU T 151
SER T 190
 None
 1.29A 6a7pA-3icqT:
2.2		 6a7pA-3icqT:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 ASN A 447
VAL A 358
LEU A 348
SER A 373
 None
 1.23A 6a7pA-3kxwA:
undetectable		 6a7pA-3kxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 TYR A 225
VAL A 194
LEU A 262
SER A 256
 None
 1.21A 6a7pA-3l7zA:
undetectable		 6a7pA-3l7zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9k RE64145P

(Drosophila
melanogaster) 		PF03259
(Robl_LC7) 		4 ASN A  94
VAL A  81
LEU A  70
SER A  74
 None
 1.29A 6a7pA-3l9kA:
undetectable		 6a7pA-3l9kA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASN A 688
TYR A 410
VAL A 416
LEU A 415
 None
 1.30A 6a7pA-3la4A:
undetectable		 6a7pA-3la4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 303
TYR A 194
VAL A  67
LEU A  83
 None
SO4  A 400 (-4.9A)
None
None
 1.15A 6a7pA-3qtyA:
undetectable		 6a7pA-3qtyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		4 ASN A  26
VAL A  37
LEU A  10
SER A   5
 None
 1.17A 6a7pA-3re2A:
undetectable		 6a7pA-3re2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 610
VAL A 728
LEU A 829
SER A 596
 None
 1.13A 6a7pA-3s9vA:
2.3		 6a7pA-3s9vA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 ASN A 246
VAL A 216
LEU A 266
SER A 250
 None
 1.19A 6a7pA-3t58A:
undetectable		 6a7pA-3t58A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-BETA-1

(Mus musculus) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 ASN C 768
VAL C 683
LEU C 709
SER C 730
 None
 1.19A 6a7pA-3tadC:
undetectable		 6a7pA-3tadC:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis) 		no annotation 4 ASN A 108
VAL A 193
LEU A 198
SER A 205
 None
 1.19A 6a7pA-3tyjA:
undetectable		 6a7pA-3tyjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ASN A 572
VAL A 609
LEU A 613
SER A 246
 None
 1.26A 6a7pA-3vf1A:
3.8		 6a7pA-3vf1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 ASN A 248
TYR A 115
VAL A 208
LEU A 179
 None
 1.22A 6a7pA-3vmnA:
undetectable		 6a7pA-3vmnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 ASN A 359
VAL A 618
LEU A 614
SER A 724
 U  C1670 ( 3.9A)
None
None
A  C1668 ( 4.7A)
 1.24A 6a7pA-3wqyA:
2.7		 6a7pA-3wqyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ASN A 100
VAL A 225
LEU A 155
SER A 131
 None
None
None
FMN  A 500 (-4.1A)
 1.30A 6a7pA-3x0yA:
2.2		 6a7pA-3x0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 ASN A 650
TYR A 344
VAL A 468
LEU A 660
 None
 1.29A 6a7pA-4bejA:
2.4		 6a7pA-4bejA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ASN A 228
TYR A 342
VAL A 338
LEU A 413
 None
 1.23A 6a7pA-4c0jA:
undetectable		 6a7pA-4c0jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3q TRANSCRIPTIONAL
REGULATORY PROTEIN
CBU_1566

(Coxiella
burnetii) 		PF01709
(Transcrip_reg) 		4 ASN A 107
TYR A  87
VAL A 230
LEU A 224
 None
 1.08A 6a7pA-4f3qA:
2.4		 6a7pA-4f3qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 ASN A 242
TYR A 357
VAL A 360
LEU A 655
 None
 1.30A 6a7pA-4fyeA:
2.6		 6a7pA-4fyeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE

(Methylococcus
capsulatus) 		PF00815
(Histidinol_dh) 		4 ASN A 174
VAL A 186
LEU A 162
SER A 146
 None
 1.24A 6a7pA-4gicA:
undetectable		 6a7pA-4gicA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3o LECTIN

(Allium sativum) 		PF01453
(B_lectin) 		4 ASN A  44
VAL A  95
LEU A  89
SER A  39
 None
 1.30A 6a7pA-4h3oA:
undetectable		 6a7pA-4h3oA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE

(Leishmania
infantum) 		PF00155
(Aminotran_1_2) 		4 ASN A  59
TYR A 398
VAL A 409
LEU A 421
 None
 1.16A 6a7pA-4ix8A:
undetectable		 6a7pA-4ix8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASN A 324
VAL A 354
LEU A 335
SER A 269
 None
None
None
GYP  A 502 ( 4.8A)
 1.29A 6a7pA-4jreA:
3.2		 6a7pA-4jreA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 ASN A 246
VAL A 216
LEU A 266
SER A 250
 None
 1.02A 6a7pA-4p2lA:
2.0		 6a7pA-4p2lA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 ASN A 391
VAL A 431
LEU A 352
SER A 613
 None
 1.30A 6a7pA-4p7hA:
undetectable		 6a7pA-4p7hA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 ASN A 391
TYR A 411
LEU A 460
SER A 489
 NPS  A 601 (-4.3A)
NPS  A 601 (-4.3A)
None
NPS  A 601 (-3.1A)
 0.97A 6a7pA-4po0A:
45.4		 6a7pA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlz CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 ASN A 394
VAL A 351
LEU A 369
SER A 357
 GOL  A 601 (-3.3A)
None
None
GOL  A 601 (-4.7A)
 1.22A 6a7pA-4rlzA:
undetectable		 6a7pA-4rlzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 ASN L  32
TYR L  37
LEU H  45
SER H  99
 None
 1.18A 6a7pA-4uomL:
undetectable		 6a7pA-4uomL:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ASN A 828
TYR D  29
LEU D 218
SER D  60
 None
 1.31A 6a7pA-4xgcA:
undetectable		 6a7pA-4xgcA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 ASN A 257
VAL A 297
LEU A 291
SER A 283
 None
 1.23A 6a7pA-5a4jA:
undetectable		 6a7pA-5a4jA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 295
TYR A 190
VAL A  63
LEU A  79
 None
 1.21A 6a7pA-5avmA:
undetectable		 6a7pA-5avmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8i SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin) 		4 ASN A 246
VAL A 216
LEU A 266
SER A 250
 None
 1.10A 6a7pA-5d8iA:
undetectable		 6a7pA-5d8iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 ASN B 128
VAL B  67
LEU B  58
SER B  38
 GNP  B 301 (-3.2A)
None
None
None
 1.30A 6a7pA-5di3B:
undetectable		 6a7pA-5di3B:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 ASN A 390
TYR A 410
LEU A 459
SER A 488
 None
 1.10A 6a7pA-5dqfA:
45.4		 6a7pA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASN A 341
TYR A 118
VAL A 407
LEU A 402
 None
 1.23A 6a7pA-5g2vA:
undetectable		 6a7pA-5g2vA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 ASN A 391
TYR A 411
VAL A 426
SER A 489
 None
 1.20A 6a7pA-5ghkA:
44.2		 6a7pA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 ASN A 391
VAL A 426
LEU A 460
SER A 489
 None
 0.75A 6a7pA-5ghkA:
44.2		 6a7pA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 ASN A 341
TYR A 264
VAL A 267
LEU A 191
 None
 1.25A 6a7pA-5intA:
undetectable		 6a7pA-5intA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 ASN A 411
VAL A 416
LEU A  90
SER A 177
 GST  A 502 (-3.7A)
None
None
XBU  A 501 (-2.7A)
 1.24A 6a7pA-5kd0A:
undetectable		 6a7pA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 TYR A  38
VAL A 475
LEU A 455
SER A 510
 None
 1.15A 6a7pA-5l5gA:
undetectable		 6a7pA-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 4 ASN A 477
VAL A 470
LEU A 335
SER A 484
 None
 1.16A 6a7pA-5lj6A:
3.3		 6a7pA-5lj6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 ASN A  32
TYR A 232
VAL A1004
LEU A1036
 None
 1.04A 6a7pA-5mzoA:
undetectable		 6a7pA-5mzoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878

(Staphylococcus
aureus) 		no annotation 4 ASN A 157
VAL A 227
LEU A 174
SER A 259
 None
 1.04A 6a7pA-5na4A:
undetectable		 6a7pA-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ASN A 379
VAL A 133
LEU A 136
SER A 100
 None
 1.15A 6a7pA-5nbsA:
undetectable		 6a7pA-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 4 TYR A 184
VAL A 186
LEU A 237
SER A 218
 None
 1.24A 6a7pA-5o96A:
undetectable		 6a7pA-5o96A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 TYR W1192
VAL W1257
LEU W1261
SER W1132
 None
 1.28A 6a7pA-5o9gW:
undetectable		 6a7pA-5o9gW:
16.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 ASN A 390
TYR A 410
LEU A 459
SER A 488
 None
 1.03A 6a7pA-5oriA:
44.1		 6a7pA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 4 TYR A 716
VAL A 719
LEU A 655
SER A 660
 None
 1.25A 6a7pA-5u30A:
3.5		 6a7pA-5u30A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 ASN f 473
VAL f 504
LEU f 501
SER f 481
 None
 1.17A 6a7pA-5vhif:
undetectable		 6a7pA-5vhif:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 ASN A 220
VAL A  21
LEU A 234
SER A 227
 None
NAG  A1409 (-3.3A)
None
None
 1.31A 6a7pA-5x59A:
4.8		 6a7pA-5x59A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 ASN A 391
TYR A 411
VAL A 426
LEU A 460
SER A 489
 None
 0.98A 6a7pA-5yxeA:
44.9		 6a7pA-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 4 ASN A 357
VAL A 455
LEU A 387
SER A 426
 None
 1.31A 6a7pA-6ax8A:
undetectable		 6a7pA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 4 ASN A 348
VAL A 284
LEU A 454
SER A 458
 PO4  A1003 (-2.8A)
None
None
None
 1.30A 6a7pA-6brsA:
undetectable		 6a7pA-6brsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g47 FIBER-1

(Human
mastadenovirus
G) 		no annotation 4 ASN A 307
VAL A 228
LEU A 221
SER A 337
 None
 1.23A 6a7pA-6g47A:
undetectable		 6a7pA-6g47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 ASN A 576
TYR A 534
VAL A 561
LEU A 540
 None
 1.27A 6a7pA-6g9oA:
4.3		 6a7pA-6g9oA:
undetectable