SIMILAR PATTERNS OF AMINO ACIDS FOR 6A60_D_9CRD501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE


(Escherichia
coli)
PF00809
(Pterin_bind)
5 ILE A 254
ALA A 246
ALA A 251
LEU A 214
ILE A  54
None
1.06A 6a60D-1ajzA:
undetectable
6a60D-1ajzA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8)
PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C)
5 ALA C 200
ALA C 199
LEU C 228
ALA C 238
LEU C 162
None
1.00A 6a60D-1g3nC:
undetectable
6a60D-1g3nC:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster)
PF00104
(Hormone_recep)
5 LEU A 322
ILE A 385
CYH A 472
HIS A 475
LEU A 476
LPP  A   1 ( 4.8A)
None
LPP  A   1 ( 4.2A)
None
LPP  A   1 (-4.2A)
0.55A 6a60D-1hg4A:
24.7
6a60D-1hg4A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
5 ILE A 428
ALA A 388
LEU A 441
ILE A 455
LEU A 486
None
0.99A 6a60D-1j0hA:
undetectable
6a60D-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3s HYPOTHETICAL PROTEIN
YCKF


(Bacillus
subtilis)
PF01380
(SIS)
5 ILE A  39
ALA A  55
ILE A 107
HIS A  32
LEU A  29
None
1.01A 6a60D-1m3sA:
undetectable
6a60D-1m3sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
5 ALA A 268
ALA A 267
GLN A 269
ILE A 257
LEU A 246
None
1.01A 6a60D-1mu2A:
undetectable
6a60D-1mu2A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI


(Escherichia
coli)
PF01784
(NIF3)
6 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
None
0.79A 6a60D-1nmoA:
undetectable
6a60D-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1


(Elephantulus
edwardii)
PF00171
(Aldedh)
5 ALA A 170
LEU A 174
ALA A 194
ILE A  95
CYH A 125
None
None
NAD  A1501 (-4.1A)
None
None
1.01A 6a60D-1o9jA:
undetectable
6a60D-1o9jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on0 YYCN PROTEIN

(Bacillus
subtilis)
PF00583
(Acetyltransf_1)
5 ILE A   3
ALA A 112
LEU A  76
ALA A 116
LEU A  96
None
None
None
None
SO4  A 401 (-4.8A)
1.03A 6a60D-1on0A:
undetectable
6a60D-1on0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE


(Pseudomonas
aeruginosa)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ILE A 324
ALA A  66
ALA A  67
GLN A  70
LEU A  50
None
1.04A 6a60D-1ortA:
undetectable
6a60D-1ortA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psz PROTEIN (SURFACE
ANTIGEN PSAA)


(Streptococcus
pneumoniae)
PF01297
(ZnuA)
5 ILE A  42
GLN A 157
LEU A  84
ILE A  59
LEU A  56
None
1.05A 6a60D-1pszA:
undetectable
6a60D-1pszA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN
(SUBUNIT S5)


(Bordetella
pertussis)
PF09276
(Pertus-S5-tox)
5 ILE F  70
ALA F  60
LEU F  15
ALA F  65
LEU F  86
None
0.99A 6a60D-1ptoF:
undetectable
6a60D-1ptoF:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF04107
(GCS2)
5 ILE A  83
ALA A  86
ALA A  87
LEU A  92
ALA A  40
None
0.99A 6a60D-1tt4A:
undetectable
6a60D-1tt4A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE


(Thermus
thermophilus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A   6
LEU A 133
ALA A  68
HIS A 121
LEU A 117
None
None
None
GOL  A 402 ( 4.6A)
None
1.03A 6a60D-1ub7A:
undetectable
6a60D-1ub7A:
15.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 339
ALA A 342
ALA A 343
GLN A 346
LEU A 380
PHE A 384
ARG A 387
ALA A 398
ILE A 416
CYH A 503
HIS A 506
LEU A 507
MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
MEI  A1001 (-4.0A)
None
MEI  A1001 (-4.6A)
0.65A 6a60D-1uhlA:
35.6
6a60D-1uhlA:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG


(Bacillus
subtilis)
PF05343
(Peptidase_M42)
5 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
None
0.96A 6a60D-1vheA:
undetectable
6a60D-1vheA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)


(Mus musculus)
PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer)
5 ILE B 494
ALA B 497
ALA B 498
GLN B 501
LEU B 451
None
1.05A 6a60D-1vkxB:
undetectable
6a60D-1vkxB:
14.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata)
PF00104
(Hormone_recep)
12 ILE A 242
ALA A 245
ALA A 246
GLN A 249
LEU A 283
PHE A 287
ARG A 290
ALA A 301
ILE A 319
CYH A 406
HIS A 409
LEU A 410
9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
0.35A 6a60D-1xiuA:
32.3
6a60D-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
0.40A 6a60D-1xlsA:
35.0
6a60D-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 452
ALA A 451
GLN A 453
ALA A 435
ILE A 418
None
None
GOL  A3003 ( 3.8A)
None
None
1.01A 6a60D-1zk7A:
undetectable
6a60D-1zk7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE


(Klebsiella
aerogenes)
PF00144
(Beta-lactamase)
5 ALA A 163
ALA A 164
LEU A 174
ALA A  78
ILE A 225
None
0.84A 6a60D-1zkjA:
undetectable
6a60D-1zkjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A  57
ALA A  58
LEU A   5
ALA A  29
LEU A 171
None
0.85A 6a60D-2dpnA:
undetectable
6a60D-2dpnA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fow RIBOSOMAL PROTEIN
L11


(Geobacillus
stearothermophilus)
PF00298
(Ribosomal_L11)
5 ILE A  56
ALA A  58
ALA A  59
LEU A  51
ALA A  54
None
1.06A 6a60D-2fowA:
undetectable
6a60D-2fowA:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A  88
PHE A  92
ARG A  95
ALA A 106
ILE A 124
CYH A 211
None
0.67A 6a60D-2gl8A:
28.0
6a60D-2gl8A:
77.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc)
5 ILE A  41
ALA A  42
ALA A 277
HIS A 207
LEU A 206
None
1.02A 6a60D-2hg4A:
undetectable
6a60D-2hg4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
5 ILE A  45
ALA A  48
LEU A  79
ALA A  30
ILE A 129
None
0.88A 6a60D-2ntbA:
undetectable
6a60D-2ntbA:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
None
0.97A 6a60D-2nxxA:
25.1
6a60D-2nxxA:
52.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Clostridium
acetobutylicum)
PF08241
(Methyltransf_11)
6 ILE A 125
ALA A 200
ALA A 123
LEU A 117
ILE A  79
CYH A  29
None
None
None
None
GOL  A 213 ( 4.6A)
None
1.35A 6a60D-2p8jA:
undetectable
6a60D-2p8jA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
None
0.89A 6a60D-2ptzA:
undetectable
6a60D-2ptzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred)
5 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
None
0.99A 6a60D-2pziA:
undetectable
6a60D-2pziA:
8.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
6 LEU A 184
PHE A 188
ARG A 191
ALA A 202
ILE A 220
CYH A 307
None
0.71A 6a60D-2q60A:
27.0
6a60D-2q60A:
54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql2 TRANSCRIPTION FACTOR
E2-ALPHA
NEUROGENIC
DIFFERENTIATION
FACTOR 1


(Mus musculus;
Mus musculus)
PF00010
(HLH)
PF00010
(HLH)
5 LEU A 583
ILE B 150
CYH A 569
HIS A 572
LEU A 573
None
1.02A 6a60D-2ql2A:
undetectable
6a60D-2ql2A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens)
PF00144
(Beta-lactamase)
5 ALA A 162
ALA A 163
LEU A 173
ALA A  77
ILE A 224
None
0.91A 6a60D-2qz6A:
undetectable
6a60D-2qz6A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)


(Mycobacterium
tuberculosis)
PF13185
(GAF_2)
6 ALA A 194
ALA A 196
LEU A 170
ALA A 191
ILE A 125
HIS A  93
None
1.44A 6a60D-2w3gA:
undetectable
6a60D-2w3gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00121
(TIM)
6 ILE A 147
ALA A 149
ALA A 151
LEU A 154
ALA A 110
ILE A 208
None
1.48A 6a60D-2x2gA:
undetectable
6a60D-2x2gA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
5 ILE C 247
ALA C 251
ALA C 250
LEU C 232
LEU C 166
None
1.05A 6a60D-2ynmC:
undetectable
6a60D-2ynmC:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea)
PF16499
(Melibiase_2)
5 ILE A  28
ALA A  31
ALA A  32
LEU A  88
ILE A  76
None
0.91A 6a60D-3a5vA:
undetectable
6a60D-3a5vA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE


(Magnetospirillum
magnetotacticum)
PF01408
(GFO_IDH_MocA)
6 ALA A 113
ALA A 112
ALA A 117
ILE A  74
HIS A  81
LEU A 101
None
1.28A 6a60D-3c1aA:
undetectable
6a60D-3c1aA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE


(Thiobacillus
denitrificans)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
5 ALA A 171
LEU A 234
ILE A 166
CYH A 258
LEU A 261
None
1.02A 6a60D-3cr8A:
undetectable
6a60D-3cr8A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 ILE C 195
ALA C 193
GLN C 192
ILE C 262
LEU C 258
None
1.05A 6a60D-3degC:
undetectable
6a60D-3degC:
9.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 (-4.3A)
9CR  A7223 ( 4.7A)
0.62A 6a60D-3dzuA:
34.4
6a60D-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1)
no annotation 5 ILE A 722
ALA A 755
GLN A 752
ILE A 784
LEU A 762
None
1.02A 6a60D-3f95A:
undetectable
6a60D-3f95A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE


(Rhodopseudomonas
palustris)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
5 ILE P 245
ALA P 248
ALA P 249
ILE P  32
LEU P 104
None
None
None
FAD  P 449 ( 4.5A)
None
0.99A 6a60D-3fg2P:
undetectable
6a60D-3fg2P:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 ALA B 339
ALA B 340
GLN B 343
LEU B 295
HIS B 254
None
1.02A 6a60D-3h1lB:
undetectable
6a60D-3h1lB:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Haemophilus
influenzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ILE A 137
ALA A  91
GLN A  93
ALA A  52
ILE A 165
None
1.00A 6a60D-3il3A:
undetectable
6a60D-3il3A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF07470
(Glyco_hydro_88)
5 ILE A 228
ALA A 232
ALA A 230
GLN A 233
LEU A 164
None
0.99A 6a60D-3k11A:
undetectable
6a60D-3k11A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE


(Brucella
abortus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
6 ALA A  51
LEU A  48
ALA A  74
ILE A  20
HIS A  38
LEU A  39
None
1.40A 6a60D-3k5pA:
undetectable
6a60D-3k5pA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 ILE A  76
ALA A  79
ALA A 311
ILE A  67
HIS A  71
None
1.01A 6a60D-3l44A:
undetectable
6a60D-3l44A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens)
PF04777
(Evr1_Alr)
5 ALA A 418
ALA A 419
GLN A 421
ALA A 432
LEU A 528
None
1.05A 6a60D-3llkA:
undetectable
6a60D-3llkA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE


(Oleispira
antarctica)
PF00857
(Isochorismatase)
5 ALA A 146
ALA A  35
GLN A  38
ALA A 182
ILE A  77
None
1.05A 6a60D-3lqyA:
undetectable
6a60D-3lqyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY


(Ruegeria
pomeroyi)
PF00211
(Guanylate_cyc)
5 ALA A  66
ALA A  67
LEU A   8
ALA A  45
ILE A 102
None
1.02A 6a60D-3mr7A:
undetectable
6a60D-3mr7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY


(Paenarthrobacter
aurescens)
PF04198
(Sugar-bind)
5 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
None
1.02A 6a60D-3nzeA:
undetectable
6a60D-3nzeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01230
(HIT)
6 ILE A  67
ALA A  70
ALA A  71
LEU A  76
ALA A 135
HIS A 101
None
None
None
None
None
AMP  A 155 (-3.8A)
1.22A 6a60D-3o0mA:
undetectable
6a60D-3o0mA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE


(Rhodopseudomonas
palustris)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 ALA A 332
GLN A 329
PHE A 234
ALA A 324
ILE A 340
None
1.04A 6a60D-3pm9A:
undetectable
6a60D-3pm9A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
5 ALA A  77
ALA A  76
ALA A 232
HIS A 347
LEU A 348
None
0.82A 6a60D-3qqvA:
undetectable
6a60D-3qqvA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr8 BASEPLATE ASSEMBLY
PROTEIN V


(Escherichia
virus P2)
PF04717
(Phage_base_V)
5 ILE A  69
ALA A  71
ALA A  79
ILE A  23
CYH A  33
None
1.05A 6a60D-3qr8A:
undetectable
6a60D-3qr8A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE


(Toxoplasma
gondii)
no annotation 5 ILE A 157
ALA A 160
ALA A 161
LEU A 172
HIS A 189
None
1.00A 6a60D-3qyqA:
undetectable
6a60D-3qyqA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187


(Thermus
thermophilus)
no annotation 5 ALA A 164
LEU A  71
ALA A   9
HIS A 153
LEU A 154
None
1.02A 6a60D-3skdA:
undetectable
6a60D-3skdA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14


(Pyrococcus
furiosus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ILE A 206
ALA A 207
ALA A 209
LEU A  74
ARG A 191
None
1.04A 6a60D-3tm5A:
undetectable
6a60D-3tm5A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ALA A 173
ALA A 175
GLN A 174
LEU A  53
ARG A 158
None
1.02A 6a60D-3tmaA:
undetectable
6a60D-3tmaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE


(Eisenia fetida)
PF00759
(Glyco_hydro_9)
6 ALA A 178
ALA A 177
PHE A  87
ALA A  86
ILE A 332
LEU A 280
None
1.05A 6a60D-3wc3A:
undetectable
6a60D-3wc3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
5 ALA A  47
ALA A 103
ILE A  17
CYH A  29
LEU A  33
None
MG  A1255 ( 4.8A)
None
None
None
1.06A 6a60D-3zdbA:
undetectable
6a60D-3zdbA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ILE A 333
ALA A 336
GLN A 340
LEU A 368
ALA A 427
None
0.67A 6a60D-3zyvA:
undetectable
6a60D-3zyvA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF04760
(IF2_N)
5 ILE A 149
ALA A 147
ALA A 173
HIS A  84
LEU A  86
None
1.02A 6a60D-4b43A:
undetectable
6a60D-4b43A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0o PROTEIN ARGONAUTE 5

(Arabidopsis
thaliana)
PF02171
(Piwi)
5 ILE A 629
ALA A 633
ALA A 611
ILE A 653
CYH A 657
None
1.03A 6a60D-4g0oA:
undetectable
6a60D-4g0oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
None
0.90A 6a60D-4g7fA:
undetectable
6a60D-4g7fA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
5 ALA A 366
ALA A 367
LEU A 356
ALA A 401
LEU A 343
None
1.04A 6a60D-4gfjA:
undetectable
6a60D-4gfjA:
8.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 12 ILE D 268
ALA D 271
ALA D 272
GLN D 275
LEU D 309
PHE D 313
ARG D 316
ALA D 327
ILE D 345
CYH D 432
HIS D 435
LEU D 436
None
0.48A 6a60D-4j5xD:
33.8
6a60D-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
None
0.41A 6a60D-4nn1A:
undetectable
6a60D-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A6123
ALA A6124
ALA A6352
HIS A6282
LEU A6281
None
1.03A 6a60D-4opfA:
undetectable
6a60D-4opfA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus)
PF00476
(DNA_pol_A)
5 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
None
1.02A 6a60D-4uqgA:
undetectable
6a60D-4uqgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN


(Mycolicibacterium
smegmatis)
no annotation 5 ILE A  71
ALA A  74
ALA A  75
LEU A   9
HIS A  17
None
0.84A 6a60D-4wj1A:
undetectable
6a60D-4wj1A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728)
PF01261
(AP_endonuc_2)
6 ILE A 231
ALA A 232
ALA A 234
GLN A 233
LEU A 199
HIS A 242
None
1.49A 6a60D-4xiaA:
undetectable
6a60D-4xiaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum)
PF13432
(TPR_16)
5 ILE A  46
ALA A  49
ALA A  50
LEU A  74
ALA A  37
None
0.88A 6a60D-4ynvA:
undetectable
6a60D-4ynvA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A


(Betula pendula)
PF00407
(Bet_v_1)
5 ALA A 146
LEU A  29
PHE A  30
ILE A 102
LEU A  18
None
0.81A 6a60D-4z3lA:
undetectable
6a60D-4z3lA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA


(Staphylococcus
aureus)
PF00291
(PALP)
6 ILE A  80
ALA A  81
ALA A  83
LEU A  93
ALA A  51
ILE A 101
None
1.48A 6a60D-5d86A:
undetectable
6a60D-5d86A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 ILE A  15
ALA A  18
ALA A  19
ALA A  39
HIS A  56
None
0.97A 6a60D-5dajA:
undetectable
6a60D-5dajA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602)
no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
None
0.98A 6a60D-5gt5A:
undetectable
6a60D-5gt5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII


(Escherichia
coli)
no annotation 5 ILE C  30
ALA C  46
GLN C  49
PHE C  27
LEU C  35
None
0.95A 6a60D-5j5vC:
undetectable
6a60D-5j5vC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8


(Clostridioides
difficile)
PF04122
(CW_binding_2)
6 ILE A 584
ALA A 585
ALA A 588
LEU A 559
ILE A 552
LEU A 577
None
SO4  A 705 (-3.8A)
None
None
None
None
1.49A 6a60D-5j6qA:
undetectable
6a60D-5j6qA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE


(Myxococcus
xanthus)
PF00378
(ECH_1)
5 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
None
1.02A 6a60D-5jbwA:
undetectable
6a60D-5jbwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans)
PF01997
(Translin)
5 ALA B  59
GLN B  62
LEU B  80
ILE B  37
LEU B  87
None
1.01A 6a60D-5jr9B:
undetectable
6a60D-5jr9B:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
5 ALA A 878
ALA A 877
LEU A 876
ALA A 974
ILE A 935
None
0.92A 6a60D-5mzaA:
undetectable
6a60D-5mzaA:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 7 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
ALA A 327
ILE A 428
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
1.46A 6a60D-5uanA:
34.5
6a60D-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 11 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
0.59A 6a60D-5uanA:
34.5
6a60D-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 11 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
LEU A 436
9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
0.69A 6a60D-5uanA:
34.5
6a60D-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN


(Ruminiclostridium
thermocellum)
PF11969
(DcpS_C)
5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
None
0.88A 6a60D-5uvmA:
undetectable
6a60D-5uvmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4a GLYCOSYLTRANSFERASE
(DUF1792)


(Streptococcus
sanguinis)
PF08759
(GT-D)
5 ILE A 183
ALA A 186
LEU A 144
ALA A 269
LEU A 211
None
1.04A 6a60D-5v4aA:
undetectable
6a60D-5v4aA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus)
no annotation 5 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
None
0.92A 6a60D-5xnzA:
undetectable
6a60D-5xnzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L22


(Mycolicibacterium
smegmatis)
PF00237
(Ribosomal_L22)
5 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
None
0.96A 6a60D-5xymS:
undetectable
6a60D-5xymS:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L22


(Mycolicibacterium
smegmatis)
PF00237
(Ribosomal_L22)
6 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ALA S  10
ILE S  42
None
1.16A 6a60D-5xymS:
undetectable
6a60D-5xymS:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-)
no annotation 5 ALA A 256
ALA A 255
LEU A 251
PHE A 252
LEU A  28
None
1.01A 6a60D-5zmyA:
undetectable
6a60D-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Campylobacter
jejuni)
no annotation 5 ILE A 184
ALA A 182
LEU A 140
ALA A 177
ILE A  54
None
1.05A 6a60D-6bmaA:
undetectable
6a60D-6bmaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE


(Staphylococcus
aureus)
no annotation 5 ILE A 185
ALA A 189
GLN A 191
ILE A 117
LEU A 170
None
1.05A 6a60D-6c4rA:
undetectable
6a60D-6c4rA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 ILE A 129
ALA A 132
ALA A 133
ALA A 266
ILE A 180
None
0.94A 6a60D-6d95A:
undetectable
6a60D-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 ILE A 129
ALA A 132
ALA A 133
LEU A 138
ALA A 266
None
0.90A 6a60D-6d95A:
undetectable
6a60D-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eih 14-3-3 PROTEIN
EPSILON


(Homo sapiens)
no annotation 5 ALA A 145
ALA A 144
ILE A  53
CYH A  97
LEU A 101
None
1.05A 6a60D-6eihA:
undetectable
6a60D-6eihA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 5 ILE A1791
ALA A1794
ALA A1795
LEU A1741
HIS A1781
None
1.04A 6a60D-6ez8A:
undetectable
6a60D-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 5 ILE A1791
ALA A1794
PHE A1736
ILE A1680
HIS A1781
None
0.99A 6a60D-6ez8A:
undetectable
6a60D-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A


(Escherichia
coli;
Homo sapiens)
no annotation 5 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
None
0.98A 6a60D-6gdgA:
undetectable
6a60D-6gdgA:
17.11