SIMILAR PATTERNS OF AMINO ACIDS FOR 6A5Z_L_9CRL501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 387
ALA A 357
LEU A 383
ALA A 384
ILE A 310
 None
 0.97A 6a5zL-1dabA:
undetectable		 6a5zL-1dabA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A  37
ALA A  34
LEU A  97
ALA A  96
LEU A 234
 None
 0.96A 6a5zL-1e19A:
undetectable		 6a5zL-1e19A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emy MYOGLOBIN

(Elephas maximus) 		PF00042
(Globin) 		5 ILE A 107
ALA A 110
PHE A  29
LEU A  32
LEU A  72
 HEM  A 154 ( 3.9A)
None
CYN  A 155 ( 4.9A)
None
HEM  A 154 ( 4.3A)
 0.95A 6a5zL-1emyA:
undetectable		 6a5zL-1emyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.92A 6a5zL-1fc4A:
undetectable		 6a5zL-1fc4A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 LEU A 366
ILE A 385
CYH A 472
HIS A 475
LEU A 476
 LPP  A   1 ( 4.4A)
None
LPP  A   1 ( 4.2A)
None
LPP  A   1 (-4.2A)
 0.74A 6a5zL-1hg4A:
24.9		 6a5zL-1hg4A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.78A 6a5zL-1j0hA:
undetectable		 6a5zL-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 ALA A 268
ALA A 267
GLN A 269
ILE A 257
LEU A 246
 None
 0.92A 6a5zL-1mu2A:
undetectable		 6a5zL-1mu2A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		6 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
 None
 0.79A 6a5zL-1nmoA:
undetectable		 6a5zL-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 0.96A 6a5zL-1przA:
undetectable		 6a5zL-1przA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 ARG A 297
LEU A 325
ILE A 344
HIS A 434
LEU A 435
 None
None
EPH  A4000 ( 4.1A)
None
EPH  A4000 ( 4.6A)
 0.77A 6a5zL-1r20A:
24.3		 6a5zL-1r20A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
ILE A 416
CYH A 503
HIS A 506
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
None
MEI  A1001 (-4.0A)
None
MEI  A1001 (-4.6A)
 0.65A 6a5zL-1uhlA:
35.4		 6a5zL-1uhlA:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.92A 6a5zL-1ukwA:
undetectable		 6a5zL-1ukwA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
 None
 0.89A 6a5zL-1vheA:
undetectable		 6a5zL-1vheA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		6 ALA A 155
ALA A  43
ALA A 141
ILE A 286
HIS A 332
LEU A 336
 None
 1.43A 6a5zL-1x9eA:
undetectable		 6a5zL-1x9eA:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
GLN A 249
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 319
CYH A 406
HIS A 409
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
 0.40A 6a5zL-1xiuA:
32.3		 6a5zL-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
 0.34A 6a5zL-1xlsA:
34.7		 6a5zL-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		6 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
HIS U 373
 None
 1.40A 6a5zL-1z5xU:
22.6		 6a5zL-1z5xU:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.86A 6a5zL-1zk7A:
undetectable		 6a5zL-1zk7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
 None
 0.76A 6a5zL-2fv2A:
undetectable		 6a5zL-2fv2A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A  92
ARG A  95
LEU A 105
ALA A 106
ILE A 124
CYH A 211
 None
 0.73A 6a5zL-2gl8A:
28.2		 6a5zL-2gl8A:
77.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ILE A  41
ALA A  42
ALA A 277
HIS A 207
LEU A 206
 None
 0.96A 6a5zL-2hg4A:
undetectable		 6a5zL-2hg4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		5 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 0.95A 6a5zL-2istA:
undetectable		 6a5zL-2istA:
12.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.77A 6a5zL-2nxxA:
25.2		 6a5zL-2nxxA:
52.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.94A 6a5zL-2oi2A:
undetectable		 6a5zL-2oi2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
ILE A 132
 None
 0.85A 6a5zL-2p6wA:
undetectable		 6a5zL-2p6wA:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		5 PHE A 188
ARG A 191
ALA A 202
ILE A 220
CYH A 307
 None
 0.59A 6a5zL-2q60A:
26.9		 6a5zL-2q60A:
54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.97A 6a5zL-2q8wA:
undetectable		 6a5zL-2q8wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
 None
 0.95A 6a5zL-2xaxA:
undetectable		 6a5zL-2xaxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
LEU A 328
 None
 0.97A 6a5zL-2xgoA:
undetectable		 6a5zL-2xgoA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.96A 6a5zL-3afgA:
undetectable		 6a5zL-3afgA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ILE B  11
GLN B  14
LEU B 196
ALA B 195
ILE B 119
 None
 0.97A 6a5zL-3al0B:
undetectable		 6a5zL-3al0B:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 ALA C 146
ALA C 145
ILE C  54
CYH C  98
LEU C 102
 None
 0.97A 6a5zL-3axyC:
undetectable		 6a5zL-3axyC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE

(Magnetospirillum
magnetotacticum) 		PF01408
(GFO_IDH_MocA) 		6 ALA A 113
ALA A 112
ALA A 117
ILE A  74
HIS A  81
LEU A 101
 None
 1.28A 6a5zL-3c1aA:
undetectable		 6a5zL-3c1aA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
 None
 0.88A 6a5zL-3d0qA:
undetectable		 6a5zL-3d0qA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.84A 6a5zL-3d8uA:
undetectable		 6a5zL-3d8uA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 (-4.3A)
9CR  A7223 ( 4.7A)
 0.68A 6a5zL-3dzuA:
34.0		 6a5zL-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ILE P 245
ALA P 248
ALA P 249
ILE P  32
LEU P 104
 None
None
None
FAD  P 449 ( 4.5A)
None
 0.95A 6a5zL-3fg2P:
undetectable		 6a5zL-3fg2P:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.93A 6a5zL-3h5kA:
undetectable		 6a5zL-3h5kA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
 None
 0.73A 6a5zL-3hveA:
undetectable		 6a5zL-3hveA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.73A 6a5zL-3hveA:
undetectable		 6a5zL-3hveA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
 None
 0.77A 6a5zL-3hveB:
undetectable		 6a5zL-3hveB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
 None
 0.90A 6a5zL-3hveB:
undetectable		 6a5zL-3hveB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.89A 6a5zL-3ic5A:
undetectable		 6a5zL-3ic5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 ILE A 228
ALA A 232
ALA A 230
GLN A 233
LEU A 164
 None
 0.94A 6a5zL-3k11A:
undetectable		 6a5zL-3k11A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp6 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Mycobacterium
tuberculosis) 		PF00731
(AIRC) 		6 ILE A  66
ALA A  58
ALA A  55
LEU A  63
ALA A  59
LEU A  76
 None
None
None
None
None
FMT  A 177 ( 4.2A)
 1.46A 6a5zL-3lp6A:
undetectable		 6a5zL-3lp6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.81A 6a5zL-3msuA:
undetectable		 6a5zL-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		6 ILE A 246
ALA A 312
PHE A 276
LEU A 252
ALA A 263
HIS A 296
 None
 1.44A 6a5zL-3nk4A:
undetectable		 6a5zL-3nk4A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 5 ILE A  77
ALA A  80
PHE A 130
LEU A 133
ALA A 132
 None
 0.89A 6a5zL-3nkuA:
2.9		 6a5zL-3nkuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY

(Paenarthrobacter
aurescens) 		PF04198
(Sugar-bind) 		5 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
 None
 0.92A 6a5zL-3nzeA:
undetectable		 6a5zL-3nzeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		6 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 0.87A 6a5zL-3o0mA:
undetectable		 6a5zL-3o0mA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens) 		PF05168
(HEPN) 		5 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.87A 6a5zL-3o10A:
undetectable		 6a5zL-3o10A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
 None
 0.94A 6a5zL-3oksA:
undetectable		 6a5zL-3oksA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		5 ILE A 188
ALA A 187
LEU A  49
ILE A 275
LEU A 203
 None
 0.95A 6a5zL-3p8rA:
undetectable		 6a5zL-3p8rA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		6 ILE A 965
GLN A 955
PHE A 956
LEU A1076
ALA A1077
HIS A 986
 None
 1.37A 6a5zL-3poyA:
undetectable		 6a5zL-3poyA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		6 ILE A 949
GLN A 939
PHE A 940
LEU A1060
ALA A1061
HIS A 970
 None
 1.41A 6a5zL-3qcwA:
undetectable		 6a5zL-3qcwA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ALA A  77
ALA A  76
ALA A 232
HIS A 347
LEU A 348
 None
 0.95A 6a5zL-3qqvA:
undetectable		 6a5zL-3qqvA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.97A 6a5zL-3rkoN:
undetectable		 6a5zL-3rkoN:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 0.95A 6a5zL-3s5wA:
undetectable		 6a5zL-3s5wA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 ILE A 540
ALA A 539
GLN A 542
LEU A 541
CYH A 676
LEU A 751
 None
 1.49A 6a5zL-3ui7A:
undetectable		 6a5zL-3ui7A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		6 ILE A 379
ALA A 375
LEU A 313
ALA A 309
ILE A 250
LEU A 407
 None
 1.37A 6a5zL-3vcyA:
undetectable		 6a5zL-3vcyA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		6 ALA A 178
ALA A 177
PHE A  87
ALA A  86
ILE A 332
LEU A 280
 None
 1.02A 6a5zL-3wc3A:
undetectable		 6a5zL-3wc3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.75A 6a5zL-3wxwA:
undetectable		 6a5zL-3wxwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		5 ALA A  47
LEU A  18
ILE A   7
HIS A 154
LEU A 155
 None
 0.96A 6a5zL-3zj0A:
undetectable		 6a5zL-3zj0A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 6a5zL-4b8bA:
undetectable		 6a5zL-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 ILE A 137
ALA A 141
LEU A 150
ILE A 107
LEU A 201
 None
 0.98A 6a5zL-4g7aA:
undetectable		 6a5zL-4g7aA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.69A 6a5zL-4ia4A:
undetectable		 6a5zL-4ia4A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
GLN D 275
PHE D 313
ARG D 316
LEU D 326
ALA D 327
ILE D 345
CYH D 432
HIS D 435
LEU D 436
 None
 0.56A 6a5zL-4j5xD:
33.3		 6a5zL-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ILE A 261
ALA A 264
ALA A 265
LEU A  57
ILE A 249
 None
 0.95A 6a5zL-4mijA:
undetectable		 6a5zL-4mijA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.48A 6a5zL-4nn1A:
undetectable		 6a5zL-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A6123
ALA A6124
ALA A6352
HIS A6282
LEU A6281
 None
 0.97A 6a5zL-4opfA:
undetectable		 6a5zL-4opfA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.79A 6a5zL-4qpnA:
undetectable		 6a5zL-4qpnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		6 ILE A 379
ALA A 375
LEU A 313
ALA A 309
ILE A 250
LEU A 407
 None
 1.34A 6a5zL-4r7uA:
undetectable		 6a5zL-4r7uA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.93A 6a5zL-4rrjA:
undetectable		 6a5zL-4rrjA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		6 ILE A 259
ALA A 320
ALA A 317
ARG A 253
LEU A 256
ILE A 295
 None
 1.47A 6a5zL-4s3nA:
undetectable		 6a5zL-4s3nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
 None
 0.97A 6a5zL-4wtvA:
undetectable		 6a5zL-4wtvA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.40A 6a5zL-4xboA:
undetectable		 6a5zL-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.98A 6a5zL-4xeeA:
undetectable		 6a5zL-4xeeA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ALA A 322
ALA A 321
LEU A 348
ALA A 347
ILE A 398
 None
 0.88A 6a5zL-4xg0A:
undetectable		 6a5zL-4xg0A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		6 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
LEU A 230
 None
 1.08A 6a5zL-4xgjA:
undetectable		 6a5zL-4xgjA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.62A 6a5zL-5bt1A:
undetectable		 6a5zL-5bt1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 ALA A1131
PHE A1155
LEU A1135
ALA A1132
ILE A1080
 None
 0.92A 6a5zL-5eutA:
undetectable		 6a5zL-5eutA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 0.91A 6a5zL-5f2oA:
undetectable		 6a5zL-5f2oA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.94A 6a5zL-5gt5A:
undetectable		 6a5zL-5gt5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		5 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
 None
 0.96A 6a5zL-5i14A:
undetectable		 6a5zL-5i14A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.46A 6a5zL-5lpzA:
undetectable		 6a5zL-5lpzA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		6 ILE A  60
GLN A  63
PHE A  62
LEU A   6
ALA A   7
ILE A 138
 None
 1.40A 6a5zL-5lvaA:
undetectable		 6a5zL-5lvaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.91A 6a5zL-5mzyA:
undetectable		 6a5zL-5mzyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
 None
 0.95A 6a5zL-5n0gA:
undetectable		 6a5zL-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A 196
ALA A  44
ALA A  43
LEU A  49
ILE A 160
 None
None
8F5  A 301 ( 4.1A)
None
None
 0.90A 6a5zL-5n0gA:
undetectable		 6a5zL-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 ILE A   9
LEU A  35
ILE A   5
CYH A 131
HIS A 150
 None
 0.96A 6a5zL-5o8rA:
undetectable		 6a5zL-5o8rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.83A 6a5zL-5ohsA:
undetectable		 6a5zL-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 5 ALA A 150
PHE A 147
ALA A 149
ILE A  89
LEU A  79
 None
 0.96A 6a5zL-5ol0A:
undetectable		 6a5zL-5ol0A:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 8 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.40A 6a5zL-5uanA:
34.4		 6a5zL-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.58A 6a5zL-5uanA:
34.4		 6a5zL-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF06833
(MdcE)
PF01039
(Carboxyl_trans) 		5 ILE A 111
GLN A 113
LEU A 115
ALA A 116
ILE B 189
 None
 0.94A 6a5zL-5vipA:
undetectable		 6a5zL-5vipA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
ILE A 180
 None
 1.05A 6a5zL-6d95A:
undetectable		 6a5zL-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.84A 6a5zL-6euxA:
undetectable		 6a5zL-6euxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 ILE A1791
ALA A1794
PHE A1736
ILE A1680
HIS A1781
 None
 0.96A 6a5zL-6ez8A:
undetectable		 6a5zL-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
 None
 0.92A 6a5zL-6f5oC:
undetectable		 6a5zL-6f5oC:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.91A 6a5zL-6gdgA:
undetectable		 6a5zL-6gdgA:
17.11