SIMILAR PATTERNS OF AMINO ACIDS FOR 6A7J_A_TESA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)

(Bos taurus) 		PF00637
(Clathrin) 		4 LEU A1364
LEU A1349
ALA A1351
ALA A1352
 None
 0.79A 6a7jA-1b89A:
undetectable		 6a7jA-1b89A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  30
LEU A  13
ALA A  16
ALA A  17
 None
 0.69A 6a7jA-1bvuA:
undetectable		 6a7jA-1bvuA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvo FERTILITY INHIBITION
PROTEIN O

(Escherichia
coli) 		PF04352
(ProQ)
PF12602
(FinO_N) 		4 LEU A 104
LEU A 120
ALA A 123
THR A 128
 None
 0.60A 6a7jA-1dvoA:
undetectable		 6a7jA-1dvoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 410
ALA A 168
THR A 165
THR A 163
 None
 0.78A 6a7jA-1e5mA:
undetectable		 6a7jA-1e5mA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A  93
ALA A 241
ALA A 242
THR A 246
THR A 289
 HEM  A1414 ( 4.5A)
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 ( 4.4A)
 0.58A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A  93
LEU A 238
ALA A 242
THR A 246
THR A 289
 HEM  A1414 ( 4.5A)
HEM  A1414 ( 4.3A)
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 ( 4.4A)
 0.57A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 177
LEU A 238
ALA A 242
THR A 246
 None
HEM  A1414 ( 4.3A)
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 0.59A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 247
LEU A 131
ALA A 389
THR A 408
 None
 0.88A 6a7jA-1k0gA:
undetectable		 6a7jA-1k0gA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		4 LEU A 141
LEU A 192
ALA A 195
ALA A 196
 None
 0.60A 6a7jA-1mxfA:
undetectable		 6a7jA-1mxfA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0r 4 ANKYRIN REPEATS

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU A 121
LEU A 105
ALA A 108
ALA A 109
 None
 0.84A 6a7jA-1n0rA:
undetectable		 6a7jA-1n0rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		4 LEU A 194
LEU A 139
ALA A 141
ALA A 142
 None
 0.72A 6a7jA-1o5hA:
undetectable		 6a7jA-1o5hA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7y 50S RIBOSOMAL
PROTEIN L31E

(Haloarcula
marismortui) 		PF01198
(Ribosomal_L31e) 		4 LEU Y  50
ALA Y  57
ALA Y  58
THR Y  66
 C  A1384 ( 4.3A)
None
None
None
 0.66A 6a7jA-1q7yY:
undetectable		 6a7jA-1q7yY:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU 3 211
LEU 3  45
ALA 3  48
THR 3  89
 None
 0.89A 6a7jA-1qgc3:
undetectable		 6a7jA-1qgc3:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 LEU A  81
ALA A  84
ALA A 139
THR A  11
 None
 0.77A 6a7jA-1qgiA:
undetectable		 6a7jA-1qgiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 LEU A  86
LEU A  32
ALA A  34
THR A  97
 None
 0.73A 6a7jA-1uiyA:
undetectable		 6a7jA-1uiyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 LEU A 417
LEU A 447
ALA A 449
ALA A 450
 None
 0.67A 6a7jA-1ulvA:
undetectable		 6a7jA-1ulvA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 LEU A 208
ALA A 211
ALA A 212
THR A 216
 None
 0.72A 6a7jA-1upxA:
undetectable		 6a7jA-1upxA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		4 LEU A  32
ALA A  34
ALA A  35
THR A 258
 None
 0.77A 6a7jA-1vsgA:
undetectable		 6a7jA-1vsgA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 297
PHE A 320
LEU A 332
ALA A 328
 None
 0.88A 6a7jA-1wp9A:
undetectable		 6a7jA-1wp9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 623
LEU A 637
ALA A 682
ALA A 683
 None
 0.86A 6a7jA-1xm9A:
undetectable		 6a7jA-1xm9A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzv HYPOTHETICAL PROTEIN

(Trypanosoma
cruzi) 		PF00857
(Isochorismatase) 		4 LEU A 151
LEU A 117
ALA A 120
ALA A 121
 None
 0.89A 6a7jA-1yzvA:
undetectable		 6a7jA-1yzvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz2 CYANOGLOBIN

(Synechocystis
sp. PCC 6803) 		PF01152
(Bac_globin) 		4 LEU A  95
LEU A  91
ALA A 112
ALA A  54
 None
 0.85A 6a7jA-2hz2A:
undetectable		 6a7jA-2hz2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		4 LEU A  47
ALA A  66
ALA A  67
THR A  71
 None
 0.81A 6a7jA-2i7gA:
undetectable		 6a7jA-2i7gA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 LEU 1 628
PHE 1 217
ALA 1 212
THR 1 587
 None
 0.88A 6a7jA-2ijd1:
undetectable		 6a7jA-2ijd1:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 LEU A 298
LEU A 327
ALA A 217
THR A 229
 None
 0.78A 6a7jA-2iw1A:
undetectable		 6a7jA-2iw1A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6r HEAD-TO-TAIL JOINING
PROTEIN W (GPW) FROM
BACTERIOPHAGE ORIGIN

(Escherichia
virus Lambda) 		PF02831
(gpW) 		4 LEU A  50
LEU A   7
ALA A   9
ALA A  10
 None
 0.79A 6a7jA-2l6rA:
undetectable		 6a7jA-2l6rA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0y TRANSCRIPTIONAL
REGULATOR

(Rhodococcus sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 LEU A 148
LEU A 158
ALA A 160
ALA A 161
 None
 0.69A 6a7jA-2o0yA:
undetectable		 6a7jA-2o0yA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE

(Escherichia
coli) 		PF03308
(ArgK) 		4 LEU A  22
LEU A  14
ALA A 144
THR A  54
 None
 0.84A 6a7jA-2p67A:
undetectable		 6a7jA-2p67A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 LEU A  19
LEU A  24
ALA A  26
ALA A  27
 None
CYC  B1153 (-4.1A)
None
None
 0.75A 6a7jA-2vmlA:
undetectable		 6a7jA-2vmlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wui TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 LEU A  17
ALA A  19
ALA A  20
THR A  32
 None
 0.81A 6a7jA-2wuiA:
undetectable		 6a7jA-2wuiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 LEU A 321
ALA A 266
ALA A 265
THR A 257
 None
 0.89A 6a7jA-2xhgA:
undetectable		 6a7jA-2xhgA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 LEU A 288
ALA A 291
ALA A 292
THR A 296
 None
 0.62A 6a7jA-2xuzA:
undetectable		 6a7jA-2xuzA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 134
PHE A  99
LEU A   4
ALA A  20
 None
 0.78A 6a7jA-2yquA:
undetectable		 6a7jA-2yquA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 LEU A 137
LEU A 135
ALA A 126
ALA A 125
 None
 0.68A 6a7jA-2zwvA:
undetectable		 6a7jA-2zwvA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 LEU A  86
ALA A  62
ALA A  61
THR A  54
 None
 0.70A 6a7jA-3b1fA:
undetectable		 6a7jA-3b1fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		4 LEU A 466
ALA A  49
ALA A  50
THR A  54
 None
 0.84A 6a7jA-3b98A:
26.4		 6a7jA-3b98A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 LEU A 154
ALA A 156
ALA A 157
THR A  69
 None
 0.70A 6a7jA-3bolA:
undetectable		 6a7jA-3bolA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 LEU A 107
LEU A  51
ALA A  73
ALA A  72
 None
 0.75A 6a7jA-3ed3A:
undetectable		 6a7jA-3ed3A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME

(Bacillus
subtilis) 		PF00067
(p450) 		4 LEU B 230
ALA B 234
THR B 238
THR B 281
 HEM  B 405 ( 4.6A)
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
HEM  B 405 (-4.1A)
 0.64A 6a7jA-3ejbB:
44.0		 6a7jA-3ejbB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 LEU A 103
LEU A   3
ALA A   6
ALA A   7
 None
 0.79A 6a7jA-3g5aA:
undetectable		 6a7jA-3g5aA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 LEU A 201
LEU A 197
ALA A 191
THR A 213
 None
 0.67A 6a7jA-3gafA:
undetectable		 6a7jA-3gafA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		4 LEU A 180
ALA A  53
ALA A  54
THR A  77
 None
 0.83A 6a7jA-3it7A:
undetectable		 6a7jA-3it7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 LEU A 321
LEU A 101
ALA A 104
ALA A  90
 None
 0.89A 6a7jA-3jz4A:
undetectable		 6a7jA-3jz4A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 LEU A1163
LEU A1168
ALA A1170
ALA A1171
 None
 0.88A 6a7jA-3kg9A:
undetectable		 6a7jA-3kg9A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 LEU A 334
PHE A 441
LEU A 327
ALA A 330
 None
 0.88A 6a7jA-3m6xA:
undetectable		 6a7jA-3m6xA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgl SULFATE PERMEASE
FAMILY PROTEIN

(Vibrio cholerae) 		PF01740
(STAS) 		4 LEU A 475
LEU A 447
ALA A 455
ALA A 456
 None
 0.81A 6a7jA-3mglA:
undetectable		 6a7jA-3mglA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		4 ALA B  73
ALA B  72
THR B  49
THR B  53
 None
 0.75A 6a7jA-3ph2B:
undetectable		 6a7jA-3ph2B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU C  36
LEU C  41
ALA C  43
ALA C  44
 None
 0.73A 6a7jA-3q9nC:
undetectable		 6a7jA-3q9nC:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 LEU A  98
LEU A 252
ALA A 256
THR A 260
 HEM  A 501 (-4.1A)
HEM  A 501 ( 4.5A)
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
 0.74A 6a7jA-3r9bA:
44.0		 6a7jA-3r9bA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqb UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF13622
(4HBT_3) 		4 LEU A  62
LEU A  46
ALA A  48
ALA A  49
 None
 0.80A 6a7jA-3rqbA:
undetectable		 6a7jA-3rqbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6d PHOTOSYNTHETIC
REACTION CENTER
M-SUBUNIT

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 LEU M 212
ALA M 215
ALA M 216
THR M 220
 MQ9  M 501 (-4.7A)
None
MQ9  M 501 ( 4.1A)
MQ9  M 501 (-3.5A)
 0.48A 6a7jA-3t6dM:
undetectable		 6a7jA-3t6dM:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 LEU A 942
LEU A 873
ALA A 875
ALA A 876
 None
 0.89A 6a7jA-3ummA:
undetectable		 6a7jA-3ummA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		4 LEU A 116
LEU A  89
ALA A  91
ALA A  92
 None
 0.75A 6a7jA-3vcoA:
undetectable		 6a7jA-3vcoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		4 PHE A  98
LEU A 240
ALA A 149
THR A 211
 HEM  A 501 (-3.7A)
None
None
None
 0.89A 6a7jA-3vooA:
32.0		 6a7jA-3vooA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A  54
ALA A  56
ALA A  57
THR A  67
 None
 0.89A 6a7jA-3vrbA:
undetectable		 6a7jA-3vrbA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  63
LEU A 114
ALA A 117
ALA A 118
 None
 0.77A 6a7jA-3zo9A:
undetectable		 6a7jA-3zo9A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 LEU A 210
LEU A 223
ALA A 226
THR A 231
 None
 0.59A 6a7jA-4d2iA:
undetectable		 6a7jA-4d2iA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb7 NIFU PROTEIN
(NIFU-1)

(Archaeoglobus
fulgidus) 		PF01592
(NifU_N) 		4 PHE C   7
ALA C  59
ALA C  60
THR C  64
 None
 0.78A 6a7jA-4eb7C:
undetectable		 6a7jA-4eb7C:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 LEU A 471
PHE A 531
THR A 365
THR A 527
 None
None
GOL  A 627 ( 4.1A)
None
 0.72A 6a7jA-4epsA:
undetectable		 6a7jA-4epsA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 LEU A  74
LEU A  97
ALA A  99
ALA A 100
 None
 0.85A 6a7jA-4fwtA:
undetectable		 6a7jA-4fwtA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb5 ENGINEERED PROTEIN

(synthetic
construct) 		PF12796
(Ank_2) 		4 LEU A  24
LEU A   8
ALA A  11
ALA A  12
 None
 0.88A 6a7jA-4hb5A:
undetectable		 6a7jA-4hb5A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		4 PHE A 179
ALA A 243
ALA A 244
THR A 248
 STR  A 501 (-4.0A)
STR  A 501 ( 3.7A)
HEM  A 502 (-3.2A)
HEM  A 502 ( 3.4A)
 0.26A 6a7jA-4j6cA:
58.6		 6a7jA-4j6cA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 LEU A 384
ALA A  85
ALA A  86
THR A  93
 None
 0.75A 6a7jA-4js5A:
undetectable		 6a7jA-4js5A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js7 CELLULOSE BINDING
PROTEIN

(Clavibacter
michiganensis) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		4 ALA A  46
ALA A  47
THR A  50
THR A 101
 None
 0.86A 6a7jA-4js7A:
undetectable		 6a7jA-4js7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  71
LEU A 122
ALA A 125
ALA A 126
 None
None
SO4  A 707 ( 3.9A)
None
 0.82A 6a7jA-4lxfA:
undetectable		 6a7jA-4lxfA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		4 LEU A 469
ALA A 472
ALA A 473
THR A 477
 None
LFA  A 602 ( 4.6A)
None
LFA  A 602 (-3.8A)
 0.57A 6a7jA-4mndA:
undetectable		 6a7jA-4mndA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 LEU A 906
ALA A 909
ALA A 910
THR A 914
 None
 0.56A 6a7jA-4mt1A:
undetectable		 6a7jA-4mt1A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU A 735
ALA A 727
ALA A 728
THR A 774
 None
 0.87A 6a7jA-4p72A:
undetectable		 6a7jA-4p72A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 4 LEU B 212
ALA B 215
ALA B 216
THR B 220
 None
 0.66A 6a7jA-4qezB:
undetectable		 6a7jA-4qezB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		4 LEU A 135
ALA A 138
ALA A 139
THR A 143
 None
 0.64A 6a7jA-4rl1A:
undetectable		 6a7jA-4rl1A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2319
LEU A2303
ALA A2306
ALA A2307
 None
 0.88A 6a7jA-4rlvA:
undetectable		 6a7jA-4rlvA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 203
LEU A 208
ALA A 210
ALA A 211
 None
 0.84A 6a7jA-4rquA:
undetectable		 6a7jA-4rquA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 LEU A2378
LEU A2268
ALA A2271
ALA A2272
 None
 0.81A 6a7jA-4tvcA:
undetectable		 6a7jA-4tvcA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 LEU A  93
LEU A 237
ALA A 241
THR A 245
 HEM  A 501 ( 4.1A)
DIF  A 502 (-4.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.3A)
 0.68A 6a7jA-4ubsA:
29.8		 6a7jA-4ubsA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		4 ALA A 106
ALA A 105
THR A 118
THR A 166
 None
 0.89A 6a7jA-4x2xA:
undetectable		 6a7jA-4x2xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE

(Homo sapiens;
Homo sapiens) 		PF00992
(Troponin)
PF00992
(Troponin)
PF11636
(Troponin-I_N) 		4 LEU B 224
LEU B 229
ALA B 233
ALA C  97
 None
 0.88A 6a7jA-4y99B:
undetectable		 6a7jA-4y99B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE

(Homo sapiens;
Homo sapiens) 		PF00992
(Troponin)
PF00992
(Troponin)
PF11636
(Troponin-I_N) 		4 LEU C  88
LEU C  93
ALA C  97
ALA B 233
 None
 0.89A 6a7jA-4y99C:
undetectable		 6a7jA-4y99C:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 PHE A  80
LEU A  22
ALA A  48
ALA A  49
 None
 0.83A 6a7jA-4zadA:
undetectable		 6a7jA-4zadA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9t PUTATIVE
DEHYDROGENASE

(Amycolatopsis
orientalis) 		PF03446
(NAD_binding_2) 		4 LEU A  75
LEU A  69
ALA A  11
THR A   9
 None
 0.83A 6a7jA-5a9tA:
undetectable		 6a7jA-5a9tA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		4 LEU A 112
ALA A 217
ALA A 216
THR A 121
 None
 0.84A 6a7jA-5b7nA:
undetectable		 6a7jA-5b7nA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B

(Bacillus
subtilis) 		PF02386
(TrkH) 		4 LEU I  51
ALA I  54
ALA I  55
THR I  59
 None
 0.64A 6a7jA-5butI:
undetectable		 6a7jA-5butI:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		4 LEU A 162
ALA A 165
ALA A 166
THR A 170
 None
 0.53A 6a7jA-5ci5A:
undetectable		 6a7jA-5ci5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 4 LEU C 311
LEU C 315
ALA C 122
ALA C  98
 None
 0.89A 6a7jA-5cw2C:
undetectable		 6a7jA-5cw2C:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		4 LEU A 336
LEU A 316
ALA A 163
THR A 145
 None
 0.87A 6a7jA-5e4yA:
undetectable		 6a7jA-5e4yA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE

(Micromonospora
griseorubida) 		PF00067
(p450) 		5 LEU A  80
LEU A 223
ALA A 226
ALA A 227
THR A 231
 HEM  A 413 ( 3.7A)
MY8  A 414 (-4.0A)
MY8  A 414 ( 3.9A)
HEM  A 413 ( 3.7A)
HEM  A 413 (-3.6A)
 0.72A 6a7jA-5foiA:
43.7		 6a7jA-5foiA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 LEU B 523
ALA B 525
ALA B 526
THR B 627
 None
 0.89A 6a7jA-5fuuB:
undetectable		 6a7jA-5fuuB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 PHE C  65
ALA C 248
ALA C 247
THR C 254
 None
PLP  C 501 (-3.1A)
None
None
 0.87A 6a7jA-5gp4C:
undetectable		 6a7jA-5gp4C:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 LEU A 329
ALA A 224
THR A 149
THR A 131
 None
 0.85A 6a7jA-5j84A:
undetectable		 6a7jA-5j84A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jff PROBABLE ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FIC

(Escherichia
coli) 		PF02661
(Fic) 		4 LEU A  32
ALA A  35
ALA A  36
THR A  40
 None
None
CL  B 101 ( 4.0A)
CL  B 101 ( 4.8A)
 0.62A 6a7jA-5jffA:
undetectable		 6a7jA-5jffA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LEU A 335
LEU A 244
ALA A 278
ALA A 279
 None
 0.87A 6a7jA-5jjuA:
undetectable		 6a7jA-5jjuA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 LEU A 413
ALA A 350
THR A 354
THR A 635
 None
MAN  A 708 ( 3.3A)
None
MAN  A 709 (-3.1A)
 0.85A 6a7jA-5kkbA:
undetectable		 6a7jA-5kkbA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A 156
LEU A 130
ALA A 132
ALA A 133
 NDP  A 702 (-4.7A)
None
None
None
 0.78A 6a7jA-5t0lA:
undetectable		 6a7jA-5t0lA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz6 CURJ

(Moorea
producens) 		PF14765
(PS-DH) 		4 LEU A 994
ALA A 997
ALA A 998
THR A1002
 None
 0.81A 6a7jA-5tz6A:
undetectable		 6a7jA-5tz6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 LEU 2 553
LEU 2 605
ALA 2 566
THR 6 671
 None
 0.87A 6a7jA-5udb2:
undetectable		 6a7jA-5udb2:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 4 LEU A 263
LEU A 259
ALA A 232
ALA A 231
 None
 0.87A 6a7jA-5w7kA:
undetectable		 6a7jA-5w7kA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 LEU A  97
ALA A 100
ALA A 101
THR A 105
 None
 0.82A 6a7jA-5wmmA:
undetectable		 6a7jA-5wmmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 4 PHE E  22
LEU E  60
ALA E  62
ALA E  63
 ADP  E1001 (-3.3A)
None
None
None
 0.78A 6a7jA-5x06E:
undetectable		 6a7jA-5x06E:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		4 LEU A 183
ALA A 186
ALA A 187
THR A 251
 None
 0.88A 6a7jA-5y79A:
undetectable		 6a7jA-5y79A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 4 LEU A 103
LEU A 256
ALA A 260
THR A 264
 HEM  A 501 ( 4.2A)
HEM  A 501 ( 4.8A)
HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
 0.57A 6a7jA-6bldA:
40.2		 6a7jA-6bldA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 4 LEU A  88
LEU A  96
ALA A 142
THR A 160
 None
None
SAH  A 501 ( 4.7A)
SAH  A 501 ( 4.8A)
 0.79A 6a7jA-6gkvA:
undetectable		 6a7jA-6gkvA:
23.60